NQO1 (NAD(P)H quinone dehydrogenase 1) - Rat Genome Database

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Gene: NQO1 (NAD(P)H quinone dehydrogenase 1) Sus scrofa
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Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
RGD ID: 13888687
Description: ENCODES a protein that exhibits NAD(P)H dehydrogenase (quinone) activity (ortholog); superoxide dismutase activity (ortholog); INVOLVED IN aging (ortholog); cellular response to hydrogen peroxide (ortholog); cellular response to metal ion (ortholog); PARTICIPATES IN doxorubicin pharmacokinetics pathway; nuclear factor, erythroid 2 like 2 signaling pathway; oxidative stress response pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); dendrite (ortholog); INTERACTS WITH (-)-epigallocatechin 3-gallate; 3,3',4,4',5-pentachlorobiphenyl; cadmium atom
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: NAD(P)H dehydrogenase [quinone] 1; NAD(P)H dehydrogenase, quinone 1; NADPH-d; nicotinamide adenine dinucleotide phosphate diaphorase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl617,292,769 - 17,302,590 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1617,292,962 - 17,302,593 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2616,238,853 - 16,248,813 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
asthma  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Carbon Tetrachloride Poisoning  (ISO)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Chromosome 8, Trisomy  (ISO)
chronic kidney disease  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
colon cancer  (ISO)
Colorectal Neoplasms  (ISO)
contact dermatitis  (ISO)
Diabetic Nephropathies  (ISO)
disease of cellular proliferation  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
Experimental Pancreatitis, Chronic  (ISO)
fatty liver disease  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhage  (ISO)
hyperglycemia  (ISO)
Hyperoxia  (ISO)
Hyperoxic Lung Injury  (ISO)
hypertension  (ISO)
Intestinal Reperfusion Injury  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
Lead Poisoning  (ISO)
Left Ventricular Hypertrophy  (ISO)
leukemia  (ISO)
liver benign neoplasm  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
lung disease  (ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (ISO)
macular degeneration  (ISO)
membranous glomerulonephritis  (ISO)
mental depression  (ISO)
Mercury Poisoning  (ISO)
middle cerebral artery infarction  (ISO)
multiple myeloma  (ISO)
myelodysplastic syndrome  (ISO)
myeloid leukemia  (ISO)
myeloid neoplasm  (ISO)
neurodegenerative disease  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (ISO)
Occupational Diseases  (ISO)
Overactive Urinary Bladder  (ISO)
papilloma  (ISO)
Parkinson's disease  (ISO)
Poisoning  (ISO)
Prostatic Neoplasms  (ISO)
prostatitis  (ISO)
pulmonary emphysema  (ISO)
renal fibrosis  (ISO)
small cell carcinoma  (ISO)
Spinal Cord Injuries  (ISO)
spinocerebellar ataxia type 17  (ISO)
status epilepticus  (ISO)
Subarachnoid Hemorrhage  (ISO)
toxic encephalopathy  (ISO)
transient cerebral ischemia  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
urinary system cancer  (ISO)
visual epilepsy  (ISO)
warfarin sensitivity  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
cytosol  (IBA,IEA,ISO)
dendrite  (ISO)
neuronal cell body  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:15679890   PMID:17145712   PMID:18165177   PMID:20307898  


Genomics

Comparative Map Data
NQO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl617,292,769 - 17,302,590 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1617,292,962 - 17,302,593 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2616,238,853 - 16,248,813 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NQO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1669,706,996 - 69,726,668 (-)EnsemblGRCh38hg38GRCh38
GRCh381669,709,401 - 69,726,560 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371669,743,304 - 69,760,463 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361668,300,805 - 68,318,034 (-)NCBINCBI36hg18NCBI36
Build 341668,300,809 - 68,317,893NCBI
Celera1654,257,766 - 54,274,991 (-)NCBI
Cytogenetic Map16q22.1NCBI
HuRef1655,621,397 - 55,638,606 (-)NCBIHuRef
CHM1_11671,151,192 - 71,168,417 (-)NCBICHM1_1
Nqo1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398108,114,856 - 108,139,012 (-)NCBIGRCm39mm39
GRCm39 Ensembl8108,114,857 - 108,129,838 (-)Ensembl
GRCm388107,388,225 - 107,403,205 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8107,388,225 - 107,403,206 (-)EnsemblGRCm38mm10GRCm38
MGSCv378109,912,125 - 109,927,105 (-)NCBIGRCm37mm9NCBIm37
MGSCv368110,277,349 - 110,292,395 (-)NCBImm8
Celera8111,617,929 - 111,633,856 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map854.08NCBI
Nqo1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21935,295,633 - 35,310,528 (-)NCBI
Rnor_6.0 Ensembl1938,422,164 - 38,437,180 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01938,422,210 - 38,437,103 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01949,291,903 - 49,306,856 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41937,251,147 - 37,266,040 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11937,255,967 - 37,270,906 (-)NCBI
Celera1934,717,059 - 34,731,947 (-)NCBICelera
Cytogenetic Map19q12NCBI
Nqo1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554847,012,506 - 7,027,604 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554847,012,373 - 7,028,182 (+)NCBIChiLan1.0ChiLan1.0
NQO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11669,472,529 - 69,489,731 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1669,470,288 - 69,489,731 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01650,090,696 - 50,106,495 (-)NCBIMhudiblu_PPA_v0panPan3
NQO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1579,979,593 - 79,990,875 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl579,978,865 - 79,989,860 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha579,968,342 - 79,979,690 (+)NCBI
ROS_Cfam_1.0580,409,927 - 80,421,414 (+)NCBI
UMICH_Zoey_3.1580,237,718 - 80,249,198 (+)NCBI
UNSW_CanFamBas_1.0579,927,217 - 79,938,546 (+)NCBI
UU_Cfam_GSD_1.0580,560,166 - 80,571,660 (+)NCBI
Nqo1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934939,803,797 - 39,817,919 (+)NCBI
SpeTri2.0NW_00493647519,771,384 - 19,785,034 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NQO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1557,676,547 - 57,695,434 (+)NCBI
ChlSab1.1 Ensembl557,675,981 - 57,716,599 (+)Ensembl
Vero_WHO_p1.0NW_02366604720,406,748 - 20,425,872 (+)NCBI
Nqo1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474616,684,620 - 16,698,194 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 7 3 2 2 15 1 1
Low 3 4 3 8 2 2 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000003051   ⟹   ENSSSCP00000002972
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl617,292,769 - 17,302,581 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000073441   ⟹   ENSSSCP00000068184
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl617,292,769 - 17,301,971 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000084074   ⟹   ENSSSCP00000061540
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl617,292,769 - 17,301,971 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000085311   ⟹   ENSSSCP00000063923
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl617,295,671 - 17,302,590 (+)Ensembl
RefSeq Acc Id: NM_001159613   ⟹   NP_001153085
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1617,292,962 - 17,302,593 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001153085 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001153085   ⟸   NM_001159613
- UniProtKB: F1S395 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000061540   ⟸   ENSSSCT00000084074
RefSeq Acc Id: ENSSSCP00000068184   ⟸   ENSSSCT00000073441
RefSeq Acc Id: ENSSSCP00000063923   ⟸   ENSSSCT00000085311
RefSeq Acc Id: ENSSSCP00000002972   ⟸   ENSSSCT00000003051
Protein Domains
Flavodoxin_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000002754 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070001147 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000002972 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000061540 UniProtKB/TrEMBL
  ENSSSCP00000063923 UniProtKB/TrEMBL
  ENSSSCP00000068184 UniProtKB/TrEMBL
  ENSSSCP00070001841 UniProtKB/TrEMBL
  ENSSSCP00070001852 UniProtKB/TrEMBL
  ENSSSCP00070001859 UniProtKB/TrEMBL
  ENSSSCP00070001864 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000003051 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000073441 UniProtKB/TrEMBL
  ENSSSCT00000084074 UniProtKB/TrEMBL
  ENSSSCT00000085311 UniProtKB/TrEMBL
  ENSSSCT00070002198 UniProtKB/TrEMBL
  ENSSSCT00070002209 UniProtKB/TrEMBL
  ENSSSCT00070002217 UniProtKB/TrEMBL
  ENSSSCT00070002223 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.360 UniProtKB/TrEMBL
InterPro Flavodoxin_fold UniProtKB/TrEMBL
  Flavoprotein-like_sf UniProtKB/TrEMBL
KEGG Report ssc:100286873 UniProtKB/TrEMBL
NCBI Gene NQO1 ENTREZGENE
Pfam Flavodoxin_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF52218 UniProtKB/TrEMBL
UniProt A0A4X1SHT1_PIG UniProtKB/TrEMBL
  A0A4X1SHU0_PIG UniProtKB/TrEMBL
  A0A4X1SJ22_PIG UniProtKB/TrEMBL
  A0A4X1SJ27_PIG UniProtKB/TrEMBL
  A0A5G2QPB5_PIG UniProtKB/TrEMBL
  A0A5G2QTR3_PIG UniProtKB/TrEMBL
  A0A5G2RC40_PIG UniProtKB/TrEMBL
  F1S395 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:96630 ENTREZGENE