REN (renin) - Rat Genome Database

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Gene: REN (renin) Canis lupus familiaris
Analyze
Symbol: REN
Name: renin
RGD ID: 12158997
Description: ENCODES a protein that exhibits endopeptidase activity (ortholog); insulin-like growth factor receptor binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN amyloid-beta metabolic process (ortholog); angiotensin maturation (ortholog); cell maturation (ortholog); PARTICIPATES IN benazepril pharmacodynamics pathway; candesartan pharmacodynamics pathway; captopril pharmacodynamics pathway; ASSOCIATED WITH acute kidney failure (ortholog); Albuminuria (ortholog); anemia (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH (R)-noradrenaline; amlodipine; amphotericin B
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: angiotensinogenase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.138744,540 - 766,998 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl38744,614 - 755,012 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha38840,126 - 850,501 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.038740,693 - 762,325 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl38740,767 - 751,204 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.138736,523 - 746,891 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0381,127,902 - 1,138,260 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0381,328,102 - 1,338,487 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Albuminuria  (ISO)
anemia  (ISO)
atrial fibrillation  (ISO)
autistic disorder  (ISO)
Autosomal Dominant Tubulointerstitial Kidney Disease 4  (ISO)
Azotemia  (ISO)
Bartter disease  (ISO)
Cardiomegaly  (ISO)
chronic fatigue syndrome  (ISO)
Chronic Intermittent Hypoxia  (ISO)
colitis  (ISO)
congenital adrenal hyperplasia  (ISO)
congestive heart failure  (ISO)
Critical Illness  (ISO)
depressive disorder  (ISO)
Diabetic Nephropathies  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Endotoxemia  (ISO)
essential hypertension  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial adult myoclonic epilepsy 5  (ISO)
Fetal Growth Retardation  (ISO)
Fibrosis  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
hand, foot and mouth disease  (ISO)
Hemorrhage  (ISO)
hepatoblastoma  (ISO)
human cytomegalovirus infection  (ISO)
hypertension  (ISO)
Hypokalemic Periodic Paralysis, Type 1  (ISO)
Hyponatremia  (ISO)
Hypotension  (ISO)
ischemia  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Left Ventricular Hypertrophy  (ISO)
Liddle syndrome  (ISO)
liver cirrhosis  (ISO)
malignant hypertension  (ISO)
myocardial infarction  (ISO)
nephrosis  (ISO)
nephrotic syndrome  (ISO)
obesity  (ISO)
osteoporosis  (ISO)
parathyroid carcinoma  (ISO)
periodontal disease  (ISO)
portal hypertension  (ISO)
Preeclamptic Toxemia  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
primary biliary cholangitis  (ISO)
primary hyperaldosteronism  (ISO)
proteinuria  (ISO)
psoriasis  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
Renal Tubular Dysgenesis  (ISO)
renovascular hypertension  (ISO)
Retina Reperfusion Injury  (ISO)
toxic shock syndrome  (ISO)
withdrawal disorder  (ISO)

References
Additional References at PubMed
PMID:8855304   PMID:17942478   PMID:19073902   PMID:19930429   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
REN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.138744,540 - 766,998 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl38744,614 - 755,012 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha38840,126 - 850,501 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.038740,693 - 762,325 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl38740,767 - 751,204 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.138736,523 - 746,891 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0381,127,902 - 1,138,260 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0381,328,102 - 1,338,487 (-)NCBIUU_Cfam_GSD_1.0
REN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381204,154,819 - 204,166,337 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1204,154,819 - 204,190,324 (-)EnsemblGRCh38hg38GRCh38
GRCh371204,123,947 - 204,135,465 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361202,390,571 - 202,402,088 (-)NCBINCBI36Build 36hg18NCBI36
Build 341200,855,604 - 200,867,122NCBI
Celera1177,259,194 - 177,270,715 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1175,289,120 - 175,300,481 (-)NCBIHuRef
CHM1_11205,547,624 - 205,559,145 (-)NCBICHM1_1
T2T-CHM13v2.01203,418,967 - 203,430,485 (-)NCBIT2T-CHM13v2.0
Ren1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391133,278,412 - 133,288,058 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1133,278,248 - 133,288,063 (+)EnsemblGRCm39 Ensembl
GRCm381133,350,674 - 133,360,320 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1133,350,510 - 133,360,325 (+)EnsemblGRCm38mm10GRCm38
MGSCv371135,247,251 - 135,256,894 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361135,178,238 - 135,187,863 (+)NCBIMGSCv36mm8
Celera1135,963,151 - 135,972,794 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map157.91NCBI
Ren
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21344,796,260 - 44,807,491 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1344,796,091 - 44,807,489 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1347,406,270 - 47,416,579 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01348,694,375 - 48,704,684 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01345,952,438 - 45,963,417 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01350,502,724 - 50,513,953 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1350,502,724 - 50,514,151 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01355,555,583 - 55,566,812 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41346,262,936 - 46,275,213 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11346,277,000 - 46,288,249 (+)NCBI
Celera1345,129,122 - 45,139,889 (+)NCBICelera
RH 3.4 Map13170.9RGD
Cytogenetic Map13q13NCBI
Ren
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540640,016,630 - 40,026,286 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540640,016,624 - 40,026,286 (-)NCBIChiLan1.0ChiLan1.0
REN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1145,175,312 - 45,186,915 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01179,757,653 - 179,769,530 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11184,045,917 - 184,057,431 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1184,046,117 - 184,057,393 (-)Ensemblpanpan1.1panPan2
Ren
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934471,363,409 - 71,373,041 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936567598,048 - 607,497 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936567598,044 - 607,628 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
REN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl964,809,146 - 64,822,658 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1964,809,143 - 64,822,605 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2971,147,542 - 71,151,808 (-)NCBISscrofa10.2Sscrofa10.2susScr3
REN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12525,159,816 - 25,193,620 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2525,183,037 - 25,193,420 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605525,943,204 - 25,954,169 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ren
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248076,817,195 - 6,827,462 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248076,817,472 - 6,827,374 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in REN
382 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 8 1
Below cutoff 2 1 22 6 5 6 4 12 8 5

Sequence


RefSeq Acc Id: ENSCAFT00000015286   ⟹   ENSCAFP00000014146
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl38744,614 - 755,012 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000088123   ⟹   ENSCAFP00000061818
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl38744,614 - 755,012 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845036641   ⟹   ENSCAFP00845028677
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl38740,767 - 751,204 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845036704   ⟹   ENSCAFP00845028734
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl38740,767 - 751,204 (-)Ensembl
RefSeq Acc Id: NM_001003194   ⟹   NP_001003194
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.138744,614 - 755,012 (-)NCBI
Dog10K_Boxer_Tasha38840,126 - 850,501 (-)NCBI
ROS_Cfam_1.038740,767 - 751,135 (-)NCBI
UMICH_Zoey_3.138736,523 - 746,891 (-)NCBI
UNSW_CanFamBas_1.0381,127,902 - 1,138,260 (-)NCBI
UU_Cfam_GSD_1.0381,328,102 - 1,338,487 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038448122   ⟹   XP_038304050
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.038740,693 - 751,210 (-)NCBI
RefSeq Acc Id: XM_038448123   ⟹   XP_038304051
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.038741,320 - 751,211 (-)NCBI
RefSeq Acc Id: XM_038448124   ⟹   XP_038304052
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.038740,693 - 762,325 (-)NCBI
RefSeq Acc Id: NP_001003194   ⟸   NM_001003194
- Peptide Label: precursor
- UniProtKB: Q6DYE7 (UniProtKB/Swiss-Prot),   A0A8C0K308 (UniProtKB/TrEMBL),   A0A8I3PE23 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000014146   ⟸   ENSCAFT00000015286
RefSeq Acc Id: ENSCAFP00000061818   ⟸   ENSCAFT00000088123
RefSeq Acc Id: XP_038304052   ⟸   XM_038448124
- Peptide Label: isoform X3
- UniProtKB: A0A8C0N006 (UniProtKB/TrEMBL),   A0A8P0PAT1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038304050   ⟸   XM_038448122
- Peptide Label: isoform X1
- UniProtKB: A0A8I3PKY8 (UniProtKB/TrEMBL),   A0A8C0N006 (UniProtKB/TrEMBL),   A0A8P0PAT1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038304051   ⟸   XM_038448123
- Peptide Label: isoform X2
- UniProtKB: A0A8C0N006 (UniProtKB/TrEMBL),   A0A8P0PAT1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845028734   ⟸   ENSCAFT00845036704
RefSeq Acc Id: ENSCAFP00845028677   ⟸   ENSCAFT00845036641
Protein Domains
Peptidase A1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000009623 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00030011832 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00040013534 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00805022704 UniProtKB/Swiss-Prot
  ENSCAFG00845020764 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000015286.5 UniProtKB/Swiss-Prot
  ENSCAFT00000088123.2 UniProtKB/TrEMBL
  ENSCAFT00030022220.1 UniProtKB/TrEMBL
  ENSCAFT00030022244.1 UniProtKB/Swiss-Prot
  ENSCAFT00040025325.1 UniProtKB/TrEMBL
  ENSCAFT00040025395.1 UniProtKB/Swiss-Prot
  ENSCAFT00805040970 UniProtKB/Swiss-Prot
  ENSCAFT00845036641 ENTREZGENE
  ENSCAFT00845036641.1 UniProtKB/TrEMBL
  ENSCAFT00845036704 ENTREZGENE
  ENSCAFT00845036704.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.70.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aspartic_peptidase_A1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aspartic_peptidase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aspartic_peptidase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEPTIDASE_A1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_aspartic_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Renin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403838 UniProtKB/Swiss-Prot
NCBI Gene REN ENTREZGENE
PANTHER PTHR47966 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RENIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam A1_Propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Asp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS PEPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASP_PROTEASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEPTIDASE_A1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
Superfamily-SCOP SSF50630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0K308 ENTREZGENE
  A0A8C0N006 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PE23 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PKY8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PAT1 ENTREZGENE
  Q6DYE7 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0A8P0PAT1 UniProtKB/TrEMBL
VGNC ID VGNC:45474 ENTREZGENE