REN (renin) - Rat Genome Database
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Gene: REN (renin) Canis lupus familiaris
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Symbol: REN
Name: renin
RGD ID: 12158997
Description: ENCODES a protein that exhibits endopeptidase activity (ortholog); insulin-like growth factor receptor binding (ortholog); peptidase activity (ortholog); INVOLVED IN amyloid-beta metabolic process (ortholog); cellular response to drug (ortholog); kidney development (ortholog); PARTICIPATES IN benazepril pharmacodynamics pathway; candesartan pharmacodynamics pathway; captopril pharmacodynamics pathway; ASSOCIATED WITH Albuminuria (ortholog); Allanson Pantzar McLeod Syndrome (ortholog); anemia (ortholog); FOUND IN cytoplasm (ortholog); INTERACTS WITH (R)-noradrenaline; amlodipine; amphotericin B
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: angiotensinogenase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl38744,614 - 755,012 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.138744,540 - 766,998 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:8855304   PMID:17942478   PMID:19073902   PMID:19930429  


Genomics

Comparative Map Data
REN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl38744,614 - 755,012 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.138744,540 - 766,998 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
REN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1204,154,819 - 204,190,324 (-)EnsemblGRCh38hg38GRCh38
GRCh381204,154,819 - 204,166,337 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371204,123,944 - 204,135,465 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361202,390,571 - 202,402,088 (-)NCBINCBI36hg18NCBI36
Build 341200,855,604 - 200,867,122NCBI
Celera1177,259,194 - 177,270,715 (-)NCBI
Cytogenetic Map1q32.1NCBI
HuRef1175,289,120 - 175,300,481 (-)NCBIHuRef
CHM1_11205,547,624 - 205,559,145 (-)NCBICHM1_1
Ren1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391133,278,412 - 133,288,058 (+)NCBIGRCm39mm39
GRCm381133,350,674 - 133,360,320 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1133,350,510 - 133,360,325 (+)EnsemblGRCm38mm10GRCm38
MGSCv371135,247,251 - 135,256,894 (+)NCBIGRCm37mm9NCBIm37
MGSCv361135,178,238 - 135,187,863 (+)NCBImm8
Celera1135,963,151 - 135,972,794 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map157.91NCBI
Ren
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01350,502,724 - 50,513,953 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1350,502,724 - 50,514,151 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01355,555,583 - 55,566,812 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41346,262,936 - 46,275,213 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11346,277,000 - 46,288,249 (+)NCBI
Celera1345,129,122 - 45,139,889 (+)NCBICelera
Cytogenetic Map13q13NCBI
RH 3.4 Map13170.9RGD
Ren
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540640,016,630 - 40,026,286 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540640,016,624 - 40,026,286 (-)NCBIChiLan1.0ChiLan1.0
REN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11184,045,917 - 184,057,431 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1184,046,117 - 184,057,393 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01179,757,653 - 179,769,530 (-)NCBIMhudiblu_PPA_v0panPan3
Ren
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936567598,044 - 607,628 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
REN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl964,809,146 - 64,822,636 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1964,809,143 - 64,822,605 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2971,147,542 - 71,151,808 (-)NCBISscrofa10.2Sscrofa10.2susScr3
REN
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12525,159,816 - 25,193,620 (+)NCBI
ChlSab1.1 Ensembl2525,183,037 - 25,193,420 (+)Ensembl
Ren
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248076,817,472 - 6,827,374 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 8 1
Below cutoff 2 1 22 6 5 6 4 12 8 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000015286   ⟹   ENSCAFP00000014146
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl38744,614 - 755,012 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000088123   ⟹   ENSCAFP00000061818
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl38744,614 - 755,012 (-)Ensembl
RefSeq Acc Id: NM_001003194   ⟹   NP_001003194
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.138744,614 - 755,012 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005640752   ⟹   XP_005640809
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.138744,540 - 755,090 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022415287   ⟹   XP_022270995
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.138744,540 - 766,998 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005640809   ⟸   XM_005640752
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001003194   ⟸   NM_001003194
- Peptide Label: precursor
- UniProtKB: Q6DYE7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_022270995   ⟸   XM_022415287
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCAFP00000014146   ⟸   ENSCAFT00000015286
RefSeq Acc Id: ENSCAFP00000061818   ⟸   ENSCAFT00000088123
Protein Domains
Peptidase A1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000009623 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00030011832 UniProtKB/Swiss-Prot
  ENSCAFG00040013534 UniProtKB/Swiss-Prot
Ensembl Protein ENSCAFP00000014146 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSCAFP00000061818 UniProtKB/TrEMBL
  ENSCAFP00030019403 UniProtKB/Swiss-Prot
  ENSCAFP00040022078 UniProtKB/Swiss-Prot
Ensembl Transcript ENSCAFT00000015286 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSCAFT00000088123 UniProtKB/TrEMBL
  ENSCAFT00030022244 UniProtKB/Swiss-Prot
  ENSCAFT00040025395 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.70.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aspartic_peptidase_A1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aspartic_peptidase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aspartic_peptidase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEPTIDASE_A1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_aspartic_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Renin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403838 UniProtKB/Swiss-Prot
NCBI Gene REN ENTREZGENE
PANTHER PTHR13683 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam A1_Propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Asp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS PEPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASP_PROTEASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEPTIDASE_A1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Cfa.3701 ENTREZGENE
UniProt A0A5F4D5T4_CANLF UniProtKB/TrEMBL
  Q6DYE7 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:45474 ENTREZGENE