F2 (coagulation factor II, thrombin) - Rat Genome Database

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Gene: F2 (coagulation factor II, thrombin) Sus scrofa
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Symbol: F2
Name: coagulation factor II, thrombin
RGD ID: 13986341
Description: ENCODES a protein that exhibits peptidase activity (ortholog); INVOLVED IN blood coagulation (ortholog); cellular response to mechanical stimulus (ortholog); platelet activation (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH acquired angioedema (ortholog); Acute Coronary Syndrome (ortholog); Acute Lung Injury (ortholog); FOUND IN collagen-containing extracellular matrix (ortholog); external side of plasma membrane (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: prothrombin; thrombin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,791,451 - 15,819,138 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1215,793,257 - 15,819,151 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2217,145,002 - 17,170,975 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acquired angioedema  (ISO)
Acute Coronary Syndrome  (ISO)
Acute Lung Injury  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
appendicitis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
autoimmune hepatitis  (ISO)
bacterial pneumonia  (ISO)
blood coagulation disease  (ISO)
brain edema  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
bullous pemphigoid  (ISO)
calcium oxalate nephrolithiasis  (ISO)
carotid stenosis  (ISO)
celiac disease  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
Chagas disease  (ISO)
chronic obstructive pulmonary disease  (ISO)
clear cell renal cell carcinoma  (ISO)
congenital disorder of glycosylation type IIc  (ISO)
Congenital Prothrombin Deficiency  (ISO)
Contusions  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
dengue disease  (ISO)
Diabetic Nephropathies  (ISO)
disseminated intravascular coagulation  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
eye disease  (ISO)
factor VIII deficiency  (ISO)
Familial Amyloid Polyneuropathies  (ISO)
familial Mediterranean fever  (ISO)
fatty liver disease  (ISO)
Femur Head Necrosis  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
hemolytic-uremic syndrome  (ISO)
hemophilia B  (ISO)
Hemorrhage  (ISO)
Hemorrhagic Shock  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
hereditary angioedema  (ISO)
herpes zoster  (ISO)
high grade glioma  (ISO)
Human Viral Hepatitis  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (ISO)
hyperglycemia  (ISO)
hyperhomocysteinemia  (ISO)
Hypertrophy  (ISO)
intellectual disability  (ISO)
intracranial sinus thrombosis  (ISO)
Kidney Calculi  (ISO)
Knee Osteoarthritis  (ISO)
leptospirosis  (ISO)
liver cirrhosis  (ISO)
Liver Failure  (ISO)
Mesenteric Ischemia  (ISO)
middle cerebral artery infarction  (ISO)
myocardial infarction  (ISO)
Neoplasm Metastasis  (ISO)
nephrosis  (ISO)
Nerve Degeneration  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (ISO)
ovarian cancer  (ISO)
Paratuberculosis  (ISO)
Pediatric Crohn's Disease  (ISO)
portal vein thrombosis  (ISO)
pre-eclampsia  (ISO)
prostate cancer  (ISO)
prothrombin deficiency  (ISO)
pulmonary embolism  (ISO)
pulmonary fibrosis  (ISO)
Reperfusion Injury  (ISO)
retinal vein occlusion  (ISO)
rheumatoid arthritis  (ISO)
schizophrenia  (ISO)
sensorineural hearing loss  (ISO)
Sepsis  (ISO)
Septic Peritonitis  (ISO)
sickle cell anemia  (ISO)
Spinal Cord Injuries  (ISO)
Spontaneous Abortions  (ISO)
Stroke  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
Thromboembolism  (ISO)
thrombophilia  (ISO)
thrombophilia due to thrombin defect  (ISO)
thrombosis  (ISO)
toxic shock syndrome  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
Urinary Calculi  (ISO)
urticaria  (ISO)
vascular skin disease  (ISO)
Venous Thromboembolism  (ISO)
Venous Thrombosis  (ISO)
Ventricular Dysfunction, Left  (ISO)
Ventricular Fibrillation  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (IEA)
antimicrobial humoral immune response mediated by antimicrobial peptide  (IEA)
blood coagulation  (ISO)
cell surface receptor signaling pathway  (IEA)
cellular response to mechanical stimulus  (ISO)
cytolysis by host of symbiont cells  (IEA)
fibrinolysis  (IEA)
negative regulation of astrocyte differentiation  (IEA)
negative regulation of cytokine production involved in inflammatory response  (IEA)
negative regulation of proteolysis  (IEA)
neutrophil-mediated killing of gram-negative bacterium  (IEA)
platelet activation  (IBA,ISO)
positive regulation of blood coagulation  (IBA,ISO)
positive regulation of cell growth  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of collagen biosynthetic process  (IEA)
positive regulation of lipid kinase activity  (IEA)
positive regulation of phosphatidylinositol 3-kinase signaling  (IEA,ISO)
positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway  (IEA)
positive regulation of protein localization to nucleus  (IEA)
positive regulation of protein phosphorylation  (IEA)
positive regulation of reactive oxygen species metabolic process  (IEA)
positive regulation of release of sequestered calcium ion into cytosol  (IEA)
proteolysis  (IEA)
regulation of cell shape  (IEA,ISO)
regulation of cytosolic calcium ion concentration  (ISO)
regulation of gene expression  (ISO)
response to inactivity  (ISO)
response to Thyroglobulin triiodothyronine  (ISO)
response to thyrotropin-releasing hormone  (ISO)
response to thyroxine  (ISO)
response to wounding  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:14983233   PMID:18374141   PMID:18444940   PMID:19150392   PMID:19574550  


Genomics

Comparative Map Data
F2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,791,451 - 15,819,138 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1215,793,257 - 15,819,151 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2217,145,002 - 17,170,975 (-)NCBISscrofa10.2Sscrofa10.2susScr3
F2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1146,719,196 - 46,739,506 (+)EnsemblGRCh38hg38GRCh38
GRCh381146,719,213 - 46,739,506 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371146,740,763 - 46,761,056 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361146,697,331 - 46,717,631 (+)NCBINCBI36hg18NCBI36
Build 341146,697,330 - 46,717,631NCBI
Celera1146,888,702 - 46,909,014 (+)NCBI
Cytogenetic Map11p11.2NCBI
HuRef1146,446,660 - 46,466,973 (+)NCBIHuRef
CHM1_11146,739,149 - 46,759,462 (+)NCBICHM1_1
F2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39291,442,742 - 91,466,802 (-)NCBIGRCm39mm39
GRCm39 Ensembl291,455,665 - 91,466,759 (-)Ensembl
GRCm38291,612,397 - 91,636,457 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,625,320 - 91,636,414 (-)EnsemblGRCm38mm10GRCm38
MGSCv37291,465,477 - 91,476,571 (-)NCBIGRCm37mm9NCBIm37
MGSCv36291,426,159 - 91,437,253 (-)NCBImm8
Celera293,014,831 - 93,025,920 (-)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.63NCBI
F2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2377,596,196 - 77,609,486 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl380,529,428 - 80,543,031 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0380,529,468 - 80,542,993 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0387,228,703 - 87,242,228 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4376,005,318 - 76,018,603 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1375,901,694 - 75,914,982 (-)NCBI
Celera376,801,000 - 76,814,280 (-)NCBICelera
Cytogenetic Map3q24NCBI
F2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554221,356,769 - 1,367,517 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554221,356,675 - 1,367,788 (-)NCBIChiLan1.0ChiLan1.0
F2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11147,227,891 - 47,249,157 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,227,891 - 47,249,157 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01146,669,925 - 46,690,391 (+)NCBIMhudiblu_PPA_v0panPan3
F2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,782,744 - 42,799,531 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1842,782,751 - 42,799,459 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1841,511,662 - 41,528,485 (-)NCBI
ROS_Cfam_1.01843,438,760 - 43,455,850 (-)NCBI
UMICH_Zoey_3.11842,924,063 - 42,940,888 (-)NCBI
UNSW_CanFamBas_1.01842,479,219 - 42,496,510 (-)NCBI
UU_Cfam_GSD_1.01843,208,980 - 43,225,802 (-)NCBI
F2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494720,260,330 - 20,277,033 (-)NCBI
SpeTri2.0NW_0049365622,371,725 - 2,388,617 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247671,876,974 - 1,887,720 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2
Low 1 3
Below cutoff 7 1 3 3 1 14 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000014473   ⟹   ENSSSCP00000014081
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl215,791,451 - 15,819,138 (-)Ensembl
RefSeq Acc Id: NM_001122985   ⟹   NP_001116457
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1215,793,262 - 15,819,123 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021076838   ⟹   XP_020932497
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1215,793,257 - 15,819,151 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001116457 (Get FASTA)   NCBI Sequence Viewer  
  XP_020932497 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAR99595 (Get FASTA)   NCBI Sequence Viewer  
  ABF82359 (Get FASTA)   NCBI Sequence Viewer  
  ABV53442 (Get FASTA)   NCBI Sequence Viewer  
  Q19AZ8 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020932497   ⟸   XM_021076838
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001116457   ⟸   NM_001122985
- Peptide Label: precursor
- UniProtKB: Q19AZ8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000014081   ⟸   ENSSSCT00000014473
Protein Domains
Gla   Kringle   Peptidase S1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000013252 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070026255 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000014081 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070044559 UniProtKB/TrEMBL
  ENSSSCP00070044562 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000014473 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070052632 UniProtKB/TrEMBL
  ENSSSCT00070052634 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.140.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GLA-like_dom_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prothrombin/thrombin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thrombin_light_chain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thrombin_light_chain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100144442 UniProtKB/Swiss-Prot
NCBI Gene F2 ENTREZGENE
PANTHER PTHR24254:SF10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Gla UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thrombin_light UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF Thrombin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLABLOOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTHROMBIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRINGLE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRINGLE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART GLA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1VLZ9_PIG UniProtKB/TrEMBL
  A0A4X1VTP8_PIG UniProtKB/TrEMBL
  F1SIB1_PIG UniProtKB/TrEMBL
  Q19AZ8 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:97993 ENTREZGENE