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Gene: Mis12 (MIS12 kinetochore complex component) Mus musculus
Analyze
Symbol:
Mis12
Name:
MIS12 kinetochore complex component
RGD ID:
1557060
MGI Page
MGI
Description:
Orthologous to human MIS12 (MIS12 kinetochore complex component); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; carbon nanotube.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
2510025F08Rik; AU044651; MIS12 homolog; Misc12; protein MIS12 homolog; RP23-83I13.9
RGD Orthologs
Alliance Genes
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
MIS12 (MIS12 kinetochore complex component)
HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Mis12 (MIS12 kinetochore complex component)
HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Mis12 (MIS12 kinetochore complex component)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
MIS12 (MIS12 kinetochore complex component)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
MIS12 (MIS12 kinetochore complex component)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Mis12 (MIS12 kinetochore complex component)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
MIS12 (MIS12 kinetochore complex component)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
MIS12 (MIS12 kinetochore complex component)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Mis12 (MIS12 kinetochore complex component)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
MIS12 (MIS12 kinetochore complex component)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Rattus norvegicus (Norway rat):
Mis12 (MIS12 kinetochore complex component)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Danio rerio (zebrafish):
mis12 (MIS12 kinetochore complex component)
Alliance
DIOPT (PhylomeDB|ZFIN)
Related Pseudogenes:
Gm18154
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 11 70,910,394 - 70,918,197 (+) NCBI GRCm39 mm39 GRCm39 Ensembl 11 70,910,437 - 70,918,197 (+) Ensembl GRCm38 11 71,019,568 - 71,027,371 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 11 71,019,611 - 71,027,371 (+) Ensembl GRCm38 mm10 GRCm38 MGSCv37 11 70,833,113 - 70,840,636 (+) NCBI GRCm37 mm9 NCBIm37 MGSCv36 11 70,835,806 - 70,843,329 (+) NCBI mm8 Celera 11 78,574,026 - 78,581,549 (+) NCBI Celera Cytogenetic Map 11 B4 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Disease Annotations - CTD
(+)-schisandrin B multiple interactions ISO RGD:1564837 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of MIS12 mRNA] CTD PMID:31150632 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1564837 6480464 Tetrachlorodibenzodioxin affects the expression of MIS12 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1564837 6480464 Tetrachlorodibenzodioxin results in increased expression of MIS12 mRNA CTD PMID:32109520 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of MIS12 mRNA CTD PMID:25975270 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1346036 6480464 Tetrachlorodibenzodioxin affects the expression of MIS12 mRNA CTD PMID:22574217 2,3,7,8-Tetrachlorodibenzofuran increases expression ISO RGD:1564837 6480464 2 more ... CTD PMID:32109520 3,4-methylenedioxymethamphetamine decreases expression EXP 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of MIS12 mRNA CTD PMID:26251327 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:1346036 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MIS12 mRNA CTD PMID:28628672 acetamide decreases expression ISO RGD:1564837 6480464 acetamide results in decreased expression of MIS12 mRNA CTD PMID:31881176 atrazine decreases expression ISO RGD:1346036 6480464 Atrazine results in decreased expression of MIS12 mRNA CTD PMID:22378314 benzo[a]pyrene diol epoxide I increases expression ISO RGD:1346036 6480464 7 more ... CTD PMID:19150397 bisphenol A decreases expression ISO RGD:1564837 6480464 bisphenol A results in decreased expression of MIS12 mRNA CTD PMID:25181051 bisphenol A increases expression ISO RGD:1564837 6480464 bisphenol A results in increased expression of MIS12 mRNA CTD PMID:30816183 bisphenol A multiple interactions ISO RGD:1346036 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MIS12 mRNA CTD PMID:28628672 cadmium dichloride increases expression ISO RGD:1346036 6480464 Cadmium Chloride results in increased expression of MIS12 mRNA CTD PMID:26472689 carbon nanotube increases expression EXP 6480464 Nanotubes, Carbon results in increased expression of MIS12 mRNA CTD PMID:25554681 chlordecone increases expression EXP 6480464 Chlordecone results in increased expression of MIS12 mRNA CTD PMID:29980752 cobalt dichloride decreases expression ISO RGD:1346036 6480464 cobaltous chloride results in decreased expression of MIS12 mRNA CTD PMID:19376846 cyclosporin A increases expression ISO RGD:1346036 6480464 Cyclosporine results in increased expression of MIS12 mRNA CTD PMID:20106945 , PMID:27989131 cyclosporin A increases expression EXP 6480464 Cyclosporine results in increased expression of MIS12 mRNA CTD PMID:19770486 dexamethasone multiple interactions ISO RGD:1346036 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MIS12 mRNA CTD PMID:28628672 dicrotophos decreases expression ISO RGD:1346036 6480464 dicrotophos results in decreased expression of MIS12 mRNA CTD PMID:28302478 elemental selenium decreases expression ISO RGD:1346036 6480464 Selenium results in decreased expression of MIS12 mRNA CTD PMID:19244175 enzyme inhibitor multiple interactions ISO RGD:1346036 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of MIS12 protein CTD PMID:23301498 hydralazine multiple interactions ISO RGD:1346036 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of MIS12 mRNA CTD PMID:17183730 indometacin multiple interactions ISO RGD:1346036 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MIS12 mRNA CTD PMID:28628672 ketamine decreases expression ISO RGD:1564837 6480464 Ketamine results in decreased expression of MIS12 mRNA CTD PMID:20080153 methapyrilene decreases expression ISO RGD:1564837 6480464 Methapyrilene results in decreased expression of MIS12 mRNA CTD PMID:30467583 oxaliplatin multiple interactions ISO RGD:1564837 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of MIS12 mRNA CTD PMID:25729387 phenobarbital multiple interactions EXP 6480464 NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of MIS12 mRNA] CTD PMID:19482888 phenobarbital decreases expression EXP 6480464 Phenobarbital results in decreased expression of MIS12 mRNA CTD PMID:19482888 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of MIS12 mRNA CTD PMID:23811191 propiconazole increases expression EXP 6480464 propiconazole results in increased expression of MIS12 mRNA CTD PMID:21278054 selenium atom decreases expression ISO RGD:1346036 6480464 Selenium results in decreased expression of MIS12 mRNA CTD PMID:19244175 tetrachloromethane multiple interactions ISO RGD:1564837 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of MIS12 mRNA] CTD PMID:31150632 tetrachloromethane increases expression ISO RGD:1564837 6480464 Carbon Tetrachloride results in increased expression of MIS12 mRNA CTD PMID:31150632 topotecan multiple interactions ISO RGD:1564837 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of MIS12 mRNA CTD PMID:25729387 tunicamycin increases expression ISO RGD:1346036 6480464 Tunicamycin results in increased expression of MIS12 mRNA CTD PMID:22378314 , PMID:29453283 valproic acid multiple interactions ISO RGD:1346036 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of MIS12 mRNA CTD PMID:17183730 valproic acid decreases expression ISO RGD:1346036 6480464 Valproic Acid results in decreased expression of MIS12 mRNA CTD PMID:28001369 vitamin E decreases expression ISO RGD:1346036 6480464 Vitamin E results in decreased expression of MIS12 mRNA CTD PMID:19244175 zinc atom decreases expression ISO RGD:1346036 6480464 Zinc deficiency results in decreased expression of MIS12 mRNA CTD PMID:22171008 zinc atom multiple interactions ISO RGD:1346036 6480464 [PCI 5002 co-treated with Zinc] results in increased expression of MIS12 mRNA CTD PMID:18593933 zinc(0) decreases expression ISO RGD:1346036 6480464 Zinc deficiency results in decreased expression of MIS12 mRNA CTD PMID:22171008 zinc(0) multiple interactions ISO RGD:1346036 6480464 [PCI 5002 co-treated with Zinc] results in increased expression of MIS12 mRNA CTD PMID:18593933
Biological Process
attachment of mitotic spindle microtubules to kinetochore involved_in ISO RGD:1346036 9068941 PMID:23891108 UniProt PMID:23891108 attachment of mitotic spindle microtubules to kinetochore involved_in ISO UniProtKB:Q9H081 2290270 MGI GO_REF:0000096, MGI:4834177 cell division acts_upstream_of_or_within IEA UniProtKB-KW:KW-0132 2290270 UniProt GO_REF:0000004, MGI:1354194 chromosome segregation involved_in ISO RGD:1346036 9068941 PMID:12515822 , PMID:16585270 UniProt PMID:12515822 , PMID:16585270 chromosome segregation acts_upstream_of_or_within ISO RefSeq:NP_076944 2290270 MGI GO_REF:0000008, MGI:2154458 chromosome segregation involved_in ISO UniProtKB:Q9H081 2290270 MGI GO_REF:0000096, MGI:4834177 kinetochore assembly involved_in IBA PANTHER:PTN001427121 2290270 MGI:6201960 , PMID:21873635 GO_Central MGI:6201960 , PMID:21873635 kinetochore assembly involved_in ISO RGD:1346036 9068941 PMID:16585270 UniProt PMID:16585270 kinetochore assembly involved_in ISO UniProtKB:Q9H081 2290270 MGI GO_REF:0000096, MGI:4834177 mitotic cell cycle involved_in IEA InterPro:IPR008685 2290270 UniProt GO_REF:0000002, MGI:2152098 mitotic sister chromatid segregation involved_in IBA PANTHER:PTN001427121 2290270 MGI:6201960 , PMID:21873635 GO_Central MGI:6201960 , PMID:21873635 protein localization to kinetochore involved_in IBA PANTHER:PTN001427121 2290270 MGI:6201960 , PMID:21873635 GO_Central MGI:6201960 , PMID:21873635
References
Additional References at PubMed
Genomics
QTLs in Region (GRCm38)
26884453 Sklq16_m skull length QTL 16, 16 week (mouse) 11 3300000 72800000 Mouse 13208559 Wght10_m weight 10 (mouse) 11 4000000 89000000 Mouse 13208558 Lgth12_m body length 12 (mouse) 11 4000000 95000000 Mouse 1300905 Scc6_m colon tumor susceptibility 6 (mouse) Not determined 11 6930277 89128908 Mouse 1357859 Lvrq7_m liver weight QTL 7 (mouse) Not determined 11 12318637 118131898 Mouse 39128214 Lwq20_m liver weight QTL 20 (mouse) 11 12318637 118131898 Mouse 4141894 Nidd6k_m Nidd6 on KK-A (mouse) Not determined 19174204 97007000 Mouse 10412246 Dfs2_m dental fluorosis suseptibility 2 (mouse) Not determined 11 21857364 95990405 Mouse 13208569 Bmiq10_m body mass index QTL 10 (mouse) 11 36000000 85000000 Mouse 1301328 Mol4_m modifier of LPS-response 4 (mouse) Not determined 11 36391750 83590530 Mouse 4141853 Skmw17_m skeletal muscle weight 17 (mouse) Not determined 11 37190115 71190238 Mouse 10766457 Nwa3_m New Zealand White autoimmunity 3 (mouse) 11 38125289 72125383 Mouse 11532698 Sluc36a_m susceptibility to lung cancer 36a (mouse) 11 42365791 76365904 Mouse 11532699 Sluc36b_m susceptibility to lung cancer 36b (mouse) 11 42365791 76365904 Mouse 4142300 Ctrq3_m C. trachomatis resistance QTL 3 (mouse) Not determined 11 44739211 76963931 Mouse 4141367 Inf1_m acute ozone induced inflammation (mouse) Not determined 44739211 113167183 Mouse 4141000 Nidd3_m non-insulin-dependent diabetes mellitus 3 (mouse) Not determined 45151201 79151308 Mouse 1302021 Nidd1n_m non-insulin-dependent diabetes mellitus 1 in NSY (mouse) Not determined 11 45275046 80087498 Mouse 1357878 Mastr_m modifier of astrocytoma (mouse) Not determined 11 45817754 89927907 Mouse 1300765 Bbaa4_m B.burgdorferi-associated arthritis 4 (mouse) Not determined 11 46294341 80294436 Mouse 1301988 Bmd11_m bone mineral density 11 (mouse) Not determined 11 46428581 80428696 Mouse 1301830 Ssta4_m susceptibility to Salmonella typhimurium antigens 4 (mouse) Not determined 11 50187365 84187585 Mouse 13524840 Ppiq9a_m prepulse inhibition QTL 9a (mouse) 11 52603559 86603559 Mouse 1300774 Pgia7_m proteoglycan induced arthritis 7 (mouse) Not determined 11 53499762 87499911 Mouse 4141830 Pregq1_m pregnancy QTL 1 (mouse) Not determined 11 54235926 83842826 Mouse 4141875 Etax9_m ethanol induced ataxia 9 (mouse) Not determined 55394159 72319101 Mouse 4142121 Tmc1m2_m Tmc1 modifier 2 (mouse) Not determined 11 56973201 114267131 Mouse 1300664 Etohcta9_m ethanol conditioned taste aversion 9 (mouse) Not determined 11 57863834 91863932 Mouse 10053682 Eae45_m experimental allergic encephalomyelitis susceptibility 45 (mouse) Not determined 11 58599729 74863932 Mouse 1300924 Ity2_m immunity to S. typhimurium 2 (mouse) Not determined 1 58617204 87804412 Mouse 4141982 Skts-fp2_m skin tumor susceptibility in FVB and PWK 2 (mouse) Not determined 58828440 85175703 Mouse 1301987 Pid3_m prior incubation determinant 3 (mouse) Not determined 11 61795994 88808902 Mouse 1301319 Dautb4_m dopamine uptake transporter binding 4 (mouse) Not determined 11 62265179 96265327 Mouse 27226730 Tibmd1_m tibia midshaft diameter 1, 5 week (mouse) 11 62700000 109500000 Mouse 1301999 Lmr15_m leishmaniasis resistance 15 (mouse) Not determined 11 63428581 81939647 Mouse 10044004 Stzid3_m streptozotocin induced diabetes susceptibility 3 (mouse) Not determined 11 63428581 94173092 Mouse 11039501 Ltpr6a_m Leishmania tropica response 6a (mouse) 11 64939510 98939647 Mouse 11039502 Ltpr6b_m Leishmania tropica response 6b (mouse) 11 64939510 98939647 Mouse 11039515 Ltpr6_m Leishmania tropica response 6 (mouse) 11 64939510 98939647 Mouse 1301546 Pcir2_m periosteal circumference 2 (mouse) Not determined 11 66842594 100842826 Mouse 1357766 Si5lq6_m serum IGFBP-5 level QTL 6 (mouse) Not determined 11 66842594 100842826 Mouse 4141012 Femwf6_m femur work to failure 6 (mouse) Not determined 66842594 100842826 Mouse 1301833 Tbbmd5_m total body bone mineral density 5 (mouse) Not determined 11 66842594 100842826 Mouse 1300784 Prdt3_m prion disease incubation time 3 (mouse) Not determined 11 66842594 100842826 Mouse 1300628 Lgth6_m body length 6 (mouse) Not determined 11 66842594 100842826 Mouse 4142316 Ity2b_m immunity to S. typhimurium 2b (mouse) Not determined 11 67187365 79923086 Mouse 27226783 Tibl5_m tibia length 5, 5 week (mouse) 11 68300000 102000000 Mouse 36049778 Ars6_m antibody response to SARS-CoV 6, day 15, IgM (mouse) 11 69100000 72600000 Mouse 36049779 Ars7_m antibody response to SARS-CoV 7, day 29, IgG1 (mouse) 11 69100000 72600000 Mouse 36049784 Ars8_m antibody response to SARS-CoV 8, day 29, IgG2a+IgG2c (mouse) 11 69100000 72600000 Mouse 36049785 Ars9_m antibody response to SARS-CoV 9, day 29, IgM (mouse) 11 69100000 72600000 Mouse 36049786 Ars10_m antibody response to SARS-CoV 10, 4 days post-rechallenge, IgG2a+IgG2c (mouse) 11 69100000 72600000 Mouse 36049787 Ars11_m antibody response to SARS-CoV 11, 4 days post-rechallenge, IgM (mouse) 11 69100000 72600000 Mouse 36049788 Ars1_m antibody response to SARS-CoV 1, day 7, IgG1 (mouse) 11 69100000 72600000 Mouse 36049789 Ars2_m antibody response to SARS-CoV 2, day 7, IgG2a+IgG2c (mouse) 11 69100000 72600000 Mouse 36049790 Ars3_m antibody response to SARS-CoV 3, day 7, IgG2b (mouse) 11 69100000 72600000 Mouse 36049791 Ars4_m antibody response to SARS-CoV 4, day 7, IgG3 (mouse) 11 69100000 72600000 Mouse 36049792 Ars5_m antibody response to SARS-CoV 5, day 7, IgM (mouse) 11 69100000 72600000 Mouse 35673314 Ari2_m antibody response to influenza 2, day 10, IgG3 (mouse) 11 69100000 72600000 Mouse 1300651 Pcyts3_m plasmacytoma susceptibility 3 (mouse) Not determined 11 70800372 104800540 Mouse 1301681 Sle13_m systematic lupus erythematosus susceptibility 13 (mouse) Not determined 11 70800372 104800540 Mouse 1558812 Rafar_m retinoic acid induced forelimb autopod reduction (mouse) Not determined 11 70800372 104800540 Mouse 4141339 Nilac2_m nicotine induced locomotor activity 2 (mouse) Not determined 11 70800372 104800540 Mouse