CYP27A1 (cytochrome P450 family 27 subfamily A member 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: CYP27A1 (cytochrome P450 family 27 subfamily A member 1) Sus scrofa
Analyze
Symbol: CYP27A1
Name: cytochrome P450 family 27 subfamily A member 1
RGD ID: 14029165
Description: ENCODES a protein that exhibits cholesterol 26-hydroxylase activity (ortholog); Hsp70 protein binding (ortholog); vitamin D3 25-hydroxylase activity (ortholog); INVOLVED IN cholesterol metabolic process (ortholog); PARTICIPATES IN bile acid biosynthetic pathway; bile acid signaling pathway; cerebrotendinous xanthomatosis pathway; ASSOCIATED WITH alacrima, achalasia, and impaired intellectual development syndrome (ortholog); atherosclerosis (ortholog); cerebrotendinous xanthomatosis (ortholog); FOUND IN mitochondrial envelope (ortholog); mitochondrial inner membrane (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cytochrome P450, family 27, subfamily A, polypeptide 1; sterol 26-hydroxylase, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15120,809,959 - 120,852,193 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115120,809,886 - 120,852,196 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215133,798,107 - 133,831,191 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
CYP27A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15120,809,959 - 120,852,193 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115120,809,886 - 120,852,196 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215133,798,107 - 133,831,191 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CYP27A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382218,782,147 - 218,815,293 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2218,781,749 - 218,815,293 (+)EnsemblGRCh38hg38GRCh38
GRCh372219,646,870 - 219,680,016 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,354,949 - 219,388,259 (+)NCBINCBI36hg18NCBI36
Build 342219,472,209 - 219,505,520NCBI
Celera2213,414,219 - 213,447,784 (+)NCBI
Cytogenetic Map2q35NCBI
HuRef2211,499,575 - 211,533,141 (+)NCBIHuRef
CHM1_12219,653,385 - 219,686,914 (+)NCBICHM1_1
T2T-CHM13v2.02219,268,705 - 219,301,851 (+)NCBI
Cyp27a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39174,752,311 - 74,777,056 (+)NCBIGRCm39mm39
GRCm39 Ensembl174,752,733 - 74,777,051 (+)Ensembl
GRCm38174,713,148 - 74,737,897 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,713,574 - 74,737,892 (+)EnsemblGRCm38mm10GRCm38
MGSCv37174,760,148 - 74,784,464 (+)NCBIGRCm37mm9NCBIm37
MGSCv36174,646,781 - 74,671,097 (+)NCBImm8
Celera175,268,638 - 75,292,903 (+)NCBICelera
Cytogenetic Map1C4NCBI
cM Map138.54NCBI
Cyp27a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2976,264,655 - 76,294,551 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl976,264,860 - 76,294,551 (+)Ensembl
Rnor_6.0981,968,285 - 81,998,213 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl981,968,332 - 81,998,169 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0981,730,705 - 81,760,595 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,039,204 - 74,068,648 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1974,186,068 - 74,215,629 (+)NCBI
Celera973,837,312 - 73,867,002 (+)NCBICelera
Cytogenetic Map9q33NCBI
LOC102004889
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545314,601,444 - 14,647,366 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545314,601,495 - 14,647,383 (-)NCBIChiLan1.0ChiLan1.0
CYP27A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B224,637,238 - 224,671,474 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B224,637,238 - 224,671,474 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B106,042,235 - 106,076,840 (+)NCBIMhudiblu_PPA_v0panPan3
CYP27A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13725,366,475 - 25,401,978 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3725,366,472 - 25,401,509 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3726,186,269 - 26,221,708 (+)NCBI
ROS_Cfam_1.03725,381,673 - 25,417,125 (+)NCBI
ROS_Cfam_1.0 Ensembl3725,382,000 - 25,602,692 (+)Ensembl
UMICH_Zoey_3.13725,286,426 - 25,321,814 (+)NCBI
UNSW_CanFamBas_1.03725,221,115 - 25,256,548 (+)NCBI
UU_Cfam_GSD_1.03725,241,871 - 25,277,345 (+)NCBI
LOC101963150
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303174,870,819 - 174,907,409 (+)NCBI
SpeTri2.0NW_0049365691,213,700 - 1,250,181 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP27A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110104,682,437 - 104,723,781 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl10104,682,673 - 104,726,687 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604094,685,776 - 94,722,151 (-)NCBIVero_WHO_p1.0
LOC101700018
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248236,200,047 - 6,258,001 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248236,199,807 - 6,258,273 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 2 3 1 1 4 2 1
Low 9 2 4 1 19 2 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000017640   ⟹   ENSSSCP00000017162
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15120,812,385 - 120,852,193 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000028116   ⟹   ENSSSCP00000020985
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15120,809,959 - 120,852,192 (+)Ensembl
RefSeq Acc Id: NM_001243304   ⟹   NP_001230233
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115120,809,886 - 120,852,196 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001230233 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABS58492 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001230233   ⟸   NM_001243304
- UniProtKB: I3LAB7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000017162   ⟸   ENSSSCT00000017640
RefSeq Acc Id: ENSSSCP00000020985   ⟸   ENSSSCT00000028116


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000016199 Ensembl, UniProtKB/TrEMBL
  ENSSSCG00005026824 UniProtKB/TrEMBL
  ENSSSCG00025018315 UniProtKB/TrEMBL
  ENSSSCG00035027462 UniProtKB/TrEMBL
  ENSSSCG00040020135 UniProtKB/TrEMBL
  ENSSSCG00045035919 UniProtKB/TrEMBL
  ENSSSCG00055000469 UniProtKB/TrEMBL
  ENSSSCG00060020515 UniProtKB/TrEMBL
  ENSSSCG00065005810 UniProtKB/TrEMBL
  ENSSSCG00070017094 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000017162 UniProtKB/TrEMBL
  ENSSSCP00000020985 UniProtKB/TrEMBL
  ENSSSCP00005026121 UniProtKB/TrEMBL
  ENSSSCP00005026168 UniProtKB/TrEMBL
  ENSSSCP00025010516 UniProtKB/TrEMBL
  ENSSSCP00035014439 UniProtKB/TrEMBL
  ENSSSCP00040011499 UniProtKB/TrEMBL
  ENSSSCP00045043432 UniProtKB/TrEMBL
  ENSSSCP00055000567 UniProtKB/TrEMBL
  ENSSSCP00060011906 UniProtKB/TrEMBL
  ENSSSCP00065003313 UniProtKB/TrEMBL
  ENSSSCP00070028129 UniProtKB/TrEMBL
  ENSSSCP00070028134 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000017640 UniProtKB/TrEMBL
  ENSSSCT00000028116 UniProtKB/TrEMBL
  ENSSSCT00005042675 UniProtKB/TrEMBL
  ENSSSCT00005042744 UniProtKB/TrEMBL
  ENSSSCT00025024885 UniProtKB/TrEMBL
  ENSSSCT00035036306 UniProtKB/TrEMBL
  ENSSSCT00040027209 UniProtKB/TrEMBL
  ENSSSCT00045061783 UniProtKB/TrEMBL
  ENSSSCT00055000805 UniProtKB/TrEMBL
  ENSSSCT00060027810 UniProtKB/TrEMBL
  ENSSSCT00065007823 UniProtKB/TrEMBL
  ENSSSCT00070033702 UniProtKB/TrEMBL
  ENSSSCT00070033707 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
KEGG Report ssc:100126282 UniProtKB/TrEMBL
NCBI Gene CYP27A1 ENTREZGENE
Pfam p450 UniProtKB/TrEMBL
PRINTS EP450I UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/TrEMBL
UniProt A0A480IQ19_PIG UniProtKB/TrEMBL
  A0A4X1UIJ8_PIG UniProtKB/TrEMBL
  A0A4X1UIK2_PIG UniProtKB/TrEMBL
  A7KZR6_PIG UniProtKB/TrEMBL
  F1SRX1_PIG UniProtKB/TrEMBL
  I3LAB7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:103372 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-21 CYP27A1  cytochrome P450 family 27 subfamily A member 1  CYP27A1  cytochrome P450, family 27, subfamily A, polypeptide 1  Symbol and/or name change 19259463 PROVISIONAL