ABCG8 (ATP binding cassette subfamily G member 8) - Rat Genome Database

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Gene: ABCG8 (ATP binding cassette subfamily G member 8) Sus scrofa
Analyze
Symbol: ABCG8
Name: ATP binding cassette subfamily G member 8
RGD ID: 13911241
Description: ENCODES a protein that exhibits ATP binding (ortholog); ATP hydrolysis activity (ortholog); ATPase-coupled transmembrane transporter activity (ortholog); INVOLVED IN bile acid signaling pathway (ortholog); cholesterol homeostasis (ortholog); phospholipid transport (ortholog); PARTICIPATES IN bile acid signaling pathway; ASSOCIATED WITH arteriosclerosis (ortholog); cholestasis (ortholog); congenital hemolytic anemia (ortholog); FOUND IN apical plasma membrane (inferred); ATP-binding cassette (ABC) transporter complex (inferred); integral component of membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Also known as: ATP-binding cassette sub-family G member 8; ATP-binding cassette, sub-family G (WHITE), member 8 (sterolin 2)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl396,594,778 - 96,616,229 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1396,596,975 - 96,616,224 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23102,751,981 - 102,768,385 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
ABCG8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl396,594,778 - 96,616,229 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1396,596,975 - 96,616,224 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23102,751,981 - 102,768,385 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ABCG8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl243,831,942 - 43,882,988 (+)EnsemblGRCh38hg38GRCh38
GRCh38243,831,942 - 43,882,988 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37244,066,110 - 44,110,127 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36243,919,607 - 43,959,109 (+)NCBINCBI36hg18NCBI36
Build 34243,977,753 - 44,017,255NCBI
Celera243,904,835 - 43,944,326 (+)NCBI
Cytogenetic Map2p21NCBI
HuRef243,802,799 - 43,841,930 (+)NCBIHuRef
CHM1_1243,995,502 - 44,035,021 (+)NCBICHM1_1
Abcg8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391784,983,730 - 85,007,761 (+)NCBIGRCm39mm39
GRCm39 Ensembl1784,983,730 - 85,007,761 (+)Ensembl
GRCm381784,676,302 - 84,700,333 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1784,676,302 - 84,700,333 (+)EnsemblGRCm38mm10GRCm38
MGSCv371785,082,471 - 85,099,673 (+)NCBIGRCm37mm9NCBIm37
MGSCv361784,591,457 - 84,608,659 (+)NCBImm8
Celera1789,050,583 - 89,068,069 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1755.02NCBI
Abcg8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.269,945,629 - 9,964,912 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl69,945,629 - 9,964,912 (-)Ensembl
Rnor_6.067,961,413 - 7,980,708 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl67,961,413 - 7,980,708 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.067,897,005 - 7,916,593 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.468,064,631 - 8,083,271 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.168,064,630 - 8,083,271 (+)NCBI
Celera69,667,270 - 9,686,500 (-)NCBICelera
Cytogenetic Map6q12NCBI
Abcg8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544110,982,307 - 11,009,116 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544110,982,307 - 11,004,789 (+)NCBIChiLan1.0ChiLan1.0
ABCG8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A44,771,247 - 44,905,375 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A44,771,247 - 44,904,830 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A43,922,787 - 43,966,678 (+)NCBIMhudiblu_PPA_v0panPan3
ABCG8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11046,300,142 - 46,319,592 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1046,300,165 - 46,319,229 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1046,161,869 - 46,181,385 (+)NCBI
ROS_Cfam_1.01047,178,745 - 47,198,241 (+)NCBI
UMICH_Zoey_3.11046,887,146 - 46,906,668 (+)NCBI
UNSW_CanFamBas_1.01047,176,806 - 47,196,259 (+)NCBI
UU_Cfam_GSD_1.01047,360,439 - 47,379,994 (+)NCBI
Abcg8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629236,645,685 - 36,664,967 (-)NCBI
SpeTri2.0NW_0049365088,074,697 - 8,093,424 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCG8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11463,389,817 - 63,420,048 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1463,390,433 - 63,413,906 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604548,472,611 - 48,497,995 (+)NCBIVero_WHO_p1.0
Abcg8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473825,310,740 - 25,330,097 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 4 2 2 2 2 2 2 2
Below cutoff 3 4 3 4 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000009255   ⟹   ENSSSCP00000009021
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl396,596,541 - 96,616,182 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000069275   ⟹   ENSSSCP00000068229
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl396,598,584 - 96,616,229 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000084080   ⟹   ENSSSCP00000064000
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl396,594,778 - 96,616,229 (-)Ensembl
RefSeq Acc Id: XM_021087569   ⟹   XP_020943228
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1396,596,975 - 96,616,222 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021087570   ⟹   XP_020943229
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1396,596,975 - 96,616,224 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020943228 (Get FASTA)   NCBI Sequence Viewer  
  XP_020943229 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABO93311 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020943229   ⟸   XM_021087570
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020943228   ⟸   XM_021087569
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSSSCP00000064000   ⟸   ENSSSCT00000084080
RefSeq Acc Id: ENSSSCP00000009021   ⟸   ENSSSCT00000009255
RefSeq Acc Id: ENSSSCP00000068229   ⟸   ENSSSCT00000069275
Protein Domains
ABC transporter


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000008453 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070001889 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000009021 UniProtKB/TrEMBL
  ENSSSCP00000064000 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000068229 UniProtKB/TrEMBL
  ENSSSCP00070002929 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000009255 UniProtKB/TrEMBL
  ENSSSCT00000069275 UniProtKB/TrEMBL
  ENSSSCT00000084080 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070003538 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro ABC_2_trans UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/TrEMBL
  ABCG_dom UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene ABCG8 ENTREZGENE
Pfam ABC2_membrane UniProtKB/TrEMBL
  ABC2_membrane_7 UniProtKB/TrEMBL
  ABC_tran UniProtKB/TrEMBL
PROSITE ABC_TRANSPORTER_1 UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A4X1SKL6_PIG UniProtKB/TrEMBL
  A0A5G2R0G3_PIG UniProtKB/TrEMBL
  A0A5G2RC81_PIG UniProtKB/TrEMBL
  A4URS9_PIG UniProtKB/TrEMBL
  F1S5I9_PIG UniProtKB/TrEMBL
VGNC ID VGNC:96913 ENTREZGENE