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Gene: CYP27A1 (cytochrome P450 family 27 subfamily A member 1) Canis lupus familiaris

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Symbol:

CYP27A1

Name:

cytochrome P450 family 27 subfamily A member 1

RGD ID:

12230964

Description:

ENCODES a protein that exhibits cholesterol 26-hydroxylase activity (ortholog); Hsp70 protein binding (ortholog); vitamin D 25-hydroxylase activity (ortholog); INVOLVED IN bile acid metabolic process (ortholog); cholesterol metabolic process (ortholog); vitamin D3 biosynthetic process (ortholog); PARTICIPATES IN bile acid biosynthetic pathway; bile acid signaling pathway; cerebrotendinous xanthomatosis pathway; ASSOCIATED WITH atherosclerosis (ortholog); autism spectrum disorder (ortholog); Breast Cancer, Familial (ortholog); FOUND IN mitochondrion (ortholog); INTERACTS WITH bisphenol A

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cytochrome P450, family 27, subfamily A, polypeptide 1; sterol 26-hydroxylase, mitochondrial

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	25,366,475 - 25,401,978 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	25,366,472 - 25,401,509 (+)	Ensembl		CanFam3.1 Ensembl	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	37	26,186,269 - 26,221,708 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	37	25,381,673 - 25,417,125 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	37	25,382,000 - 25,602,692 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	37	25,286,426 - 25,321,814 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	25,221,115 - 25,256,548 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	25,241,871 - 25,277,345 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

atherosclerosis (ISO)

autism spectrum disorder (ISO)

Breast Cancer, Familial (ISO)

cerebrotendinous xanthomatosis (ISO)

cholestasis (ISO)

clear cell renal cell carcinoma (ISO)

coronary artery disease (ISO)

dystonia (ISO)

epilepsy (ISO)

extrahepatic cholestasis (ISO)

Gait Ataxia (ISO)

Gliosis (ISO)

hypothyroidism (ISO)

intellectual disability (ISO)

leukodystrophy (ISO)

liver cirrhosis (ISO)

Metabolic Bone Diseases (ISO)

metabolic dysfunction-associated steatohepatitis (ISO)

musculoskeletal system disease (ISO)

ovarian serous cystadenocarcinoma (ISO)

restless legs syndrome (ISO)

sarcoma (ISO)

stomach cancer (ISO)

urinary bladder cancer (ISO)

uterine corpus endometrial carcinoma (ISO)

Vision Disorders (ISO)

xanthomatosis (ISO)

Zellweger syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

bisphenol A (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bile acid biosynthetic process (IEA)

bile acid metabolic process (ISO)

C21-steroid hormone biosynthetic process (IEA)

calcitriol biosynthetic process from calciol (IBA,IEA)

cellular response to peptide hormone stimulus (IEA)

cholesterol catabolic process (IEA)

cholesterol metabolic process (IBA,IEA,ISO)

cortisol metabolic process (IEA)

glucocorticoid biosynthetic process (IEA)

positive regulation of smoothened signaling pathway (IEA)

steroid metabolic process (IEA)

vitamin D3 biosynthetic process (ISO)

Cellular Component

mitochondrial inner membrane (IEA)

mitochondrion (IBA,ISO)

Molecular Function

cholestanetetraol 26-dehydrogenase activity (IEA)

cholesterol 26-hydroxylase activity (IBA,IEA,ISO)

heme binding (IEA)

Hsp70 protein binding (ISO)

iron ion binding (IEA)

monooxygenase activity (IEA)

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (IEA)

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen (IEA)

vitamin D 25-hydroxylase activity (IBA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

bile acid biosynthetic pathway (ISO)

bile acid signaling pathway (ISO)

cerebrotendinous xanthomatosis pathway (ISO)

congenital bile acid synthesis defect pathway (ISO)

familial hypercholanemia pathway (ISO)

reverse cholesterol transport pathway (ISO)

Zellweger syndrome pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CYP27A1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	25,366,475 - 25,401,978 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	25,366,472 - 25,401,509 (+)	Ensembl		CanFam3.1 Ensembl	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	37	26,186,269 - 26,221,708 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	37	25,381,673 - 25,417,125 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	37	25,382,000 - 25,602,692 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	37	25,286,426 - 25,321,814 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	25,221,115 - 25,256,548 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	25,241,871 - 25,277,345 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

CYP27A1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	218,782,147 - 218,815,293 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	218,781,688 - 218,825,335 (+)	Ensembl		GRCh38.p14 Ensembl	hg38	GRCh38
GRCh37	2	219,646,870 - 219,680,016 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	219,354,949 - 219,388,259 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	219,472,209 - 219,505,520	NCBI
Celera	2	213,414,219 - 213,447,784 (+)	NCBI		Celera
Cytogenetic Map	2	q35	NCBI
HuRef	2	211,499,575 - 211,533,141 (+)	NCBI		HuRef
CHM1_1	2	219,653,385 - 219,686,914 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	219,268,705 - 219,301,851 (+)	NCBI		T2T-CHM13v2.0

Cyp27a1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	74,752,311 - 74,777,056 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	74,752,314 - 74,777,056 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	74,713,148 - 74,737,897 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	74,713,574 - 74,737,892 (+)	Ensembl		GRCm38.p6 Ensembl	mm10	GRCm38
MGSCv37	1	74,760,148 - 74,784,464 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	74,646,781 - 74,671,097 (+)	NCBI		MGSCv36	mm8
Celera	1	75,268,638 - 75,292,903 (+)	NCBI		Celera
Cytogenetic Map	1	C4	NCBI
cM Map	1	38.54	NCBI

Cyp27a1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	83,712,402 - 83,743,222 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	83,713,293 - 83,743,215 (+)	Ensembl				GRCr8
mRatBN7.2	9	76,264,655 - 76,294,551 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	76,264,860 - 76,294,551 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	84,709,826 - 84,739,736 (+)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	89,838,774 - 89,868,679 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	88,224,941 - 88,254,850 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	9	87,364,125 - 87,393,859 (+)	NCBI
Lyon_Normotensive	9	83,184,432 - 83,214,167 (+)	NCBI
Lyon_Hypertensive	9	83,326,687 - 83,356,378 (+)	NCBI
F344_StmMcwi	9	85,287,283 - 85,316,977 (+)	NCBI
Rnor_6.0	9	81,968,285 - 81,998,213 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	81,968,332 - 81,998,169 (+)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	9	81,730,705 - 81,760,595 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	74,039,204 - 74,068,648 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	73,837,312 - 73,867,002 (+)	NCBI		Celera
RGSC_v3.1	9	74,186,068 - 74,215,629 (+)	NCBI
Cytogenetic Map	9	q33	NCBI

LOC102004889
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955453	14,601,444 - 14,647,366 (-)	Ensembl		ChiLan1.0 Ensembl
ChiLan1.0	NW_004955453	14,601,495 - 14,647,383 (-)	NCBI	ChiLan1.0	ChiLan1.0

CYP27A1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	121,414,455 - 121,449,699 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	121,430,782 - 121,464,669 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	106,042,235 - 106,076,840 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	224,637,238 - 224,671,474 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	224,637,238 - 224,671,474 (+)	Ensembl		PanPan1.1 Ensembl	panPan2	panpan1.1

Cyp27a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mIctTri1.hap1	7	180,753,433 - 180,791,214 (+)	NCBI		mIctTri1.hap1
HiC_Itri_2	NW_024405303	174,870,819 - 174,907,409 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936569	1,213,573 - 1,250,589 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936569	1,213,700 - 1,250,181 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CYP27A1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	120,809,959 - 120,852,192 (+)	Ensembl		Sscrofa11.1 Ensembl	susScr11	Sscrofa11.1
Sscrofa11.1	15	120,809,886 - 120,852,196 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	133,798,107 - 133,831,191 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CYP27A1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mChlSab1.0.hap1	10	106,268,418 - 106,304,003 (+)	NCBI		mChlSab1.0.hap1
Vero_WHO_p1.0	NW_023666040	94,685,776 - 94,722,151 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0
ChlSab1.1	10	104,682,437 - 104,723,781 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	104,682,673 - 104,726,687 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM

LOC101700018
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624823	6,199,807 - 6,258,273 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2
HetGla_female_1.0 Ensembl	NW_004624823	6,200,047 - 6,258,001 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl	25	28,719,839 - 28,779,162 (+)	Ensembl

LOC116899511
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	148,129,007 - 148,157,627 (+)	NCBI	Rrattus_CSIRO_v1	Rrattus_CSIRO_v1

Variants

Variants in CYP27A1
470 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_038447973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038447974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038463843	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038521948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038521949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038585908	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038650145	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038650146	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_848001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000037	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000357	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000083	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000368	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000037	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000023712 ⟹ ENSCAFP00000022013

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	37	25,366,472 - 25,401,509 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845050015 ⟹ ENSCAFP00845039214

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	37	25,382,000 - 25,602,692 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845050090 ⟹ ENSCAFP00845039275

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	37	25,382,000 - 25,417,002 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845050164 ⟹ ENSCAFP00845039333

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	37	25,382,056 - 25,417,112 (+)	Ensembl

RefSeq Acc Id:

XM_038447973 ⟹ XP_038303901

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	37	25,381,673 - 25,417,125 (+)	NCBI

RefSeq Acc Id:

XM_038447974 ⟹ XP_038303902

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	37	25,395,550 - 25,417,125 (+)	NCBI

RefSeq Acc Id:

XM_038463843 ⟹ XP_038319771

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	37	26,200,108 - 26,221,708 (+)	NCBI

RefSeq Acc Id:

XM_038521948 ⟹ XP_038377876

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	37	25,286,426 - 25,321,814 (+)	NCBI

RefSeq Acc Id:

XM_038521949 ⟹ XP_038377877

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	37	25,300,224 - 25,321,814 (+)	NCBI

RefSeq Acc Id:

XM_038585908 ⟹ XP_038441836

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	37	25,241,871 - 25,277,345 (+)	NCBI

RefSeq Acc Id:

XM_038650145 ⟹ XP_038506073

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	37	25,221,115 - 25,256,548 (+)	NCBI

RefSeq Acc Id:

XM_038650146 ⟹ XP_038506074

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	37	25,234,946 - 25,256,548 (+)	NCBI

RefSeq Acc Id:

XM_848001 ⟹ XP_853094

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	37	25,366,475 - 25,401,978 (+)	NCBI
Dog10K_Boxer_Tasha	37	26,186,269 - 26,221,708 (+)	NCBI

Sequence:

show sequence

GGCTTCAGCCTCCCGGTGTCGCTGCTGGGGGCGCGGGGGGCTCCGGCCGGTCTCTGTCCAAGAG
GGGCCAGAGCCAAGGCCGCGATCCCCGCCGCCGTCCCGGCCACCGCCGAGACTCCTGGAAACGG
GCCTGGCGCCCGGAGGCTAAGGACGCTGGAGGAGCTTCCAGGGCCCGGGCAGCTGCGCTTCTTA
TTCCAGCTGTTAGGGCAAGGCTACGTTCTGCAGTTACACAAGCTCCAGGTGCTGAACAAGGCCA
AGTATGGTCCAATGTGGGTAACCCACGCAGGGCCCCAGACCCATGTGAACCTGGCCAGTGCCCC
CCTCCTGGAGCAAGTGATGCGGCAAGAGGGCAAGTACCCAGTACGGAACGACATGGAACTATGG
AAGGAGCATCGGGACCAGCAGGGCCTGGCTTATGGGCCCTTCACCACCGAAGGACACCACTGGT
ACCAACTGCGCCACGCTCTGAACCAGCGGATGCTGAAGCCAAGTGAGGCTGCGCTGTACACTGA
TGCTTTGAATGAGGTGGTCGACGACTTCATGGCCCACCTGAGCCAGCTGTTGGCAGAGAGCCCC
TCCGGGAACCAAGTGTCCGACATGGCTCACCAATTCTACTACTTTGCCTTGGAAGCTATTTGCT
ACATCCTGTTTGAGAAACGTATTGGCTGCCTGGAGCGCCCCATCCCCCAGGACACGGTGGCCTT
CGTCAGATCTGTCGGGCTCATGTTCCAGAACTCAGTCTATGTCACCTTCCTCCCCAAGTGGACC
CGGCCCCTACTGCCTTTCTGGAAGCGCTACCTGGATGGCTGGAACACCATCTTCTCTTTTGGCA
AGAAGCTGATTGATCAGAAACTCAAGGAGATAGAGACCCAGCTTCAGACAAAGGGGCCAGATGA
AGTCGAGATATCTGGCTACCTGCACTTCTTGCTGACCAGAGGACAGCTCAGTACTCGTGAGGCC
ATGGGCAGCCTGCCTGAGCTGCTCCTGGCTGGTGTAGACACGACATCCAACACAATGACATGGG
CCCTGTACCATCTTTCCAAGAACCCAGAGATCCAGGCTGCTTTGCATAAGGAAGTGGTGGGTGT
GGTGCCCCCCGGGCAGGTGCCCCAGCAGAAGGACTTTGCCCACATGCCCCTGCTCAAAGCTGTT
CTTAAGGAGACCCTGCGCCTCTACCCTGTGGTCCCCATAAACTCCCGGGTCATCACGGAAAAGG
AGATTGAAGTCAATGGCTTCCTCTTCCCCAAGAACACCCAGTTTGTGTTCTGTCACTATGTGGT
GTCCCGTGACCCAGACATCTTCCCTGAGCCAGAGAGCTTCCAGCCTTACCGCTGGCTCAGGAAG
AGCCAGCTTGCTGCCCCTGGGGTCCATCATGCATTTGGCTCCGTGCCCTTTGGCTACGGGGTCC
GGGCCTGCCTGGGCCGCAGGATTGCAGAGCTGGAGATGCAGCTGCTGCTGTCAAGGCTGATCCA
GCAGTACCAGGTGGTCCTGGCCCCCGAGACAGGGGAGGTGAAGAGCTTGGCCCGCATCGTCCTG
GTTCCCAATAAGAAGGTGAGCCTGCATTTCCAGCCGAGACAGTGCTGAGCTGGGCCCGGCCTCC
TGGGAGCCGCCCCCTTCTCTCTCCCAGGCGCAGTCATTCCAGGCCACCGCCCGTGTCTCAGACG
GGAAGGGGGAGAAGGTGGCTGCCGGACCCGGAGATCGAAGAAACCCAGCGCACTTTCTGTAGGA
CCTTGAGCTTTTGCCACTTTAATCATTTCCAATGTCTCCGTCTCAGATAGGAGGCCACCCCGTG
CCACATTGCTATCCTTGGAAAAAATACAGAATAAAGGGACTCTGGTGGATAATTGGAGACCTGT
GTCATTCTTTGTGATGACCCAGCATCTGAAGCCCTTGCTGTGTTTGGGGAACAGCCTCTCCCCT
CTTAGGGATCTTGTGGGAGGCGGAGCCCTCTCCCTCCAAGGAAAGTGAGAAGGCCTGTGCTCTC
CTGCACCGCACAGAGGCGAAGGCCTCACCACCCTGTGCTGGCTGAAGCCGGCCCGAGCAGGACC
TGCAGAACCACCCTCCGGACACCTAGAGGGACACCCATCTGGGGACAGGAAGTGCTCTGACAGA
GGCAGTGAAGTGCTGCAAAAATGGATGGAGGGGCTCCCGGCTGGATCTACAGGACTGGGTCCAG
GGGCTACCGATCGGCCCGGGAAGCACCAGGTTGGCACCCTCAGGAGCATGAGTGCTGGGAAGTA
TCACAACAGCTGCCGGCCCGAGGGAGCCTCCGTGTCTCCTGGGTGGGGTCAGTGCTGCCAGTAG
GAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_038303901	(Get FASTA)	NCBI Sequence Viewer
	XP_038303902	(Get FASTA)	NCBI Sequence Viewer
	XP_038319771	(Get FASTA)	NCBI Sequence Viewer
	XP_038377876	(Get FASTA)	NCBI Sequence Viewer
	XP_038377877	(Get FASTA)	NCBI Sequence Viewer
	XP_038441836	(Get FASTA)	NCBI Sequence Viewer
	XP_038506073	(Get FASTA)	NCBI Sequence Viewer
	XP_038506074	(Get FASTA)	NCBI Sequence Viewer
	XP_853094	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00845039214.1
	ENSCAFP00845039275
	ENSCAFP00845039275.1
	ENSCAFP00845039333.1

RefSeq Acc Id:	XP_853094 ⟸ XM_848001
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I3PW50 (UniProtKB/TrEMBL)
- Sequence:	show sequence GFSLPVSLLGARGAPAGLCPRGARAKAAIPAAVPATAETPGNGPGARRLRTLEELPGPGQLRFL FQLLGQGYVLQLHKLQVLNKAKYGPMWVTHAGPQTHVNLASAPLLEQVMRQEGKYPVRNDMELW KEHRDQQGLAYGPFTTEGHHWYQLRHALNQRMLKPSEAALYTDALNEVVDDFMAHLSQLLAESP SGNQVSDMAHQFYYFALEAICYILFEKRIGCLERPIPQDTVAFVRSVGLMFQNSVYVTFLPKWT RPLLPFWKRYLDGWNTIFSFGKKLIDQKLKEIETQLQTKGPDEVEISGYLHFLLTRGQLSTREA MGSLPELLLAGVDTTSNTMTWALYHLSKNPEIQAALHKEVVGVVPPGQVPQQKDFAHMPLLKAV LKETLRLYPVVPINSRVITEKEIEVNGFLFPKNTQFVFCHYVVSRDPDIFPEPESFQPYRWLRK SQLAAPGVHHAFGSVPFGYGVRACLGRRIAELEMQLLLSRLIQQYQVVLAPETGEVKSLARIVL VPNKKVSLHFQPRQC hide sequence

Ensembl Acc Id:

ENSCAFP00000022013 ⟸ ENSCAFT00000023712

RefSeq Acc Id:	XP_038377876 ⟸ XM_038521948
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038377877 ⟸ XM_038521949
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038506073 ⟸ XM_038650145
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038506074 ⟸ XM_038650146
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038303901 ⟸ XM_038447973
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I3PW50 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038303902 ⟸ XM_038447974
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0LTJ4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038319771 ⟸ XM_038463843
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0LTJ4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038441836 ⟸ XM_038585908
- Peptide Label:	isoform X3

Ensembl Acc Id:

ENSCAFP00845039214 ⟸ ENSCAFT00845050015

Ensembl Acc Id:

ENSCAFP00845039333 ⟸ ENSCAFT00845050164

Ensembl Acc Id:

ENSCAFP00845039275 ⟸ ENSCAFT00845050090

Promoters

RGD ID:

13689153

Promoter ID:

EPDNEW_C7221

Type:

single initiation site

Name:

CYP27A1_1

Description:

cytochrome P450 family 27 subfamily A member 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	37	25,365,983 - 25,366,043	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000014943	Ensembl
	ENSCAFG00845028313	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00845050015.1	UniProtKB/TrEMBL
	ENSCAFT00845050090	ENTREZGENE
	ENSCAFT00845050090.1	UniProtKB/TrEMBL
	ENSCAFT00845050164.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.630.10	UniProtKB/TrEMBL
InterPro	CYP11_CYP27_families	UniProtKB/TrEMBL
	Cyt_P450	UniProtKB/TrEMBL
	Cyt_P450_CS	UniProtKB/TrEMBL
	Cyt_P450_E_grp-I	UniProtKB/TrEMBL
	Cyt_P450_sf	UniProtKB/TrEMBL
NCBI Gene	CYP27A1	ENTREZGENE
PANTHER	CYTOCHROME P450 FAMILY 27 SUBFAMILY A MEMBER 1	UniProtKB/TrEMBL
	PTHR24279	UniProtKB/TrEMBL
Pfam	p450	UniProtKB/TrEMBL
PRINTS	EP450I	UniProtKB/TrEMBL
	P450	UniProtKB/TrEMBL
PROSITE	CYTOCHROME_P450	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48264	UniProtKB/TrEMBL
UniProt	A0A8C0LTJ4	ENTREZGENE
	A0A8I3PW50	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3S6P6_CANLF	UniProtKB/TrEMBL
	A0A8I3SBF3_CANLF	UniProtKB/TrEMBL
VGNC ID	VGNC:50342	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-01-09	CYP27A1	cytochrome P450 family 27 subfamily A member 1		cytochrome P450, family 27, subfamily A, polypeptide 1	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB