CA1 (carbonic anhydrase 1) - Rat Genome Database

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Gene: CA1 (carbonic anhydrase 1) Sus scrofa
Analyze
Symbol: CA1
Name: carbonic anhydrase 1
RGD ID: 14269064
Description: ENCODES a protein that exhibits arylesterase activity (inferred); carbonate dehydratase activity (inferred); zinc ion binding (inferred); INVOLVED IN one-carbon metabolic process (inferred); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine pharmacodynamics pathway; ASSOCIATED WITH adenocarcinoma (ortholog); esophagus squamous cell carcinoma (ortholog); inherited metabolic disorder (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC100153915
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl451,302,406 - 51,353,127 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1451,343,548 - 51,353,127 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2456,358,354 - 56,367,895 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)

Molecular Function

References
Additional References at PubMed
PMID:15679890  


Genomics

Comparative Map Data
CA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl451,302,406 - 51,353,127 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1451,343,548 - 51,353,127 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2456,358,354 - 56,367,895 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl885,327,608 - 85,379,014 (-)EnsemblGRCh38hg38GRCh38
GRCh38885,327,608 - 85,378,113 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37886,239,837 - 86,290,342 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36886,427,709 - 86,477,594 (-)NCBINCBI36hg18NCBI36
Build 34886,427,708 - 86,477,594NCBI
Celera882,245,509 - 82,295,378 (-)NCBI
Cytogenetic Map8q21.2NCBI
HuRef881,734,656 - 81,784,498 (-)NCBIHuRef
CHM1_1886,292,190 - 86,342,064 (-)NCBICHM1_1
Car1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39314,831,274 - 14,873,425 (-)NCBIGRCm39mm39
GRCm39 Ensembl314,831,276 - 14,873,428 (-)Ensembl
GRCm38314,766,214 - 14,808,365 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl314,766,216 - 14,808,368 (-)EnsemblGRCm38mm10GRCm38
MGSCv37314,766,214 - 14,808,365 (-)NCBIGRCm37mm9NCBIm37
MGSCv36314,742,975 - 14,767,557 (-)NCBImm8
Celera314,771,712 - 14,813,913 (-)NCBICelera
Cytogenetic Map3A1NCBI
cM Map33.18NCBI
Car1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2286,829,436 - 86,872,209 (+)NCBI
Rnor_6.0 Ensembl288,217,188 - 88,227,479 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0288,185,204 - 88,227,486 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02107,958,483 - 108,000,765 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4288,166,412 - 88,210,693 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1288,143,727 - 88,155,654 (+)NCBI
Celera282,427,032 - 82,469,698 (+)NCBICelera
Cytogenetic Map2q23NCBI
Ca1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554173,270,619 - 3,305,756 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554173,270,619 - 3,313,261 (-)NCBIChiLan1.0ChiLan1.0
CA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1883,464,680 - 83,515,359 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl883,463,434 - 83,526,899 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0881,854,390 - 81,905,728 (-)NCBIMhudiblu_PPA_v0panPan3
CA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12931,858,644 - 31,868,135 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2931,858,636 - 31,868,158 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2932,144,441 - 32,154,240 (-)NCBI
ROS_Cfam_1.02932,007,771 - 32,017,260 (-)NCBI
UMICH_Zoey_3.12932,058,957 - 32,068,728 (-)NCBI
UNSW_CanFamBas_1.02932,080,387 - 32,089,882 (-)NCBI
UU_Cfam_GSD_1.02932,466,958 - 32,476,446 (-)NCBI
Ca1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530347,504,905 - 47,545,941 (+)NCBI
SpeTri2.0NW_004936544246,797 - 257,798 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CA1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1880,699,114 - 80,729,932 (-)NCBI
ChlSab1.1 Ensembl880,699,651 - 80,712,858 (-)Ensembl
Ca1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247446,244,872 - 6,324,722 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system hemolymphoid system renal system respiratory system
High 1
Medium 3
Low 2 1 2 1
Below cutoff 1 3 3 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000040854   ⟹   ENSSSCP00000043600
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl451,302,406 - 51,353,124 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000058517   ⟹   ENSSSCP00000059384
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl451,302,406 - 51,353,124 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000085334   ⟹   ENSSSCP00000060966
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl451,343,689 - 51,353,127 (+)Ensembl
RefSeq Acc Id: XM_001924183   ⟹   XP_001924218
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1451,343,548 - 51,353,127 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_001924218 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_001924218   ⟸   XM_001924183
- UniProtKB: A0A287AI92 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000043600   ⟸   ENSSSCT00000040854
RefSeq Acc Id: ENSSSCP00000059384   ⟸   ENSSSCT00000058517
RefSeq Acc Id: ENSSSCP00000060966   ⟸   ENSSSCT00000085334
Protein Domains
Alpha-carbonic anhydrase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000040770 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070016340 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000043600 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000059384 UniProtKB/TrEMBL
  ENSSSCP00000060966 UniProtKB/TrEMBL
  ENSSSCP00070026840 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000040854 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000058517 UniProtKB/TrEMBL
  ENSSSCT00000085334 UniProtKB/TrEMBL
  ENSSSCT00070032167 UniProtKB/TrEMBL
Gene3D-CATH 3.10.200.10 UniProtKB/TrEMBL
InterPro CA_dom UniProtKB/TrEMBL
  CA_dom_sf UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class_CS UniProtKB/TrEMBL
  Carbonic_anhydrase_CA1 UniProtKB/TrEMBL
KEGG Report ssc:100153915 UniProtKB/TrEMBL
NCBI Gene LOC100153915 ENTREZGENE
PANTHER PTHR18952 UniProtKB/TrEMBL
  PTHR18952:SF82 UniProtKB/TrEMBL
Pfam Carb_anhydrase UniProtKB/TrEMBL
PROSITE ALPHA_CA_1 UniProtKB/TrEMBL
  ALPHA_CA_2 UniProtKB/TrEMBL
SMART Carb_anhydrase UniProtKB/TrEMBL
Superfamily-SCOP SSF51069 UniProtKB/TrEMBL
UniProt A0A287AI92 ENTREZGENE, UniProtKB/TrEMBL
  A0A287BS87_PIG UniProtKB/TrEMBL
  A0A4X1UEM5_PIG UniProtKB/TrEMBL
  A0A5G2QAD6_PIG UniProtKB/TrEMBL
VGNC ID VGNC:98744 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-03-10 CA1  carbonic anhydrase 1  LOC100153915  carbonic anhydrase 1  Symbol and/or name change 5135510 APPROVED