AKT1 (AKT serine/threonine kinase 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: AKT1 (AKT serine/threonine kinase 1) Sus scrofa
Analyze
Symbol: AKT1
Name: AKT serine/threonine kinase 1
RGD ID: 13974772
Description: ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); ATP binding (ortholog); calmodulin binding (ortholog); INVOLVED IN activation-induced cell death of T cells (ortholog); aging (ortholog); apoptotic mitochondrial changes (ortholog); PARTICIPATES IN adenosine signaling pathway; altered phosphatidylinositol 3-kinase-Akt signaling pathway; ceramide signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); acute promyelocytic leukemia (ortholog); adult hepatocellular carcinoma (ortholog); FOUND IN cell-cell junction (ortholog); ciliary basal body (ortholog); cytoplasm (ortholog); INTERACTS WITH 17beta-estradiol; anthra[1,9-cd]pyrazol-6(2H)-one; bifenthrin
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Akt; PKB; protein kinase B; RAC-alpha serine/threonine-protein kinase; v-akt murine thymoma viral oncogene homolog 1; v-akt murine thymoma viral oncogene-like 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
acute promyelocytic leukemia  (ISO)
adult hepatocellular carcinoma  (ISO)
Alzheimer's disease  (ISO)
amphetamine abuse  (ISO)
amyotrophic lateral sclerosis  (ISO)
Animal Disease Models  (ISO)
atherosclerosis  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
bipolar disorder  (ISO)
bladder urothelial carcinoma  (ISO)
bone osteosarcoma  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast adenocarcinoma  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
Breast Neoplasms  (ISO)
calcification of aortic valve  (ISO)
cannabis abuse  (ISO)
Carcinogenesis  (ISO)
cardiac arrest  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
chronic myeloid leukemia  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
coronary artery disease  (ISO)
Cowden syndrome 6  (ISO)
diabetic retinopathy  (ISO)
Endometrioid Carcinomas  (ISO)
Endotoxemia  (ISO)
epilepsy  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial adenomatous polyposis  (ISO)
fatty liver disease  (ISO)
Fibrosis  (ISO)
gastric adenocarcinoma  (ISO)
glioblastoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (ISO)
Hepatomegaly  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
impotence  (ISO)
in situ carcinoma  (ISO)
Inflammation  (ISO)
intermediate coronary syndrome  (ISO)
Intervertebral Disc Displacement  (ISO)
invasive ductal carcinoma  (ISO)
Kidney Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung oat cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Macrocephaly Mesodermal Hamartoma Spectrum  (ISO)
malignant astrocytoma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
melanoma  (ISO)
Meningeal Neoplasms  (ISO)
meningioma  (ISO)
muscular atrophy  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
obesity  (ISO)
osteosarcoma  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
Pain  (ISO)
pancreatic cancer  (ISO)
pancreatic intraductal papillary-mucinous neoplasm  (ISO)
paraplegia  (ISO)
Parkinson's disease  (ISO)
pre-malignant neoplasm  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
Proteus syndrome  (ISO)
pulmonary tuberculosis  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Right Ventricular Hypertrophy  (ISO)
schizophrenia  (ISO)
skin melanoma  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
Staphylococcal Pneumonia  (ISO)
Stroke  (ISO)
substance-induced psychosis  (ISO)
T-Cell Lymphoma  (ISO)
Thyroid Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Ventilator-Induced Lung Injury  (ISO)
vulva cancer  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation-induced cell death of T cells  (ISO)
aging  (ISO)
apoptotic mitochondrial changes  (ISO)
apoptotic process  (ISO)
behavioral response to pain  (ISO)
cell migration involved in sprouting angiogenesis  (ISO)
cell projection organization  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to decreased oxygen levels  (ISO)
cellular response to DNA damage stimulus  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to oxidised low-density lipoprotein particle stimulus  (ISO)
cellular response to peptide  (ISO)
cellular response to prostaglandin E stimulus  (ISO)
cellular response to reactive oxygen species  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
epidermal growth factor receptor signaling pathway  (ISO)
establishment of protein localization to mitochondrion  (ISO)
execution phase of apoptosis  (ISO)
gene expression  (ISO)
germ cell development  (ISO)
glucose homeostasis  (ISO)
glucose metabolic process  (IEA,ISO)
glycogen biosynthetic process  (IEA)
glycogen cell differentiation involved in embryonic placenta development  (ISO)
glycogen metabolic process  (ISO)
I-kappaB kinase/NF-kappaB signaling  (ISO)
inflammatory response  (ISO)
insulin receptor signaling pathway  (ISO)
insulin-like growth factor receptor signaling pathway  (ISO)
interleukin-18-mediated signaling pathway  (ISO)
intracellular signal transduction  (ISO)
labyrinthine layer blood vessel development  (ISO)
lipopolysaccharide-mediated signaling pathway  (ISO)
maintenance of protein location in mitochondrion  (ISO)
maternal placenta development  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of autophagy  (ISO)
negative regulation of calcium import into the mitochondrion  (ISO)
negative regulation of cell size  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of endopeptidase activity  (ISO)
negative regulation of fatty acid beta-oxidation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of intrinsic apoptotic signaling pathway  (ISO)
negative regulation of JNK cascade  (ISO)
negative regulation of leukocyte cell-cell adhesion  (ISO)
negative regulation of long-chain fatty acid import across plasma membrane  (ISO)
negative regulation of lymphocyte migration  (ISO)
negative regulation of protein binding  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of protein ubiquitination  (ISO)
negative regulation of proteolysis  (ISO)
negative regulation of release of cytochrome c from mitochondria  (ISO)
negative regulation of superoxide anion generation  (ISO)
NIK/NF-kappaB signaling  (ISO)
osteoblast differentiation  (ISO)
peptidyl-serine phosphorylation  (IBA,ISO)
peptidyl-threonine phosphorylation  (ISO)
peripheral nervous system myelin maintenance  (ISO)
phosphatidylinositol 3-kinase signaling  (ISO)
phosphorylation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular protein metabolic process  (ISO)
positive regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of endodeoxyribonuclease activity  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of fat cell differentiation  (ISO)
positive regulation of fibroblast migration  (ISO)
positive regulation of G1/S transition of mitotic cell cycle  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glucose import  (ISO)
positive regulation of glucose metabolic process  (ISO)
positive regulation of glycogen biosynthetic process  (ISO)
positive regulation of I-kappaB phosphorylation  (ISO)
positive regulation of lipid biosynthetic process  (ISO)
positive regulation of mitochondrial membrane potential  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of nitric-oxide synthase activity  (ISO)
positive regulation of organ growth  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of protein localization to cell surface  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of sodium ion transport  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of vasoconstriction  (ISO)
protein catabolic process  (ISO)
protein import into nucleus  (ISO)
protein kinase B signaling  (IEA,ISO)
protein phosphorylation  (IEA,ISO)
protein ubiquitination  (ISO)
regulation of aerobic respiration  (ISO)
regulation of apoptotic process  (ISO)
regulation of cell migration  (ISO)
regulation of glycogen biosynthetic process  (ISO)
regulation of myelination  (ISO)
regulation of neuron projection development  (ISO)
regulation of protein localization  (ISO)
response to fluid shear stress  (ISO)
response to food  (ISO)
response to growth factor  (ISO)
response to heat  (ISO)
response to hormone  (ISO)
response to ischemia  (ISO)
response to organic substance  (ISO)
response to UV-A  (ISO)
signal transduction  (ISO)
sphingosine-1-phosphate receptor signaling pathway  (ISO)
spinal cord development  (ISO)
striated muscle cell differentiation  (ISO)
translation  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:16189199   PMID:17121993   PMID:17132910   PMID:18050339   PMID:18420583   PMID:19038864   PMID:19633130   PMID:20017192   PMID:24532302   PMID:25660453   PMID:27225947   PMID:28025803  
PMID:28285136   PMID:28551414   PMID:28799830   PMID:29871929   PMID:31394126  


Genomics

Comparative Map Data
AKT1
(Sus scrofa - pig)
No map positions available.
AKT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl14104,769,349 - 104,795,751 (-)EnsemblGRCh38hg38GRCh38
GRCh3814104,769,349 - 104,795,748 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3714105,235,686 - 105,262,085 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614104,306,731 - 104,333,125 (-)NCBINCBI36hg18NCBI36
Build 3414104,306,752 - 104,330,608NCBI
Celera1485,290,760 - 85,317,154 (-)NCBI
Cytogenetic Map14q32.33NCBI
HuRef1485,432,617 - 85,464,212 (-)NCBIHuRef
CHM1_114105,173,739 - 105,200,089 (-)NCBICHM1_1
Akt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912112,620,255 - 112,641,318 (-)NCBIGRCm39mm39
GRCm39 Ensembl12112,620,255 - 112,641,318 (-)Ensembl
GRCm3812112,653,821 - 112,674,884 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12112,653,821 - 112,674,884 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712113,892,032 - 113,912,487 (-)NCBIGRCm37mm9NCBIm37
MGSCv3612113,101,629 - 113,121,998 (-)NCBImm8
Celera12113,867,449 - 113,888,183 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.2NCBI
Akt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26131,713,716 - 131,735,319 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl6131,713,720 - 131,733,921 (-)Ensembl
Rnor_6.06137,218,398 - 137,239,970 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,218,376 - 137,236,258 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06146,225,955 - 146,247,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46137,640,482 - 137,657,552 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16137,646,668 - 137,663,739 (-)NCBI
Celera6129,262,032 - 129,279,096 (-)NCBICelera
RH 3.4 Map6782.49RGD
Cytogenetic Map6q32NCBI
Akt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555383,208,710 - 3,229,904 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555383,208,711 - 3,224,386 (-)NCBIChiLan1.0ChiLan1.0
AKT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.114105,211,645 - 105,236,756 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14105,208,128 - 105,236,756 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01485,417,229 - 85,444,722 (-)NCBIMhudiblu_PPA_v0panPan3
AKT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1872,317,399 - 72,335,686 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl872,317,869 - 72,335,193 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha871,823,163 - 71,843,039 (-)NCBI
ROS_Cfam_1.0872,592,378 - 72,612,252 (-)NCBI
UMICH_Zoey_3.1872,275,001 - 72,294,850 (-)NCBI
UNSW_CanFamBas_1.0872,318,256 - 72,338,331 (-)NCBI
UU_Cfam_GSD_1.0872,717,834 - 72,737,716 (-)NCBI
Akt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086401,791,300 - 1,810,158 (+)NCBI
SpeTri2.0NW_004936621620,163 - 639,115 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12482,704,087 - 82,730,711 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2482,704,068 - 82,727,698 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605370,125,334 - 70,153,468 (-)NCBIVero_WHO_p1.0
Akt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624734507,880 - 525,295 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 1 3 1 1 1 2
Low 9 3 3 2 1 22 2 2 1
Below cutoff

Sequence


Protein Sequences
Protein RefSeqs NP_001153248 (Get FASTA)   NCBI Sequence Viewer  
  XP_020937158 (Get FASTA)   NCBI Sequence Viewer  
  XP_020937159 (Get FASTA)   NCBI Sequence Viewer  
  XP_020937160 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AEV40677 (Get FASTA)   NCBI Sequence Viewer  
  BAH57696 (Get FASTA)   NCBI Sequence Viewer  
Protein Domains
AGC-kinase C-terminal   PH   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000039139 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070012730 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000029569 UniProtKB/TrEMBL
  ENSSSCP00000044582 UniProtKB/TrEMBL
  ENSSSCP00000046325 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000050721 UniProtKB/TrEMBL
  ENSSSCP00070020588 UniProtKB/TrEMBL
  ENSSSCP00070020610 UniProtKB/TrEMBL
  ENSSSCP00070020616 UniProtKB/TrEMBL
  ENSSSCP00070020637 UniProtKB/TrEMBL
  ENSSSCP00070020655 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000033477 UniProtKB/TrEMBL
  ENSSSCT00000050545 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000050885 UniProtKB/TrEMBL
  ENSSSCT00000059398 UniProtKB/TrEMBL
  ENSSSCT00070024851 UniProtKB/TrEMBL
  ENSSSCT00070024874 UniProtKB/TrEMBL
  ENSSSCT00070024882 UniProtKB/TrEMBL
  ENSSSCT00070024907 UniProtKB/TrEMBL
  ENSSSCT00070024929 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  Akt1 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PH_PKB UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  RAC_alpha/beta UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report ssc:100126861 UniProtKB/TrEMBL
NCBI Gene AKT1 ENTREZGENE
PANTHER PTHR24351:SF200 UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A287AL02_PIG UniProtKB/TrEMBL
  A0A287AR39_PIG UniProtKB/TrEMBL
  A0A287B2S5_PIG UniProtKB/TrEMBL
  A0A4X1TTM8_PIG UniProtKB/TrEMBL
  A0A4X1TYJ7_PIG UniProtKB/TrEMBL
  A0A4X1TYL9_PIG UniProtKB/TrEMBL
  A0A4X1TYM4_PIG UniProtKB/TrEMBL
  A0A4X1TZ38_PIG UniProtKB/TrEMBL
  C1PIG3 ENTREZGENE, UniProtKB/TrEMBL
  G9BWQ1_PIG UniProtKB/TrEMBL
  K7GNW4_PIG UniProtKB/TrEMBL
VGNC ID VGNC:96930 ENTREZGENE