SHCBP1 (SHC binding and spindle associated 1) - Rat Genome Database

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Gene: SHCBP1 (SHC binding and spindle associated 1) Sus scrofa
Analyze
Symbol: SHCBP1
Name: SHC binding and spindle associated 1
RGD ID: 13984265
Description: ENCODES a protein that exhibits SH2 domain binding (ortholog); INVOLVED IN regulation of neural precursor cell proliferation (ortholog); ASSOCIATED WITH COVID-19 (ortholog); Experimental Liver Cirrhosis (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); cytoskeleton (inferred); spindle (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: SHC SH2 domain-binding protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl638,029,864 - 38,063,859 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1638,029,869 - 38,063,773 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2633,218,790 - 33,224,681 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytoskeleton  (IEA)
spindle  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SHCBP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl638,029,864 - 38,063,859 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1638,029,869 - 38,063,773 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2633,218,790 - 33,224,681 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SHCBP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381646,578,591 - 46,621,379 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1646,578,591 - 46,621,379 (-)EnsemblGRCh38hg38GRCh38
GRCh371646,612,503 - 46,655,291 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361645,171,968 - 45,212,785 (-)NCBINCBI36Build 36hg18NCBI36
Build 341645,171,967 - 45,212,785NCBI
Celera1631,122,631 - 31,163,484 (-)NCBICelera
Cytogenetic Map16q11.2NCBI
HuRef1632,503,090 - 32,544,039 (-)NCBIHuRef
CHM1_11648,021,380 - 48,062,245 (-)NCBICHM1_1
T2T-CHM13v2.01652,375,421 - 52,418,229 (-)NCBIT2T-CHM13v2.0
Shcbp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3984,785,976 - 4,829,549 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl84,785,976 - 4,829,567 (-)EnsemblGRCm39 Ensembl
GRCm3884,735,976 - 4,779,567 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl84,735,976 - 4,779,567 (-)EnsemblGRCm38mm10GRCm38
MGSCv3784,735,980 - 4,779,534 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3684,735,980 - 4,779,534 (-)NCBIMGSCv36mm8
Celera84,929,794 - 4,973,513 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map82.09NCBI
Shcbp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81691,373,843 - 91,405,409 (+)NCBIGRCr8
mRatBN7.21684,672,277 - 84,703,843 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1684,672,321 - 84,703,844 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1689,951,043 - 89,989,091 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01693,403,611 - 93,441,659 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01688,677,422 - 88,715,471 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01690,613,826 - 90,642,683 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1690,613,870 - 90,641,420 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01689,996,147 - 90,027,873 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41690,002,645 - 90,022,167 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1682,361,107 - 82,392,376 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
Shcbp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544872,191 - 141,588 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544874,969 - 141,627 (-)NCBIChiLan1.0ChiLan1.0
SHCBP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21856,040,875 - 56,084,765 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11661,946,030 - 61,989,903 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01626,847,164 - 26,890,762 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11645,741,706 - 45,783,226 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1645,741,101 - 45,783,632 (-)Ensemblpanpan1.1panPan2
SHCBP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1158,465,366 - 8,491,085 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl158,465,409 - 8,490,214 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha158,619,202 - 8,644,900 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0158,581,757 - 8,607,467 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl158,581,788 - 8,607,462 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1158,410,759 - 8,436,448 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0158,491,552 - 8,517,342 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0158,507,310 - 8,533,000 (+)NCBIUU_Cfam_GSD_1.0
LOC101957263
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213121,415,130 - 121,418,030 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936597440,126 - 442,842 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SHCBP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1532,438,918 - 32,480,410 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl532,438,361 - 32,480,284 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604744,123,360 - 44,164,876 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Shcbp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462491439,197 - 107,922 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SHCBP1
757 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 1 3 1
Low 8 1 2 1 2 2
Below cutoff 2 3 13 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000003150   ⟹   ENSSSCP00000003069
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl638,029,572 - 38,063,859 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000024648   ⟹   ENSSSCP00000024201
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl638,029,864 - 38,063,859 (+)Ensembl
RefSeq Acc Id: XM_021094249   ⟹   XP_020949908
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1638,029,869 - 38,063,773 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020949908   ⟸   XM_021094249
- UniProtKB: A0A4X1TX06 (UniProtKB/TrEMBL),   I3LJE1 (UniProtKB/TrEMBL),   A0A480DWB6 (UniProtKB/TrEMBL),   A0A8D1HCD5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000024201   ⟸   ENSSSCT00000024648
RefSeq Acc Id: ENSSSCP00000003069   ⟸   ENSSSCT00000003150
Protein Domains
Right handed beta helix


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000002849 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005037891 UniProtKB/TrEMBL
  ENSSSCG00015046105 UniProtKB/TrEMBL
  ENSSSCG00025038455 UniProtKB/TrEMBL
  ENSSSCG00030055199 UniProtKB/TrEMBL
  ENSSSCG00035047148 UniProtKB/TrEMBL
  ENSSSCG00040066518 UniProtKB/TrEMBL
  ENSSSCG00045014272 UniProtKB/TrEMBL
  ENSSSCG00050042995 UniProtKB/TrEMBL
  ENSSSCG00060071998 UniProtKB/TrEMBL
  ENSSSCG00065050326 UniProtKB/TrEMBL
  ENSSSCG00070012284 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000024648 ENTREZGENE
  ENSSSCT00000024648.4 UniProtKB/TrEMBL
  ENSSSCT00005060562.1 UniProtKB/TrEMBL
  ENSSSCT00015061493.1 UniProtKB/TrEMBL
  ENSSSCT00025052254.1 UniProtKB/TrEMBL
  ENSSSCT00030076896.1 UniProtKB/TrEMBL
  ENSSSCT00035062752.1 UniProtKB/TrEMBL
  ENSSSCT00040090861.1 UniProtKB/TrEMBL
  ENSSSCT00045024320.1 UniProtKB/TrEMBL
  ENSSSCT00045024360.1 UniProtKB/TrEMBL
  ENSSSCT00050058456.1 UniProtKB/TrEMBL
  ENSSSCT00060098348.1 UniProtKB/TrEMBL
  ENSSSCT00065068946.1 UniProtKB/TrEMBL
  ENSSSCT00070023985.1 UniProtKB/TrEMBL
  ENSSSCT00070023990.1 UniProtKB/TrEMBL
Gene3D-CATH 2.160.20.10 UniProtKB/TrEMBL
InterPro Beta_helix UniProtKB/TrEMBL
  PbH1 UniProtKB/TrEMBL
  Pectin_lyas_fold UniProtKB/TrEMBL
  Pectin_lyase_fold/virulence UniProtKB/TrEMBL
  SHCBP1-like UniProtKB/TrEMBL
NCBI Gene SHCBP1 ENTREZGENE
PANTHER PTHR14695 UniProtKB/TrEMBL
  SHC SH2 DOMAIN-BINDING PROTEIN 1 UniProtKB/TrEMBL
Pfam Beta_helix UniProtKB/TrEMBL
SMART PbH1 UniProtKB/TrEMBL
Superfamily-SCOP SSF51126 UniProtKB/TrEMBL
UniProt A0A480DWB6 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TTV7_PIG UniProtKB/TrEMBL
  A0A4X1TX06 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0K3Z9_PIG UniProtKB/TrEMBL
  A0A8D1HCD5 ENTREZGENE, UniProtKB/TrEMBL
  I3LJE1 ENTREZGENE
UniProt Secondary I3LJE1 UniProtKB/TrEMBL
VGNC ID VGNC:92839 ENTREZGENE