CXCL8 (C-X-C motif chemokine ligand 8) - Rat Genome Database

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Gene: CXCL8 (C-X-C motif chemokine ligand 8) Sus scrofa
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Symbol: CXCL8
Name: C-X-C motif chemokine ligand 8
RGD ID: 14244462
Description: ENCODES a protein that exhibits chemokine activity (inferred); interleukin-8 receptor binding (inferred); INVOLVED IN chemotaxis (ortholog); hemopoiesis (ortholog); inflammatory response (ortholog); PARTICIPATES IN chemokine (C-X-C motif) ligand 8 signaling pathway; mTOR signaling pathway; syndecan signaling pathway; ASSOCIATED WITH acute asthma (ortholog); Acute Lung Injury (ortholog); Acute-On-Chronic Liver Failure (ortholog); FOUND IN extracellular region (ortholog); INTERACTS WITH 3',4',5'-Trimethoxyflavone; anthra[1,9-cd]pyrazol-6(2H)-one; apigenin
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: alveolar macrophage chemotactic factor I; alveolar macrophage-derived chemotactic factor-I; AMCF-I; C-X-C motif chemokine 8; chemokine (C-X-C motif) ligand 8; IL-8; IL8; interleukin-8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl869,932,643 - 69,935,861 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1869,932,646 - 69,935,861 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2874,083,530 - 74,086,749 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute asthma  (ISO)
Acute Lung Injury  (ISO)
Acute-On-Chronic Liver Failure  (ISO)
adenocarcinoma  (ISO)
alcoholic hepatitis  (ISO)
allergic disease  (ISO)
Bacterial Eye Infections  (ISO)
bacterial gastritis  (ISO)
Bacterial Lung Diseases  (ISO)
Barrett's esophagus  (ISO)
Behcet's disease  (ISO)
biliary atresia  (ISO)
Breast Neoplasms  (ISO)
bullous pemphigoid  (ISO)
Cachexia  (ISO)
Cardiotoxicity  (ISO)
chikungunya  (ISO)
cholestasis  (ISO)
Chronic Hepatitis B  (ISO)
chronic obstructive pulmonary disease  (ISO)
colitis  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
COVID-19  (ISO)
cryptococcosis  (ISO)
cutaneous leishmaniasis  (ISO)
cystic fibrosis  (ISO)
Down syndrome  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Edema  (ISO)
Endometrial Neoplasms  (ISO)
Experimental Colitis  (ISO)
extrapulmonary tuberculosis  (ISO)
fatty liver disease  (ISO)
Fever  (ISO)
gastroesophageal reflux disease  (ISO)
glioblastoma  (ISO)
glomerulonephritis  (ISO)
Helicobacter Infections  (ISO)
hepatocellular carcinoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hyperalgesia  (ISO)
Inflammation  (ISO)
Inflammatory Breast Neoplasms  (ISO)
intermediate coronary syndrome  (ISO)
Intractable Pain  (ISO)
intrahepatic cholestasis  (ISO)
keratitis  (ISO)
Klebsiella pneumonia  (ISO)
lichen disease  (ISO)
liver cirrhosis  (ISO)
Liver Failure  (ISO)
Liver Metastasis  (ISO)
lung non-small cell carcinoma  (ISO)
Lyme Neuroborreliosis  (ISO)
malignant mesothelioma  (ISO)
multiple sclerosis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplastic Cell Transformation  (ISO)
Neurosyphilis  (ISO)
oral submucous fibrosis  (ISO)
otitis media  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
peptic esophagitis  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
Postherpetic Neuralgia  (ISO)
primary biliary cholangitis  (ISO)
Prostatic Neoplasms  (ISO)
Pseudomonas Infections  (ISO)
psoriatic arthritis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
Reperfusion Injury  (ISO)
rheumatoid arthritis  (ISO)
Salmonella Infections, Animal  (ISO)
severe acute respiratory syndrome  (ISO)
squamous cell carcinoma  (ISO)
Staphylococcal Infections  (ISO)
stomach carcinoma  (ISO)
Stomach Neoplasms  (ISO)
Thyroid Neoplasms  (ISO)
Tobacco Use Disorder  (ISO)
Toxoplasma Chorioretinitis  (ISO)
Triple Negative Breast Neoplasms  (ISO)
tropical spastic paraparesis  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
viral encephalitis  (ISO)
viral pneumonia  (ISO)
visceral leishmaniasis  (ISO)
Wilson disease  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:1420165   PMID:1850745   PMID:8276881   PMID:12464027   PMID:14681463   PMID:15528384   PMID:15912099   PMID:17145712   PMID:19232500   PMID:21314908   PMID:21318239   PMID:23102097  
PMID:23751822   PMID:23879680   PMID:24792438   PMID:25147235   PMID:25575706   PMID:26581603   PMID:28347884   PMID:29521102   PMID:31831027  


Genomics

Comparative Map Data
CXCL8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl869,932,643 - 69,935,861 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1869,932,646 - 69,935,861 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2874,083,530 - 74,086,749 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CXCL8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl473,740,541 - 73,743,716 (+)EnsemblGRCh38hg38GRCh38
GRCh38473,740,569 - 73,743,716 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37474,606,286 - 74,609,433 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36474,825,139 - 74,828,297 (+)NCBINCBI36hg18NCBI36
Build 34474,971,309 - 74,974,466NCBI
Celera471,966,137 - 71,969,295 (+)NCBI
Cytogenetic Map4q13.3NCBI
HuRef470,417,707 - 70,420,917 (+)NCBIHuRef
CHM1_1474,642,243 - 74,645,454 (+)NCBICHM1_1
Cxcl15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39590,942,393 - 90,950,926 (+)NCBIGRCm39mm39
GRCm39 Ensembl590,942,393 - 90,950,926 (+)Ensembl
GRCm38590,794,534 - 90,803,067 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl590,794,534 - 90,803,067 (+)EnsemblGRCm38mm10GRCm38
MGSCv37591,223,560 - 91,232,093 (+)NCBIGRCm37mm9NCBIm37
MGSCv36591,869,771 - 91,877,088 (+)NCBImm8
Celera588,946,158 - 88,954,669 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.78NCBI
Cxcl8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955474241,501 - 250,643 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955474247,326 - 250,355 (+)NCBIChiLan1.0ChiLan1.0
CXCL8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1456,285,026 - 56,288,308 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl456,286,708 - 56,288,083 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0450,452,857 - 50,456,015 (-)NCBIMhudiblu_PPA_v0panPan3
CXCL8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11362,435,035 - 62,438,354 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1362,434,422 - 62,438,354 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1362,104,414 - 62,107,728 (+)NCBI
ROS_Cfam_1.01363,245,400 - 63,248,688 (+)NCBI
UMICH_Zoey_3.11362,855,624 - 62,858,940 (+)NCBI
UNSW_CanFamBas_1.01362,345,249 - 62,348,566 (+)NCBI
UU_Cfam_GSD_1.01363,485,538 - 63,488,849 (+)NCBI
LOC101964975
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528513,326,322 - 13,329,490 (-)NCBI
SpeTri2.0NW_0049365981,779,471 - 1,781,353 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CXCL8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1722,202,497 - 22,205,730 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl722,202,527 - 22,204,068 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666084587,605 - 589,481 (-)NCBIVero_WHO_p1.0
Cxcl8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247301,744,097 - 1,747,206 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 1 1 3
Low 1 3 4 1
Below cutoff 1 1 2 4 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000009807   ⟹   ENSSSCP00000009554
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl869,932,644 - 69,935,860 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000068386   ⟹   ENSSSCP00000061888
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl869,932,643 - 69,935,861 (+)Ensembl
RefSeq Acc Id: NM_213867   ⟹   NP_999032
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1869,932,646 - 69,935,861 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_999032   ⟸   NM_213867
- Peptide Label: precursor
- UniProtKB: P26894 (UniProtKB/Swiss-Prot),   Q68CM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000009554   ⟸   ENSSSCT00000009807
RefSeq Acc Id: ENSSSCP00000061888   ⟸   ENSSSCT00000068386
Protein Domains
SCY


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000008953 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00005040921 UniProtKB/Swiss-Prot
  ENSSSCG00025017428 UniProtKB/Swiss-Prot
  ENSSSCG00030036565 UniProtKB/Swiss-Prot
  ENSSSCG00035071462 UniProtKB/Swiss-Prot
  ENSSSCG00040074984 UniProtKB/Swiss-Prot
  ENSSSCG00045009964 UniProtKB/Swiss-Prot
  ENSSSCG00055030636 UniProtKB/Swiss-Prot
  ENSSSCG00060039839 UniProtKB/Swiss-Prot
  ENSSSCG00070006372 UniProtKB/Swiss-Prot
Ensembl Protein ENSSSCP00000009554 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCP00000061888 UniProtKB/TrEMBL
  ENSSSCP00005040562 UniProtKB/Swiss-Prot
  ENSSSCP00025009879 UniProtKB/Swiss-Prot
  ENSSSCP00030023129 UniProtKB/Swiss-Prot
  ENSSSCP00035040729 UniProtKB/Swiss-Prot
  ENSSSCP00040047190 UniProtKB/Swiss-Prot
  ENSSSCP00045011673 UniProtKB/Swiss-Prot
  ENSSSCP00055048957 UniProtKB/Swiss-Prot
  ENSSSCP00060023007 UniProtKB/Swiss-Prot
  ENSSSCP00070010025 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000009807 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCT00000068386 UniProtKB/TrEMBL
  ENSSSCT00005065575 UniProtKB/Swiss-Prot
  ENSSSCT00025023573 UniProtKB/Swiss-Prot
  ENSSSCT00030050860 UniProtKB/Swiss-Prot
  ENSSSCT00035096660 UniProtKB/Swiss-Prot
  ENSSSCT00040103852 UniProtKB/Swiss-Prot
  ENSSSCT00045016902 UniProtKB/Swiss-Prot
  ENSSSCT00055061067 UniProtKB/Swiss-Prot
  ENSSSCT00060053953 UniProtKB/Swiss-Prot
  ENSSSCT00070012189 UniProtKB/Swiss-Prot
InterPro Chemokine_CXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_CXC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CXC_Chemokine_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interleukin-8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:396880 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene CXCL8 ENTREZGENE
PANTHER PTHR10179 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10179:SF42 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS SMALLCYTKCXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SMALL_CYTOKINES_CXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SCY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A5G2QBL8_PIG UniProtKB/TrEMBL
  G8EGP8_PIG UniProtKB/TrEMBL
  IL8_PIG UniProtKB/Swiss-Prot, ENTREZGENE
  Q68CM2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P22951 UniProtKB/Swiss-Prot
VGNC ID VGNC:87106 ENTREZGENE