IL6 (interleukin 6) - Rat Genome Database

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Gene: IL6 (interleukin 6) Sus scrofa
Analyze
Symbol: IL6
Name: interleukin 6
RGD ID: 14098222
Description: ENCODES a protein that exhibits cytokine activity (ortholog); interleukin-6 receptor binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN positive regulation of estradiol secretion; bone remodeling (ortholog); branching involved in salivary gland morphogenesis (ortholog); PARTICIPATES IN interleukin-23 signaling pathway; interleukin-27 signaling pathway; interleukin-6 signaling pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); Acute Hepatitis (ortholog); acute kidney failure (ortholog); FOUND IN external side of plasma membrane (ortholog); extracellular space (ortholog); INTERACTS WITH 1,3-thiazolidine-2,4-dione; acrylamide; ambrisentan
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IL-6; IL-6; interleukin 6 (interferon, beta 2); interleukin-6; interleukin-6 protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
NCBI Annotation Information: Note: LOC100628202 and IL6 (GeneID 399500) are annotated as independent loci in Sus scrofa build 10.2. It is unclear at this time if this is from an error in the assembly or if the two are very similar but independent loci in pig. [17 Jun 2014]
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl991,506,421 - 91,511,263 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1991,506,421 - 91,510,830 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29101,081,042 - 101,085,451 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap9q14-q15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Coronary Syndrome  (ISO)
Acute Hepatitis  (ISO)
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
acute myeloid leukemia  (ISO)
acute myocardial infarction  (ISO)
acute necrotizing pancreatitis  (ISO)
Acute-Phase Reaction  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
aggressive periodontitis  (ISO)
Albuminuria  (ISO)
alcoholic liver cirrhosis  (ISO)
Alcoholic Liver Diseases  (ISO)
allergic disease  (ISO)
Alveolar Bone Loss  (ISO)
Alzheimer's disease  (ISO)
amnestic disorder  (ISO)
anemia  (ISO)
Aneurysm  (ISO)
Animal Toxoplasmosis  (ISO)
ankylosing spondylitis  (ISO)
anogenital venereal wart  (ISO)
aortic valve disease 1  (ISO)
arteriovenous malformations of the brain  (ISO)
Ascorbic Acid Deficiency  (ISO)
aseptic meningitis  (ISO)
asthma  (ISO)
ataxia telangiectasia  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thyroiditis  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
bacterial pneumonia  (ISO)
basal cell carcinoma  (ISO)
Behcet's disease  (ISO)
berylliosis  (ISO)
beta thalassemia  (ISO)
Bile Duct Neoplasms  (ISO)
biliary tract benign neoplasm  (ISO)
Brain Concussion  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
bronchiolitis obliterans  (ISO)
Burns  (ISO)
Cachexia  (ISO)
Cadmium Poisoning  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
Cardiovascular Pregnancy Complications  (ISO)
Castleman disease  (ISO)
celiac disease  (ISO)
central nervous system disease  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chemical Burns  (ISO)
Chemically-Induced Disorders  (ISO)
cholangiocarcinoma  (ISO)
cholestasis  (ISO)
cholesteatoma of middle ear  (ISO)
chorioamnionitis  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
cochlear disease  (ISO)
colitis  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (ISO)
congestive heart failure  (ISO)
conjunctival disease  (ISO)
corneal ulcer  (ISO)
coronary artery disease  (ISO)
Coronavirus infectious disease  (ISO)
COVID-19  (ISO)
Coxsackievirus Infections  (ISO)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
depressive disorder  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
diffuse scleroderma  (ISO)
disseminated intravascular coagulation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dry eye syndrome  (ISO)
Eales Disease  (ISO)
eclampsia  (ISO)
Edema  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Entamoebiasis  (ISO)
epididymitis  (ISO)
epilepsy  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
extrahepatic cholestasis  (ISO)
familial Mediterranean fever  (ISO)
Femoral Fractures  (ISO)
Fetal Inflammatory Response Syndrome  (ISO)
Fever  (ISO)
Foot Injuries  (ISO)
gastric adenocarcinoma  (ISO)
gastric dilatation  (ISO)
gestational diabetes  (ISO)
gingivitis  (ISO)
glomerulonephritis  (ISO)
glucosephosphate dehydrogenase deficiency  (ISO)
Graves' disease  (ISO)
Hashimoto Disease  (ISO)
Headache  (ISO)
Hearing Loss, Noise-Induced  (ISO)
Heart Injuries  (ISO)
Heat Stress Disorders  (ISO)
Heat Stroke  (ISO)
Helicobacter Infections  (ISO)
hemarthrosis  (ISO)
Hemifacial Spasm  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhagic Shock  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
HIV Wasting Syndrome  (ISO)
Hodgkin's lymphoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (ISO)
hypercalcemia  (ISO)
hyperglycemia  (ISO)
hyperinsulinism  (ISO)
Hyperoxaluria  (ISO)
Hyperoxia  (ISO)
hypertension  (ISO)
Hypoalbuminemia  (ISO)
hypogonadism  (ISO)
hypomyelinating leukodystrophy 5  (ISO)
Hypotension  (ISO)
idiopathic interstitial pneumonia  (ISO)
impotence  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
Insulin Resistance  (ISO)
Intestinal Reperfusion Injury  (ISO)
intracranial aneurysm  (ISO)
Intracranial Hemorrhages  (ISO)
Intraventricular Hemorrhage  (ISO)
iron deficiency anemia  (ISO)
ischemia  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kaposi's sarcoma  (ISO)
keratitis  (ISO)
keratoconjunctivitis sicca  (ISO)
Kidney Reperfusion Injury  (ISO)
Klebsiella Infections  (ISO)
Kuhnt-Junius degeneration  (ISO)
learning disability  (ISO)
leishmaniasis  (ISO)
lichen disease  (ISO)
liver cirrhosis  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
Lung Reperfusion Injury  (ISO)
lymphoplasmacytic lymphoma  (ISO)
macular retinal edema  (ISO)
major depressive disorder  (ISO)
malignant mesothelioma  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
Middle East respiratory syndrome  (ISO)
mitochondrial myopathy  (ISO)
multiple myeloma  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
neovascular glaucoma  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
neurodegenerative disease  (ISO)
neuromyelitis optica  (ISO)
nicotine dependence  (ISO)
nodular goiter  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
oral squamous cell carcinoma  (ISO)
oral submucous fibrosis  (ISO)
osteoporosis  (ISO)
otitis media  (ISO)
ovarian hyperstimulation syndrome  (ISO)
Ovarian Neoplasms  (ISO)
pancreas disease  (ISO)
pancreatic cancer  (ISO)
Parkinson's disease  (ISO)
perinatal necrotizing enterocolitis  (ISO)
periodontal disease  (ISO)
periodontitis  (ISO)
Peripheral Nerve Injuries  (ISO)
peripheral nervous system disease  (ISO)
peripheral vascular disease  (ISO)
peritonitis  (ISO)
Plaque, Atherosclerotic  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
pleural disease  (ISO)
pleurisy  (ISO)
Pneumococcal Meningitis  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
polyneuropathy  (ISO)
Postmenopausal Osteoporosis  (ISO)
Postoperative Atrial Fibrillation  (ISO)
Postoperative Cognitive Dysfunction  (ISO)
pre-eclampsia  (ISO)
pre-malignant neoplasm  (ISO)
prediabetes syndrome  (ISO)
Premature Birth  (ISO)
Premature Obstetric Labor  (ISO)
primary biliary cholangitis  (ISO)
primary ciliary dyskinesia  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
Pseudomonas Infections  (ISO)
psoriasis  (ISO)
Pulmonary Contusion  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Pulmonary Hypertension, Hypoxia-Induced  (ISO)
pulmonary tuberculosis  (ISO)
quadriplegia  (ISO)
rectum cancer  (ISO)
renal cell carcinoma  (ISO)
renal hypertension  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Retina Reperfusion Injury  (ISO)
retinal artery occlusion  (ISO)
retinal detachment  (ISO)
retinal vasculitis  (ISO)
retinal vein occlusion  (ISO)
rheumatoid arthritis  (ISO)
Right Ventricular Hypertrophy  (ISO)
Sarcopenia  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
secondary hyperparathyroidism  (ISO)
Sepsis  (ISO)
Septic Peritonitis  (ISO)
severe acute respiratory syndrome  (ISO)
Shwartzman phenomenon  (ISO)
Sjogren's syndrome  (ISO)
skin disease  (ISO)
small cell carcinoma  (ISO)
Spinal Cord Compression  (ISO)
spinal cord disease  (ISO)
Spinal Cord Injuries  (ISO)
Spine Osteoarthritis  (ISO)
spondyloarthropathy  (ISO)
Spontaneous Abortions  (ISO)
squamous cell carcinoma  (ISO)
steatotic liver disease  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Streptococcus pneumonia  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
Subretinal Fibrosis  (ISO)
Sudden Cardiac Death  (ISO)
Sudden Hearing Loss  (ISO)
Systemic Juvenile Rheumatoid Arthritis  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
thrombocytopenia  (ISO)
Thyroid Neoplasms  (ISO)
toxic shock syndrome  (ISO)
Toxoplasma Chorioretinitis  (ISO)
transverse myelitis  (ISO)
Tympanic Membrane Perforation  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
uveitis  (ISO)
Ventricular Dysfunction, Left  (ISO)
Viral Bronchiolitis  (ISO)
Viral Myocarditis  (ISO)
visceral leishmaniasis  (ISO)
Wilson disease  (ISO)
Wounds and Injuries  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (IEA)
bone remodeling  (ISO)
branching involved in salivary gland morphogenesis  (ISO)
cell differentiation  (IEA)
cell redox homeostasis  (ISO)
cell surface receptor signaling pathway via JAK-STAT  (IEA)
cell surface receptor signaling pathway via STAT  (IEA)
cellular response to cytokine stimulus  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to hydrogen peroxide  (IEA,ISO)
cellular response to interleukin-1  (ISO)
cellular response to interleukin-17  (ISO)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to nutrient levels  (ISO)
cellular response to prolactin  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to virus  (ISO)
cytokine-mediated signaling pathway  (IEA)
defense response to protozoan  (ISO)
defense response to virus  (IEA)
endocrine pancreas development  (ISO)
epithelial cell proliferation involved in salivary gland morphogenesis  (ISO)
gene expression  (ISO)
germinal center B cell differentiation  (ISO)
glucagon secretion  (ISO)
glucose homeostasis  (IEA,ISO,ISS)
hepatic immune response  (IEA)
hepatocyte proliferation  (ISS)
immune response  (IEA)
inflammatory response  (IEA)
inflammatory response to wounding  (IEA)
interleukin-6-mediated signaling pathway  (IEA,ISO,ISS)
liver regeneration  (ISS)
lymphocyte costimulation  (ISO)
muscle cell cellular homeostasis  (ISO)
myeloid cell homeostasis  (ISO)
negative regulation of apoptotic process  (IEA)
negative regulation of bone resorption  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of chemokine production  (ISO)
negative regulation of collagen biosynthetic process  (IEA)
negative regulation of gluconeogenesis  (ISO)
negative regulation of hormone secretion  (ISO)
negative regulation of interleukin-1-mediated signaling pathway  (ISO)
negative regulation of membrane potential  (ISO)
negative regulation of muscle organ development  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of primary miRNA processing  (IEA,ISO)
negative regulation of protein kinase activity  (ISO)
neuron projection development  (IEA)
neutrophil apoptotic process  (IEA,ISO)
positive regulation of acute inflammatory response  (IEA)
positive regulation of apoptotic DNA fragmentation  (IEA)
positive regulation of apoptotic process  (IEA)
positive regulation of B cell activation  (IEA)
positive regulation of cell population proliferation  (IBA,IEA)
positive regulation of cell proliferation in bone marrow  (ISO)
positive regulation of chemokine production  (IEA)
positive regulation of cytokine production involved in inflammatory response  (IEA)
positive regulation of DNA replication  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of epithelial to mesenchymal transition  (IEA)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of estradiol secretion  (IDA)
positive regulation of extracellular matrix disassembly  (IEA)
positive regulation of gene expression  (IEA,ISO)
positive regulation of glial cell proliferation  (IEA)
positive regulation of gliogenesis  (ISO)
positive regulation of immunoglobulin production  (IEA)
positive regulation of interleukin-1 beta production  (IEA)
positive regulation of interleukin-10 production  (IEA)
positive regulation of interleukin-17 production  (ISO)
positive regulation of interleukin-21 production  (ISO)
positive regulation of interleukin-6 production  (IEA)
positive regulation of interleukin-8 production  (IEA)
positive regulation of leukocyte adhesion to vascular endothelial cell  (IEA,ISO)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of miRNA transcription  (IEA)
positive regulation of multicellular organismal process  (IEA)
positive regulation of neuron differentiation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of osteoblast differentiation  (IEA)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of platelet aggregation  (IEA,ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (IBA,IEA,ISO)
positive regulation of receptor signaling pathway via STAT  (IEA,ISO,ISS)
positive regulation of smooth muscle cell proliferation  (IEA)
positive regulation of T cell proliferation  (IEA)
positive regulation of T-helper 2 cell cytokine production  (ISO)
positive regulation of T-helper 2 cell differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of translation  (IEA)
positive regulation of transmission of nerve impulse  (ISO)
positive regulation of tumor necrosis factor production  (IEA)
positive regulation of vascular endothelial growth factor production  (IEA)
regulation of apoptotic process  (ISO)
regulation of cell population proliferation  (ISO)
regulation of cell shape  (ISO)
regulation of circadian sleep/wake cycle, non-REM sleep  (ISO)
regulation of glucagon secretion  (IEA,ISS)
regulation of insulin secretion  (IEA,ISS)
regulation of vascular endothelial growth factor production  (IEA)
response to activity  (ISS)
response to amino acid  (ISO)
response to auditory stimulus  (ISO)
response to bacterium  (ISO)
response to caffeine  (ISO)
response to calcium ion  (ISO)
response to cytokine  (ISO)
response to electrical stimulus  (ISO)
response to ethanol  (ISO)
response to glucocorticoid  (IEA)
response to Gram-positive bacterium  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to wounding  (ISO)
response to xenobiotic stimulus  (ISO)
response to yeast  (ISO)
signal transduction  (IEA)
T cell activation  (ISO)
T follicular helper cell differentiation  (ISO)
T-helper 17 cell lineage commitment  (ISS)
T-helper 2 cell differentiation  (ISO)
vascular endothelial growth factor production  (IEA,ISS)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:1497880   PMID:1873476   PMID:8661698   PMID:8697800   PMID:9162522   PMID:9420012   PMID:15050130   PMID:15509024   PMID:16229816   PMID:17272928   PMID:17510233   PMID:17903420  
PMID:18607788   PMID:19016005   PMID:19520150   PMID:19605905   PMID:19766617   PMID:21471537   PMID:21884347   PMID:22301074   PMID:22482797   PMID:22522232   PMID:22850468   PMID:22920593  
PMID:24020676   PMID:24139936   PMID:27125399   PMID:27385686   PMID:28193578   PMID:30032202   PMID:30317108  


Genomics

Comparative Map Data
IL6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl991,506,421 - 91,511,263 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1991,506,421 - 91,510,830 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29101,081,042 - 101,085,451 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap9q14-q15NCBI
IL6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38722,727,200 - 22,731,998 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl722,725,884 - 22,732,002 (+)EnsemblGRCh38hg38GRCh38
GRCh37722,766,819 - 22,771,617 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36722,733,343 - 22,738,145 (+)NCBINCBI36Build 36hg18NCBI36
Build 34722,540,059 - 22,544,856NCBI
Celera722,752,396 - 22,757,251 (+)NCBICelera
Cytogenetic Map7p15.3NCBI
HuRef722,649,846 - 22,654,701 (+)NCBIHuRef
CHM1_1722,767,669 - 22,772,524 (+)NCBICHM1_1
T2T-CHM13v2.0722,861,319 - 22,867,916 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2722,817,875 - 22,822,730 (+)NCBI
Il6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39530,218,112 - 30,224,973 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl530,218,112 - 30,224,979 (+)EnsemblGRCm39 Ensembl
GRCm38530,013,114 - 30,019,975 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl530,013,114 - 30,019,981 (+)EnsemblGRCm38mm10GRCm38
MGSCv37530,339,701 - 30,346,508 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36530,343,948 - 30,350,755 (+)NCBIMGSCv36mm8
Celera527,530,266 - 27,537,070 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map515.7NCBI
Il6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr845,889,999 - 5,894,575 (-)NCBIGRCr8
mRatBN7.245,214,602 - 5,219,178 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl45,213,394 - 5,219,178 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx410,211,864 - 10,216,458 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.046,026,101 - 6,030,695 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.044,372,235 - 4,376,829 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.043,043,231 - 3,047,807 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl43,043,231 - 3,047,807 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.043,095,536 - 3,100,112 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44456,799 - 461,376 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14456,798 - 461,376 (-)NCBI
Celera45,093,593 - 5,098,169 (+)NCBICelera
Cytogenetic Map4q11NCBI
Il6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541025,079,835 - 25,084,390 (+)NCBIChiLan1.0ChiLan1.0
IL6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2627,593,486 - 27,598,569 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1775,918,460 - 75,923,290 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0723,415,922 - 23,420,767 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1723,027,560 - 23,032,419 (+)NCBIpanpan1.1PanPan1.1panPan2
IL6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11436,474,268 - 36,478,519 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1436,473,394 - 36,478,519 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1436,015,351 - 36,019,602 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01436,398,579 - 36,402,833 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1436,397,705 - 36,402,833 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11436,519,712 - 36,523,966 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01436,216,365 - 36,220,619 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01436,553,276 - 36,557,530 (+)NCBIUU_Cfam_GSD_1.0
Il6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213183,842,756 - 183,843,378 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365497,015,595 - 7,016,246 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12135,577,513 - 35,582,385 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2135,577,939 - 35,582,237 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604269,001,958 - 69,006,830 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247397,957,674 - 7,962,318 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247397,957,709 - 7,963,414 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in IL6
11 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 3 21 3 5 12 11 21 3 5 1

Sequence


Ensembl Acc Id: ENSSSCT00000023544   ⟹   ENSSSCP00000023819
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl991,506,421 - 91,510,830 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000025647   ⟹   ENSSSCP00000024026
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl991,506,421 - 91,511,263 (+)Ensembl
RefSeq Acc Id: NM_214399   ⟹   NP_999564
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1991,506,421 - 91,510,830 (+)NCBI
Sequence:
RefSeq Acc Id: NP_999564   ⟸   NM_214399
- Peptide Label: precursor
- UniProtKB: Q95KN6 (UniProtKB/Swiss-Prot),   P26893 (UniProtKB/Swiss-Prot),   A4D862 (UniProtKB/TrEMBL),   A0A8D0IGE6 (UniProtKB/TrEMBL),   I3LIB7 (UniProtKB/TrEMBL),   Q8MJ75 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000024026   ⟸   ENSSSCT00000025647
Ensembl Acc Id: ENSSSCP00000023819   ⟸   ENSSSCT00000023544


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000020970 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005010437 UniProtKB/TrEMBL
  ENSSSCG00015079404 UniProtKB/TrEMBL
  ENSSSCG00025055710 UniProtKB/TrEMBL
  ENSSSCG00030071702 UniProtKB/TrEMBL
  ENSSSCG00035047101 UniProtKB/TrEMBL
  ENSSSCG00040016939 UniProtKB/TrEMBL
  ENSSSCG00045035200 UniProtKB/TrEMBL
  ENSSSCG00050054010 UniProtKB/TrEMBL
  ENSSSCG00055014904 UniProtKB/TrEMBL
  ENSSSCG00060063306 UniProtKB/TrEMBL
  ENSSSCG00065044919 UniProtKB/TrEMBL
  ENSSSCG00070006735 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000023544 ENTREZGENE
  ENSSSCT00000023544.4 UniProtKB/TrEMBL
  ENSSSCT00000025647.4 UniProtKB/TrEMBL
  ENSSSCT00005016319.1 UniProtKB/TrEMBL
  ENSSSCT00005016342.1 UniProtKB/TrEMBL
  ENSSSCT00015107745.1 UniProtKB/TrEMBL
  ENSSSCT00015107854.1 UniProtKB/TrEMBL
  ENSSSCT00025076308.1 UniProtKB/TrEMBL
  ENSSSCT00025076398.1 UniProtKB/TrEMBL
  ENSSSCT00030100432.1 UniProtKB/TrEMBL
  ENSSSCT00030100482.1 UniProtKB/TrEMBL
  ENSSSCT00035062708.1 UniProtKB/TrEMBL
  ENSSSCT00035062730.1 UniProtKB/TrEMBL
  ENSSSCT00040022841.1 UniProtKB/TrEMBL
  ENSSSCT00040022937.1 UniProtKB/TrEMBL
  ENSSSCT00045060509.1 UniProtKB/TrEMBL
  ENSSSCT00045060575.1 UniProtKB/TrEMBL
  ENSSSCT00050073634.1 UniProtKB/TrEMBL
  ENSSSCT00050073644.1 UniProtKB/TrEMBL
  ENSSSCT00055029461.1 UniProtKB/TrEMBL
  ENSSSCT00055029521.1 UniProtKB/TrEMBL
  ENSSSCT00060086422.1 UniProtKB/TrEMBL
  ENSSSCT00060086571.1 UniProtKB/TrEMBL
  ENSSSCT00065061463.1 UniProtKB/TrEMBL
  ENSSSCT00065061478.1 UniProtKB/TrEMBL
  ENSSSCT00070012935.1 UniProtKB/TrEMBL
  ENSSSCT00070012945.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-6/GCSF/MGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL6/GCSF/MGF_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:399500 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene IL6 ENTREZGENE
PANTHER INTERLEUKIN-6 UniProtKB/Swiss-Prot
  INTERLEUKIN-6 UniProtKB/Swiss-Prot
  INTERLEUKIN-6 UniProtKB/TrEMBL
  INTERLEUKIN-6 UniProtKB/TrEMBL
Pfam IL6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF IL6_MGF_GCSF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS IL6GCSFMGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTERLEUKIN6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE INTERLEUKIN_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IL6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1T4A5_PIG UniProtKB/TrEMBL
  A0A4X1T6V7_PIG UniProtKB/TrEMBL
  A0A8D0IGE6 ENTREZGENE
  A0A8D0LHU3_PIG UniProtKB/TrEMBL
  A0A8D0Q939_PIG UniProtKB/TrEMBL
  A4D862 ENTREZGENE, UniProtKB/TrEMBL
  I3LIB7 ENTREZGENE
  I3LIW9_PIG UniProtKB/TrEMBL
  IL6_PIG UniProtKB/Swiss-Prot, ENTREZGENE
  Q5W7K7_PIG UniProtKB/TrEMBL
  Q8MJ75 ENTREZGENE, UniProtKB/TrEMBL
  Q95KN6 ENTREZGENE
UniProt Secondary A0A8D0IGE6 UniProtKB/TrEMBL
  I3LIB7 UniProtKB/TrEMBL
  Q95KN6 UniProtKB/Swiss-Prot
VGNC ID VGNC:108598 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-11-16 IL6  interleukin 6  IL-6  interleukin-6  Data merged from RGD:14141706 737654 PROVISIONAL