ARRB2 (arrestin beta 2) - Rat Genome Database

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Gene: ARRB2 (arrestin beta 2) Sus scrofa
Analyze
Symbol: ARRB2
Name: arrestin beta 2
RGD ID: 14062292
Description: ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); alpha-1A adrenergic receptor binding (ortholog); alpha-1B adrenergic receptor binding (ortholog); INVOLVED IN circadian rhythm (ortholog); detection of temperature stimulus involved in sensory perception of pain (ortholog); endocytosis (ortholog); PARTICIPATES IN angiotensin II signaling pathway via AT1 receptor; calcium signaling pathway via the calcium-sensing receptor; corticotropin-releasing hormone signaling pathway; ASSOCIATED WITH alcohol dependence (ortholog); amphetamine abuse (ortholog); Arteriovenous Fistula (ortholog); FOUND IN basolateral plasma membrane (ortholog); dendritic spine (ortholog); endosome (ortholog); INTERACTS WITH dibromine
Type: protein-coding
RefSeq Status: MODEL
Previously known as: beta-arrestin-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,161,778 - 52,170,342 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,161,776 - 52,170,362 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21254,280,938 - 54,286,249 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
dibromine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult walking behavior  (IEA)
cell chemotaxis  (IEA)
circadian rhythm  (ISO)
desensitization of G protein-coupled receptor signaling pathway  (IEA)
detection of temperature stimulus involved in sensory perception of pain  (ISO)
endocytosis  (ISO)
follicle-stimulating hormone signaling pathway  (ISO)
G protein-coupled receptor internalization  (IBA,IEA)
G protein-coupled receptor signaling pathway  (ISO)
modulation of chemical synaptic transmission  (IEA)
negative regulation of canonical NF-kappaB signal transduction  (IEA)
negative regulation of GTPase activity  (ISO)
negative regulation of interleukin-1 beta production  (IEA)
negative regulation of interleukin-12 production  (IEA)
negative regulation of interleukin-6 production  (IEA)
negative regulation of natural killer cell mediated cytotoxicity  (IEA)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of NF-kappaB transcription factor activity  (ISO)
negative regulation of opioid receptor signaling pathway  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of protein ubiquitination  (IEA,ISO)
negative regulation of release of cytochrome c from mitochondria  (ISO)
negative regulation of smooth muscle cell apoptotic process  (ISO)
negative regulation of toll-like receptor signaling pathway  (IEA)
negative regulation of tumor necrosis factor production  (IEA)
positive regulation of calcium ion transport  (ISO)
positive regulation of cardiac muscle cell differentiation  (IEA)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of epithelial cell apoptotic process  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IBA,IEA,ISO)
positive regulation of gene expression  (IEA)
positive regulation of glial cell proliferation  (ISO)
positive regulation of opioid receptor signaling pathway  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of receptor internalization  (IEA,ISO)
positive regulation of synaptic transmission, dopaminergic  (IEA)
postsynaptic signal transduction  (IEA)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IEA)
protein ubiquitination  (IEA)
receptor internalization  (IEA)
regulation of G protein-coupled receptor signaling pathway  (IEA,ISO)
regulation of protein phosphorylation  (ISO)
response to morphine  (ISO)
signal transduction  (IEA)
transcription by RNA polymerase II  (IEA)
transforming growth factor beta receptor signaling pathway  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:14681463   PMID:15679890   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ARRB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,161,778 - 52,170,342 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,161,776 - 52,170,362 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21254,280,938 - 54,286,249 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARRB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38174,710,632 - 4,721,497 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl174,710,596 - 4,721,499 (+)EnsemblGRCh38hg38GRCh38
GRCh37174,613,927 - 4,624,792 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36174,560,538 - 4,571,544 (+)NCBINCBI36Build 36hg18NCBI36
Build 34174,560,537 - 4,571,543NCBI
Celera174,629,166 - 4,639,975 (+)NCBICelera
Cytogenetic Map17p13.2NCBI
HuRef174,502,952 - 4,513,866 (+)NCBIHuRef
CHM1_1174,622,557 - 4,633,518 (+)NCBICHM1_1
T2T-CHM13v2.0174,600,371 - 4,611,146 (+)NCBIT2T-CHM13v2.0
Arrb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,323,051 - 70,331,654 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,323,461 - 70,331,654 (+)EnsemblGRCm39 Ensembl
GRCm381170,432,485 - 70,440,828 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,432,635 - 70,440,828 (+)EnsemblGRCm38mm10GRCm38
MGSCv371170,246,155 - 70,254,176 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,248,893 - 70,257,018 (+)NCBIMGSCv36mm8
Celera1177,978,619 - 77,986,640 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.99NCBI
Arrb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,645,539 - 55,653,485 (+)NCBIGRCr8
mRatBN7.21055,146,887 - 55,154,854 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1055,146,818 - 55,154,850 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,825,196 - 59,833,080 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,313,709 - 59,321,593 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,812,911 - 54,820,795 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01057,040,252 - 57,048,045 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1057,040,267 - 57,048,134 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,797,489 - 56,805,282 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,244,071 - 57,284,166 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11057,289,995 - 57,297,789 (+)NCBI
Celera1054,285,120 - 54,301,063 (+)NCBICelera
Cytogenetic Map10q24NCBI
Arrb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546710,110,003 - 10,123,022 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546710,109,985 - 10,118,687 (+)NCBIChiLan1.0ChiLan1.0
ARRB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21912,328,333 - 12,339,069 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11714,296,695 - 14,307,332 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0174,766,616 - 4,777,253 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1174,757,048 - 4,767,517 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl174,757,048 - 4,767,517 (+)Ensemblpanpan1.1panPan2
ARRB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1531,831,208 - 31,838,875 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl531,829,864 - 31,839,454 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha531,968,270 - 31,977,918 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0531,934,052 - 31,943,706 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl531,934,872 - 31,943,667 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1531,900,361 - 31,910,009 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0531,860,046 - 31,869,691 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,036,284 - 32,045,935 (-)NCBIUU_Cfam_GSD_1.0
Arrb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560252,719,545 - 52,727,921 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366773,172,925 - 3,181,520 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366773,173,054 - 3,181,475 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARRB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,191,040 - 4,202,382 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl164,191,172 - 4,202,385 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605917,439,881 - 17,451,765 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arrb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247868,568,198 - 8,577,914 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247868,568,102 - 8,576,445 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ARRB2
152 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000019500   ⟹   ENSSSCP00000018982
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1252,161,778 - 52,170,342 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000063192   ⟹   ENSSSCP00000037785
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1252,161,778 - 52,166,473 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000090451   ⟹   ENSSSCP00000060730
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1252,161,778 - 52,170,335 (-)Ensembl
RefSeq Acc Id: XM_021067791   ⟹   XP_020923450
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11252,161,776 - 52,170,362 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021067792   ⟹   XP_020923451
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11252,161,776 - 52,170,361 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021067793   ⟹   XP_020923452
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11252,161,776 - 52,170,360 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021067794   ⟹   XP_020923453
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11252,161,776 - 52,170,358 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021067795   ⟹   XP_020923454
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11252,161,776 - 52,170,361 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021067796   ⟹   XP_020923455
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11252,161,776 - 52,170,361 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021067797   ⟹   XP_020923456
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11252,161,776 - 52,170,360 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021067798   ⟹   XP_020923457
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11252,161,776 - 52,170,347 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021067799   ⟹   XP_020923458
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11252,161,776 - 52,170,359 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020923450   ⟸   XM_021067791
- Peptide Label: isoform X1
- UniProtKB: A0A5G2QR25 (UniProtKB/TrEMBL),   A0A8D1K0K5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020923455   ⟸   XM_021067796
- Peptide Label: isoform X6
- UniProtKB: A0A480TUU9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020923454   ⟸   XM_021067795
- Peptide Label: isoform X5
- UniProtKB: A0A480TUU9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020923451   ⟸   XM_021067792
- Peptide Label: isoform X2
- UniProtKB: A0A8D0XZH3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020923456   ⟸   XM_021067797
- Peptide Label: isoform X7
- UniProtKB: A0A8D1LUC7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020923452   ⟸   XM_021067793
- Peptide Label: isoform X3
- UniProtKB: A0A480V6M7 (UniProtKB/TrEMBL),   A0A4X1UWK7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020923458   ⟸   XM_021067799
- Peptide Label: isoform X8
- UniProtKB: A0A8D1DEU0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020923453   ⟸   XM_021067794
- Peptide Label: isoform X4
- UniProtKB: A0A287A233 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020923457   ⟸   XM_021067798
- Peptide Label: isoform X8
- UniProtKB: A0A8D1DEU0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000018982   ⟸   ENSSSCT00000019500
Ensembl Acc Id: ENSSSCP00000060730   ⟸   ENSSSCT00000090451
Ensembl Acc Id: ENSSSCP00000037785   ⟸   ENSSSCT00000063192
Protein Domains
Arrestin C-terminal-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000017918 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025008232 UniProtKB/TrEMBL
  ENSSSCG00030069572 UniProtKB/TrEMBL
  ENSSSCG00035026621 UniProtKB/TrEMBL
  ENSSSCG00040011054 UniProtKB/TrEMBL
  ENSSSCG00045029286 UniProtKB/TrEMBL
  ENSSSCG00050023368 UniProtKB/TrEMBL
  ENSSSCG00055025988 UniProtKB/TrEMBL
  ENSSSCG00060039007 UniProtKB/TrEMBL
  ENSSSCG00065040786 UniProtKB/TrEMBL
  ENSSSCG00070020288 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000019500 ENTREZGENE
  ENSSSCT00000019500.4 UniProtKB/TrEMBL
  ENSSSCT00000063192 ENTREZGENE
  ENSSSCT00000063192.3 UniProtKB/TrEMBL
  ENSSSCT00000090451 ENTREZGENE
  ENSSSCT00000090451.1 UniProtKB/TrEMBL
  ENSSSCT00025011134.1 UniProtKB/TrEMBL
  ENSSSCT00025011148.1 UniProtKB/TrEMBL
  ENSSSCT00030097406.1 UniProtKB/TrEMBL
  ENSSSCT00030097516.1 UniProtKB/TrEMBL
  ENSSSCT00030097537.1 UniProtKB/TrEMBL
  ENSSSCT00030097565.1 UniProtKB/TrEMBL
  ENSSSCT00035035151.1 UniProtKB/TrEMBL
  ENSSSCT00035035174.1 UniProtKB/TrEMBL
  ENSSSCT00035035181.1 UniProtKB/TrEMBL
  ENSSSCT00040014461.1 UniProtKB/TrEMBL
  ENSSSCT00040014520.1 UniProtKB/TrEMBL
  ENSSSCT00040014555.1 UniProtKB/TrEMBL
  ENSSSCT00040014565.1 UniProtKB/TrEMBL
  ENSSSCT00045051416.1 UniProtKB/TrEMBL
  ENSSSCT00045051945.1 UniProtKB/TrEMBL
  ENSSSCT00050031547.1 UniProtKB/TrEMBL
  ENSSSCT00050031571.1 UniProtKB/TrEMBL
  ENSSSCT00050031573.1 UniProtKB/TrEMBL
  ENSSSCT00050031581.1 UniProtKB/TrEMBL
  ENSSSCT00055053608.1 UniProtKB/TrEMBL
  ENSSSCT00055053692.1 UniProtKB/TrEMBL
  ENSSSCT00060052745.1 UniProtKB/TrEMBL
  ENSSSCT00060052760.1 UniProtKB/TrEMBL
  ENSSSCT00060052768.1 UniProtKB/TrEMBL
  ENSSSCT00060052771.1 UniProtKB/TrEMBL
  ENSSSCT00065055805.1 UniProtKB/TrEMBL
  ENSSSCT00065055814.1 UniProtKB/TrEMBL
  ENSSSCT00070040332.1 UniProtKB/TrEMBL
  ENSSSCT00070040338.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.640 UniProtKB/TrEMBL
  2.60.40.840 UniProtKB/TrEMBL
InterPro Arrestin UniProtKB/TrEMBL
  Arrestin-like_N UniProtKB/TrEMBL
  Arrestin_C UniProtKB/TrEMBL
  Arrestin_C-like UniProtKB/TrEMBL
  Arrestin_CS UniProtKB/TrEMBL
  Arrestin_N UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
NCBI Gene ARRB2 ENTREZGENE
PANTHER BETA-ARRESTIN-2 UniProtKB/TrEMBL
  PTHR11792 UniProtKB/TrEMBL
Pfam Arrestin_C UniProtKB/TrEMBL
  Arrestin_N UniProtKB/TrEMBL
PRINTS ARRESTIN UniProtKB/TrEMBL
PROSITE ARRESTINS UniProtKB/TrEMBL
SMART Arrestin_C UniProtKB/TrEMBL
Superfamily-SCOP SSF81296 UniProtKB/TrEMBL
UniProt A0A287A233 ENTREZGENE, UniProtKB/TrEMBL
  A0A480TUU9 ENTREZGENE, UniProtKB/TrEMBL
  A0A480V6M7 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UWK7 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UWL2_PIG UniProtKB/TrEMBL
  A0A5G2QR25 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0XZH3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0Y4N2_PIG UniProtKB/TrEMBL
  A0A8D1DEU0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1K0K5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1LUC7 ENTREZGENE, UniProtKB/TrEMBL
  F1RFU0_PIG UniProtKB/TrEMBL
VGNC ID VGNC:85543 ENTREZGENE