SRD5A1 (steroid 5 alpha-reductase 1) - Rat Genome Database

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Gene: SRD5A1 (steroid 5 alpha-reductase 1) Sus scrofa
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Symbol: SRD5A1
Name: steroid 5 alpha-reductase 1
RGD ID: 14130190
Description: ENCODES a protein that exhibits 3-oxo-5-alpha-steroid 4-dehydrogenase activity (ortholog); amide binding (ortholog); NADPH binding (ortholog); INVOLVED IN androgen biosynthetic process (ortholog); androgen catabolic process (ortholog); androgen metabolic process (ortholog); PARTICIPATES IN testosterone biosynthetic pathway; ASSOCIATED WITH breast carcinoma (ortholog); Cardiomegaly (ortholog); COVID-19 (ortholog); FOUND IN cell body fiber (ortholog); neuronal cell body (ortholog); perinuclear region of cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 3-oxo-5-alpha-steroid 4-dehydrogenase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1675,310,211 - 75,335,391 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11675,309,830 - 75,335,438 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21681,671,335 - 81,695,167 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SRD5A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1675,310,211 - 75,335,391 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11675,309,830 - 75,335,438 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21681,671,335 - 81,695,167 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SRD5A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3856,633,440 - 6,674,386 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl56,633,290 - 6,676,539 (+)EnsemblGRCh38hg38GRCh38
GRCh3756,633,553 - 6,674,499 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3656,686,500 - 6,722,675 (+)NCBINCBI36Build 36hg18NCBI36
Build 3456,686,562 - 6,722,673NCBI
Celera56,660,560 - 6,696,748 (+)NCBICelera
Cytogenetic Map5p15.31NCBI
HuRef56,608,126 - 6,644,172 (+)NCBIHuRef
CHM1_156,633,460 - 6,669,635 (+)NCBICHM1_1
T2T-CHM13v2.056,564,115 - 6,605,062 (+)NCBIT2T-CHM13v2.0
Srd5a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391369,721,568 - 69,759,611 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1369,721,568 - 69,759,561 (-)EnsemblGRCm39 Ensembl
GRCm381369,573,449 - 69,611,485 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1369,573,449 - 69,611,442 (-)EnsemblGRCm38mm10GRCm38
MGSCv371369,712,327 - 69,750,341 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361370,040,821 - 70,078,835 (-)NCBIMGSCv36mm8
Celera1371,919,533 - 71,956,201 (-)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1335.55NCBI
Srd5a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8135,514,914 - 35,548,898 (+)NCBIGRCr8
mRatBN7.2133,686,069 - 33,720,468 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl133,686,391 - 33,720,461 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx133,515,801 - 33,550,297 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0139,514,407 - 39,548,898 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0133,714,648 - 33,748,614 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0136,320,504 - 36,354,694 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl136,320,461 - 36,354,756 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0137,717,526 - 37,751,716 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4173,845,190 - 3,879,165 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1173,845,345 - 3,877,557 (+)NCBI
Celera132,290,558 - 32,325,770 (+)NCBICelera
Cytogenetic Map1p11NCBI
Srd5a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555044,360,453 - 4,391,133 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555044,360,909 - 4,388,964 (+)NCBIChiLan1.0ChiLan1.0
SRD5A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v246,880,973 - 6,916,220 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan155,034,510 - 5,069,665 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v056,953,795 - 6,996,010 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.156,629,093 - 6,664,264 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl56,629,093 - 6,664,264 (+)Ensemblpanpan1.1panPan2
SRD5A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1347,118,814 - 7,144,828 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl347,118,814 - 7,144,828 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3411,627,110 - 11,653,073 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0347,026,936 - 7,052,848 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl347,026,936 - 7,052,848 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1347,074,036 - 7,099,998 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0347,054,526 - 7,080,522 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0347,269,539 - 7,295,565 (-)NCBIUU_Cfam_GSD_1.0
Srd5a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213240,167,012 - 240,207,515 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936634758,231 - 798,809 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRD5A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.146,312,770 - 6,348,449 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl46,312,757 - 6,350,550 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606422,370,694 - 22,406,674 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srd5a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247514,309,447 - 4,336,083 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247514,309,518 - 4,335,332 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SRD5A1
1064 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 11 2
Low 9 2 3 5 2 12 3 3
Below cutoff 1

Sequence


RefSeq Acc Id: ENSSSCT00000018621   ⟹   ENSSSCP00000018120
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1675,310,211 - 75,335,391 (-)Ensembl
RefSeq Acc Id: XM_003134156   ⟹   XP_003134204
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11675,309,830 - 75,335,438 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003134204 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000018120
  ENSSSCP00000018120.5
  ENSSSCP00040000646.1
  ENSSSCP00050040034.1
  ENSSSCP00060006064.1
  ENSSSCP00065025855.1
  ENSSSCP00070016701.1
RefSeq Acc Id: XP_003134204   ⟸   XM_003134156
- UniProtKB: A0A8D1Z226 (UniProtKB/TrEMBL),   A0A4X1TNI6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000018120   ⟸   ENSSSCT00000018621

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000017103 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00040001940 UniProtKB/TrEMBL
  ENSSSCG00050068035 UniProtKB/TrEMBL
  ENSSSCG00060011885 UniProtKB/TrEMBL
  ENSSSCG00065043554 UniProtKB/TrEMBL
  ENSSSCG00070010322 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000018621 ENTREZGENE
  ENSSSCT00000018621.5 UniProtKB/TrEMBL
  ENSSSCT00040002322.1 UniProtKB/TrEMBL
  ENSSSCT00050092832.1 UniProtKB/TrEMBL
  ENSSSCT00060015522.1 UniProtKB/TrEMBL
  ENSSSCT00065059594.1 UniProtKB/TrEMBL
  ENSSSCT00070020086.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.1630 UniProtKB/TrEMBL
InterPro 3-oxo-5-alpha-steroid_4-DH UniProtKB/TrEMBL
  3-oxo-5_a-steroid_4-DH_C UniProtKB/TrEMBL
  SRD5A/TECR UniProtKB/TrEMBL
NCBI Gene SRD5A1 ENTREZGENE
PANTHER 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE 1 UniProtKB/TrEMBL
  PTHR10556 UniProtKB/TrEMBL
Pfam Steroid_dh UniProtKB/TrEMBL
PIRSF 5_alpha-SR2 UniProtKB/TrEMBL
PROSITE S5A_REDUCTASE UniProtKB/TrEMBL
UniProt A0A4X1TNI6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1Z226 ENTREZGENE, UniProtKB/TrEMBL
  F1S0R8_PIG UniProtKB/TrEMBL