Ren (renin) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ren (renin) Chinchilla lanigera
Analyze
Symbol: Ren
Name: renin
RGD ID: 9066599
Description: ENCODES a protein that exhibits aspartic-type endopeptidase activity (ortholog); endopeptidase activity (ortholog); insulin-like growth factor receptor binding (ortholog); INVOLVED IN amyloid-beta metabolic process (ortholog); angiotensin maturation (ortholog); cell maturation (ortholog); PARTICIPATES IN benazepril pharmacodynamics pathway; candesartan pharmacodynamics pathway; captopril pharmacodynamics pathway; ASSOCIATED WITH acute kidney failure (ortholog); Albuminuria (ortholog); anemia (ortholog); FOUND IN apical part of cell (ortholog); cytoplasm (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540640,016,630 - 40,026,286 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540640,016,624 - 40,026,286 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Albuminuria  (ISO)
anemia  (ISO)
atrial fibrillation  (ISO)
autistic disorder  (ISO)
Autosomal Dominant Tubulointerstitial Kidney Disease 4  (ISO)
Azotemia  (ISO)
Bartter disease  (ISO)
Cardiomegaly  (ISO)
chronic fatigue syndrome  (ISO)
colitis  (ISO)
congenital adrenal hyperplasia  (ISO)
congestive heart failure  (ISO)
Critical Illness  (ISO)
Diabetic Nephropathies  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Endotoxemia  (ISO)
essential hypertension  (ISO)
Experimental Diabetes Mellitus  (ISO)
Fetal Growth Retardation  (ISO)
Fibrosis  (ISO)
gastrointestinal stromal tumor  (ISO)
hand, foot and mouth disease  (ISO)
Hemorrhage  (ISO)
hepatoblastoma  (ISO)
human cytomegalovirus infection  (ISO)
hypertension  (ISO)
Hyponatremia  (ISO)
Hypotension  (ISO)
ischemia  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Left Ventricular Hypertrophy  (ISO)
Liddle syndrome  (ISO)
liver cirrhosis  (ISO)
malignant hypertension  (ISO)
mental depression  (ISO)
myocardial infarction  (ISO)
nephrosis  (ISO)
nephrotic syndrome  (ISO)
obesity  (ISO)
osteoporosis  (ISO)
parathyroid carcinoma  (ISO)
periodontal disease  (ISO)
portal hypertension  (ISO)
Preeclamptic Toxemia  (ISO)
primary biliary cholangitis  (ISO)
primary hyperaldosteronism  (ISO)
proteinuria  (ISO)
psoriasis  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
Renal Tubular Dysgenesis  (ISO)
renovascular hypertension  (ISO)
Retina Reperfusion Injury  (ISO)
toxic shock syndrome  (ISO)
withdrawal disorder  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISS annotations to Chinchilla, Squirrel, Bonobo and/or Dog genes from Human gene annotations
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline

Genomics

Comparative Map Data
Ren
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540640,016,630 - 40,026,286 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540640,016,624 - 40,026,286 (-)NCBIChiLan1.0ChiLan1.0
REN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381204,154,819 - 204,166,337 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1204,154,819 - 204,190,324 (-)EnsemblGRCh38hg38GRCh38
GRCh371204,123,947 - 204,135,465 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361202,390,571 - 202,402,088 (-)NCBINCBI36Build 36hg18NCBI36
Build 341200,855,604 - 200,867,122NCBI
Celera1177,259,194 - 177,270,715 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1175,289,120 - 175,300,481 (-)NCBIHuRef
CHM1_11205,547,624 - 205,559,145 (-)NCBICHM1_1
T2T-CHM13v2.01203,418,967 - 203,430,485 (-)NCBIT2T-CHM13v2.0
Ren1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391133,278,412 - 133,288,058 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1133,278,248 - 133,288,063 (+)EnsemblGRCm39 Ensembl
GRCm381133,350,674 - 133,360,320 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1133,350,510 - 133,360,325 (+)EnsemblGRCm38mm10GRCm38
MGSCv371135,247,251 - 135,256,894 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361135,178,238 - 135,187,863 (+)NCBIMGSCv36mm8
Celera1135,963,151 - 135,972,794 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map157.91NCBI
Ren
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21344,796,260 - 44,807,491 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1344,796,091 - 44,807,489 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1347,406,270 - 47,416,579 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01348,694,375 - 48,704,684 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01345,952,438 - 45,963,417 (+)NCBIRnor_WKY
Rnor_6.01350,502,724 - 50,513,953 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1350,502,724 - 50,514,151 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01355,555,583 - 55,566,812 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41346,262,936 - 46,275,213 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11346,277,000 - 46,288,249 (+)NCBI
Celera1345,129,122 - 45,139,889 (+)NCBICelera
RH 3.4 Map13170.9RGD
Cytogenetic Map13q13NCBI
REN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11184,045,917 - 184,057,431 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1184,046,117 - 184,057,393 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01179,757,653 - 179,769,530 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
REN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.138744,540 - 766,998 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl38744,614 - 755,012 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha38840,126 - 850,501 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.038740,693 - 762,325 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl38740,767 - 751,204 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.138736,523 - 746,891 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0381,127,902 - 1,138,260 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0381,328,102 - 1,338,487 (-)NCBIUU_Cfam_GSD_1.0
Ren
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934471,363,409 - 71,373,041 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936567598,044 - 607,628 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
REN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl964,809,146 - 64,822,658 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1964,809,143 - 64,822,605 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2971,147,542 - 71,151,808 (-)NCBISscrofa10.2Sscrofa10.2susScr3
REN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12525,159,816 - 25,193,620 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2525,183,037 - 25,193,420 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605525,943,204 - 25,954,169 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ren
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248076,817,195 - 6,827,462 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248076,817,472 - 6,827,374 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005375286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AGCD01006651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCLAT00000023715   ⟹   ENSCLAP00000023493
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540640,016,630 - 40,026,286 (-)Ensembl
RefSeq Acc Id: XM_005375286   ⟹   XP_005375343
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540640,016,624 - 40,026,286 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005375343 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005375343   ⟸   XM_005375286
- Sequence:
RefSeq Acc Id: ENSCLAP00000023493   ⟸   ENSCLAT00000023715
Protein Domains
Peptidase A1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000016114 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCLAP00000023493 ENTREZGENE
  ENSCLAP00000023493.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000023715 ENTREZGENE
  ENSCLAT00000023715.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.70.10 UniProtKB/TrEMBL
InterPro Aspartic_peptidase_A1 UniProtKB/TrEMBL
  Aspartic_peptidase_AS UniProtKB/TrEMBL
  PEPTIDASE_A1 UniProtKB/TrEMBL
  Peptidase_aspartic_dom_sf UniProtKB/TrEMBL
NCBI Gene Ren ENTREZGENE
PANTHER PTHR47966 UniProtKB/TrEMBL
Pfam Asp UniProtKB/TrEMBL
PRINTS PEPSIN UniProtKB/TrEMBL
PROSITE ASP_PROTEASE UniProtKB/TrEMBL
  PEPTIDASE_A1 UniProtKB/TrEMBL
Superfamily-SCOP SSF50630 UniProtKB/TrEMBL
UniProt A0A8C2W0T1_CHILA UniProtKB/TrEMBL