CDKN1A (cyclin dependent kinase inhibitor 1A) - Rat Genome Database

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Gene: CDKN1A (cyclin dependent kinase inhibitor 1A) Sus scrofa
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Symbol: CDKN1A
Name: cyclin dependent kinase inhibitor 1A
RGD ID: 14043378
Description: ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); cellular response to DNA damage stimulus (ortholog); cellular response to gamma radiation (ortholog); PARTICIPATES IN G1/S transition pathway; Notch signaling pathway; nuclear factor, erythroid 2 like 2 signaling pathway; ASSOCIATED WITH acoustic neuroma (ortholog); Acute Experimental Pancreatitis (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); perinuclear region of cytoplasm (ortholog); INTERACTS WITH bis(2-chloroethyl) sulfide; bisphenol A; paracetamol
Type: protein-coding
RefSeq Status: MODEL
Also known as: Cyclin Dependent Kinase ininhibitor 1A; cyclin-dependent kinase inhibitor 1; LOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl732,359,455 - 32,363,761 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1732,354,776 - 32,363,771 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2737,258,037 - 37,267,157 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acoustic neuroma  (ISO)
Acute Experimental Pancreatitis  (ISO)
Animal Mammary Neoplasms  (ISO)
Arsenic Poisoning  (ISO)
atrial fibrillation  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
Barrett's esophagus  (ISO)
Bowen's Disease  (ISO)
Brain Injuries  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
cervix uteri carcinoma in situ  (ISO)
cholesteatoma of middle ear  (ISO)
Colonic Neoplasms  (ISO)
Congenital Cholesteatoma  (ISO)
Diabetic Nephropathies  (ISO)
ductal carcinoma in situ  (ISO)
Endometrial Neoplasms  (ISO)
Esophageal Neoplasms  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
facioscapulohumeral muscular dystrophy  (ISO)
Fuchs' endothelial dystrophy  (ISO)
growth hormone secreting pituitary adenoma  (ISO)
Hearing Loss, Noise-Induced  (ISO)
high grade glioma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hyperoxia  (ISO)
Hyperplasia  (ISO)
Hypertrophy  (ISO)
Hypovolemia  (ISO)
Intestinal Neoplasms  (ISO)
inverted papilloma  (ISO)
kidney disease  (ISO)
laryngeal squamous cell carcinoma  (ISO)
Lip Neoplasms  (ISO)
lipoid nephrosis  (ISO)
liver benign neoplasm  (ISO)
Liver Neoplasms  (ISO)
localized scleroderma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
malignant mesothelioma  (ISO)
maxillary sinus squamous cell carcinoma  (ISO)
melanoma  (ISO)
Neoplasm Metastasis  (ISO)
ocular hypertension  (ISO)
Oral Lichen Planus  (ISO)
oral mucosa leukoplakia  (ISO)
oral squamous cell carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic carcinoma  (ISO)
pancreatic ductal carcinoma  (ISO)
papilloma  (ISO)
Phyllodes Tumor  (ISO)
Pituitary Neoplasms  (ISO)
pre-malignant neoplasm  (ISO)
Premature Aging  (ISO)
primary biliary cholangitis  (ISO)
primary open angle glaucoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
pulmonary hypertension  (ISO)
renal hypertension  (ISO)
Reperfusion Injury  (ISO)
Salivary Gland Neoplasms  (ISO)
sarcoidosis  (ISO)
Sarcopenia  (ISO)
sebaceous gland neoplasm  (ISO)
Sepsis  (ISO)
serous cystadenocarcinoma  (ISO)
Skin Neoplasms  (ISO)
squamous cell carcinoma  (ISO)
stomach carcinoma  (ISO)
Stomach Neoplasms  (ISO)
T-Cell Lymphoma  (ISO)
Thyroid Neoplasms  (ISO)
Tongue Neoplasms  (ISO)
tongue squamous cell carcinoma  (ISO)
transitional cell carcinoma  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
cellular response to amino acid starvation  (IEA)
cellular response to DNA damage stimulus  (IEA,ISO)
cellular response to extracellular stimulus  (IEA)
cellular response to gamma radiation  (IEA,ISO)
cellular response to heat  (ISO)
cellular response to ionizing radiation  (IEA)
cellular response to UV-B  (IEA)
cellular senescence  (IEA)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  (IEA)
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator  (IEA,ISO)
heart development  (IEA)
intestinal epithelial cell maturation  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IEA,ISO)
mitotic G2 DNA damage checkpoint signaling  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of cardiac muscle tissue regeneration  (IEA)
negative regulation of catalytic activity  (IEA)
negative regulation of cell growth  (IEA)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of cyclin-dependent protein kinase activity  (IEA)
negative regulation of cyclin-dependent protein serine/threonine kinase activity  (IEA,ISO)
negative regulation of DNA biosynthetic process  (IEA)
negative regulation of G1/S transition of mitotic cell cycle  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of phosphorylation  (IEA)
negative regulation of protein binding  (IEA)
negative regulation of vascular associated smooth muscle cell proliferation  (IEA)
phosphorylation  (IEA)
positive regulation of B cell proliferation  (IEA,ISO)
positive regulation of cell death  (ISO)
positive regulation of cyclin-dependent protein kinase activity  (IEA)
positive regulation of fibroblast proliferation  (IEA)
positive regulation of programmed cell death  (IEA,ISO)
positive regulation of protein kinase activity  (IEA,ISO)
positive regulation of reactive oxygen species metabolic process  (IEA)
protein import into nucleus  (IEA,ISO)
Ras protein signal transduction  (IEA)
regulation of cell cycle  (IEA,ISO)
regulation of cell cycle G1/S phase transition  (IEA)
regulation of cyclin-dependent protein serine/threonine kinase activity  (IEA,ISO)
regulation of DNA biosynthetic process  (IEA,ISO)
regulation of G1/S transition of mitotic cell cycle  (IEA)
regulation of G2/M transition of mitotic cell cycle  (IEA)
regulation of macromolecule metabolic process  (IEA)
regulation of mitotic cell cycle  (IEA,ISO)
replicative senescence  (IEA)
response to arsenic-containing substance  (ISO)
response to corticosterone  (ISO)
response to glucocorticoid  (ISO)
response to hyperoxia  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to organonitrogen compound  (ISO)
response to toxic substance  (ISO)
response to UV  (IEA,ISO)
response to X-ray  (ISO)
response to xenobiotic stimulus  (ISO)
signal transduction by p53 class mediator  (IEA)
tissue regeneration  (IEA)
wound healing  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:14681463   PMID:30772521  


Genomics

Comparative Map Data
CDKN1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl732,359,455 - 32,363,761 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1732,354,776 - 32,363,771 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2737,258,037 - 37,267,157 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDKN1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl636,676,460 - 36,687,337 (+)EnsemblGRCh38hg38GRCh38
GRCh38636,676,463 - 36,687,332 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37636,644,240 - 36,655,109 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36636,754,465 - 36,763,087 (+)NCBINCBI36hg18NCBI36
Build 34636,754,464 - 36,763,086NCBI
Celera638,201,500 - 38,210,146 (+)NCBI
Cytogenetic Map6p21.2NCBI
HuRef636,362,600 - 36,373,330 (+)NCBIHuRef
CHM1_1636,645,994 - 36,657,029 (+)NCBICHM1_1
Cdkn1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391729,309,953 - 29,319,696 (+)NCBIGRCm39mm39
GRCm39 Ensembl1729,309,950 - 29,319,701 (+)Ensembl
GRCm381729,090,979 - 29,100,722 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1729,090,976 - 29,100,727 (+)EnsemblGRCm38mm10GRCm38
MGSCv371729,227,931 - 29,237,667 (+)NCBIGRCm37mm9NCBIm37
MGSCv361728,821,439 - 28,828,386 (+)NCBImm8
Celera1729,647,617 - 29,657,304 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1715.12NCBI
Cdkn1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2207,149,177 - 7,159,727 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl207,149,217 - 7,159,585 (+)Ensembl
Rnor_6.0206,348,422 - 6,358,864 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl206,351,458 - 6,358,864 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,592,437 - 8,602,879 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4207,376,325 - 7,386,778 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1207,379,612 - 7,385,803 (+)NCBI
Celera208,699,290 - 8,709,718 (+)NCBICelera
Cytogenetic Map20p12NCBI
Cdkn1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554376,254,309 - 6,261,479 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554376,254,638 - 6,261,278 (-)NCBIChiLan1.0ChiLan1.0
CDKN1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1637,436,963 - 37,445,599 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl637,436,990 - 37,445,599 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0636,241,405 - 36,250,032 (+)NCBIMhudiblu_PPA_v0panPan3
CDKN1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1125,746,898 - 5,755,103 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl125,745,852 - 5,892,281 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha125,765,839 - 5,774,065 (+)NCBI
ROS_Cfam_1.0126,095,734 - 6,103,965 (+)NCBI
UMICH_Zoey_3.1125,750,615 - 5,758,848 (+)NCBI
UNSW_CanFamBas_1.0125,829,928 - 5,838,160 (+)NCBI
UU_Cfam_GSD_1.0125,928,229 - 5,936,457 (+)NCBI
Cdkn1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494641,235,060 - 41,242,922 (+)NCBI
SpeTri2.0NW_00493647622,717,308 - 22,725,127 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDKN1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11735,445,668 - 35,454,334 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1735,445,223 - 35,454,342 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604436,625,094 - 36,634,245 (+)NCBIVero_WHO_p1.0
Cdkn1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475421,109,074 - 21,115,869 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 1 2 2 1 3
Low 2 4 3 4 20 2 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000001744   ⟹   ENSSSCP00000001700
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl732,359,455 - 32,363,761 (+)Ensembl
RefSeq Acc Id: XM_013977858   ⟹   XP_013833312
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1732,354,776 - 32,363,771 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013833312 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAF32805 (Get FASTA)   NCBI Sequence Viewer  
  JAG69646 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013833312   ⟸   XM_013977858
- Sequence:
RefSeq Acc Id: ENSSSCP00000001700   ⟸   ENSSSCT00000001744
Protein Domains
CDI


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000001565 Ensembl, UniProtKB/TrEMBL
  ENSSSCG00070003808 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000001700 UniProtKB/TrEMBL
  ENSSSCP00070005834 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000001744 UniProtKB/TrEMBL
  ENSSSCT00070007135 UniProtKB/TrEMBL
InterPro CDI UniProtKB/TrEMBL
  CDKN1A UniProtKB/TrEMBL
NCBI Gene CDKN1A ENTREZGENE
PANTHER PTHR46778 UniProtKB/TrEMBL
Pfam CDI UniProtKB/TrEMBL
UniProt A0A4X1SSN3_PIG UniProtKB/TrEMBL
  F1RVT3_PIG UniProtKB/TrEMBL
  Q700R1_PIG UniProtKB/TrEMBL
VGNC ID VGNC:86514 ENTREZGENE