INS (insulin) - Rat Genome Database

Name: INS
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: INS (insulin) Sus scrofa

Analyze

Symbol:

INS

Name:

insulin

RGD ID:

14043101

Description:

ENCODES a protein that exhibits hormone activity; identical protein binding; insulin-like growth factor receptor binding; INVOLVED IN glycoprotein biosynthetic process; lactate biosynthetic process; lipid biosynthetic process; PARTICIPATES IN altered insulin signaling pathway; forkhead class A signaling pathway; gliclazide pharmacodynamics pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Liver Failure (ortholog); adenoma (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); extracellular space (ortholog); INTERACTS WITH aldehydo-D-glucose; alpha-(methylamino)isobutyric acid; androst-4-ene-3,17-dione

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

preproinsulin; proinsulin

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	INS (insulin)	HGNC	Ensembl, Inparanoid, NCBI, OrthoDB
Mus musculus (house mouse):	Ins2 (insulin II)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Ins2 (insulin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ins (insulin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	INS (insulin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	INS (insulin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ins (insulin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	INS (insulin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ins (insulin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	INS-IGF2 (INS-IGF2 readthrough)	HGNC	OrthoDB

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	1,496,842 - 1,497,841 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	1,496,842 - 1,498,052 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute kidney failure (ISO)

Acute Liver Failure (ISO)

adenoma (ISO)

Albuminuria (ISO)

Alzheimer's disease (ISO)

bipolar disorder (ISO)

bladder disease (ISO)

cardiac arrest (ISO)

cholangiocarcinoma (ISO)

cognitive disorder (ISO)

congestive heart failure (ISO)

cystic kidney disease (ISO)

delta beta-thalassemia (ISO)

developmental and epileptic encephalopathy (ISO)

diabetes mellitus (ISO)

Diabetic Cardiomyopathies (ISO)

diabetic ketoacidosis (ISO)

Diabetic Nephropathies (ISO)

diabetic retinopathy (ISO)

disease of metabolism (ISO)

early infantile epileptic encephalopathy (ISO)

Edema (ISO)

Experimental Liver Cirrhosis (ISO)

fatty liver disease (ISO)

generalized dystonia (ISO)

genetic disease (ISO)

gestational diabetes (ISO)

glucose intolerance (ISO)

hepatitis (ISO)

hepatocellular carcinoma (ISO)

hyperglycemia (ISO)

hyperinsulinism (ISO)

Hyperkalemia (ISO)

Hyperproinsulinemia (ISO)

hypertension (ISO)

Hypertriglyceridemia (ISO)

hypertrophic cardiomyopathy (ISO)

hyperuricemia (ISO)

hypoglycemia (ISO)

Hypoinsulinemia (ISO)

hypokalemia (ISO)

Hypotension (ISO)

immunodeficiency 39 (ISO)

Insulin Resistance (ISO)

insulinoma (ISO)

kidney disease (ISO)

kidney failure (ISO)

Lewy body dementia (ISO)

liver disease (ISO)

maturity-onset diabetes of the young (ISO)

maturity-onset diabetes of the young type 1 (ISO)

maturity-onset diabetes of the young type 10 (ISO)

Memory Disorders (ISO)

Metabolic Syndrome (ISO)

Micronuclei, Chromosome-Defective (ISO)

MPTP Poisoning (ISO)

muscular disease (ISO)

neonatal diabetes (ISO)

Neoplasm Invasiveness (ISO)

neural tube defect (ISO)

neuronal ceroid lipofuscinosis (ISO)

non-alcoholic fatty liver disease (ISO)

obesity (ISO)

osteoarthritis (ISO)

pancreatic cancer (ISO)

pancreatic ductal carcinoma (ISO)

pancreatitis (ISO)

panic disorder (ISO)

Paralysis (ISO)

Paresthesia (ISO)

Parkinson's disease (ISO)

permanent neonatal diabetes mellitus (ISO)

Permanent Neonatal Diabetes Mellitus 4 (ISO)

Phelan-McDermid syndrome (ISO)

polycystic ovary syndrome (ISO)

prostate cancer (ISO)

Prostatic Neoplasms (ISO)

Rhabdomyolysis (ISO)

Segawa Syndrome, Autosomal Recessive (ISO)

Tachycardia (ISO)

transient neonatal diabetes mellitus (ISO)

type 1 diabetes mellitus (ISO)

type 1 diabetes mellitus 2 (ISO)

type 2 diabetes mellitus (ISO)

Type 2 Diabetes Mellitus 1 (ISO)

Ventricular Dysfunction, Left (ISO)

Ventricular Fibrillation (ISO)

Ventricular Outflow Obstruction (ISO)

Weight Loss (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

aldehydo-D-glucose (EXP)

alpha-(methylamino)isobutyric acid (EXP)

androst-4-ene-3,17-dione (EXP)

chromium atom (EXP)

D-glucose (EXP)

dimercaprol (EXP)

glucose (EXP)

lipopolysaccharide (EXP)

phenylarsine oxide (EXP)

prostaglandin J2 (EXP)

sirolimus (EXP)

testosterone (EXP)

tris(picolinato)chromium (EXP)

troglitazone (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of protein kinase B activity (IEA)

acute-phase response (IEA)

alpha-beta T cell activation (IEA)

carbohydrate metabolic process (IEA)

ER overload response (ISO)

fatty acid homeostasis (IEA)

G protein-coupled receptor signaling pathway (IEA)

glucose homeostasis (IBA,IEA,ISO)

glucose metabolic process (IEA,ISO)

glycoprotein biosynthetic process (IMP)

insulin processing (ISO)

insulin receptor signaling pathway (IEA,ISO)

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (ISO)

lactate biosynthetic process (IMP)

lipid biosynthetic process (IMP)

lipid catabolic process (ISO)

lipoprotein biosynthetic process (IMP)

myoblast fusion (ISO)

myotube differentiation (ISO)

negative regulation of acute inflammatory response (IEA)

negative regulation of fatty acid metabolic process (IEA)

negative regulation of feeding behavior (IEA)

negative regulation of gene expression (IEA,ISO)

negative regulation of gluconeogenesis (IMP)

negative regulation of glycogen catabolic process (IEA)

negative regulation of lipid catabolic process (IEA)

negative regulation of NAD(P)H oxidase activity (IEA)

negative regulation of protein catabolic process (IEA)

negative regulation of protein secretion (IEA)

negative regulation of proteolysis (IEA)

negative regulation of reactive oxygen species biosynthetic process (IEA)

negative regulation of respiratory burst involved in inflammatory response (IEA)

negative regulation of transcription by RNA polymerase II (ISO)

neuron projection maintenance (IEA)

nitric oxide-cGMP-mediated signaling pathway (IEA)

positive regulation of cell migration (IMP)

positive regulation of cell population proliferation (IEA)

positive regulation of cytokine production (IEA)

positive regulation of dendritic spine maintenance (IEA)

positive regulation of DNA replication (IDA)

positive regulation of ERK1 and ERK2 cascade (ISO)

positive regulation of fatty acid biosynthetic process (IDA)

positive regulation of gene expression (IEA)

positive regulation of glucose import (IEA)

positive regulation of glucose metabolic process (IDA)

positive regulation of glycogen biosynthetic process (IEA)

positive regulation of glycolytic process (IEA)

positive regulation of insulin receptor signaling pathway (IDA,IEA)

positive regulation of lipoprotein lipase activity (IDA)

positive regulation of MAPK cascade (IEA)

positive regulation of mitotic nuclear division (IEA)

positive regulation of NF-kappaB transcription factor activity (IEA)

positive regulation of nitric oxide mediated signal transduction (IEA)

positive regulation of peptidyl-tyrosine phosphorylation (IDA,ISO)

positive regulation of phosphatidylinositol 3-kinase activity (ISO)

positive regulation of phosphatidylinositol 3-kinase signaling (IEA)

positive regulation of protein autophosphorylation (IDA)

positive regulation of protein kinase B signaling (IEA)

positive regulation of protein localization to nucleus (IEA)

positive regulation of protein metabolic process (IEA)

positive regulation of protein secretion (IBA)

positive regulation of respiratory burst (IEA)

protein hexamerization (ISO)

receptor internalization (ISO)

regulation of cellular amino acid metabolic process (IEA)

regulation of gene expression (ISO)

regulation of phosphorylation (ISO)

regulation of protein binding (ISO)

regulation of protein localization (IEA)

regulation of protein localization to plasma membrane (IEA)

regulation of protein secretion (IEA)

regulation of transmembrane transporter activity (IEA)

response to L-arginine (ISS)

vasodilation (IEA)

wound healing (IEA)

Cellular Component

cytoplasm (ISO)

cytosol (ISO)

extracellular region (IEA)

extracellular space (IBA,IEA,ISO,ISS)

nucleus (ISO)

secretory granule (ISO)

sno(s)RNA-containing ribonucleoprotein complex (ISO)

Molecular Function

1-phosphatidylinositol-3-kinase activity (ISO)

hormone activity (IEA,IMP)

identical protein binding (IEA,IPI)

insulin receptor binding (IEA,ISO)

insulin-like growth factor receptor binding (IEA,IMP)

protease binding (IEA)

protein binding (ISO)

zinc ion binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

altered insulin signaling pathway (ISO)

forkhead class A signaling pathway (ISO)

gliclazide pharmacodynamics pathway (ISO)

glyburide pharmacodynamics pathway (ISO)

insulin responsive facilitative sugar transporter mediated glucose transport pathway (ISO)

insulin signaling pathway (ISO)

potassium channel inhibitors pharmacodynamics pathway (ISO)

type 2 diabetes mellitus pathway (ISO)

References

Additional References at PubMed

PMID:1772633	PMID:2025410	PMID:2905485	PMID:2967174	PMID:3518947	PMID:5657063	PMID:7492558	PMID:7513704	PMID:7782332	PMID:8069456	PMID:12138094	PMID:12140686
PMID:14574411	PMID:14677856	PMID:15299880	PMID:15326283	PMID:16800793	PMID:17914645	PMID:17991146	PMID:18071885	PMID:18700853	PMID:19321435	PMID:19682540	PMID:19770501
PMID:20399063	PMID:20683642	PMID:21635573	PMID:21871559	PMID:23274907	PMID:23416304	PMID:24041697	PMID:24811232	PMID:24825179	PMID:24846393	PMID:25687571	PMID:27748508
PMID:28445749	PMID:29691708	PMID:30267353	PMID:31394126	PMID:32663503

Genomics

Comparative Map Data

INS
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	1,496,842 - 1,497,841 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	1,496,842 - 1,498,052 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

INS
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	2,159,779 - 2,161,209 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	11	2,159,779 - 2,161,221 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	2,181,009 - 2,182,439 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	2,137,585 - 2,139,015 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	2,137,584 - 2,139,000	NCBI
Celera	11	2,217,516 - 2,218,946 (-)	NCBI		Celera
Cytogenetic Map	11	p15.5	NCBI
HuRef	11	1,971,272 - 1,972,702 (-)	NCBI		HuRef
CHM1_1	11	2,179,957 - 2,181,387 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	2,247,427 - 2,248,857 (-)	NCBI		T2T-CHM13v2.0

Ins2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	142,232,393 - 142,233,463 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	142,232,393 - 142,297,118 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	142,678,656 - 142,679,726 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	142,678,656 - 142,743,381 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	149,864,561 - 149,865,613 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	142,488,051 - 142,489,098 (-)	NCBI		MGSCv36	mm8
Celera	7	142,434,985 - 142,436,037 (-)	NCBI		Celera
Cytogenetic Map	7	F5	NCBI
cM Map	7	88.0	NCBI

Ins2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	197,843,277 - 197,992,522 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	197,843,281 - 197,864,775 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	206,216,147 - 206,217,214 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	1	213,302,063 - 213,303,130 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	1	205,976,222 - 205,977,289 (-)	NCBI	Rnor_WKY
Rnor_6.0	1	215,856,967 - 215,858,034 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	215,856,971 - 215,858,034 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	222,751,786 - 222,756,821 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	202,935,548 - 202,936,379 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	203,123,613 - 203,124,445 (-)	NCBI
Celera	1	195,461,309 - 195,462,376 (-)	NCBI		Celera
Cytogenetic Map	1	q41	NCBI

Ins
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	13,909,407 - 13,910,419 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	13,909,408 - 13,910,419 (-)	NCBI	ChiLan1.0	ChiLan1.0

INS
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	11	3,797,925 - 3,799,616 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	2,200,785 - 2,202,579 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	2,230,309 - 2,231,666 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	2,218,117 - 2,231,666 (-)	Ensembl	panpan1.1		panPan2

INS
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	46,324,047 - 46,324,933 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	46,324,041 - 46,325,122 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	44,933,843 - 44,934,720 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	47,003,520 - 47,004,406 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	47,003,520 - 47,004,411 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	46,452,280 - 46,453,156 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	46,032,597 - 46,033,483 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	46,779,045 - 46,779,926 (-)	NCBI		UU_Cfam_GSD_1.0

Ins
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	1,748,017 - 1,749,237 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936816	1,002,137 - 1,003,357 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936816	1,002,137 - 1,003,357 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

INS
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	1,965,128 - 1,969,090 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666038	99,163,059 - 99,164,540 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ins
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624767	14,999,088 - 15,000,035 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624767	14,999,088 - 15,000,035 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109772	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021081278	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF064555	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY044828	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY242098	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY242099	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY242100	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY242101	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY242102	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY242103	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY242104	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY242105	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY242106	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY242107	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY242108	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY242109	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY242110	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY242111	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY242112	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSSSCT00000064136 ⟹ ENSSSCP00000044635

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	2	1,496,842 - 1,497,841 (-)	Ensembl

RefSeq Acc Id:

NM_001109772 ⟹ NP_001103242

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	2	1,496,855 - 1,497,841 (-)	NCBI

Sequence:

show sequence

AGCCCTCTGGGACCAGCTGTGTTCCCAGGCCACCGGCAAGCAGGTCCTCACCCCCCGCCATGGC
CCTGTGGACGCGCCTCCTGCCCCTGCTGGCCCTGCTGGCCCTCTGGGCGCCCGCCCCGGCCCAG
GCCTTCGTGAACCAGCACCTGTGCGGCTCCCACCTGGTGGAGGCGCTGTACCTGGTGTGCGGGG
AGCGCGGCTTCTTCTACACGCCCAAGGCCCGTCGGGAGGCGGAGAACCCTCAGGCAGGTGCCGT
GGAGCTGGGCGGAGGCCTGGGCGGCCTGCAGGCCCTGGCGCTGGAGGGGCCCCCGCAGAAGCGT
GGCATCGTGGAGCAGTGCTGCACCAGCATCTGTTCCCTCTACCAGCTGGAGAACTACTGCAACT
AGGCCGCCCCTGAGGGCGCCTGCTGCTCCCCGCACCCCAAAACCCAATAAA

hide sequence

RefSeq Acc Id:

XM_021081278 ⟹ XP_020936937

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	2	1,496,842 - 1,498,052 (-)	NCBI

Sequence:

show sequence

TGGCCCTCAGGCCGCTCGTTAAGACTCTAATGACCTCAAGGCCCCCAGAGGCGCTGATGACCCA
CGGAGATGATCCCGCAGGCCTGGCAGCAGGGAAATGATCCAGAAAGTGCCACCTCAGCCCCCAG
CCATCTGCCACCCACCTGGAGGCCCTCAGGGGCCGGGCGCCGGGGGGCAGGCGCTATAAAGCCG
GCCGGGCCCAGCCGCCCCCAGCCCTCTGGGACCAGCTGCGTTCCCAGGCCGCCGGCAAGCAGGT
CCTCACCCCCCGCCATGGCCCTGTGGACGCGCCTCCTGCCCCTGCTGGCCCTGCTGGCCCTCTG
GGCGCCCGCCCCGGCCCAGGCCTTCGTGAACCAGCACCTGTGCGGCTCCCACCTGGTGGAGGCG
CTGTACCTGGTGTGCGGGGAGCGCGGCTTCTTCTACACGCCCAAGGCCCGTCGGGAGGCGGAGA
ACCCTCAGGCAGGTGCCGTGGAGCTGGGCGGAGGCCTGGGCGGCCTGCAGGCCCTGGCGCTGGA
GGGGCCCCCGCAGAAGCGTGGCATCGTGGAGCAGTGCTGCACCAGCATCTGTTCCCTCTACCAG
CTGGAGAACTACTGCAACTAGGCCGCCCCTGAGGGCGCCTGCTGCTCCCCGCACCCCAAAACCC
AATAAAGTCCTGAATGAGC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001103242	(Get FASTA)	NCBI Sequence Viewer
	XP_020936937	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC77920	(Get FASTA)	NCBI Sequence Viewer
	AAL69550	(Get FASTA)	NCBI Sequence Viewer
	AAQ00952	(Get FASTA)	NCBI Sequence Viewer
	AAQ00954	(Get FASTA)	NCBI Sequence Viewer
	AAQ00957	(Get FASTA)	NCBI Sequence Viewer
	AAQ00960	(Get FASTA)	NCBI Sequence Viewer
	AAQ00963	(Get FASTA)	NCBI Sequence Viewer
	AAQ00966	(Get FASTA)	NCBI Sequence Viewer
	AAQ00969	(Get FASTA)	NCBI Sequence Viewer
	AAQ00972	(Get FASTA)	NCBI Sequence Viewer
	AAQ00975	(Get FASTA)	NCBI Sequence Viewer
	AAQ00978	(Get FASTA)	NCBI Sequence Viewer
	AAQ00981	(Get FASTA)	NCBI Sequence Viewer
	AAQ00983	(Get FASTA)	NCBI Sequence Viewer
	AAQ00985	(Get FASTA)	NCBI Sequence Viewer
	AAQ00987	(Get FASTA)	NCBI Sequence Viewer
	AAQ00990	(Get FASTA)	NCBI Sequence Viewer
	P01315	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	XP_020936937 ⟸ XM_021081278
- Peptide Label:	isoform X1
- Sequence:	show sequence MIPQAWQQGNDPESATSAPSHLPPTWRPSGAGRRGAGAIKPAGPSRPQPSGTSCVPRPPASRSS PPAMALWTRLLPLLALLALWAPAPAQAFVNQHLCGSHLVEALYLVCGERGFFYTPKARREAENP QAGAVELGGGLGGLQALALEGPPQKRGIVEQCCTSICSLYQLENYCN hide sequence

RefSeq Acc Id:	NP_001103242 ⟸ NM_001109772
- Peptide Label:	precursor
- UniProtKB:	Q9TSJ5 (UniProtKB/Swiss-Prot), P01315 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MALWTRLLPLLALLALWAPAPAQAFVNQHLCGSHLVEALYLVCGERGFFYTPKARREAENPQAG AVELGGGLGGLQALALEGPPQKRGIVEQCCTSICSLYQLENYCN hide sequence

RefSeq Acc Id:

ENSSSCP00000044635 ⟸ ENSSSCT00000064136

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000033740	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSSSCG00015004005	UniProtKB/Swiss-Prot
	ENSSSCG00025023773	UniProtKB/Swiss-Prot
	ENSSSCG00030073948	UniProtKB/Swiss-Prot
	ENSSSCG00035019667	UniProtKB/Swiss-Prot
	ENSSSCG00040017207	UniProtKB/Swiss-Prot
	ENSSSCG00045005189	UniProtKB/Swiss-Prot
	ENSSSCG00050008342	UniProtKB/Swiss-Prot
	ENSSSCG00055016292	UniProtKB/Swiss-Prot
	ENSSSCG00060035069	UniProtKB/Swiss-Prot
	ENSSSCG00065063887	UniProtKB/Swiss-Prot
	ENSSSCG00070015252	UniProtKB/Swiss-Prot
Ensembl Protein	ENSSSCP00000044635	ENTREZGENE
	ENSSSCP00000044635.1	UniProtKB/Swiss-Prot
	ENSSSCP00015002060.1	UniProtKB/Swiss-Prot
	ENSSSCP00025013482.1	UniProtKB/Swiss-Prot
	ENSSSCP00030047908.1	UniProtKB/Swiss-Prot
	ENSSSCP00035009642.1	UniProtKB/Swiss-Prot
	ENSSSCP00040009750.1	UniProtKB/Swiss-Prot
	ENSSSCP00045005838.1	UniProtKB/Swiss-Prot
	ENSSSCP00050004834.1	UniProtKB/Swiss-Prot
	ENSSSCP00055025559.1	UniProtKB/Swiss-Prot
	ENSSSCP00060020355.1	UniProtKB/Swiss-Prot
	ENSSSCP00065038365.1	UniProtKB/Swiss-Prot
	ENSSSCP00070024989.1	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSSSCT00000064136	ENTREZGENE
	ENSSSCT00000064136.1	UniProtKB/Swiss-Prot
	ENSSSCT00015005290.1	UniProtKB/Swiss-Prot
	ENSSSCT00025032226.1	UniProtKB/Swiss-Prot
	ENSSSCT00030103634.1	UniProtKB/Swiss-Prot
	ENSSSCT00035025488.1	UniProtKB/Swiss-Prot
	ENSSSCT00040023180.1	UniProtKB/Swiss-Prot
	ENSSSCT00045008618.1	UniProtKB/Swiss-Prot
	ENSSSCT00050011348.1	UniProtKB/Swiss-Prot
	ENSSSCT00055032104.1	UniProtKB/Swiss-Prot
	ENSSSCT00060047539.1	UniProtKB/Swiss-Prot
	ENSSSCT00065087685.1	UniProtKB/Swiss-Prot
	ENSSSCT00070029958.1	UniProtKB/Swiss-Prot
Gene3D-CATH	Insulin-like	UniProtKB/Swiss-Prot
InterPro	Insulin	UniProtKB/Swiss-Prot
	Insulin-like	UniProtKB/Swiss-Prot
	Insulin-like_sf	UniProtKB/Swiss-Prot
	Insulin_CS	UniProtKB/Swiss-Prot
	Insulin_family	UniProtKB/Swiss-Prot
KEGG Report	ssc:397415	UniProtKB/Swiss-Prot
NCBI Gene	INS	ENTREZGENE
PANTHER	INSULIN	UniProtKB/Swiss-Prot
	PTHR11454	UniProtKB/Swiss-Prot
Pfam	Insulin	UniProtKB/Swiss-Prot
PRINTS	INSULIN	UniProtKB/Swiss-Prot
	INSULINFAMLY	UniProtKB/Swiss-Prot
PROSITE	INSULIN	UniProtKB/Swiss-Prot
SMART	IlGF	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF56994	UniProtKB/Swiss-Prot
UniProt	INS_PIG	UniProtKB/Swiss-Prot, ENTREZGENE
	Q9TSJ5	ENTREZGENE
UniProt Secondary	Q9TSJ5	UniProtKB/Swiss-Prot
VGNC ID	VGNC:99778	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)