F5 (coagulation factor V) - Rat Genome Database

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Gene: F5 (coagulation factor V) Sus scrofa
Analyze
Symbol: F5
Name: coagulation factor V
RGD ID: 14067632
Description: ENCODES a protein that exhibits copper ion binding (inferred); INVOLVED IN blood circulation (ortholog); blood coagulation (ortholog); response to vitamin K (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH 1q24 Deletion Syndrome (ortholog); Acute Liver Failure (ortholog); blood coagulation disease (ortholog); FOUND IN endoplasmic reticulum (ortholog); extracellular region (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: activated protein C cofactor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl481,403,232 - 81,485,055 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1481,403,273 - 81,484,908 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2489,027,936 - 89,109,573 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
1q24 Deletion Syndrome  (ISO)
Acute Liver Failure  (ISO)
Behcet's disease  (ISO)
blood coagulation disease  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Budd-Chiari syndrome  (ISO)
cerebral infarction  (ISO)
Colonic Neoplasms  (ISO)
colorectal adenoma  (ISO)
COVID-19  (ISO)
Dysarthria  (ISO)
Dyspnea  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Experimental Liver Cirrhosis  (ISO)
factor V deficiency  (ISO)
familial adenomatous polyposis  (ISO)
Femur Head Necrosis  (ISO)
Fetal Death  (ISO)
gastrointestinal stromal tumor  (ISO)
Habitual Abortions  (ISO)
hemorrhagic disease  (ISO)
hepatitis  (ISO)
Hereditary Thrombophilia  (ISO)
Hirschsprung's disease  (ISO)
hypereosinophilic syndrome  (ISO)
liver cirrhosis  (ISO)
membranoproliferative glomerulonephritis  (ISO)
Mesenteric Ischemia  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
non-arteritic anterior ischemic optic neuropathy  (ISO)
parathyroid carcinoma  (ISO)
Peritoneal Fibrosis  (ISO)
portal hypertension  (ISO)
pre-eclampsia  (ISO)
prostate cancer  (ISO)
pulmonary embolism  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
retinal artery occlusion  (ISO)
retinal vein occlusion  (ISO)
sagittal sinus thrombosis  (ISO)
sensorineural hearing loss  (ISO)
Sepsis  (ISO)
Septic Peritonitis  (ISO)
Spontaneous Abortions  (ISO)
Stroke  (ISO)
thrombocytopenia  (ISO)
Thromboembolism  (ISO)
thrombophilia due to activated protein C resistance  (ISO)
thrombophilia due to thrombin defect  (ISO)
thrombosis  (ISO)
Venous Thromboembolism  (ISO)
Venous Thrombosis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:11229814  


Genomics

Comparative Map Data
F5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl481,403,232 - 81,485,055 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1481,403,273 - 81,484,908 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2489,027,936 - 89,109,573 (+)NCBISscrofa10.2Sscrofa10.2susScr3
F5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1169,511,951 - 169,586,588 (-)EnsemblGRCh38hg38GRCh38
GRCh381169,511,951 - 169,586,630 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371169,481,189 - 169,555,719 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,747,816 - 167,822,393 (-)NCBINCBI36hg18NCBI36
Build 341166,215,066 - 166,287,379NCBI
Celera1142,590,970 - 142,665,548 (-)NCBI
Cytogenetic Map1q24.2NCBI
HuRef1140,703,881 - 140,778,453 (-)NCBIHuRef
CHM1_11170,903,222 - 170,977,927 (-)NCBICHM1_1
F5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391163,979,404 - 164,047,846 (+)NCBIGRCm39mm39
GRCm39 Ensembl1163,979,407 - 164,047,846 (+)Ensembl
GRCm381164,151,835 - 164,220,277 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1164,151,838 - 164,220,277 (+)EnsemblGRCm38mm10GRCm38
MGSCv371166,081,990 - 166,150,405 (+)NCBIGRCm37mm9NCBIm37
MGSCv361165,988,633 - 166,056,215 (+)NCBImm8
Celera1166,589,960 - 166,658,650 (+)NCBICelera
Cytogenetic Map1H2.2NCBI
cM Map171.46NCBI
F5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21376,513,463 - 76,583,106 (+)NCBI
Rnor_6.0 Ensembl1382,479,998 - 82,535,534 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01382,479,997 - 82,535,540 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01387,355,980 - 87,417,686 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41379,934,956 - 79,997,285 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1376,256,969 - 76,316,731 (+)NCBICelera
Cytogenetic Map13q23NCBI
F5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554627,694,939 - 7,757,463 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554627,695,004 - 7,757,832 (+)NCBIChiLan1.0ChiLan1.0
F5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11148,718,748 - 148,791,049 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1148,718,897 - 148,790,915 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01144,996,757 - 145,070,046 (-)NCBIMhudiblu_PPA_v0panPan3
F5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1728,999,481 - 29,069,603 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl728,999,512 - 29,069,296 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha728,531,164 - 28,601,084 (+)NCBI
ROS_Cfam_1.0728,801,509 - 28,871,406 (+)NCBI
UMICH_Zoey_3.1728,649,506 - 28,719,863 (+)NCBI
UNSW_CanFamBas_1.0728,685,240 - 28,755,563 (+)NCBI
UU_Cfam_GSD_1.0728,922,027 - 28,992,360 (+)NCBI
F5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934499,267,628 - 99,332,463 (+)NCBI
SpeTri2.0NW_00493648117,114,441 - 17,178,902 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12559,465,610 - 59,539,022 (+)NCBI
ChlSab1.1 Ensembl2559,466,378 - 59,538,872 (+)Ensembl
Vero_WHO_p1.0NW_02366605561,142,905 - 61,215,886 (+)NCBI
F5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248267,438,632 - 7,507,322 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 1 9 1
Low 9 1 3 4 2 14 1 3 2
Below cutoff 1 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000006892   ⟹   ENSSSCP00000006704
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl481,403,232 - 81,485,055 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000065000   ⟹   ENSSSCP00000056114
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl481,403,232 - 81,485,055 (+)Ensembl
RefSeq Acc Id: NM_214120   ⟹   NP_999285
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1481,403,273 - 81,484,908 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_999285 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG28381 (Get FASTA)   NCBI Sequence Viewer  
  Q9GLP1 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_999285   ⟸   NM_214120
- Peptide Label: precursor
- UniProtKB: Q9GLP1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000056114   ⟸   ENSSSCT00000065000
RefSeq Acc Id: ENSSSCP00000006704   ⟸   ENSSSCT00000006892
Protein Domains
F5/8 type A   F5/8 type C   Plastocyanin-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000006289 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070020414 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000006704 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000056114 UniProtKB/TrEMBL
  ENSSSCP00070034171 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000006892 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000065000 UniProtKB/TrEMBL
  ENSSSCT00070040725 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.260 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.420 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Coagulation_factor_V_LSPD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu-oxidase_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu_oxidase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cupredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FA58C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Factor_5/8-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397217 UniProtKB/Swiss-Prot
NCBI Gene F5 ENTREZGENE
Pfam Cu-oxidase_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  F5_F8_type_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LSPR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF Factors_V_VIII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FA58C_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FA58C_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FA58C_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MULTICOPPER_OXIDASE1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FA58C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49503 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A287BJ70_PIG UniProtKB/TrEMBL
  A0A4X1V0I5_PIG UniProtKB/TrEMBL
  F1RPW2_PIG UniProtKB/TrEMBL
  FA5_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:87865 ENTREZGENE