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Gene: CYP27A1 (cytochrome P450 family 27 subfamily A member 1) Homo sapiens
Symbol: CYP27A1
Name: cytochrome P450 family 27 subfamily A member 1
RGD ID: 1346613
Description: Exhibits heme binding activity and monooxygenase activity. Involved in bile acid biosynthetic process; calcitriol biosynthetic process from calciol; and cholesterol catabolic process. Localizes to mitochondrion. Implicated in cerebrotendinous xanthomatosis. Biomarker of non-alcoholic steatohepatitis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 26-hydroxylase; 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 27-hydroxylase; 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase; cholestanetriol 26-monooxygenase; CP27; CTX; CYP27; cytochrome P-450C27/25; cytochrome P450 27; cytochrome P450, family 27, subfamily A, polypeptide 1; cytochrome P450, subfamily XXVIIA (steroid 27-hydroxylase, cerebrotendinous xanthomatosis), polypeptide 1; sterol 26-hydroxylase, mitochondrial; sterol 27-hydroxylase; vitamin D(3) 25-hydroxylase
Mus musculus (house mouse) : Cyp27a1 (cytochrome P450, family 27, subfamily a, polypeptide 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cyp27a1 (cytochrome P450, family 27, subfamily a, polypeptide 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102004889 (sterol 26-hydroxylase, mitochondrial)
Pan paniscus (bonobo/pygmy chimpanzee) : CYP27A1 (cytochrome P450 family 27 subfamily A member 1)
Canis lupus familiaris (dog) : CYP27A1 (cytochrome P450 family 27 subfamily A member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101963150 (sterol 26-hydroxylase, mitochondrial)
Sus scrofa (pig) : CYP27A1 (cytochrome P450, family 27, subfamily A, polypeptide 1)
Chlorocebus sabaeus (African green monkey) : CYP27A1 (cytochrome P450 family 27 subfamily A member 1)
Heterocephalus glaber (naked mole-rat) : LOC101700018 (sterol 26-hydroxylase, mitochondrial)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2218,781,749 - 218,815,293 (+)EnsemblGRCh38hg38GRCh38
GRCh382218,781,733 - 218,815,293 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372219,646,472 - 219,680,016 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,354,949 - 219,388,259 (+)NCBINCBI36hg18NCBI36
Build 342219,472,209 - 219,505,520NCBI
Celera2213,414,219 - 213,447,784 (+)NCBI
Cytogenetic Map2q35NCBI
HuRef2211,499,575 - 211,533,141 (+)NCBIHuRef
CHM1_12219,653,385 - 219,686,914 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CYP27A1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1346613
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.