PTGS1 (prostaglandin-endoperoxide synthase 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: PTGS1 (prostaglandin-endoperoxide synthase 1) Sus scrofa
Analyze
Symbol: PTGS1
Name: prostaglandin-endoperoxide synthase 1
RGD ID: 13857165
Description: ENCODES a protein that exhibits heme binding (inferred); metal ion binding (inferred); peroxidase activity (inferred); INVOLVED IN aging (ortholog); learning (ortholog); maintenance of blood-brain barrier (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Anaphylaxis (ortholog); bipolar disorder (ortholog); FOUND IN cytoplasm (ortholog); intracellular membrane-bounded organelle (ortholog); nuclear envelope (ortholog); INTERACTS WITH folic acid; glycine
Type: protein-coding
RefSeq Status: MODEL
Also known as: COX-1; cyclooxygenase-1; PGHS-1; prostaglandin G/H synthase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1262,456,155 - 262,483,035 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11262,456,106 - 262,482,159 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21294,753,789 - 294,779,835 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
folic acid  (EXP)
glycine  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
acetylsalicylic acid pharmacodynamics pathway  (ISO)
antipyrine drug pathway  (ISO)
arachidonic acid metabolic pathway  (ISO)
celecoxib pharmacodynamics pathway  (ISO)
celecoxib pharmacokinetics pathway  (ISO)
cyclooxygenase mediated pathway of arachidonic acid metabolism  (ISO)
diclofenac pharmacodynamics pathway  (ISO)
diflunisal pharmacodynamics pathway  (ISO)
etodolac pharmacodynamics pathway  (ISO)
etoposide pharmacodynamics pathway  (ISO)
etoposide pharmacokinetics pathway  (ISO)
fenoprofen pharmacodynamics pathway  (ISO)
flurbiprofen pharmacodynamics pathway  (ISO)
ibuprofen pharmacodynamics pathway  (ISO)
ibuprofen pharmacokinetics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
ketoprofen pharmacodynamics pathway  (ISO)
ketorolac pharmacodynamics pathway  (ISO)
leukotriene C4 synthase deficiency pathway  (ISO)
lornoxicam pharmacodynamics pathway  (ISO)
magnesium salicylate pharmacodynamics pathway  (ISO)
mefenamic acid pharmacodynamics pathway  (ISO)
meloxicam pharmacodynamics pathway  (ISO)
nabumetone pharmacodynamics pathway  (ISO)
naproxen pharmacodynamics pathway  (ISO)
paracetamol drug pathway  (ISO)
piroxicam pharmacodynamics pathway  (ISO)
prostanoid biosynthetic pathway  (ISO)
salicylic acid pharmacodynamics pathway  (ISO)
sodium salicylate pharmacodynamics pathway  (ISO)
sulindac pharmacodynamics pathway  (ISO)
tenoxicam pharmacodynamics pathway  (ISO)
tiaprofenic acid pharmacodynamics pathway  (ISO)
tolmetin pharmacodynamics pathway  (ISO)
valdecoxib pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:14681463   PMID:16452463   PMID:24320706  


Genomics

Comparative Map Data
PTGS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1262,456,155 - 262,483,035 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11262,456,106 - 262,482,159 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21294,753,789 - 294,779,835 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTGS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9122,370,530 - 122,395,703 (+)EnsemblGRCh38hg38GRCh38
GRCh389122,369,906 - 122,395,703 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379125,132,812 - 125,157,982 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369124,173,050 - 124,197,802 (+)NCBINCBI36hg18NCBI36
Build 349122,212,782 - 122,237,535NCBI
Celera995,781,549 - 95,806,298 (+)NCBI
Cytogenetic Map9q33.2NCBI
HuRef994,747,532 - 94,772,698 (+)NCBIHuRef
CHM1_19125,280,871 - 125,306,038 (+)NCBICHM1_1
Ptgs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39236,106,758 - 36,142,287 (+)NCBIGRCm39mm39
GRCm39 Ensembl236,120,438 - 36,142,284 (+)Ensembl
GRCm38236,216,742 - 36,258,593 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl236,230,426 - 36,252,272 (+)EnsemblGRCm38mm10GRCm38
MGSCv37236,085,946 - 36,107,789 (+)NCBIGRCm37mm9NCBIm37
MGSCv36236,052,536 - 36,074,271 (+)NCBImm8
Celera235,934,252 - 35,956,092 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map224.19NCBI
Ptgs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2319,584,015 - 19,605,589 (+)NCBI
Rnor_6.0 Ensembl315,560,712 - 15,582,344 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0315,560,685 - 15,582,339 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0320,869,915 - 20,891,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4315,343,832 - 15,365,412 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1315,240,203 - 15,261,784 (+)NCBI
Celera314,295,836 - 14,317,392 (+)NCBICelera
Cytogenetic Map3p11NCBI
Ptgs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554195,678,694 - 5,699,305 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554195,678,750 - 5,699,305 (-)NCBIChiLan1.0ChiLan1.0
PTGS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19121,837,095 - 121,859,283 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9121,837,095 - 121,859,283 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0993,495,365 - 93,517,557 (+)NCBIMhudiblu_PPA_v0panPan3
PTGS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1960,195,118 - 60,216,847 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl960,195,124 - 60,216,819 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha959,390,579 - 59,412,227 (-)NCBI
ROS_Cfam_1.0961,110,468 - 61,132,351 (-)NCBI
UMICH_Zoey_3.1959,884,516 - 59,906,289 (-)NCBI
UNSW_CanFamBas_1.0960,200,281 - 60,222,098 (-)NCBI
UU_Cfam_GSD_1.0960,289,919 - 60,311,671 (-)NCBI
Ptgs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947190,976,385 - 190,990,294 (+)NCBI
SpeTri2.0NW_00493648710,745,465 - 10,758,812 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGS1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11217,195,403 - 17,218,450 (-)NCBI
ChlSab1.1 Ensembl1217,192,628 - 17,218,315 (-)Ensembl
Vero_WHO_p1.0NW_02366603525,831,631 - 25,856,861 (+)NCBI
Ptgs1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476012,917,244 - 12,937,858 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2
Low 10 4 3 3 2 21 1 2 3
Below cutoff 2 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000053729   ⟹   ENSSSCP00000045461
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1262,456,155 - 262,483,035 (+)Ensembl
RefSeq Acc Id: XM_001926129   ⟹   XP_001926164
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11262,456,106 - 262,482,159 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_001926164 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF20941 (Get FASTA)   NCBI Sequence Viewer  
  AAZ17476 (Get FASTA)   NCBI Sequence Viewer  
  ACV74240 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_001926164   ⟸   XM_001926129
- Sequence:
RefSeq Acc Id: ENSSSCP00000045461   ⟸   ENSSSCT00000053729
Protein Domains
EGF-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000005533 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000045461 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000053729 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.640.10 UniProtKB/TrEMBL
InterPro COX-1 UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  Haem_peroxidase_animal UniProtKB/TrEMBL
  Haem_peroxidase_sf UniProtKB/TrEMBL
  Haem_peroxidase_sf_animal UniProtKB/TrEMBL
NCBI Gene PTGS1 ENTREZGENE
PANTHER PTHR11903:SF6 UniProtKB/TrEMBL
Pfam An_peroxidase UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
PRINTS ANPEROXIDASE UniProtKB/TrEMBL
PROSITE EGF_3 UniProtKB/TrEMBL
  PEROXIDASE_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF48113 UniProtKB/TrEMBL
UniProt A0A287ANF9_PIG UniProtKB/TrEMBL
VGNC ID VGNC:91958 ENTREZGENE