FMO1 (flavin containing dimethylaniline monoxygenase 1) - Rat Genome Database
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Gene: FMO1 (flavin containing dimethylaniline monoxygenase 1) Sus scrofa
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Symbol: FMO1
Name: flavin containing dimethylaniline monoxygenase 1
RGD ID: 14137184
Description: ENCODES a protein that exhibits N,N-dimethylaniline monooxygenase activity; INVOLVED IN NADPH oxidation; organic acid metabolic process; toxin metabolic process; PARTICIPATES IN tamoxifen pharmacodynamics pathway; tamoxifen pharmacokinetics pathway; ASSOCIATED WITH 1q24 Deletion Syndrome (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN intracellular membrane-bounded organelle (ortholog); INTERACTS WITH chlorpromazine; cysteamine; imipramine
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: dimethylaniline monooxygenase [N-oxide-forming] 1; dimethylaniline oxidase 1; flavin containing monooxygenase 1; FMO 1; hepatic flavin-containing monooxygenase (FMO); hepatic flavin-containing monooxygenase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl963,812,103 - 63,895,077 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1963,860,957 - 63,895,086 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2970,137,610 - 70,171,700 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:2322534   PMID:2383273   PMID:7758472   PMID:9778310   PMID:14681463   PMID:15144220   PMID:23623750  


Genomics

Comparative Map Data
FMO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl963,812,103 - 63,895,077 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1963,860,957 - 63,895,086 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2970,137,610 - 70,171,700 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FMO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1171,248,471 - 171,285,978 (+)EnsemblGRCh38hg38GRCh38
GRCh381171,248,473 - 171,285,978 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371171,217,610 - 171,255,113 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,484,287 - 169,521,737 (+)NCBINCBI36hg18NCBI36
Build 341167,949,320 - 167,986,769NCBI
Celera1144,327,502 - 144,364,465 (+)NCBI
Cytogenetic Map1q24.3NCBI
HuRef1142,440,949 - 142,478,265 (+)NCBIHuRef
CHM1_11172,639,748 - 172,677,231 (+)NCBICHM1_1
Fmo1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391162,657,130 - 162,694,179 (-)NCBIGRCm39mm39
GRCm381162,829,561 - 162,866,610 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1162,829,561 - 162,866,610 (-)EnsemblGRCm38mm10GRCm38
MGSCv371164,759,692 - 164,796,679 (-)NCBIGRCm37mm9NCBIm37
MGSCv361164,666,236 - 164,703,223 (-)NCBImm8
Celera1165,273,712 - 165,303,556 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map170.34NCBI
Fmo1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01380,712,885 - 80,745,095 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1380,712,882 - 80,745,347 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01385,607,539 - 85,639,778 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41378,503,770 - 78,536,359 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11378,517,957 - 78,550,547 (-)NCBI
Celera1374,919,415 - 74,951,610 (-)NCBICelera
Cytogenetic Map13q22NCBI
Fmo1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540611,881,882 - 11,916,323 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540611,882,656 - 11,915,875 (+)NCBIChiLan1.0ChiLan1.0
FMO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11150,456,729 - 150,492,527 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1150,456,729 - 150,492,527 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01146,742,505 - 146,778,560 (+)NCBIMhudiblu_PPA_v0panPan3
FMO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl727,599,267 - 27,618,237 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1727,599,230 - 27,623,081 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
FMO1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12557,781,273 - 57,819,787 (-)NCBI
ChlSab1.1 Ensembl2557,782,085 - 57,819,408 (-)Ensembl
Fmo1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477110,358,422 - 10,386,015 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 3 1 2 2 2
Low 10 1 3 2 22 1 1
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000016637   ⟹   ENSSSCP00000016191
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl963,812,103 - 63,895,077 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000056435   ⟹   ENSSSCP00000036498
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl963,861,217 - 63,895,077 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000059500   ⟹   ENSSSCP00000051826
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl963,812,103 - 63,895,077 (+)Ensembl
RefSeq Acc Id: NM_214064   ⟹   NP_999229
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1963,861,240 - 63,895,079 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005656645   ⟹   XP_005656702
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1963,860,957 - 63,895,086 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002346938
RefSeq Status:
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1963,860,983 - 63,895,086 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_999229 (Get FASTA)   NCBI Sequence Viewer  
  XP_005656702 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA31033 (Get FASTA)   NCBI Sequence Viewer  
  ABF72125 (Get FASTA)   NCBI Sequence Viewer  
  AHH29285 (Get FASTA)   NCBI Sequence Viewer  
  P16549 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005656702   ⟸   XM_005656645
- Peptide Label: isoform X1
- UniProtKB: P16549 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_999229   ⟸   NM_214064
- UniProtKB: P16549 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000016191   ⟸   ENSSSCT00000016637
RefSeq Acc Id: ENSSSCP00000051826   ⟸   ENSSSCT00000059500
RefSeq Acc Id: ENSSSCP00000036498   ⟸   ENSSSCT00000056435


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000015268 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00005018850 UniProtKB/Swiss-Prot
  ENSSSCG00035056479 UniProtKB/Swiss-Prot
  ENSSSCG00045033391 UniProtKB/Swiss-Prot
  ENSSSCG00050061478 UniProtKB/Swiss-Prot
  ENSSSCG00055012560 UniProtKB/Swiss-Prot
  ENSSSCG00065033525 UniProtKB/Swiss-Prot
  ENSSSCG00070021841 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000016191 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCP00000036498 UniProtKB/TrEMBL
  ENSSSCP00000051826 UniProtKB/TrEMBL
  ENSSSCP00005018242 UniProtKB/Swiss-Prot
  ENSSSCP00005018261 UniProtKB/Swiss-Prot
  ENSSSCP00005018283 UniProtKB/Swiss-Prot
  ENSSSCP00005018288 UniProtKB/Swiss-Prot
  ENSSSCP00035030726 UniProtKB/Swiss-Prot
  ENSSSCP00045039947 UniProtKB/Swiss-Prot
  ENSSSCP00050035963 UniProtKB/Swiss-Prot
  ENSSSCP00055019643 UniProtKB/Swiss-Prot
  ENSSSCP00065019538 UniProtKB/Swiss-Prot
  ENSSSCP00065019546 UniProtKB/Swiss-Prot
  ENSSSCP00065019551 UniProtKB/Swiss-Prot
  ENSSSCP00070036573 UniProtKB/Swiss-Prot
  ENSSSCP00070036581 UniProtKB/Swiss-Prot
  ENSSSCP00070036597 UniProtKB/Swiss-Prot
  ENSSSCP00070036606 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000016637 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCT00000056435 UniProtKB/TrEMBL
  ENSSSCT00000059500 UniProtKB/TrEMBL
  ENSSSCT00005029955 UniProtKB/Swiss-Prot
  ENSSSCT00005029982 UniProtKB/Swiss-Prot
  ENSSSCT00005030014 UniProtKB/Swiss-Prot
  ENSSSCT00005030021 UniProtKB/Swiss-Prot
  ENSSSCT00035075473 UniProtKB/Swiss-Prot
  ENSSSCT00045057157 UniProtKB/Swiss-Prot
  ENSSSCT00050083786 UniProtKB/Swiss-Prot
  ENSSSCT00055024748 UniProtKB/Swiss-Prot
  ENSSSCT00065045563 UniProtKB/Swiss-Prot
  ENSSSCT00065045579 UniProtKB/Swiss-Prot
  ENSSSCT00065045588 UniProtKB/Swiss-Prot
  ENSSSCT00070043455 UniProtKB/Swiss-Prot
  ENSSSCT00070043463 UniProtKB/Swiss-Prot
  ENSSSCT00070043480 UniProtKB/Swiss-Prot
  ENSSSCT00070043489 UniProtKB/TrEMBL
Gene3D-CATH 3.50.50.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FAD/NAD-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavin_mOase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavin_mOase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavin_mOase_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397132 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene FMO1 ENTREZGENE
Pfam FMO-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF FMO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS FMOXYGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FMOXYGENASE1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51905 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Ssc.229 ENTREZGENE
UniProt A0A1R7SPQ1_PIG UniProtKB/TrEMBL
  A0A480Y4M1_PIG UniProtKB/TrEMBL
  A0A4X1V620_PIG UniProtKB/TrEMBL
  A0A5S6H998_PIG UniProtKB/TrEMBL
  A0A5S6I6E9_PIG UniProtKB/TrEMBL
  A3QT03_PIG UniProtKB/TrEMBL
  FMO1_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:88170 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-30 FMO1  flavin containing dimethylaniline monoxygenase 1    flavin containing monooxygenase 1  Symbol and/or name change 5135510 APPROVED