AHR (aryl hydrocarbon receptor) - Rat Genome Database

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Gene: AHR (aryl hydrocarbon receptor) Sus scrofa
Analyze
Symbol: AHR
Name: aryl hydrocarbon receptor
RGD ID: 14051818
Description: ENCODES a protein that exhibits aryl hydrocarbon receptor binding (ortholog); chaperone binding (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); INVOLVED IN B cell homeostasis (ortholog); blood circulation (ortholog); blood vessel development (ortholog); PARTICIPATES IN aryl hydrocarbon receptor signaling pathway; ASSOCIATED WITH acanthosis nigricans (ortholog); Adult Pancreatic Cancer (ortholog); Animal Disease Models (ortholog); FOUND IN cytosol (ortholog); nucleus (ortholog); INTERACTS WITH (-)-epigallocatechin 3-gallate; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl986,511,369 - 86,555,943 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1986,511,866 - 86,555,950 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2995,511,269 - 95,542,794 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acanthosis nigricans  (ISO)
Adult Pancreatic Cancer  (ISO)
Animal Disease Models  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
Atrophy  (ISO)
Behcet's disease  (ISO)
Birth Weight  (ISO)
bladder calculus  (ISO)
bone resorption disease  (ISO)
Breast Neoplasms  (ISO)
Cardiomegaly  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronobiology Disorders  (ISO)
colitis  (ISO)
congenital heart disease  (ISO)
congenital nystagmus  (ISO)
contact dermatitis  (ISO)
disease of cellular proliferation  (ISO)
disease of metabolism  (ISO)
Dyslipidemias  (ISO)
Endotoxemia  (ISO)
Experimental Arthritis  (ISO)
Experimental Neoplasms  (ISO)
glucose intolerance  (ISO)
Growth Disorders  (ISO)
Hepatomegaly  (ISO)
Hyperoxia  (ISO)
Hyperpigmentation  (ISO)
hypertension  (ISO)
Hypertrophy  (ISO)
Hyperventilation  (ISO)
hypoglycemia  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
keratosis  (ISO)
Left Ventricular Hypertrophy  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
Lung Injury  (ISO)
male infertility  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (ISO)
pancreatic cancer  (ISO)
peanut allergy  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
pneumonia  (ISO)
Prostatic Neoplasms  (ISO)
Pruritus  (ISO)
Pulmonary Arterial Hypertension  (ISO)
retinitis pigmentosa 85  (ISO)
rheumatoid arthritis  (ISO)
Salmonella Infections, Animal  (ISO)
silicosis  (ISO)
splenic disease  (ISO)
Splenomegaly  (ISO)
Spontaneous Abortions  (ISO)
Stomach Neoplasms  (ISO)
Tachycardia  (ISO)
Tobacco Use Disorder  (ISO)
Ureteral Neoplasms  (ISO)
vascular disease  (ISO)
Weight Gain  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell homeostasis  (ISO)
blood circulation  (ISO)
blood vessel development  (ISO)
blood vessel diameter maintenance  (ISO)
blood vessel morphogenesis  (ISO)
blood vessel remodeling  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
camera-type eye development  (ISO)
cAMP-mediated signaling  (IEA)
cardiac left ventricle morphogenesis  (ISO)
cell morphogenesis  (ISO)
cellular response to 2,3,7,8-tetrachlorodibenzodioxine  (IEA)
cellular response to 3-methylcholanthrene  (ISO)
cellular response to cAMP  (IEA)
cellular response to forskolin  (IEA)
cellular response to glucocorticoid stimulus  (ISO)
circadian regulation of gene expression  (ISO)
circumferential growth involved in left ventricle morphogenesis  (ISO)
common bile duct development  (ISO)
embryonic hemopoiesis  (ISO)
gland development  (ISO)
glomerulus morphogenesis  (ISO)
immune system process  (ISO)
intracellular receptor signaling pathway  (IEA)
kidney morphogenesis  (ISO)
liver development  (ISO)
lymphocyte homeostasis  (ISO)
negative regulation of alkaline phosphatase activity  (ISO)
negative regulation of calcium ion transmembrane transport  (ISO)
negative regulation of DNA biosynthetic process  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of necrotic cell death  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of osteoblast proliferation  (ISO)
negative regulation of systemic arterial blood pressure  (ISO)
negative regulation of T cell mediated immune response to tumor cell  (IEA)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of vasoconstriction  (ISO)
ovarian follicle development  (ISO)
positive regulation of cell size  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of growth rate  (ISO)
positive regulation of RNA polymerase II transcription preinitiation complex assembly  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
post-embryonic hemopoiesis  (ISO)
prostate gland development  (ISO)
regulation of adaptive immune response  (IEA)
regulation of B cell proliferation  (IEA)
regulation of DNA-templated transcription  (IEA)
regulation of gene expression  (IEA)
regulation of transcription by RNA polymerase II  (IBA,IEA)
reproductive structure development  (ISO)
response to estradiol  (ISO)
response to organic cyclic compound  (ISO)
response to toxic substance  (IEA)
response to xenobiotic stimulus  (IEA,ISO)
rhythmic process  (IEA)
smooth muscle tissue development  (ISO)
spleen development  (ISO)
T cell homeostasis  (ISO)
transcription by RNA polymerase II  (ISO)
venous blood vessel development  (ISO)
xenobiotic metabolic process  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:23363321   PMID:24278102   PMID:26568065   PMID:27288759  


Genomics

Comparative Map Data
AHR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl986,511,369 - 86,555,943 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1986,511,866 - 86,555,950 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2995,511,269 - 95,542,794 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AHR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38717,298,652 - 17,346,147 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl716,916,359 - 17,346,152 (+)EnsemblGRCh38hg38GRCh38
GRCh37717,338,276 - 17,385,771 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36717,304,832 - 17,352,299 (+)NCBINCBI36Build 36hg18NCBI36
Build 34717,111,485 - 17,158,632NCBI
Celera717,318,278 - 17,365,781 (+)NCBICelera
Cytogenetic Map7p21.1NCBI
HuRef717,224,763 - 17,272,268 (+)NCBIHuRef
CHM1_1717,339,112 - 17,386,607 (+)NCBICHM1_1
T2T-CHM13v2.0717,428,395 - 17,475,891 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2717,391,672 - 17,439,185 (+)NCBI
Ahr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391235,547,978 - 35,584,988 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1235,547,973 - 35,585,037 (-)EnsemblGRCm39 Ensembl
GRCm381235,497,979 - 35,534,989 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1235,497,974 - 35,535,038 (-)EnsemblGRCm38mm10GRCm38
MGSCv371236,182,651 - 36,219,661 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361236,083,094 - 36,119,976 (-)NCBIMGSCv36mm8
Celera1236,948,584 - 36,984,257 (-)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1215.78NCBI
Ahr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2652,234,089 - 52,271,568 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl652,234,089 - 52,271,568 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0654,963,990 - 55,001,806 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl654,963,990 - 55,001,464 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0664,589,066 - 64,624,078 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4654,205,104 - 54,240,268 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1654,206,846 - 54,243,423 (-)NCBI
Celera651,391,870 - 51,429,719 (-)NCBICelera
RH 3.4 Map6350.2RGD
Cytogenetic Map6q16NCBI
Ahr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541020,428,546 - 20,456,836 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541020,428,531 - 20,459,482 (+)NCBIChiLan1.0ChiLan1.0
AHR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1717,278,637 - 17,326,171 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl717,278,637 - 17,326,171 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0717,949,254 - 17,998,737 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
AHR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11431,743,704 - 31,793,484 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1431,686,170 - 31,791,444 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1431,264,779 - 31,314,544 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01431,661,762 - 31,711,544 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1431,661,088 - 31,711,540 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11431,766,284 - 31,816,050 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01431,476,179 - 31,525,758 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01431,792,396 - 31,842,188 (+)NCBIUU_Cfam_GSD_1.0
Ahr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511876,062,814 - 76,108,403 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365463,737,908 - 3,783,492 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AHR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12140,778,198 - 40,826,491 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2140,778,218 - 40,826,478 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604263,692,229 - 63,740,600 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ahr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473912,942,165 - 12,987,973 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473912,939,183 - 12,987,574 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 9 2 4 3 3
Low 1 2 3 1 2 22 2
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000031031   ⟹   ENSSSCP00000022722
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl986,511,369 - 86,555,943 (+)Ensembl
RefSeq Acc Id: NM_001303026   ⟹   NP_001289955
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1986,511,866 - 86,555,950 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001289955   ⟸   NM_001303026
- UniProtKB: A0A0A1ERS1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000022722   ⟸   ENSSSCT00000031031
Protein Domains
bHLH   PAS   PAS_3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000030484 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005008436 UniProtKB/TrEMBL
  ENSSSCG00015023701 UniProtKB/TrEMBL
  ENSSSCG00030052086 UniProtKB/TrEMBL
  ENSSSCG00035039174 UniProtKB/TrEMBL
  ENSSSCG00040016633 UniProtKB/TrEMBL
  ENSSSCG00045011121 UniProtKB/TrEMBL
  ENSSSCG00050014008 UniProtKB/TrEMBL
  ENSSSCG00055013930 UniProtKB/TrEMBL
  ENSSSCG00060062540 UniProtKB/TrEMBL
  ENSSSCG00070008757 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000022722 ENTREZGENE
  ENSSSCP00000022722.2 UniProtKB/TrEMBL
  ENSSSCP00005007740.1 UniProtKB/TrEMBL
  ENSSSCP00015012424.1 UniProtKB/TrEMBL
  ENSSSCP00015012522.1 UniProtKB/TrEMBL
  ENSSSCP00030033122.1 UniProtKB/TrEMBL
  ENSSSCP00030033148.1 UniProtKB/TrEMBL
  ENSSSCP00030033169.1 UniProtKB/TrEMBL
  ENSSSCP00035020911.1 UniProtKB/TrEMBL
  ENSSSCP00035020923.1 UniProtKB/TrEMBL
  ENSSSCP00035020929.1 UniProtKB/TrEMBL
  ENSSSCP00040009371.1 UniProtKB/TrEMBL
  ENSSSCP00040009393.1 UniProtKB/TrEMBL
  ENSSSCP00045012999.1 UniProtKB/TrEMBL
  ENSSSCP00045013047.1 UniProtKB/TrEMBL
  ENSSSCP00050007819.1 UniProtKB/TrEMBL
  ENSSSCP00050007832.1 UniProtKB/TrEMBL
  ENSSSCP00050007841.1 UniProtKB/TrEMBL
  ENSSSCP00055021841.1 UniProtKB/TrEMBL
  ENSSSCP00055021918.1 UniProtKB/TrEMBL
  ENSSSCP00055021993.1 UniProtKB/TrEMBL
  ENSSSCP00060036901.1 UniProtKB/TrEMBL
  ENSSSCP00060036941.1 UniProtKB/TrEMBL
  ENSSSCP00060036972.1 UniProtKB/TrEMBL
  ENSSSCP00070014121.1 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000031031 ENTREZGENE
  ENSSSCT00000031031.3 UniProtKB/TrEMBL
  ENSSSCT00005013090.1 UniProtKB/TrEMBL
  ENSSSCT00015031449.1 UniProtKB/TrEMBL
  ENSSSCT00015031638.1 UniProtKB/TrEMBL
  ENSSSCT00030072584.1 UniProtKB/TrEMBL
  ENSSSCT00030072634.1 UniProtKB/TrEMBL
  ENSSSCT00030072678.1 UniProtKB/TrEMBL
  ENSSSCT00035052037.1 UniProtKB/TrEMBL
  ENSSSCT00035052056.1 UniProtKB/TrEMBL
  ENSSSCT00035052072.1 UniProtKB/TrEMBL
  ENSSSCT00040022391.1 UniProtKB/TrEMBL
  ENSSSCT00040022423.1 UniProtKB/TrEMBL
  ENSSSCT00045018903.1 UniProtKB/TrEMBL
  ENSSSCT00045018990.1 UniProtKB/TrEMBL
  ENSSSCT00050018911.1 UniProtKB/TrEMBL
  ENSSSCT00050018939.1 UniProtKB/TrEMBL
  ENSSSCT00050018959.1 UniProtKB/TrEMBL
  ENSSSCT00055027446.1 UniProtKB/TrEMBL
  ENSSSCT00055027541.1 UniProtKB/TrEMBL
  ENSSSCT00055027627.1 UniProtKB/TrEMBL
  ENSSSCT00060085302.1 UniProtKB/TrEMBL
  ENSSSCT00060085385.1 UniProtKB/TrEMBL
  ENSSSCT00060085455.1 UniProtKB/TrEMBL
  ENSSSCT00070017060.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro AHR UniProtKB/TrEMBL
  AHR/AHRR UniProtKB/TrEMBL
  bHLH_dom UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  PAC UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/TrEMBL
  PAS_fold UniProtKB/TrEMBL
  PAS_fold_3 UniProtKB/TrEMBL
KEGG Report ssc:396654 UniProtKB/TrEMBL
NCBI Gene AHR ENTREZGENE
PANTHER PTHR10649 UniProtKB/TrEMBL
  PTHR10649:SF9 UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
  PAS_3 UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
  PAC UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/TrEMBL
  SSF55785 UniProtKB/TrEMBL
UniProt A0A0A1EP60_PIG UniProtKB/TrEMBL
  A0A0A1ERS1 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TFN8_PIG UniProtKB/TrEMBL
  A0A8D0ICY0_PIG UniProtKB/TrEMBL
  A0A8D0N7A4_PIG UniProtKB/TrEMBL
  A0A8D0XD82_PIG UniProtKB/TrEMBL
  A0A8D0ZMR2_PIG UniProtKB/TrEMBL
  A0A8D0ZMS4_PIG UniProtKB/TrEMBL
  A0A8D0ZSI3_PIG UniProtKB/TrEMBL
  A0A8D1H2H1_PIG UniProtKB/TrEMBL
  A0A8D1H933_PIG UniProtKB/TrEMBL
  A0A8D1QSJ6_PIG UniProtKB/TrEMBL
  A0A8D1U2D4_PIG UniProtKB/TrEMBL
  A0A8D2BQZ0_PIG UniProtKB/TrEMBL
  E2IGU5_PIG UniProtKB/TrEMBL
  I3LF82_PIG UniProtKB/TrEMBL
  K9J4M2_PIG UniProtKB/TrEMBL