CNR1 (cannabinoid receptor 1) - Rat Genome Database

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Gene: CNR1 (cannabinoid receptor 1) Sus scrofa
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Symbol: CNR1
Name: cannabinoid receptor 1
RGD ID: 14061457
Description: ENCODES a protein that exhibits cannabinoid receptor activity (ortholog); INVOLVED IN adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); aging (ortholog); axonal fasciculation (ortholog); PARTICIPATES IN N-cadherin signaling pathway; ASSOCIATED WITH Alcohol Withdrawal Delirium (ortholog); Animal Disease Models (ortholog); anxiety disorder (ortholog); FOUND IN axon (ortholog); GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl156,466,027 - 56,492,602 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1156,466,022 - 56,493,275 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2163,201,796 - 63,224,939 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IBA)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (ISO)
aging  (ISO)
axonal fasciculation  (IEA,ISO)
cannabinoid signaling pathway  (IBA)
G protein-coupled receptor signaling pathway  (ISO)
glucose homeostasis  (IEA,ISO)
induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration  (IEA)
learning or memory  (ISO)
maternal process involved in female pregnancy  (ISO)
memory  (ISO)
negative regulation of action potential  (ISO)
negative regulation of blood pressure  (ISO)
negative regulation of dopamine secretion  (ISO)
negative regulation of fatty acid beta-oxidation  (ISO)
negative regulation of ion transport  (ISO)
negative regulation of mast cell activation  (ISO)
negative regulation of nitric-oxide synthase activity  (ISO)
negative regulation of serotonin secretion  (ISO)
positive regulation of acute inflammatory response to antigenic stimulus  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of blood pressure  (ISO)
positive regulation of fever generation  (ISO)
positive regulation of neuron projection development  (ISO)
regulation of feeding behavior  (ISO)
regulation of insulin secretion  (ISO)
regulation of lipid metabolic process  (ISO)
regulation of metabolic process  (IBA)
regulation of penile erection  (ISO)
regulation of synaptic transmission, GABAergic  (ISO)
regulation of synaptic transmission, glutamatergic  (ISO)
response to cocaine  (ISO)
response to ethanol  (ISO)
response to lipopolysaccharide  (ISO)
response to morphine  (ISO)
response to nicotine  (ISO)
response to nutrient  (ISO)
retrograde trans-synaptic signaling by endocannabinoid  (IEA)
sensory perception of pain  (ISO)
spermatogenesis  (ISO)
trans-synaptic signaling by endocannabinoid, modulating synaptic transmission  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:25537261   PMID:32599254  


Genomics

Comparative Map Data
CNR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl156,466,027 - 56,492,602 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1156,466,022 - 56,493,275 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2163,201,796 - 63,224,939 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CNR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl688,139,864 - 88,166,347 (-)EnsemblGRCh38hg38GRCh38
GRCh38688,139,864 - 88,167,349 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37688,849,583 - 88,877,068 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36688,906,302 - 88,911,775 (-)NCBINCBI36hg18NCBI36
Build 34688,906,301 - 88,911,775NCBI
Celera689,267,475 - 89,293,659 (-)NCBI
Cytogenetic Map6q15NCBI
HuRef686,064,928 - 86,090,983 (-)NCBIHuRef
CHM1_1688,947,341 - 88,973,526 (-)NCBICHM1_1
Cnr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39433,923,171 - 33,948,831 (+)NCBIGRCm39mm39
GRCm39 Ensembl433,924,593 - 33,948,831 (+)Ensembl
GRCm38433,923,171 - 33,948,831 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl433,924,593 - 33,948,831 (+)EnsemblGRCm38mm10GRCm38
MGSCv37434,011,607 - 34,035,806 (+)NCBIGRCm37mm9NCBIm37
MGSCv36434,253,245 - 34,277,444 (+)NCBImm8
Celera433,679,304 - 33,703,476 (+)NCBICelera
Cytogenetic Map4A5NCBI
cM Map416.28NCBI
Cnr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2548,408,543 - 48,436,099 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl548,408,574 - 48,435,099 (+)Ensembl
Rnor_6.0549,307,584 - 49,333,064 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl549,311,030 - 49,333,056 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0553,878,619 - 53,904,013 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4550,427,173 - 50,445,471 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1550,427,351 - 50,445,650 (+)NCBI
Celera547,168,709 - 47,190,724 (+)NCBICelera
Cytogenetic Map5q21NCBI
Cnr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541115,052,163 - 15,077,320 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541115,052,151 - 15,077,320 (-)NCBIChiLan1.0ChiLan1.0
CNR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1689,289,102 - 89,315,174 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0686,017,141 - 86,044,889 (-)NCBIMhudiblu_PPA_v0panPan3
CNR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11247,537,240 - 47,560,723 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1247,509,583 - 47,560,983 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1247,344,588 - 47,368,064 (-)NCBI
ROS_Cfam_1.01248,342,012 - 48,365,459 (-)NCBI
UMICH_Zoey_3.11247,639,694 - 47,663,171 (-)NCBI
UNSW_CanFamBas_1.01247,561,070 - 47,584,546 (-)NCBI
UU_Cfam_GSD_1.01247,752,753 - 47,776,234 (-)NCBI
Cnr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494682,664,248 - 82,691,073 (-)NCBI
SpeTri2.0NW_0049365103,779,930 - 3,806,615 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11312,626,259 - 12,653,253 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1312,630,270 - 12,631,688 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040188,875,655 - 188,902,692 (-)NCBIVero_WHO_p1.0
Cnr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247996,100,709 - 6,126,530 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system nervous system renal system reproductive system
High
Medium 11
Low 3 12 1
Below cutoff 3 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000004764   ⟹   ENSSSCP00000004653
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl156,468,191 - 56,492,602 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000089541   ⟹   ENSSSCP00000069188
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl156,466,027 - 56,492,273 (-)Ensembl
RefSeq Acc Id: XM_005659288   ⟹   XP_005659345
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1156,466,022 - 56,491,784 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013992672   ⟹   XP_013848126
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1156,466,022 - 56,492,317 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013992673   ⟹   XP_013848127
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1156,466,022 - 56,492,686 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013992675   ⟹   XP_013848129
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1156,466,022 - 56,492,695 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013992676   ⟹   XP_013848130
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1156,466,022 - 56,490,272 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021089914   ⟹   XP_020945573
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1156,466,022 - 56,493,275 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020945573   ⟸   XM_021089914
- Sequence:
RefSeq Acc Id: XP_013848129   ⟸   XM_013992675
- UniProtKB: F1S0E6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013848127   ⟸   XM_013992673
- UniProtKB: F1S0E6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013848126   ⟸   XM_013992672
- UniProtKB: F1S0E6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005659345   ⟸   XM_005659288
- UniProtKB: F1S0E6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013848130   ⟸   XM_013992676
- UniProtKB: F1S0E6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000069188   ⟸   ENSSSCT00000089541
RefSeq Acc Id: ENSSSCP00000004653   ⟸   ENSSSCT00000004764
Protein Domains
G_PROTEIN_RECEP_F1_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000004309 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000004653 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000069188 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000004764 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000089541 ENTREZGENE, UniProtKB/TrEMBL
InterPro Canbinoid_rcpt_1 UniProtKB/TrEMBL
  Cnbnoid_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
KEGG Report ssc:100520160 UniProtKB/TrEMBL
NCBI Gene CNR1 ENTREZGENE
PANTHER PTHR22750:SF47 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PIRSF Cnoid_rcpt_1 UniProtKB/TrEMBL
PRINTS CANABINOID1R UniProtKB/TrEMBL
  CANNABINOIDR UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
UniProt F1S0E6 ENTREZGENE, UniProtKB/TrEMBL
  Q9BFD3_PIG UniProtKB/TrEMBL
VGNC ID VGNC:86843 ENTREZGENE