IL6 (interleukin 6) - Rat Genome Database

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Gene: IL6 (interleukin 6) Sus scrofa
Symbol: IL6
Name: interleukin 6
RGD ID: 14098222
Description: ENCODES a protein that exhibits cytokine activity (ortholog); interleukin-6 receptor binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN positive regulation of estradiol secretion; acute inflammatory response (ortholog); aging (ortholog); PARTICIPATES IN interleukin-23 signaling pathway; interleukin-27 signaling pathway; interleukin-6 signaling pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); Acute Hepatitis (ortholog); acute kidney failure (ortholog); FOUND IN cytoplasm (ortholog); external side of plasma membrane (ortholog); extracellular space (ortholog); INTERACTS WITH 1,3-thiazolidine-2,4-dione; acrylamide; ambrisentan
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: IL-6; interleukin 6 (interferon, beta 2); interleukin-6; interleukin-6 protein
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
NCBI Annotation Information: Note: LOC100628202 and IL6 (GeneID 399500) are annotated as independent loci in Sus scrofa build 10.2. It is unclear at this time if this is from an error in the assembly or if the two are very similar but independent loci in pig. [17 Jun 2014]
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl991,506,340 - 91,511,263 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1991,506,421 - 91,510,830 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29101,081,042 - 101,085,451 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap9q14-q15NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Acute Coronary Syndrome  (ISO)
Acute Hepatitis  (ISO)
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
acute myeloid leukemia  (ISO)
acute necrotizing pancreatitis  (ISO)
Acute-Phase Reaction  (ISO)
adult T-cell leukemia  (ISO)
aggressive periodontitis  (ISO)
Albuminuria  (ISO)
alcoholic liver cirrhosis  (ISO)
allergic disease  (ISO)
Alzheimer's disease  (ISO)
amnestic disorder  (ISO)
anemia  (ISO)
Animal Toxoplasmosis  (ISO)
ankylosing spondylitis  (ISO)
anogenital venereal wart  (ISO)
aortic valve disease 1  (ISO)
arteriovenous malformations of the brain  (ISO)
Ascorbic Acid Deficiency  (ISO)
aseptic meningitis  (ISO)
asthma  (ISO)
ataxia telangiectasia  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thyroiditis  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
bacterial pneumonia  (ISO)
basal cell carcinoma  (ISO)
Behcet's disease  (ISO)
berylliosis  (ISO)
beta thalassemia  (ISO)
Bile Duct Neoplasms  (ISO)
biliary tract benign neoplasm  (ISO)
Brain Concussion  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
bronchiolitis obliterans  (ISO)
Burns  (ISO)
Burns, Chemical  (ISO)
Cachexia  (ISO)
Cadmium Poisoning  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
Cardiovascular Pregnancy Complications  (ISO)
Castleman disease  (ISO)
celiac disease  (ISO)
central nervous system disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholangiocarcinoma  (ISO)
cholestasis  (ISO)
cholesteatoma of middle ear  (ISO)
chorioamnionitis  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
cochlear disease  (ISO)
colitis  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (ISO)
congestive heart failure  (ISO)
conjunctival disease  (ISO)
corneal ulcer  (ISO)
coronary artery disease  (ISO)
Coronavirus infectious disease  (ISO)
Coxsackievirus Infections  (ISO)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
diffuse scleroderma  (ISO)
disseminated intravascular coagulation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dry eye syndrome  (ISO)
Eales Disease  (ISO)
eclampsia  (ISO)
Edema  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Entamoebiasis  (ISO)
epididymitis  (ISO)
epilepsy  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
extrahepatic cholestasis  (ISO)
familial Mediterranean fever  (ISO)
fatty liver disease  (ISO)
Femoral Fractures  (ISO)
Fetal Inflammatory Response Syndrome  (ISO)
Fever  (ISO)
Foot Injuries  (ISO)
gastric adenocarcinoma  (ISO)
gastric dilatation  (ISO)
gestational diabetes  (ISO)
gingivitis  (ISO)
glomerulonephritis  (ISO)
glucosephosphate dehydrogenase deficiency  (ISO)
Graves' disease  (ISO)
Hashimoto Disease  (ISO)
Headache  (ISO)
Hearing Loss, Noise-Induced  (ISO)
Heat Stress Disorders  (ISO)
Heat Stroke  (ISO)
Helicobacter Infections  (ISO)
hemarthrosis  (ISO)
Hemifacial Spasm  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhagic Shock  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
HIV Wasting Syndrome  (ISO)
Hodgkin's lymphoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (ISO)
hypercalcemia  (ISO)
hyperglycemia  (ISO)
hyperinsulinism  (ISO)
Hyperoxaluria  (ISO)
Hyperoxia  (ISO)
hypertension  (ISO)
Hypoalbuminemia  (ISO)
hypogonadism  (ISO)
Hypotension  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
idiopathic interstitial pneumonia  (ISO)
impotence  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
Insulin Resistance  (ISO)
Intestinal Reperfusion Injury  (ISO)
intracranial aneurysm  (ISO)
Intracranial Hemorrhages  (ISO)
Intraventricular Hemorrhage  (ISO)
iron deficiency anemia  (ISO)
ischemia  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kaposi's sarcoma  (ISO)
keratitis  (ISO)
keratoconjunctivitis sicca  (ISO)
Klebsiella Infections  (ISO)
Kuhnt-Junius degeneration  (ISO)
learning disability  (ISO)
leishmaniasis  (ISO)
lichen disease  (ISO)
liver cirrhosis  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
macular retinal edema  (ISO)
major depressive disorder  (ISO)
malignant mesothelioma  (ISO)
mental depression  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
Middle East respiratory syndrome  (ISO)
mitochondrial myopathy  (ISO)
multiple myeloma  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
neovascular glaucoma  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
neurodegenerative disease  (ISO)
neuromyelitis optica  (ISO)
nodular goiter  (ISO)
Non-AIDS-Related Kaposi Sarcoma  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-alcoholic steatohepatitis  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
oral squamous cell carcinoma  (ISO)
oral submucous fibrosis  (ISO)
osteoporosis  (ISO)
otitis media  (ISO)
ovarian hyperstimulation syndrome  (ISO)
Ovarian Neoplasms  (ISO)
pancreas disease  (ISO)
pancreatic cancer  (ISO)
Parkinson's disease  (ISO)
periodontal disease  (ISO)
periodontitis  (ISO)
Peripheral Nerve Injuries  (ISO)
peripheral nervous system disease  (ISO)
peripheral vascular disease  (ISO)
peritonitis  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
pleural disease  (ISO)
pleurisy  (ISO)
Pneumococcal Meningitis  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
polyneuropathy  (ISO)
Postmenopausal Osteoporosis  (ISO)
Postoperative Atrial Fibrillation  (ISO)
pre-malignant neoplasm  (ISO)
prediabetes syndrome  (ISO)
Premature Birth  (ISO)
Premature Obstetric Labor  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
Pseudomonas Infections  (ISO)
psoriasis  (ISO)
Pulmonary Contusion  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
quadriplegia  (ISO)
rectum cancer  (ISO)
renal cell carcinoma  (ISO)
renal hypertension  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Retina Reperfusion Injury  (ISO)
retinal artery occlusion  (ISO)
retinal detachment  (ISO)
retinal vasculitis  (ISO)
retinal vein occlusion  (ISO)
rheumatoid arthritis  (ISO)
Sarcopenia  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
secondary hyperparathyroidism  (ISO)
Sepsis  (ISO)
Septic Peritonitis  (ISO)
severe acute respiratory syndrome  (ISO)
Shwartzman phenomenon  (ISO)
Sjogren's syndrome  (ISO)
skin disease  (ISO)
small cell carcinoma  (ISO)
Spinal Cord Compression  (ISO)
spinal cord disease  (ISO)
Spinal Cord Injuries  (ISO)
spondyloarthropathy  (ISO)
Spontaneous Abortions  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Streptococcus pneumonia  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
Subretinal Fibrosis  (ISO)
Sudden Cardiac Death  (ISO)
Sudden Hearing Loss  (ISO)
Systemic Juvenile Rheumatoid Arthritis  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
thrombocytopenia  (ISO)
Thyroid Neoplasms  (ISO)
Tobacco Use Disorder  (ISO)
toxic shock syndrome  (ISO)
Toxoplasma Chorioretinitis  (ISO)
transverse myelitis  (ISO)
Tympanic Membrane Perforation  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
uveitis  (ISO)
Ventricular Dysfunction, Left  (ISO)
Viral Bronchiolitis  (ISO)
visceral leishmaniasis  (ISO)
visual epilepsy  (ISO)
Waldenstroem's macroglobulinemia  (ISO)
Wilson disease  (ISO)
Wounds and Injuries  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute inflammatory response  (ISO)
acute-phase response  (IEA)
aging  (ISO)
bone remodeling  (ISO)
branching involved in salivary gland morphogenesis  (ISO)
cell redox homeostasis  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to hydrogen peroxide  (IEA,ISO)
cellular response to interleukin-1  (ISO)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to nutrient levels  (ISO)
cellular response to prolactin  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to virus  (ISO)
cytokine-mediated signaling pathway  (ISO)
defense response to protozoan  (ISO)
defense response to virus  (IEA)
endocrine pancreas development  (ISO)
epithelial cell proliferation involved in salivary gland morphogenesis  (ISO)
gene expression  (ISO)
germinal center B cell differentiation  (ISO)
glucagon secretion  (ISO)
glucose homeostasis  (IEA,ISO,ISS)
hepatic immune response  (IEA)
hepatocyte proliferation  (ISS)
inflammatory response  (ISO)
interleukin-6-mediated signaling pathway  (IEA,ISO,ISS)
liver regeneration  (ISS)
lymphocyte costimulation  (ISO)
muscle cell cellular homeostasis  (ISO)
myeloid cell homeostasis  (ISO)
negative regulation of apoptotic process  (IEA)
negative regulation of bone resorption  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of chemokine production  (ISO)
negative regulation of collagen biosynthetic process  (IEA)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of gluconeogenesis  (ISO)
negative regulation of hormone secretion  (ISO)
negative regulation of interleukin-1-mediated signaling pathway  (ISO)
negative regulation of membrane potential  (ISO)
negative regulation of muscle organ development  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of primary miRNA processing  (IEA,ISO)
negative regulation of protein kinase activity  (ISO)
neuron projection development  (IEA)
neutrophil apoptotic process  (IEA,ISO)
positive regulation of acute inflammatory response  (IEA)
positive regulation of apoptotic DNA fragmentation  (IEA)
positive regulation of apoptotic process  (IEA)
positive regulation of B cell activation  (IEA)
positive regulation of cell population proliferation  (IBA,ISO)
positive regulation of cell proliferation in bone marrow  (ISO)
positive regulation of chemokine production  (IEA)
positive regulation of cytokine production involved in inflammatory response  (IEA,ISO)
positive regulation of DNA replication  (ISO)
positive regulation of DNA-binding transcription factor activity  (IEA,ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of epithelial to mesenchymal transition  (IEA)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of estradiol secretion  (IDA)
positive regulation of extracellular matrix disassembly  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of glial cell proliferation  (IEA)
positive regulation of gliogenesis  (ISO)
positive regulation of immunoglobulin production  (IEA)
positive regulation of interleukin-1 beta production  (IEA,ISO)
positive regulation of interleukin-10 production  (IEA,ISO)
positive regulation of interleukin-17 production  (ISO)
positive regulation of interleukin-21 production  (ISO)
positive regulation of interleukin-6 production  (IEA)
positive regulation of interleukin-8 production  (IEA,ISO)
positive regulation of leukocyte adhesion to vascular endothelial cell  (IEA,ISO)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of osteoblast differentiation  (IEA)
positive regulation of peptidyl-serine phosphorylation  (IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of platelet aggregation  (IEA,ISO)
positive regulation of production of miRNAs involved in gene silencing by miRNA  (IEA,ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (IBA,IEA,ISO)
positive regulation of receptor signaling pathway via STAT  (ISO,ISS)
positive regulation of smooth muscle cell proliferation  (IEA)
positive regulation of T cell proliferation  (IEA)
positive regulation of T-helper 2 cell cytokine production  (ISO)
positive regulation of T-helper 2 cell differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of translation  (IEA)
positive regulation of transmission of nerve impulse  (ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (IEA,ISO)
positive regulation of vascular endothelial growth factor production  (IEA)
regulation of apoptotic process  (ISO)
regulation of cell population proliferation  (ISO)
regulation of cell shape  (ISO)
regulation of circadian sleep/wake cycle, non-REM sleep  (ISO)
regulation of glucagon secretion  (IEA,ISS)
regulation of insulin secretion  (IEA,ISS)
regulation of vascular endothelial growth factor production  (ISO)
response to activity  (ISS)
response to amino acid  (ISO)
response to antibiotic  (ISO)
response to auditory stimulus  (ISO)
response to bacterium  (ISO)
response to caffeine  (ISO)
response to calcium ion  (ISO)
response to cold  (ISO)
response to cytokine  (ISO)
response to electrical stimulus  (ISO)
response to glucocorticoid  (IEA)
response to heat  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to wounding  (ISO)
response to xenobiotic stimulus  (ISO)
response to yeast  (ISO)
signal transduction  (IEA)
T cell activation  (ISO)
T follicular helper cell differentiation  (ISO)
T-helper 17 cell lineage commitment  (IEA,ISS)
vascular endothelial growth factor production  (IEA,ISS)
wound healing  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Additional References at PubMed
PMID:1497880   PMID:1873476   PMID:8661698   PMID:8697800   PMID:9162522   PMID:9420012   PMID:15050130   PMID:15509024   PMID:16229816   PMID:17272928   PMID:17510233   PMID:17903420  
PMID:18607788   PMID:19016005   PMID:19520150   PMID:19605905   PMID:19766617   PMID:21471537   PMID:21884347   PMID:22522232   PMID:22850468   PMID:22920593   PMID:24020676   PMID:24139936  
PMID:27125399   PMID:27385686   PMID:28193578  


Comparative Map Data
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl991,506,340 - 91,511,263 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1991,506,421 - 91,510,830 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29101,081,042 - 101,085,451 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap9q14-q15NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl722,725,884 - 22,732,002 (+)EnsemblGRCh38hg38GRCh38
GRCh38722,725,889 - 22,732,002 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37722,766,819 - 22,771,617 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36722,733,343 - 22,738,145 (+)NCBINCBI36hg18NCBI36
Build 34722,540,059 - 22,544,856NCBI
Celera722,752,396 - 22,757,251 (+)NCBI
Cytogenetic Map7p15.3NCBI
HuRef722,649,846 - 22,654,701 (+)NCBIHuRef
CHM1_1722,767,669 - 22,772,524 (+)NCBICHM1_1
CRA_TCAGchr7v2722,817,875 - 22,822,730 (+)NCBI
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39530,218,112 - 30,224,973 (+)NCBIGRCm39mm39
GRCm39 Ensembl530,218,112 - 30,224,979 (+)Ensembl
GRCm38530,013,114 - 30,019,975 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl530,013,114 - 30,019,981 (+)EnsemblGRCm38mm10GRCm38
MGSCv37530,339,701 - 30,346,508 (+)NCBIGRCm37mm9NCBIm37
MGSCv36530,343,948 - 30,350,755 (+)NCBImm8
Celera527,530,266 - 27,537,070 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map515.7NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.245,214,602 - 5,219,178 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl45,213,394 - 5,219,178 (-)Ensembl
Rnor_6.043,043,231 - 3,047,807 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl43,043,231 - 3,047,807 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.043,095,536 - 3,100,112 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44456,799 - 461,376 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14456,798 - 461,376 (-)NCBI
Celera45,093,593 - 5,098,169 (+)NCBICelera
Cytogenetic Map4q11NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0NW_00495541025,079,835 - 25,084,390 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.1723,027,560 - 23,032,419 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0723,415,922 - 23,420,767 (+)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11436,474,268 - 36,478,519 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1436,473,394 - 36,478,519 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1436,015,351 - 36,019,602 (+)NCBI
ROS_Cfam_1.01436,398,579 - 36,402,833 (+)NCBI
UMICH_Zoey_3.11436,519,712 - 36,523,966 (+)NCBI
UNSW_CanFamBas_1.01436,216,365 - 36,220,619 (+)NCBI
UU_Cfam_GSD_1.01436,553,276 - 36,557,530 (+)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024407213183,842,756 - 183,843,378 (+)NCBI
SpeTri2.0NW_0049365497,015,595 - 7,016,246 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12135,577,513 - 35,582,385 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2135,577,939 - 35,582,237 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604269,001,958 - 69,006,830 (+)NCBIVero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046247397,957,709 - 7,963,414 (-)NCBIHetGla_female_1.0hetGla2


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
Low 2 2 3 5 12 2 1
Below cutoff 7 1 2 9 2


Reference Sequences
RefSeq Acc Id: ENSSSCT00000023544   ⟹   ENSSSCP00000023819
RefSeq Status:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl991,506,340 - 91,510,830 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000025647   ⟹   ENSSSCP00000024026
RefSeq Status:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl991,506,421 - 91,511,263 (+)Ensembl
RefSeq Acc Id: NM_214399   ⟹   NP_999564
RefSeq Status: VALIDATED
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1991,506,421 - 91,510,830 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_999564   ⟸   NM_214399
- Peptide Label: precursor
- UniProtKB: P26893 (UniProtKB/Swiss-Prot),   A4D862 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000024026   ⟸   ENSSSCT00000025647
RefSeq Acc Id: ENSSSCP00000023819   ⟸   ENSSSCT00000023544

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000020970 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070006735 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000023819 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000024026 UniProtKB/TrEMBL
  ENSSSCP00070010651 UniProtKB/TrEMBL
  ENSSSCP00070010658 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000023544 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000025647 UniProtKB/TrEMBL
  ENSSSCT00070012935 UniProtKB/TrEMBL
  ENSSSCT00070012945 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-6/GCSF/MGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL6/GCSF/MGF_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:399500 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR10511 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10511:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IL6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1T4A5_PIG UniProtKB/TrEMBL
  IL6_PIG UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q95KN6 UniProtKB/Swiss-Prot