Cyp27a1 (cytochrome P450, family 27, subfamily a, polypeptide 1) - Rat Genome Database

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Gene: Cyp27a1 (cytochrome P450, family 27, subfamily a, polypeptide 1) Mus musculus
Analyze
Symbol: Cyp27a1
Name: cytochrome P450, family 27, subfamily a, polypeptide 1
RGD ID: 1550475
MGI Page MGI
Description: Predicted to enable several functions, including Hsp70 protein binding activity; cholestanetetraol 26-dehydrogenase activity; and steroid hydroxylase activity. Predicted to be involved in steroid metabolic process. Located in mitochondrial inner membrane. Is expressed in several structures, including central nervous system; liver; male reproductive gland or organ; metanephros; and retina. Human ortholog(s) of this gene implicated in cerebrotendinous xanthomatosis. Orthologous to human CYP27A1 (cytochrome P450 family 27 subfamily A member 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1300013A03Rik; 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase; 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase; cholesterol 27 hydroxylase; Cyp2; Cyp27; cytochrome P-450C27/25; cytochrome P450 27; cytochrome P450, 27a1; sterol 26-hydroxylase, mitochondrial; sterol 27-hydroxylase; vitamin D(3) 25-hydroxylase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39174,752,311 - 74,777,056 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl174,752,733 - 74,777,051 (+)EnsemblGRCm39 Ensembl
GRCm38174,713,148 - 74,737,897 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,713,574 - 74,737,892 (+)EnsemblGRCm38mm10GRCm38
MGSCv37174,760,148 - 74,784,464 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36174,646,781 - 74,671,097 (+)NCBIMGSCv36mm8
Celera175,268,638 - 75,292,903 (+)NCBICelera
Cytogenetic Map1C4NCBI
cM Map138.54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (EXP)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(5alpha)-cholestan-3beta-ol  (ISO)
(S)-amphetamine  (ISO)
1,2,3-trilinolenoylglycerol  (EXP)
1,2,3-trilinoleoylglycerol  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (ISO)
2-arachidonoylglycerol  (EXP,ISO)
25-hydroxycholesterol  (EXP,ISO)
26-hydroxycholesterol  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3-methylfuran  (ISO)
3beta-hydroxycholest-5-en-26-oic acid  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (ISO)
7-ketocholesterol  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
AM-251  (EXP)
ammonium chloride  (ISO)
amphotericin B  (EXP)
ampicillin  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
atrazine  (ISO)
Augmentin  (ISO)
benzalkonium chloride  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-hexachlorocyclohexane  (EXP,ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (ISO)
bromuconazole  (ISO)
buspirone  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP)
caesium atom  (ISO)
cafestol  (ISO)
calciol  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
CGS-21680  (ISO)
chenodeoxycholic acid  (EXP,ISO)
cholesterol  (EXP,ISO)
cholic acid  (EXP,ISO)
choline  (EXP)
ciguatoxin CTX1B  (EXP)
clavulanic acid  (ISO)
clofibric acid  (ISO)
copper(II) chloride  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
DDE  (EXP,ISO)
deoxycholic acid  (EXP,ISO)
desmosterol  (ISO)
dexamethasone  (ISO)
dibenzofurans  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP)
dimethyl sulfoxide  (ISO)
Diosbulbin B  (EXP)
diosgenin  (ISO)
dioxygen  (EXP)
dipentyl phthalate  (ISO)
diquat  (EXP)
disodium selenite  (EXP)
diuron  (ISO)
elemental selenium  (EXP)
emodin  (EXP,ISO)
endosulfan  (ISO)
enilconazole  (EXP)
ethanol  (EXP)
ethylparaben  (ISO)
eugenol  (ISO)
flumequine  (EXP)
flutamide  (ISO)
folic acid  (EXP)
furan  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
guggulsterone  (ISO)
GW 4064  (EXP)
indometacin  (ISO)
irinotecan  (ISO)
isoniazide  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
lanosterol  (ISO)
lead diacetate  (EXP)
levofloxacin  (ISO)
Licochalcone B  (ISO)
linalool  (ISO)
lithocholic acid  (EXP)
melatonin  (EXP)
mercury atom  (EXP)
mercury(0)  (EXP)
metformin  (EXP)
methamphetamine  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methoxsalen  (ISO)
methyltestosterone  (ISO)
metronidazole  (EXP)
morphine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (ISO)
neomycin  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nimesulide  (ISO)
nitrofen  (ISO)
NS-398  (ISO)
obeticholic acid  (ISO)
oleanolic acid  (EXP)
oxycodone  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorodecanoic acid  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
physcion  (ISO)
pirinixic acid  (EXP)
prednisone  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
procymidone  (EXP)
progesterone  (EXP,ISO)
prothioconazole  (EXP)
Prothioconazole-desthio  (EXP)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rotenone  (ISO)
selenium atom  (EXP)
Senkirkine  (ISO)
serpentine asbestos  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium dodecyl sulfate  (ISO)
streptozocin  (EXP)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
taurocholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
theophylline  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
triolein  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
tris(2-chloroethyl) phosphate  (EXP)
trovafloxacin  (EXP)
uranium atom  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zymosterol  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis. Cali JJ, etal., J Biol Chem. 1991 Apr 25;266(12):7779-83.
2. Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD. Jiao N, etal., Gut. 2018 Oct;67(10):1881-1891. doi: 10.1136/gutjnl-2017-314307. Epub 2017 Aug 3.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. Inactivating mutations in the 25-hydroxyvitamin D3 1alpha-hydroxylase gene in patients with pseudovitamin D-deficiency rickets. Kitanaka S, etal., N Engl J Med. 1998 Mar 5;338(10):653-61.
5. Disturbed cholesterol homeostasis in a peroxisome-deficient PEX2 knockout mouse model. Kovacs WJ, etal., Mol Cell Biol. 2004 Jan;24(1):1-13.
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
8. Reverse cholesterol transport and cholesterol efflux in atherosclerosis. Ohashi R, etal., QJM. 2005 Dec;98(12):845-56. Epub 2005 Oct 28.
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Modulation of transport and metabolism of bile acids and bilirubin by chlorogenic acid against hepatotoxicity and cholestasis in bile duct ligation rats: involvement of SIRT1-mediated deacetylation of FXR and PGC-1α. Zhu L, etal., J Hepatobiliary Pancreat Sci. 2018 Mar;25(3):195-205. doi: 10.1002/jhbp.537.
Additional References at PubMed
PMID:1708392   PMID:8751373   PMID:9052933   PMID:9614081   PMID:9797378   PMID:10349636   PMID:11001949   PMID:11042159   PMID:11076861   PMID:11181760   PMID:11208732   PMID:11454857  
PMID:11682476   PMID:11714849   PMID:12020639   PMID:12119285   PMID:12477932   PMID:12509506   PMID:12745259   PMID:12865426   PMID:14681479   PMID:15489334   PMID:15520450   PMID:15825828  
PMID:16141072   PMID:16141073   PMID:16473946   PMID:16602821   PMID:16916647   PMID:17890683   PMID:18614015   PMID:19633360   PMID:19671838   PMID:20501668   PMID:20511491   PMID:21334403  
PMID:21628469   PMID:21873635   PMID:22111624   PMID:22820291   PMID:23284090   PMID:23747249   PMID:23895994   PMID:24019477   PMID:24096962   PMID:24194600   PMID:24280213   PMID:24327605  
PMID:24832732   PMID:25065682   PMID:25271621   PMID:25281859   PMID:25293590   PMID:25453744   PMID:26831518   PMID:27146480   PMID:27514747   PMID:28190002   PMID:28213512   PMID:29021522  
PMID:29191818   PMID:30448403   PMID:30471425   PMID:31048561   PMID:31053504   PMID:31655042   PMID:32325033   PMID:32698250   PMID:32861706   PMID:33526687   PMID:35245089   PMID:36658240  
PMID:36890868   PMID:37607853   PMID:37648096   PMID:38355793  


Genomics

Comparative Map Data
Cyp27a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39174,752,311 - 74,777,056 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl174,752,733 - 74,777,051 (+)EnsemblGRCm39 Ensembl
GRCm38174,713,148 - 74,737,897 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,713,574 - 74,737,892 (+)EnsemblGRCm38mm10GRCm38
MGSCv37174,760,148 - 74,784,464 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36174,646,781 - 74,671,097 (+)NCBIMGSCv36mm8
Celera175,268,638 - 75,292,903 (+)NCBICelera
Cytogenetic Map1C4NCBI
cM Map138.54NCBI
CYP27A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382218,782,147 - 218,815,293 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2218,781,749 - 218,815,293 (+)EnsemblGRCh38hg38GRCh38
GRCh372219,646,870 - 219,680,016 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,354,949 - 219,388,259 (+)NCBINCBI36Build 36hg18NCBI36
Build 342219,472,209 - 219,505,520NCBI
Celera2213,414,219 - 213,447,784 (+)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2211,499,575 - 211,533,141 (+)NCBIHuRef
CHM1_12219,653,385 - 219,686,914 (+)NCBICHM1_1
T2T-CHM13v2.02219,268,705 - 219,301,851 (+)NCBIT2T-CHM13v2.0
Cyp27a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8983,712,402 - 83,743,222 (+)NCBIGRCr8
mRatBN7.2976,264,655 - 76,294,551 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,264,860 - 76,294,551 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx984,709,826 - 84,739,736 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0989,838,774 - 89,868,679 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,224,941 - 88,254,850 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0981,968,285 - 81,998,213 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl981,968,332 - 81,998,169 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0981,730,705 - 81,760,595 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,039,204 - 74,068,648 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1974,186,068 - 74,215,629 (+)NCBI
Celera973,837,312 - 73,867,002 (+)NCBICelera
Cytogenetic Map9q33NCBI
LOC102004889
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545314,601,444 - 14,647,366 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545314,601,495 - 14,647,383 (-)NCBIChiLan1.0ChiLan1.0
CYP27A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213121,414,455 - 121,449,699 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B121,430,782 - 121,464,669 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B106,042,235 - 106,076,840 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B224,637,238 - 224,671,474 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B224,637,238 - 224,671,474 (+)Ensemblpanpan1.1panPan2
CYP27A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13725,366,475 - 25,401,978 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3725,366,472 - 25,401,509 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3726,186,269 - 26,221,708 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03725,381,673 - 25,417,125 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3725,382,000 - 25,602,692 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13725,286,426 - 25,321,814 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03725,221,115 - 25,256,548 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03725,241,871 - 25,277,345 (+)NCBIUU_Cfam_GSD_1.0
LOC101963150
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303174,870,819 - 174,907,409 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365691,213,573 - 1,250,589 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365691,213,700 - 1,250,181 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP27A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15120,809,959 - 120,852,192 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115120,809,886 - 120,852,196 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215133,798,107 - 133,831,191 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CYP27A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110104,682,437 - 104,723,781 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10104,682,673 - 104,726,687 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604094,685,776 - 94,722,151 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101700018
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248236,200,047 - 6,258,001 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248236,199,807 - 6,258,273 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cyp27a1
1336 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:119
Count of miRNA genes:109
Interacting mature miRNAs:119
Transcripts:ENSMUST00000027356
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1301714Vertcling_mvertical clinging (mouse)Not determined14293803176938167Mouse
4142394Mssq1_mmandible size and shape QTL 1 (mouse)Not determined73615692107615830Mouse
18182931Metl1_mmetabolite locus 1, pyridoxate (mouse)14127539975275399Mouse
4141305Tgq9_mtriglyceride QTL 9 (mouse)Not determined5142160585421605Mouse
4141625Emo4_memotionality 4 (mouse)Not determined6807134586235027Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1301211Bbaa11_mB.burgdorferi-associated arthritis 11 (mouse)Not determined14888900682889210Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
14697705Stsl3b_mSalmonella typhimurium susceptibility locus 3b (mouse)17413915981777715Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
1302146Cocrb1_mcocaine related behavior 1 (mouse)Not determined170133533104139557Mouse
1357505Vtbt1_mvertebral trabecular bone trait 1 (mouse)Not determined15626621490266360Mouse
4141032Wbcc1_mwhite blood cell count 1 (mouse)Not determined4225966776259667Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15794135191941351Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15854919192549443Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15799197791992080Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
14747009Manh49_mmandible shape 49 (mouse)15794135191941351Mouse
1301616Yaa2_mY-linked autoimmune acceleration 2 (mouse)Not determined14685469080854839Mouse
1300976Bmd19_mbone mineral density 19 (mouse)Not determined173266214108838414Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
10043965Obq24_mobesity QTL 24 (mouse)Not determined15089021684890216Mouse
1301430Cdcs2_mcytokine deficiency colitis susceptibility 2 (mouse)Not determined14889234582892485Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162946755120529678Mouse
1558717Ses1a_msalmonella enteritidis susceptibility 1a (mouse)Not determined15672692290727077Mouse
1301304Hrq3_mheart rate quantitative locus 3 (mouse)Not determined173615692107615830Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1558905Gct7_mgranulosa cell tumorigenesis 7 (mouse)Not determined14734989481350013Mouse
4141393Mol2_mmodifier of LPS-response 2 (mouse)Not determined7162467978183144Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15854919192549443Mouse
1558822Vas1_mautoimmune vasitis resistance 1 (mouse)Not determined14888900682889210Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167339159129727737Mouse
1302119Cia15_mcollagen induced arthritis 15 (mouse)Not determined16588900688496101Mouse
1301670Ssta1_msusceptibility to Salmonella typhimurium antigens 1 (mouse)Not determined14594675579946882Mouse
1357741Nidd5k_mNidd5 on KK-A<y> (mouse)Not determined15597494889975057Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15799197791992080Mouse
1301225Sle7_msystematic lupus erythematosus susceptibility 7 (mouse)Not determined14685469080854839Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15799197791992080Mouse
4142467Wbcq1_mwhite blood cell quantitative locus 1 (mouse)Not determined15626621490266360Mouse
1301166Thypr2_mthymocyte proliferative response 2 (mouse)Not determined14127312475273271Mouse
1301933Insq6_minsulin QTL 6 (mouse)Not determined15672692290727077Mouse

Markers in Region
Cyp27a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38174,735,351 - 74,735,927UniSTSGRCm38
MGSCv37174,781,925 - 74,782,501UniSTSGRCm37
Celera175,290,364 - 75,290,940UniSTS
Cytogenetic Map1C3UniSTS
cM Map143.1UniSTS
cM Map143.1UniSTS
Cyp27a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38174,735,571 - 74,735,963UniSTSGRCm38
MGSCv37174,782,145 - 74,782,537UniSTSGRCm37
Celera175,290,584 - 75,290,976UniSTS
Cytogenetic Map1C3UniSTS
cM Map143.1UniSTS
Cyp27a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1C3UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000027356   ⟹   ENSMUSP00000027356
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl174,752,733 - 74,777,051 (+)Ensembl
GRCm38.p6 Ensembl174,713,574 - 74,737,892 (+)Ensembl
Ensembl Acc Id: ENSMUST00000189083
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl174,775,968 - 74,776,982 (+)Ensembl
GRCm38.p6 Ensembl174,736,809 - 74,737,823 (+)Ensembl
Ensembl Acc Id: ENSMUST00000190781
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl174,774,510 - 74,775,875 (+)Ensembl
GRCm38.p6 Ensembl174,735,351 - 74,736,716 (+)Ensembl
RefSeq Acc Id: NM_024264   ⟹   NP_077226
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39174,752,694 - 74,777,056 (+)NCBI
GRCm38174,713,535 - 74,737,897 (+)NCBI
MGSCv37174,760,148 - 74,784,464 (+)RGD
Celera175,268,638 - 75,292,903 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006495607   ⟹   XP_006495670
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39174,752,311 - 74,777,054 (+)NCBI
GRCm38174,713,148 - 74,737,896 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036165651   ⟹   XP_036021544
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39174,767,975 - 74,777,054 (+)NCBI
Sequence:
RefSeq Acc Id: NP_077226   ⟸   NM_024264
- Peptide Label: precursor
- UniProtKB: Q9DBG1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006495670   ⟸   XM_006495607
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSMUSP00000027356   ⟸   ENSMUST00000027356
RefSeq Acc Id: XP_036021544   ⟸   XM_036165651
- Peptide Label: isoform X1
- UniProtKB: Q99LX3 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9DBG1-F1-model_v2 AlphaFold Q9DBG1 1-533 view protein structure

Promoters
RGD ID:6874096
Promoter ID:EPDNEW_M499
Type:multiple initiation site
Name:Cyp27a1_1
Description:Mus musculus cytochrome P450, family 27, subfamily a, polypeptide1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38174,713,562 - 74,713,622EPDNEW
RGD ID:6817572
Promoter ID:MM_KWN:1197
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Liver,   Lung
Transcripts:NM_024264
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36174,759,744 - 74,760,244 (+)MPROMDB
RGD ID:6846588
Promoter ID:MM_ACW:1314
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:CYP27A1.CSEP07,   CYP27A1.ESEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36174,782,456 - 74,783,757 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88594 AgrOrtholog
Ensembl Genes ENSMUSG00000026170 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000027356 ENTREZGENE
  ENSMUST00000027356.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CYP11_CYP27_families UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:104086 UniProtKB/Swiss-Prot
MGD MGI:88594 ENTREZGENE
NCBI Gene Cyp27a1 ENTREZGENE
PANTHER CYTOCHROME P450 FAMILY 27 SUBFAMILY A MEMBER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24279 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp27a1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CP27A_MOUSE UniProtKB/Swiss-Prot
  Q99LX3 ENTREZGENE, UniProtKB/TrEMBL
  Q9DBG1 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Cyp27a1  cytochrome P450, family 27, subfamily a, polypeptide 1  Cyp27  cytochrome P450, 27  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 Cyp27  cytochrome P450, 27  Cyp27a1  cytochrome P450, family 27, subfamily a, polypeptide 1  Symbol and/or name change 5135510 APPROVED