FGF7 (fibroblast growth factor 7) - Rat Genome Database

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Pathways
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Gene: FGF7 (fibroblast growth factor 7) Sus scrofa
Analyze
Symbol: FGF7
Name: fibroblast growth factor 7
RGD ID: 14082697
Description: ENCODES a protein that exhibits growth factor activity (ortholog); heparin binding (ortholog); type 2 fibroblast growth factor receptor binding (ortholog); INVOLVED IN branching involved in salivary gland morphogenesis (ortholog); endothelial cell proliferation (ortholog); epithelial cell proliferation (ortholog); PARTICIPATES IN glypican signaling pathway; ASSOCIATED WITH Bloom syndrome (ortholog); cervical squamous cell carcinoma (ortholog); cleft lip (ortholog); FOUND IN extracellular space (ortholog); GABA-ergic synapse (ortholog); postsynapse (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate
Type: protein-coding
RefSeq Status: MODEL
Previously known as: fibroblast growth factor 7 (keratinocyte growth factor); keratinocyte growth factor; kgf
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1122,215,882 - 122,277,750 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11122,215,878 - 122,278,705 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21135,926,619 - 135,928,879 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA)
animal organ morphogenesis  (IBA,IEA)
branching involved in salivary gland morphogenesis  (IEA,ISO)
carbohydrate phosphorylation  (IEA)
cell differentiation  (IBA,IEA)
endothelial cell proliferation  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
fibroblast growth factor receptor signaling pathway  (IBA,IEA,ISO)
galactose metabolic process  (IEA)
hair follicle morphogenesis  (IEA,ISO)
lung development  (IBA,IEA,ISO)
mesenchymal cell proliferation  (IEA)
myoblast proliferation  (IEA,ISO)
ovarian follicle development  (ISO)
phosphatidylcholine biosynthetic process  (ISO)
phospholipid biosynthetic process  (ISO)
positive chemotaxis  (IBA,IEA)
positive regulation of cell division  (IEA)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of DNA-templated transcription  (IBA,IEA)
positive regulation of endothelial cell proliferation  (IEA,ISO)
positive regulation of epithelial cell proliferation  (IBA,IEA,ISO)
positive regulation of epithelial cell proliferation involved in lung morphogenesis  (IEA,ISO)
positive regulation of gene expression  (IBA,IEA)
positive regulation of keratinocyte migration  (IEA)
positive regulation of keratinocyte proliferation  (IEA)
positive regulation of MAPK cascade  (IBA)
positive regulation of myoblast proliferation  (IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IBA,IEA)
protein localization to cell surface  (IEA)
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling  (IEA,ISO)
regulation of cell migration  (IBA,IEA)
regulation of synapse maturation  (ISO)
secretion by lung epithelial cell involved in lung growth  (IEA)
surfactant homeostasis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:10819782   PMID:15096428   PMID:15976484   PMID:17392499   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FGF7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1122,215,882 - 122,277,750 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11122,215,878 - 122,278,705 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21135,926,619 - 135,928,879 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FGF7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381549,423,242 - 49,488,775 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1549,423,237 - 49,488,775 (+)EnsemblGRCh38hg38GRCh38
GRCh371549,715,439 - 49,780,972 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361547,502,751 - 47,566,815 (+)NCBINCBI36Build 36hg18NCBI36
Build 341547,502,750 - 47,566,815NCBI
Celera1526,608,551 - 26,672,713 (+)NCBICelera
Cytogenetic Map15q21.2NCBI
HuRef1526,547,279 - 26,611,441 (+)NCBIHuRef
CHM1_11549,833,504 - 49,897,659 (+)NCBICHM1_1
T2T-CHM13v2.01547,231,591 - 47,297,131 (+)NCBIT2T-CHM13v2.0
Fgf7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392125,876,578 - 125,933,105 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2125,876,578 - 125,933,105 (+)EnsemblGRCm39 Ensembl
GRCm382126,034,658 - 126,091,185 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2126,034,658 - 126,091,185 (+)EnsemblGRCm38mm10GRCm38
MGSCv372125,860,394 - 125,916,921 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362125,726,225 - 125,781,966 (+)NCBIMGSCv36mm8
Celera2127,270,998 - 127,337,627 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.76NCBI
Fgf7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83133,734,557 - 133,786,678 (+)NCBIGRCr8
mRatBN7.23113,280,448 - 113,333,279 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3113,281,283 - 113,332,929 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3117,157,853 - 117,207,039 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03125,753,368 - 125,802,554 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03123,413,729 - 123,462,917 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03118,315,859 - 118,368,464 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3118,317,761 - 118,366,872 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03124,840,157 - 124,892,611 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43113,468,427 - 113,517,538 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13113,373,999 - 113,423,111 (+)NCBI
Celera3112,134,799 - 112,183,941 (+)NCBICelera
Cytogenetic Map3q36NCBI
Fgf7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554094,632,858 - 4,686,860 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554094,633,542 - 4,686,768 (-)NCBIChiLan1.0ChiLan1.0
FGF7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21638,669,957 - 38,734,413 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11542,853,936 - 42,921,604 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01528,378,339 - 28,442,800 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1 Ensembl1546,702,119 - 46,770,163 (+)Ensemblpanpan1.1panPan2
FGF7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13015,555,016 - 15,608,230 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3015,555,266 - 15,606,521 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3015,481,488 - 15,531,854 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03015,698,949 - 15,751,444 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3015,501,581 - 15,752,197 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13015,623,415 - 15,673,818 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03015,739,231 - 15,789,330 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03015,843,740 - 15,894,109 (+)NCBIUU_Cfam_GSD_1.0
Fgf7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864093,787,837 - 93,847,287 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647111,635,876 - 11,693,821 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647111,636,733 - 11,692,782 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGF7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12633,802,349 - 33,867,743 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2633,802,328 - 33,867,333 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048107,261,064 - 107,330,391 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgf7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473110,413,645 - 10,468,690 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473110,413,715 - 10,468,660 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FGF7
621 total Variants

Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000005136   ⟹   ENSSSCP00000005011
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1122,370,620 - 122,533,808 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000041131   ⟹   ENSSSCP00000039270
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1122,218,041 - 122,526,748 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000042027   ⟹   ENSSSCP00000053946
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1122,391,464 - 122,526,691 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000046303   ⟹   ENSSSCP00000053307
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1122,369,545 - 122,526,691 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000056886   ⟹   ENSSSCP00000040551
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1122,215,882 - 122,277,750 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000058629   ⟹   ENSSSCP00000049600
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1122,373,511 - 122,526,659 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000062092   ⟹   ENSSSCP00000033469
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1122,369,545 - 122,526,691 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000087933   ⟹   ENSSSCP00000062878
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1122,369,545 - 122,542,222 (-)Ensembl
RefSeq Acc Id: XM_013993026   ⟹   XP_013848480
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11122,215,878 - 122,278,705 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021073771   ⟹   XP_020929430
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11122,215,878 - 122,278,705 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020929430   ⟸   XM_021073771
- UniProtKB: Q9N198 (UniProtKB/Swiss-Prot),   A0A287A969 (UniProtKB/TrEMBL),   A0A4X1TGM5 (UniProtKB/TrEMBL),   A0A8D0MQA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013848480   ⟸   XM_013993026
- UniProtKB: Q9N198 (UniProtKB/Swiss-Prot),   A0A287A969 (UniProtKB/TrEMBL),   A0A4X1TGM5 (UniProtKB/TrEMBL),   A0A8D0MQA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000049600   ⟸   ENSSSCT00000058629
RefSeq Acc Id: ENSSSCP00000005011   ⟸   ENSSSCT00000005136
RefSeq Acc Id: ENSSSCP00000039270   ⟸   ENSSSCT00000041131
RefSeq Acc Id: ENSSSCP00000033469   ⟸   ENSSSCT00000062092
RefSeq Acc Id: ENSSSCP00000053307   ⟸   ENSSSCT00000046303
RefSeq Acc Id: ENSSSCP00000053946   ⟸   ENSSSCT00000042027
RefSeq Acc Id: ENSSSCP00000040551   ⟸   ENSSSCT00000056886
RefSeq Acc Id: ENSSSCP00000062878   ⟸   ENSSSCT00000087933
Protein Domains
Galactokinase N-terminal   GHMP kinase C-terminal   GHMP kinase N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000004651 Ensembl, UniProtKB/TrEMBL
  ENSSSCG00000056997 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005041906 UniProtKB/TrEMBL
  ENSSSCG00015013595 UniProtKB/TrEMBL
  ENSSSCG00025014179 UniProtKB/TrEMBL
  ENSSSCG00030020121 UniProtKB/TrEMBL
  ENSSSCG00035032507 UniProtKB/TrEMBL
  ENSSSCG00040050257 UniProtKB/TrEMBL
  ENSSSCG00045021048 UniProtKB/TrEMBL
  ENSSSCG00050058924 UniProtKB/TrEMBL
  ENSSSCG00055005206 UniProtKB/TrEMBL
  ENSSSCG00060011371 UniProtKB/TrEMBL
  ENSSSCG00065002085 UniProtKB/TrEMBL
  ENSSSCG00070008963 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000042027.3 UniProtKB/TrEMBL
  ENSSSCT00000056886 ENTREZGENE
  ENSSSCT00000056886.3 UniProtKB/TrEMBL
  ENSSSCT00000058629.1 UniProtKB/TrEMBL
  ENSSSCT00005067240.1 UniProtKB/TrEMBL
  ENSSSCT00005068322.1 UniProtKB/TrEMBL
  ENSSSCT00005068444.1 UniProtKB/TrEMBL
  ENSSSCT00005068458.1 UniProtKB/TrEMBL
  ENSSSCT00005068497.1 UniProtKB/TrEMBL
  ENSSSCT00005068520.1 UniProtKB/TrEMBL
  ENSSSCT00005068543.1 UniProtKB/TrEMBL
  ENSSSCT00005068562.1 UniProtKB/TrEMBL
  ENSSSCT00005068593.1 UniProtKB/TrEMBL
  ENSSSCT00015018120.1 UniProtKB/TrEMBL
  ENSSSCT00025018889.1 UniProtKB/TrEMBL
  ENSSSCT00030028007.1 UniProtKB/TrEMBL
  ENSSSCT00035043057.1 UniProtKB/TrEMBL
  ENSSSCT00040067789.1 UniProtKB/TrEMBL
  ENSSSCT00045035923.1 UniProtKB/TrEMBL
  ENSSSCT00050080342.1 UniProtKB/TrEMBL
  ENSSSCT00050080373.1 UniProtKB/TrEMBL
  ENSSSCT00055010166.1 UniProtKB/TrEMBL
  ENSSSCT00060014866.1 UniProtKB/TrEMBL
  ENSSSCT00060014874.1 UniProtKB/TrEMBL
  ENSSSCT00065002602.1 UniProtKB/TrEMBL
  ENSSSCT00070017443.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1440.340 UniProtKB/TrEMBL
  2.80.10.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.230.10 UniProtKB/TrEMBL
  3.30.70.3170 UniProtKB/TrEMBL
  3.30.70.890 UniProtKB/TrEMBL
InterPro Fibroblast_GF_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactokinase UniProtKB/TrEMBL
  Galactokinase_CS UniProtKB/TrEMBL
  GalKase_gal-bd UniProtKB/TrEMBL
  GHMP_kinase_C_dom UniProtKB/TrEMBL
  GHMP_kinase_C_sf UniProtKB/TrEMBL
  GHMP_kinase_N_dom UniProtKB/TrEMBL
  GHMP_knse_ATP-bd_CS UniProtKB/TrEMBL
  IL1/FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mevalonate/galactokinase UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold_subgr UniProtKB/TrEMBL
NCBI Gene FGF7 ENTREZGENE
PANTHER GALACTOKINASE-RELATED UniProtKB/TrEMBL
  MEVALONATE KINASE/GALACTOKINASE UniProtKB/TrEMBL
  PTHR11486 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11486:SF20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GalKase_gal_bdg UniProtKB/TrEMBL
  GHMP_kinases_C UniProtKB/TrEMBL
  GHMP_kinases_N UniProtKB/TrEMBL
PIRSF Galactokinase UniProtKB/TrEMBL
PRINTS GALCTOKINASE UniProtKB/TrEMBL
  HBGFFGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1HBGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MEVGALKINASE UniProtKB/TrEMBL
PROSITE GALACTOKINASE UniProtKB/TrEMBL
  GHMP_KINASES_ATP UniProtKB/TrEMBL
  HBGF_FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
SMART FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54211 UniProtKB/TrEMBL
  SSF55060 UniProtKB/TrEMBL
UniProt A0A287A969 ENTREZGENE, UniProtKB/TrEMBL
  A0A287B060_PIG UniProtKB/TrEMBL
  A0A287BCX7_PIG UniProtKB/TrEMBL
  A0A4X1TGM5 ENTREZGENE
  A0A8D0LZC4_PIG UniProtKB/TrEMBL
  A0A8D0MQA4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0TNL4_PIG UniProtKB/TrEMBL
  A0A8D1G237_PIG UniProtKB/TrEMBL
  A0A8D1N470_PIG UniProtKB/TrEMBL
  A0A8D1N8Y9_PIG UniProtKB/TrEMBL
  A0A8D1N9I6_PIG UniProtKB/TrEMBL
  A0A8D1SXR9_PIG UniProtKB/TrEMBL
  A0A8D1SZP6_PIG UniProtKB/TrEMBL
  FGF7_PIG UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A4X1TGM5 UniProtKB/TrEMBL
VGNC ID VGNC:112513 ENTREZGENE