CSF3 (colony stimulating factor 3) - Rat Genome Database

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Gene: CSF3 (colony stimulating factor 3) Sus scrofa
Analyze
Symbol: CSF3
Name: colony stimulating factor 3
RGD ID: 14099378
Description: ENCODES a protein that exhibits growth factor activity (ortholog); INVOLVED IN cell population proliferation (ortholog); cellular response to lipopolysaccharide (ortholog); negative regulation of neuron death (ortholog); ASSOCIATED WITH Acute Liver Failure (ortholog); acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: colony stimulating factor 3 (granulocyte); G-CSF; granulocyte colony-stimulating factor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,333,449 - 22,338,753 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,333,445 - 22,335,949 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21222,732,713 - 22,734,736 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
agranulocytosis  (ISO)
allergic cutaneous vasculitis  (ISO)
anemia  (ISO)
angiosarcoma  (ISO)
Animal Disease Models  (ISO)
anterior ischemic optic neuropathy  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
aplastic anemia  (ISO)
Arthralgia  (ISO)
asthma  (ISO)
B-cell lymphoma  (ISO)
bacterial pneumonia  (ISO)
bilirubin metabolic disorder  (ISO)
Bone Marrow Neoplasms  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiac Fibrosis  (ISO)
Carotid Artery Injuries  (ISO)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cognitive disorder  (ISO)
congestive heart failure  (ISO)
COVID-19  (ISO)
cystitis  (ISO)
diarrhea  (ISO)
dilated cardiomyopathy  (ISO)
Disease Susceptibility  (ISO)
Drug-Induced Agranulocytosis  (ISO)
Drug-induced Neutropenia  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Endotoxemia  (ISO)
Enterobacteriaceae Infections  (ISO)
Esophageal Neoplasms  (ISO)
Experimental Arthritis  (ISO)
Experimental Colitis  (ISO)
Experimental Liver Cirrhosis  (ISO)
Fever  (ISO)
Fibrosis  (ISO)
Gastrointestinal Diseases  (ISO)
Head and Neck Neoplasms  (ISO)
Headache  (ISO)
heart disease  (ISO)
hepatic veno-occlusive disease  (ISO)
Hodgkin's lymphoma  (ISO)
Hyperalgesia  (ISO)
Hypertrophy  (ISO)
Infarction  (ISO)
Intestinal Reperfusion Injury  (ISO)
kidney disease  (ISO)
leiomyosarcoma  (ISO)
Leukocytosis  (ISO)
leukopenia  (ISO)
Limb Ischemia  (ISO)
liver disease  (ISO)
Liver Injury  (ISO)
Liver Neoplasms  (ISO)
localized scleroderma  (ISO)
lung disease  (ISO)
Lung Injury  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
Lymphoma, AIDS-Related  (ISO)
melanoma  (ISO)
mental depression  (ISO)
middle cerebral artery infarction  (ISO)
mucositis  (ISO)
multiple myeloma  (ISO)
Muscle Weakness  (ISO)
muscular disease  (ISO)
myeloid leukemia  (ISO)
myocardial infarction  (ISO)
Neoplasm Metastasis  (ISO)
Neoplasms, Second Primary  (ISO)
nervous system disease  (ISO)
neutropenia  (ISO)
Neutrophilia  (ISO)
non-Hodgkin lymphoma  (ISO)
Optic Nerve Injuries  (ISO)
Pain  (ISO)
pancytopenia  (ISO)
peripheral nervous system disease  (ISO)
pleurisy  (ISO)
Poisoning  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Sepsis  (ISO)
Septic Peritonitis  (ISO)
Skin Neoplasms  (ISO)
Soft Tissue Neoplasms  (ISO)
Somatosensory Disorders  (ISO)
Spinal Cord Injuries  (ISO)
Spontaneous Abortions  (ISO)
Staphylococcal Infections  (ISO)
Staphylococcal Pneumonia  (ISO)
Stevens-Johnson syndrome  (ISO)
stomatitis  (ISO)
Stroke  (ISO)
Systemic Vasculitis  (ISO)
thrombocytopenia  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
Transplant Rejection  (ISO)
urinary bladder cancer  (ISO)
Uterine Neoplasms  (ISO)
Ventricular Dysfunction, Left  (ISO)

References
Additional References at PubMed
PMID:9332386   PMID:23891494  


Genomics

Comparative Map Data
CSF3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,333,449 - 22,338,753 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,333,445 - 22,335,949 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21222,732,713 - 22,734,736 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CSF3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381740,015,440 - 40,017,813 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1740,015,361 - 40,017,813 (+)EnsemblGRCh38hg38GRCh38
GRCh371738,171,693 - 38,174,066 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,425,214 - 35,427,592 (+)NCBINCBI36hg18NCBI36
Build 341735,425,213 - 35,427,591NCBI
Celera1734,831,674 - 34,834,127 (+)NCBI
Cytogenetic Map17q21.1NCBI
HuRef1733,965,611 - 33,968,064 (+)NCBIHuRef
CHM1_11738,407,306 - 38,409,759 (+)NCBICHM1_1
T2T-CHM13v2.01740,879,315 - 40,881,689 (+)NCBI
Csf3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,591,287 - 98,594,457 (+)NCBIGRCm39mm39
GRCm39 Ensembl1198,592,089 - 98,594,455 (+)Ensembl
GRCm381198,700,183 - 98,703,631 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,701,263 - 98,703,629 (+)EnsemblGRCm38mm10GRCm38
MGSCv371198,562,627 - 98,564,943 (+)NCBIGRCm37mm9NCBIm37
MGSCv361198,517,403 - 98,519,719 (+)NCBImm8
Celera11108,355,655 - 108,357,971 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1162.45NCBI
Csf3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21083,660,787 - 83,664,569 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1083,661,207 - 83,663,603 (+)Ensembl
Rnor_6.01086,616,785 - 86,619,160 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,616,785 - 86,619,157 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,413,088 - 86,415,478 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,473,990 - 87,476,365 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11087,488,359 - 87,490,732 (+)NCBI
Celera1082,409,331 - 82,411,709 (+)NCBICelera
RH 3.4 Map10850.39RGD
Cytogenetic Map10q31NCBI
Csf3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,688,181 - 14,690,126 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,688,181 - 14,690,126 (+)NCBIChiLan1.0ChiLan1.0
CSF3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11717,491,272 - 17,493,729 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1717,491,276 - 17,493,729 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01717,271,074 - 17,273,493 (-)NCBIMhudiblu_PPA_v0panPan3
CSF3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,529,643 - 22,532,326 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,530,698 - 22,533,108 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha922,001,811 - 22,004,573 (-)NCBI
ROS_Cfam_1.0923,322,490 - 23,325,252 (-)NCBI
ROS_Cfam_1.0 Ensembl923,323,327 - 23,325,322 (-)Ensembl
UMICH_Zoey_3.1922,095,850 - 22,098,611 (-)NCBI
UNSW_CanFamBas_1.0922,355,055 - 22,357,817 (-)NCBI
UU_Cfam_GSD_1.0922,479,613 - 22,482,375 (-)NCBI
Csf3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560221,929,893 - 21,934,092 (-)NCBI
SpeTri2.0NW_00493649015,142,526 - 15,146,375 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSF3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11666,162,814 - 66,166,192 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1666,163,681 - 66,165,172 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607737,070,211 - 37,072,804 (-)NCBIVero_WHO_p1.0
Csf3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247953,163,009 - 3,166,594 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247953,162,999 - 3,167,248 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system reproductive system respiratory system
High
Medium
Low 6 2 4 2 1 2 1
Below cutoff 3 1 1 9 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000019041   ⟹   ENSSSCP00000018536
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1222,333,466 - 22,335,701 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000068779   ⟹   ENSSSCP00000066068
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1222,333,466 - 22,338,753 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000080327   ⟹   ENSSSCP00000063397
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1222,333,449 - 22,335,701 (-)Ensembl
RefSeq Acc Id: NM_213842   ⟹   NP_999007
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11222,333,929 - 22,335,949 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021066184   ⟹   XP_020921843
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11222,333,445 - 22,335,484 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_999007 (Get FASTA)   NCBI Sequence Viewer  
  XP_020921843 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB70700 (Get FASTA)   NCBI Sequence Viewer  
  AAB70701 (Get FASTA)   NCBI Sequence Viewer  
  CAA71518 (Get FASTA)   NCBI Sequence Viewer  
  O02837 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020921843   ⟸   XM_021066184
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_999007   ⟸   NM_213842
- Peptide Label: precursor
- UniProtKB: O02837 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000018536   ⟸   ENSSSCT00000019041
RefSeq Acc Id: ENSSSCP00000066068   ⟸   ENSSSCT00000068779
RefSeq Acc Id: ENSSSCP00000063397   ⟸   ENSSSCT00000080327


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000017488 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005003527 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00015014893 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00025065654 UniProtKB/TrEMBL
  ENSSSCG00030037989 UniProtKB/TrEMBL
  ENSSSCG00035051503 UniProtKB/TrEMBL
  ENSSSCG00040004173 UniProtKB/TrEMBL
  ENSSSCG00045036378 UniProtKB/TrEMBL
  ENSSSCG00050073634 UniProtKB/TrEMBL
  ENSSSCG00055002870 UniProtKB/TrEMBL
  ENSSSCG00060074175 UniProtKB/TrEMBL
  ENSSSCG00065006472 UniProtKB/Swiss-Prot
  ENSSSCG00070016393 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000018536.3 UniProtKB/TrEMBL
  ENSSSCP00000063397.1 UniProtKB/TrEMBL
  ENSSSCP00000066068 ENTREZGENE
  ENSSSCP00000066068.1 UniProtKB/TrEMBL
  ENSSSCP00005003047 UniProtKB/Swiss-Prot
  ENSSSCP00005003092.1 UniProtKB/TrEMBL
  ENSSSCP00015007769 UniProtKB/Swiss-Prot
  ENSSSCP00015007792.1 UniProtKB/TrEMBL
  ENSSSCP00025039518.1 UniProtKB/TrEMBL
  ENSSSCP00025039573.1 UniProtKB/TrEMBL
  ENSSSCP00025039623.1 UniProtKB/TrEMBL
  ENSSSCP00030024175.1 UniProtKB/TrEMBL
  ENSSSCP00035027766.1 UniProtKB/TrEMBL
  ENSSSCP00040001938.1 UniProtKB/TrEMBL
  ENSSSCP00040001943.1 UniProtKB/TrEMBL
  ENSSSCP00040001947.1 UniProtKB/TrEMBL
  ENSSSCP00045044211.1 UniProtKB/TrEMBL
  ENSSSCP00050043743.1 UniProtKB/TrEMBL
  ENSSSCP00050043755.1 UniProtKB/TrEMBL
  ENSSSCP00050043763.1 UniProtKB/TrEMBL
  ENSSSCP00055004280.1 UniProtKB/TrEMBL
  ENSSSCP00060044106.1 UniProtKB/TrEMBL
  ENSSSCP00060044134.1 UniProtKB/TrEMBL
  ENSSSCP00060044161.1 UniProtKB/TrEMBL
  ENSSSCP00065003693 UniProtKB/Swiss-Prot
  ENSSSCP00070026933.1 UniProtKB/TrEMBL
  ENSSSCP00070026945.1 UniProtKB/TrEMBL
  ENSSSCP00070026951.1 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000019041.5 UniProtKB/TrEMBL
  ENSSSCT00000068779 ENTREZGENE
  ENSSSCT00000068779.1 UniProtKB/TrEMBL
  ENSSSCT00000080327.1 UniProtKB/TrEMBL
  ENSSSCT00005005326 UniProtKB/Swiss-Prot
  ENSSSCT00005005393.1 UniProtKB/TrEMBL
  ENSSSCT00015019785 UniProtKB/Swiss-Prot
  ENSSSCT00015019837.1 UniProtKB/TrEMBL
  ENSSSCT00025090200.1 UniProtKB/TrEMBL
  ENSSSCT00025090326.1 UniProtKB/TrEMBL
  ENSSSCT00025090424.1 UniProtKB/TrEMBL
  ENSSSCT00030052976.1 UniProtKB/TrEMBL
  ENSSSCT00035068595.1 UniProtKB/TrEMBL
  ENSSSCT00040005382.1 UniProtKB/TrEMBL
  ENSSSCT00040005387.1 UniProtKB/TrEMBL
  ENSSSCT00040005393.1 UniProtKB/TrEMBL
  ENSSSCT00045062750.1 UniProtKB/TrEMBL
  ENSSSCT00050100717.1 UniProtKB/TrEMBL
  ENSSSCT00050100736.1 UniProtKB/TrEMBL
  ENSSSCT00050100749.1 UniProtKB/TrEMBL
  ENSSSCT00055005530.1 UniProtKB/TrEMBL
  ENSSSCT00060101529.1 UniProtKB/TrEMBL
  ENSSSCT00060101602.1 UniProtKB/TrEMBL
  ENSSSCT00060101658.1 UniProtKB/TrEMBL
  ENSSSCT00065008751 UniProtKB/Swiss-Prot
  ENSSSCT00070032276.1 UniProtKB/TrEMBL
  ENSSSCT00070032288.1 UniProtKB/TrEMBL
  ENSSSCT00070032295.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GCSF/MGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-6/GCSF/MGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL6/GCSF/MGF_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:396839 UniProtKB/Swiss-Prot
NCBI Gene CSF3 ENTREZGENE
PANTHER PTHR10511 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GCSF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF IL6_MGF_GCSF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS IL6GCSFMGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE INTERLEUKIN_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IL6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1UAP7_PIG UniProtKB/TrEMBL
  A0A4X1UD46_PIG UniProtKB/TrEMBL
  A0A4X1UG58_PIG UniProtKB/TrEMBL
  A0A5G2QF97_PIG UniProtKB/TrEMBL
  A0A5G2QVW3_PIG UniProtKB/TrEMBL
  A0A5S6GJ84_PIG UniProtKB/TrEMBL
  A0A8D1NVU7_PIG UniProtKB/TrEMBL
  A0A8D1TQ08_PIG UniProtKB/TrEMBL
  CSF3_PIG UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O19180 UniProtKB/Swiss-Prot
VGNC ID VGNC:87034 ENTREZGENE