LOC101700018 (sterol 26-hydroxylase, mitochondrial) - Rat Genome Database

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Gene: LOC101700018 (sterol 26-hydroxylase, mitochondrial) Heterocephalus glaber
Analyze
Symbol: LOC101700018 (Ensembl: CYP27A1)
Name: sterol 26-hydroxylase, mitochondrial
RGD ID: 18933908
Description: ENCODES a protein that exhibits cholesterol 26-hydroxylase activity (ortholog); Hsp70 protein binding (ortholog); vitamin D3 25-hydroxylase activity (ortholog); INVOLVED IN cholesterol metabolic process (ortholog); PARTICIPATES IN bile acid biosynthetic pathway; bile acid signaling pathway; cerebrotendinous xanthomatosis pathway; ASSOCIATED WITH alacrima, achalasia, and impaired intellectual development syndrome (ortholog); atherosclerosis (ortholog); autism spectrum disorder (ortholog); FOUND IN mitochondrial inner membrane (inferred); mitochondrial membrane (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: CYP27A1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248236,200,047 - 6,258,001 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248236,199,807 - 6,258,273 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LOC101700018
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248236,200,047 - 6,258,001 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248236,199,807 - 6,258,273 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
CYP27A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382218,782,147 - 218,815,293 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2218,781,749 - 218,815,293 (+)EnsemblGRCh38hg38GRCh38
GRCh372219,646,870 - 219,680,016 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,354,949 - 219,388,259 (+)NCBINCBI36Build 36hg18NCBI36
Build 342219,472,209 - 219,505,520NCBI
Celera2213,414,219 - 213,447,784 (+)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2211,499,575 - 211,533,141 (+)NCBIHuRef
CHM1_12219,653,385 - 219,686,914 (+)NCBICHM1_1
T2T-CHM13v2.02219,268,705 - 219,301,851 (+)NCBIT2T-CHM13v2.0
Cyp27a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39174,752,311 - 74,777,056 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl174,752,733 - 74,777,051 (+)EnsemblGRCm39 Ensembl
GRCm38174,713,148 - 74,737,897 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,713,574 - 74,737,892 (+)EnsemblGRCm38mm10GRCm38
MGSCv37174,760,148 - 74,784,464 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36174,646,781 - 74,671,097 (+)NCBIMGSCv36mm8
Celera175,268,638 - 75,292,903 (+)NCBICelera
Cytogenetic Map1C4NCBI
cM Map138.54NCBI
Cyp27a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8983,712,402 - 83,743,222 (+)NCBIGRCr8
mRatBN7.2976,264,655 - 76,294,551 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,264,860 - 76,294,551 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx984,709,826 - 84,739,736 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0989,838,774 - 89,868,679 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,224,941 - 88,254,850 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0981,968,285 - 81,998,213 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl981,968,332 - 81,998,169 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0981,730,705 - 81,760,595 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,039,204 - 74,068,648 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1974,186,068 - 74,215,629 (+)NCBI
Celera973,837,312 - 73,867,002 (+)NCBICelera
Cytogenetic Map9q33NCBI
LOC102004889
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545314,601,444 - 14,647,366 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545314,601,495 - 14,647,383 (-)NCBIChiLan1.0ChiLan1.0
CYP27A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213121,414,455 - 121,449,699 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B121,430,782 - 121,464,669 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B106,042,235 - 106,076,840 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B224,637,238 - 224,671,474 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B224,637,238 - 224,671,474 (+)Ensemblpanpan1.1panPan2
CYP27A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13725,366,475 - 25,401,978 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3725,366,472 - 25,401,509 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3726,186,269 - 26,221,708 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03725,381,673 - 25,417,125 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3725,382,000 - 25,602,692 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13725,286,426 - 25,321,814 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03725,221,115 - 25,256,548 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03725,241,871 - 25,277,345 (+)NCBIUU_Cfam_GSD_1.0
LOC101963150
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303174,870,819 - 174,907,409 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365691,213,573 - 1,250,589 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365691,213,700 - 1,250,181 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP27A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15120,809,959 - 120,852,192 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115120,809,886 - 120,852,196 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215133,798,107 - 133,831,191 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CYP27A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110104,682,437 - 104,723,781 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10104,682,673 - 104,726,687 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604094,685,776 - 94,722,151 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000018480   ⟹   ENSHGLP00000018296
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248236,200,047 - 6,258,001 (-)Ensembl
RefSeq Acc Id: XM_004864569   ⟹   XP_004864626
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248236,199,807 - 6,258,273 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004864626 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000018296
  ENSHGLP00100023911
GenBank Protein JAN96361 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004864626   ⟸   XM_004864569
- UniProtKB: A0A0P6J7U6 (UniProtKB/TrEMBL),   G5AKL6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000018296   ⟸   ENSHGLT00000018480


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000013105 Ensembl, ENTREZGENE
  ENSHGLG00100017561 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000018480 ENTREZGENE
  ENSHGLT00100024155 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro CYP11_CYP27_families UniProtKB/TrEMBL
  Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
KEGG Report hgl:101700018 UniProtKB/TrEMBL
NCBI Gene LOC101700018 ENTREZGENE
PANTHER CYTOCHROME P450 FAMILY 27 SUBFAMILY A MEMBER 1 UniProtKB/TrEMBL
  PTHR24279 UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PRINTS EP450I UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/TrEMBL
UniProt A0A0P6J7U6 ENTREZGENE, UniProtKB/TrEMBL
  G5AKL6 ENTREZGENE, UniProtKB/TrEMBL