SMO (smoothened, frizzled class receptor) - Rat Genome Database

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Gene: SMO (smoothened, frizzled class receptor) Sus scrofa
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Symbol: SMO
Name: smoothened, frizzled class receptor
RGD ID: 13876355
Description: ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); INVOLVED IN anterior/posterior pattern specification (ortholog); astrocyte activation (ortholog); atrial septum morphogenesis (ortholog); PARTICIPATES IN altered Hedgehog signaling pathway; Hedgehog signaling pathway; ASSOCIATED WITH acute promyelocytic leukemia (ortholog); ameloblastoma (ortholog); basal cell carcinoma (ortholog); FOUND IN 9+0 non-motile cilium (ortholog); axonal growth cone (ortholog); caveola (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: smoothened homolog; smoothened, frizzled family receptor; smoothened, seven transmembrane spanning receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1819,450,734 - 19,479,374 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11819,450,730 - 19,478,796 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21820,520,306 - 20,548,303 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (IEA,ISO)
astrocyte activation  (IEA,ISO)
atrial septum morphogenesis  (IEA,ISO)
axon extension involved in axon guidance  (ISO)
cell development  (ISO)
cell fate specification  (IEA,ISO)
cellular response to cholesterol  (IEA,ISO)
central nervous system development  (IBA,ISO)
central nervous system neuron differentiation  (IEA,ISO)
cerebellar cortex morphogenesis  (IEA,ISO)
cerebral cortex development  (IEA,ISO)
commissural neuron axon guidance  (IBA,ISO)
contact inhibition  (IEA)
dentate gyrus development  (IEA,ISO)
determination of left/right asymmetry in lateral mesoderm  (IEA)
determination of left/right symmetry  (ISO)
developmental growth  (ISO)
digestive tract development  (ISO)
dorsal/ventral neural tube patterning  (IEA,ISO)
dorsal/ventral pattern formation  (ISO)
embryonic organ development  (ISO)
epithelial-mesenchymal cell signaling  (IEA,ISO)
facial nerve development  (ISO)
forebrain morphogenesis  (IEA)
G protein-coupled receptor signaling pathway  (IEA)
hair follicle morphogenesis  (IEA,ISO)
heart looping  (IEA)
heart morphogenesis  (ISO)
homeostasis of number of cells within a tissue  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
left/right axis specification  (IEA,ISO)
mammary gland epithelial cell differentiation  (IEA,ISO)
mesenchymal to epithelial transition involved in metanephric renal vesicle formation  (IEA)
midgut development  (IEA)
multicellular organism growth  (IEA,ISO)
myoblast migration  (IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of DNA binding  (IEA,ISO)
negative regulation of epithelial cell differentiation  (IEA,ISO)
negative regulation of gene expression  (IEA)
negative regulation of hair follicle development  (IEA,ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of transcription, DNA-templated  (ISO)
neural crest cell migration  (IEA,ISO)
neuron projection regeneration  (ISO)
odontogenesis of dentin-containing tooth  (IEA,ISO)
ossification  (ISO)
osteoblast differentiation  (IEA,ISO)
osteoblast proliferation  (ISO)
pancreas morphogenesis  (IEA,ISO)
pattern specification process  (ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of cell population proliferation  (ISO)
positive regulation of epithelial cell proliferation  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of hh target transcription factor activity  (IEA)
positive regulation of mesenchymal cell proliferation  (IEA,ISO)
positive regulation of multicellular organism growth  (IEA)
positive regulation of neural precursor cell proliferation  (ISO)
positive regulation of neuroblast proliferation  (IEA,ISO)
positive regulation of organ growth  (IEA)
positive regulation of protein import into nucleus  (IEA,ISO)
positive regulation of smoothened signaling pathway  (IBA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
protein localization to nucleus  (IEA,ISO)
protein stabilization  (IEA,ISO)
regulation of gene expression  (ISO)
regulation of heart morphogenesis  (IEA)
regulation of stem cell population maintenance  (IEA,ISO)
response to organic substance  (ISO)
response to wounding  (ISO)
skeletal muscle fiber development  (IEA,ISO)
smooth muscle tissue development  (IEA)
smoothened signaling pathway  (IBA,ISO)
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation  (IEA,ISO)
smoothened signaling pathway involved in ventral spinal cord patterning  (IEA,ISO)
somite development  (IEA)
spermatogenesis  (ISO)
thalamus development  (IEA,ISO)
type B pancreatic cell development  (IEA,ISO)
vasculogenesis  (IEA,ISO)
ventral midline determination  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
SMO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1819,450,734 - 19,479,374 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11819,450,730 - 19,478,796 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21820,520,306 - 20,548,303 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SMO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7129,188,633 - 129,213,545 (+)EnsemblGRCh38hg38GRCh38
GRCh387129,188,633 - 129,213,548 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377128,828,474 - 128,853,386 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367128,615,949 - 128,640,622 (+)NCBINCBI36hg18NCBI36
Build 347128,422,663 - 128,447,334NCBI
Celera7123,625,432 - 123,650,109 (+)NCBI
Cytogenetic Map7q32.1NCBI
HuRef7123,189,938 - 123,214,626 (+)NCBIHuRef
CHM1_17128,762,307 - 128,786,971 (+)NCBICHM1_1
CRA_TCAGchr7v27128,212,668 - 128,237,345 (+)NCBI
Smo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39629,735,496 - 29,761,365 (+)NCBIGRCm39mm39
GRCm39 Ensembl629,735,502 - 29,761,364 (+)Ensembl
GRCm38629,735,497 - 29,761,366 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl629,735,503 - 29,761,365 (+)EnsemblGRCm38mm10GRCm38
MGSCv37629,685,497 - 29,711,366 (+)NCBIGRCm37mm9NCBIm37
MGSCv36629,685,513 - 29,711,369 (+)NCBImm8
Celera629,744,569 - 29,772,611 (+)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.36NCBI
Smo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2458,344,101 - 58,372,828 (+)NCBI
Rnor_6.0 Ensembl457,019,941 - 57,042,770 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0457,019,941 - 57,041,779 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0456,787,102 - 56,809,935 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4456,623,494 - 56,645,571 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1456,898,313 - 56,920,866 (+)NCBI
Celera453,450,322 - 53,474,674 (+)NCBICelera
Cytogenetic Map4q22NCBI
Smo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554799,964,170 - 9,993,165 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554799,963,377 - 9,991,670 (+)NCBIChiLan1.0ChiLan1.0
SMO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17133,668,523 - 133,693,048 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7133,668,304 - 133,693,048 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07121,143,968 - 121,168,873 (+)NCBIMhudiblu_PPA_v0panPan3
SMO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1147,518,871 - 7,527,703 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl147,518,856 - 7,528,033 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha147,206,323 - 7,229,356 (-)NCBI
ROS_Cfam_1.0147,284,734 - 7,307,875 (-)NCBI
UMICH_Zoey_3.1147,489,837 - 7,512,985 (-)NCBI
UNSW_CanFamBas_1.0147,231,685 - 7,254,904 (-)NCBI
UU_Cfam_GSD_1.0147,376,821 - 7,399,952 (-)NCBI
Smo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511825,760,467 - 25,784,726 (-)NCBI
SpeTri2.0NW_0049365795,893,064 - 5,917,021 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMO
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12197,788,955 - 97,814,549 (+)NCBI
ChlSab1.1 Ensembl2197,788,624 - 97,814,709 (+)Ensembl
Vero_WHO_p1.0NW_0236660425,588,304 - 5,614,118 (-)NCBI
Smo
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247837,012,385 - 7,039,302 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 9 4 3 5 2 22 2 3 1
Below cutoff 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000018039   ⟹   ENSSSCP00000017553
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1819,450,734 - 19,479,374 (-)Ensembl
RefSeq Acc Id: XM_003134680   ⟹   XP_003134728
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11819,450,730 - 19,478,796 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003134728 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003134728   ⟸   XM_003134680
- UniProtKB: F1SMQ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000017553   ⟸   ENSSSCT00000018039
Protein Domains
FZ   G_PROTEIN_RECEP_F2_4


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000016569 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000017553 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000018039 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.2000.10 UniProtKB/TrEMBL
InterPro Frizzled/SFRP UniProtKB/TrEMBL
  Frizzled/Smoothened_TM UniProtKB/TrEMBL
  Frizzled_dom UniProtKB/TrEMBL
  Frizzled_dom_sf UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/TrEMBL
  SMO UniProtKB/TrEMBL
  SMO_7TM UniProtKB/TrEMBL
  SMO_CRD UniProtKB/TrEMBL
KEGG Report ssc:100515110 UniProtKB/TrEMBL
NCBI Gene SMO ENTREZGENE
PANTHER PTHR11309 UniProtKB/TrEMBL
  PTHR11309:SF35 UniProtKB/TrEMBL
Pfam Frizzled UniProtKB/TrEMBL
  PF01392 UniProtKB/TrEMBL
PRINTS FRIZZLED UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_4 UniProtKB/TrEMBL
  PS50038 UniProtKB/TrEMBL
SMART FRI UniProtKB/TrEMBL
  Frizzled UniProtKB/TrEMBL
Superfamily-SCOP SSF63501 UniProtKB/TrEMBL
UniProt F1SMQ3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:93258 ENTREZGENE