Mis12 (MIS12 kinetochore complex component) - Rat Genome Database
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Gene: Mis12 (MIS12 kinetochore complex component) Mus musculus
Analyze
Symbol: Mis12
Name: MIS12 kinetochore complex component
RGD ID: 1557060
MGI Page MGI
Description: Orthologous to human MIS12 (MIS12 kinetochore complex component); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; carbon nanotube.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2510025F08Rik; AU044651; MIS12 homolog; Misc12; protein MIS12 homolog; RP23-83I13.9
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm18154  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,910,394 - 70,918,197 (+)NCBIGRCm39mm39
GRCm39 Ensembl1170,910,437 - 70,918,197 (+)Ensembl
GRCm381171,019,568 - 71,027,371 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,019,611 - 71,027,371 (+)EnsemblGRCm38mm10GRCm38
MGSCv371170,833,113 - 70,840,636 (+)NCBIGRCm37mm9NCBIm37
MGSCv361170,835,806 - 70,843,329 (+)NCBImm8
Celera1178,574,026 - 78,581,549 (+)NCBICelera
Cytogenetic Map11B4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:14610273   PMID:15489334   PMID:16141072   PMID:16141073   PMID:17967808   PMID:18799693  
PMID:20360068   PMID:21677750   PMID:21873635   PMID:26496610   PMID:32341029  


Genomics

Comparative Map Data
Mis12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,910,394 - 70,918,197 (+)NCBIGRCm39mm39
GRCm39 Ensembl1170,910,437 - 70,918,197 (+)Ensembl
GRCm381171,019,568 - 71,027,371 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,019,611 - 71,027,371 (+)EnsemblGRCm38mm10GRCm38
MGSCv371170,833,113 - 70,840,636 (+)NCBIGRCm37mm9NCBIm37
MGSCv361170,835,806 - 70,843,329 (+)NCBImm8
Celera1178,574,026 - 78,581,549 (+)NCBICelera
Cytogenetic Map11B4NCBI
MIS12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl175,486,285 - 5,490,814 (+)EnsemblGRCh38hg38GRCh38
GRCh38175,486,374 - 5,490,814 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37175,389,694 - 5,394,131 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36175,330,971 - 5,334,855 (+)NCBINCBI36hg18NCBI36
Build 34175,330,970 - 5,334,852NCBI
Celera175,406,624 - 5,410,507 (+)NCBI
Cytogenetic Map17p13.2NCBI
HuRef175,279,942 - 5,284,378 (+)NCBIHuRef
CHM1_1175,399,363 - 5,403,803 (+)NCBICHM1_1
Mis12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21055,739,590 - 55,747,915 (+)NCBI
Rnor_6.0 Ensembl1057,660,067 - 57,660,687 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01057,653,685 - 57,661,833 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01057,398,658 - 57,407,046 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,927,346 - 57,928,594 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1054,891,204 - 54,892,452 (+)NCBICelera
Cytogenetic Map10q24NCBI
Mis12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546710,837,832 - 10,842,123 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546710,837,570 - 10,842,131 (+)NCBIChiLan1.0ChiLan1.0
MIS12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1175,526,376 - 5,530,955 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl175,529,017 - 5,529,634 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0175,534,305 - 5,538,736 (+)NCBIMhudiblu_PPA_v0panPan3
MIS12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1531,314,067 - 31,319,392 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Mis12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366772,323,540 - 2,328,689 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MIS12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1251,505,381 - 51,507,943 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11251,505,376 - 51,508,337 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MIS12
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,897,672 - 4,902,085 (+)NCBI
Mis12
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247869,285,475 - 9,289,659 (+)NCBI

Position Markers
AU044651  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381171,027,029 - 71,027,216UniSTSGRCm38
MGSCv371170,840,531 - 70,840,718UniSTSGRCm37
Celera1178,581,444 - 78,581,631UniSTS
Cytogenetic Map11B4UniSTS
Whitehead/MRC_RH11904.85UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11330000072800000Mouse
13208559Wght10_mweight 10 (mouse)11400000089000000Mouse
13208558Lgth12_mbody length 12 (mouse)11400000095000000Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11693027789128908Mouse
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1917420497007000Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112185736495990405Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113600000085000000Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113639175083590530Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113719011571190238Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113812528972125383Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114236579176365904Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114236579176365904Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114473921176963931Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4141000Nidd3_mnon-insulin-dependent diabetes mellitus 3 (mouse)Not determined4515120179151308Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114527504680087498Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114581775489927907Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114629434180294436Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114642858180428696Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115018736584187585Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115260355986603559Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115349976287499911Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115423592683842826Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5539415972319101Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115786383491863932Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115859972974863932Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15861720487804412Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5882844085175703Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116179599488808902Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116226517996265327Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162700000109500000Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116342858181939647Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116342858194173092Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116493951098939647Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116493951098939647Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116493951098939647Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166842594100842826Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166842594100842826Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66842594100842826Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166842594100842826Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166842594100842826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166842594100842826Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116718736579923086Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168300000102000000Mouse
36049778Ars6_mantibody response to SARS-CoV 6, day 15, IgM (mouse)116910000072600000Mouse
36049779Ars7_mantibody response to SARS-CoV 7, day 29, IgG1 (mouse)116910000072600000Mouse
36049784Ars8_mantibody response to SARS-CoV 8, day 29, IgG2a+IgG2c (mouse)116910000072600000Mouse
36049785Ars9_mantibody response to SARS-CoV 9, day 29, IgM (mouse)116910000072600000Mouse
36049786Ars10_mantibody response to SARS-CoV 10, 4 days post-rechallenge, IgG2a+IgG2c (mouse)116910000072600000Mouse
36049787Ars11_mantibody response to SARS-CoV 11, 4 days post-rechallenge, IgM (mouse)116910000072600000Mouse
36049788Ars1_mantibody response to SARS-CoV 1, day 7, IgG1 (mouse)116910000072600000Mouse
36049789Ars2_mantibody response to SARS-CoV 2, day 7, IgG2a+IgG2c (mouse)116910000072600000Mouse
36049790Ars3_mantibody response to SARS-CoV 3, day 7, IgG2b (mouse)116910000072600000Mouse
36049791Ars4_mantibody response to SARS-CoV 4, day 7, IgG3 (mouse)116910000072600000Mouse
36049792Ars5_mantibody response to SARS-CoV 5, day 7, IgM (mouse)116910000072600000Mouse
35673314Ari2_mantibody response to influenza 2, day 10, IgG3 (mouse)116910000072600000Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170800372104800540Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170800372104800540Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170800372104800540Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170800372104800540Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1073
Count of miRNA genes:480
Interacting mature miRNAs:586
Transcripts:ENSMUST00000048807, ENSMUST00000133413, ENSMUST00000136137, ENSMUST00000143762, ENSMUST00000155236, ENSMUST00000164220
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000048807   ⟹   ENSMUSP00000039500
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1171,019,611 - 71,027,371 (+)Ensembl
RefSeq Acc Id: ENSMUST00000133413   ⟹   ENSMUSP00000123291
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1171,019,611 - 71,025,178 (+)Ensembl
RefSeq Acc Id: ENSMUST00000136137   ⟹   ENSMUSP00000121057
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1171,019,891 - 71,025,195 (+)Ensembl
RefSeq Acc Id: ENSMUST00000143762   ⟹   ENSMUSP00000115256
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1171,019,862 - 71,025,158 (+)Ensembl
RefSeq Acc Id: ENSMUST00000155236   ⟹   ENSMUSP00000116762
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1171,019,859 - 71,025,167 (+)Ensembl
RefSeq Acc Id: ENSMUST00000164220   ⟹   ENSMUSP00000127782
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1171,019,611 - 71,026,066 (+)Ensembl
RefSeq Acc Id: NM_025993   ⟹   NP_080269
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,910,437 - 70,918,187 (+)NCBI
GRCm381171,019,611 - 71,027,361 (+)NCBI
MGSCv371170,833,113 - 70,840,636 (+)RGD
Celera1178,574,026 - 78,581,549 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006533968   ⟹   XP_006534031
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,910,394 - 70,918,197 (+)NCBI
GRCm381171,019,568 - 71,027,371 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006533969   ⟹   XP_006534032
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,911,013 - 70,918,197 (+)NCBI
GRCm381171,020,196 - 71,027,371 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_080269   ⟸   NM_025993
- UniProtKB: Q9CY25 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006534031   ⟸   XM_006533968
- Peptide Label: isoform X1
- UniProtKB: Q9CY25 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006534032   ⟸   XM_006533969
- Peptide Label: isoform X1
- UniProtKB: Q9CY25 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000127782   ⟸   ENSMUST00000164220
RefSeq Acc Id: ENSMUSP00000115256   ⟸   ENSMUST00000143762
RefSeq Acc Id: ENSMUSP00000123291   ⟸   ENSMUST00000133413
RefSeq Acc Id: ENSMUSP00000039500   ⟸   ENSMUST00000048807
RefSeq Acc Id: ENSMUSP00000121057   ⟸   ENSMUST00000136137
RefSeq Acc Id: ENSMUSP00000116762   ⟸   ENSMUST00000155236

Promoters
RGD ID:6820715
Promoter ID:MM_KWN:8272
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000013718,   OTTMUST00000013720,   OTTMUST00000013721,   OTTMUST00000013722,   OTTMUST00000013723,   OTTMUST00000013724,   OTTMUST00000013725,   OTTMUST00000013727,   OTTMUST00000013728,   OTTMUST00000013729,   UC007JXI.1,   UC007JXK.1,   UC007JXL.1,   UC007JXN.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361170,832,626 - 70,833,462 (-)MPROMDB
RGD ID:8675390
Promoter ID:EPDNEW_M15726
Type:initiation region
Name:Mis12_1
Description:Mus musculus MIS12 kinetochore complex component , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15728  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381171,019,611 - 71,019,671EPDNEW
RGD ID:8675396
Promoter ID:EPDNEW_M15728
Type:initiation region
Name:Mis12_2
Description:Mus musculus MIS12 kinetochore complex component , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15726  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381171,019,902 - 71,019,962EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914389 AgrOrtholog
Ensembl Genes ENSMUSG00000040599 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000039500 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000116762 UniProtKB/TrEMBL
  ENSMUSP00000121057 UniProtKB/TrEMBL
  ENSMUSP00000123291 UniProtKB/TrEMBL
  ENSMUSP00000127782 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000048807 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000133413 UniProtKB/TrEMBL
  ENSMUST00000136137 UniProtKB/TrEMBL
  ENSMUST00000155236 UniProtKB/TrEMBL
  ENSMUST00000164220 UniProtKB/Swiss-Prot
InterPro Centromere_Mis12 UniProtKB/Swiss-Prot
KEGG Report mmu:67139 UniProtKB/Swiss-Prot
MGD MGI:1914389 ENTREZGENE
NCBI Gene 67139 ENTREZGENE
PANTHER PTHR14527 UniProtKB/Swiss-Prot
Pfam Mis12 UniProtKB/Swiss-Prot
PhenoGen Mis12 PhenoGen
UniProt A0A0G2JDA2_MOUSE UniProtKB/TrEMBL
  A3QK65_MOUSE UniProtKB/TrEMBL
  A3QK66_MOUSE UniProtKB/TrEMBL
  MIS12_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q3V261 UniProtKB/Swiss-Prot
  Q5QNU7 UniProtKB/Swiss-Prot
  Q5QNU8 UniProtKB/Swiss-Prot
  Q5QNU9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Mis12  MIS12 kinetochore complex component    MIS12 homolog (yeast)  Symbol and/or name change 5135510 APPROVED