MIS12 (MIS12 kinetochore complex component) - Rat Genome Database

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Gene: MIS12 (MIS12 kinetochore complex component) Sus scrofa
Analyze
Symbol: MIS12
Name: MIS12 kinetochore complex component
RGD ID: 13903407
Description: INVOLVED IN attachment of mitotic spindle microtubules to kinetochore (inferred); chromosome segregation (inferred); kinetochore assembly (inferred); ASSOCIATED WITH developmental and epileptic encephalopathy 25 (ortholog); Experimental Liver Cirrhosis (ortholog); genetic disease (ortholog); FOUND IN chromosome (inferred); chromosome, centromeric region (inferred); kinetochore (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein MIS12 homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1251,505,381 - 51,507,943 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11251,505,376 - 51,508,337 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:15679890   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MIS12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1251,505,381 - 51,507,943 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11251,505,376 - 51,508,337 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MIS12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38175,486,374 - 5,490,811 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl175,486,285 - 5,490,814 (+)EnsemblGRCh38hg38GRCh38
GRCh37175,389,694 - 5,394,131 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36175,330,971 - 5,334,855 (+)NCBINCBI36Build 36hg18NCBI36
Build 34175,330,970 - 5,334,852NCBI
Celera175,406,624 - 5,410,507 (+)NCBICelera
Cytogenetic Map17p13.2NCBI
HuRef175,279,942 - 5,284,378 (+)NCBIHuRef
CHM1_1175,399,363 - 5,403,803 (+)NCBICHM1_1
T2T-CHM13v2.0175,380,118 - 5,384,558 (+)NCBIT2T-CHM13v2.0
Mis12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,910,394 - 70,918,197 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,910,437 - 70,918,197 (+)EnsemblGRCm39 Ensembl
GRCm381171,019,568 - 71,027,371 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,019,611 - 71,027,371 (+)EnsemblGRCm38mm10GRCm38
MGSCv371170,833,113 - 70,840,636 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,835,806 - 70,843,329 (+)NCBIMGSCv36mm8
Celera1178,574,026 - 78,581,549 (+)NCBICelera
Cytogenetic Map11B4NCBI
cM Map1143.21NCBI
Mis12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81056,238,317 - 56,246,491 (+)NCBIGRCr8
mRatBN7.21055,739,741 - 55,747,915 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1055,739,564 - 55,751,068 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1060,419,384 - 60,427,548 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,907,903 - 59,916,067 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01055,406,993 - 55,415,157 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01057,653,685 - 57,661,833 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1057,660,067 - 57,660,687 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01057,398,658 - 57,407,046 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,927,346 - 57,928,594 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1054,891,204 - 54,892,452 (+)NCBICelera
Cytogenetic Map10q24NCBI
Mis12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546710,837,832 - 10,842,123 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546710,837,570 - 10,842,131 (+)NCBIChiLan1.0ChiLan1.0
MIS12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21913,096,460 - 13,100,927 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11715,064,884 - 15,069,147 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0175,534,305 - 5,538,736 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1175,526,376 - 5,530,955 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl175,529,017 - 5,529,634 (+)Ensemblpanpan1.1panPan2
MIS12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1531,314,067 - 31,319,392 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha531,452,291 - 31,457,548 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0531,418,896 - 31,424,159 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl531,418,275 - 31,424,080 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1531,384,435 - 31,389,705 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0531,343,365 - 31,348,624 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0531,519,760 - 31,525,016 (-)NCBIUU_Cfam_GSD_1.0
Mis12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560253,572,281 - 53,577,485 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366772,323,540 - 2,328,689 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MIS12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,897,672 - 4,902,085 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605916,684,905 - 16,689,657 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mis12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247869,285,830 - 9,289,454 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247869,285,475 - 9,289,659 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MIS12
20 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 2 3 5 1 22 2 3 3
Low 2 1 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000042182   ⟹   ENSSSCP00000043729
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1251,505,381 - 51,507,943 (-)Ensembl
RefSeq Acc Id: XM_021067725   ⟹   XP_020923384
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11251,505,376 - 51,508,337 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021067726   ⟹   XP_020923385
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11251,505,376 - 51,507,948 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021067727   ⟹   XP_020923386
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11251,505,376 - 51,507,948 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020923384   ⟸   XM_021067725
- UniProtKB: A0A287AIK7 (UniProtKB/TrEMBL),   A0A4X1UPJ2 (UniProtKB/TrEMBL),   A0A0B8RTG7 (UniProtKB/TrEMBL),   A0A8D0PMJ6 (UniProtKB/TrEMBL),   A0A8D1MXT5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020923386   ⟸   XM_021067727
- UniProtKB: A0A287AIK7 (UniProtKB/TrEMBL),   A0A4X1UPJ2 (UniProtKB/TrEMBL),   A0A0B8RTG7 (UniProtKB/TrEMBL),   A0A8D0PMJ6 (UniProtKB/TrEMBL),   A0A8D1MXT5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020923385   ⟸   XM_021067726
- UniProtKB: A0A287AIK7 (UniProtKB/TrEMBL),   A0A4X1UPJ2 (UniProtKB/TrEMBL),   A0A0B8RTG7 (UniProtKB/TrEMBL),   A0A8D0PMJ6 (UniProtKB/TrEMBL),   A0A8D1MXT5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000043729   ⟸   ENSSSCT00000042182


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000034958 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005038523 UniProtKB/TrEMBL
  ENSSSCG00015065366 UniProtKB/TrEMBL
  ENSSSCG00025054716 UniProtKB/TrEMBL
  ENSSSCG00030010471 UniProtKB/TrEMBL
  ENSSSCG00035055843 UniProtKB/TrEMBL
  ENSSSCG00040042784 UniProtKB/TrEMBL
  ENSSSCG00045001537 UniProtKB/TrEMBL
  ENSSSCG00050052007 UniProtKB/TrEMBL
  ENSSSCG00055014190 UniProtKB/TrEMBL
  ENSSSCG00060072295 UniProtKB/TrEMBL
  ENSSSCG00065018384 UniProtKB/TrEMBL
  ENSSSCG00070018438 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000042182 ENTREZGENE
  ENSSSCT00000042182.2 UniProtKB/TrEMBL
  ENSSSCT00005061551.1 UniProtKB/TrEMBL
  ENSSSCT00015087531.1 UniProtKB/TrEMBL
  ENSSSCT00025074846.1 UniProtKB/TrEMBL
  ENSSSCT00030014360.1 UniProtKB/TrEMBL
  ENSSSCT00035074508.1 UniProtKB/TrEMBL
  ENSSSCT00040057231.1 UniProtKB/TrEMBL
  ENSSSCT00045002447.1 UniProtKB/TrEMBL
  ENSSSCT00050070830.1 UniProtKB/TrEMBL
  ENSSSCT00055027963.1 UniProtKB/TrEMBL
  ENSSSCT00060098799.1 UniProtKB/TrEMBL
  ENSSSCT00065024435.1 UniProtKB/TrEMBL
  ENSSSCT00070036403.1 UniProtKB/TrEMBL
InterPro Centromere_Mis12 UniProtKB/TrEMBL
NCBI Gene MIS12 ENTREZGENE
PANTHER PROTEIN MIS12 HOMOLOG UniProtKB/TrEMBL
  PTHR14527 UniProtKB/TrEMBL
Pfam Mis12 UniProtKB/TrEMBL
UniProt A0A0B8RTG7 ENTREZGENE
  A0A287AIK7 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UPJ2 ENTREZGENE
  A0A8D0PMJ6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1MXT5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A4X1UPJ2 UniProtKB/TrEMBL
VGNC ID VGNC:90238 ENTREZGENE