ABCC2 (ATP binding cassette subfamily C member 2) - Rat Genome Database

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Gene: ABCC2 (ATP binding cassette subfamily C member 2) Sus scrofa
Analyze
Symbol: ABCC2
Name: ATP binding cassette subfamily C member 2
RGD ID: 14141671
Description: ENCODES a protein that exhibits protein domain specific binding (ortholog); INVOLVED IN antibiotic metabolic process (ortholog); benzylpenicillin metabolic process (ortholog); canalicular bile acid transport (ortholog); PARTICIPATES IN docetaxel pharmacodynamics pathway; doxorubicin pharmacokinetics pathway; irinotecan pharmacodynamics pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); acute lymphoblastic leukemia (ortholog); alopecia (ortholog); FOUND IN apical plasma membrane (ortholog); brush border membrane (ortholog); intracellular canaliculus (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ATP-binding cassette, sub-family C, member 2; canalicular multispecific organic anion transporter 1; MRP2; multidrug resistance associated protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14110,955,582 - 111,038,898 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114110,955,698 - 111,038,898 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214120,400,787 - 120,484,137 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:12429346   PMID:14681463   PMID:15180328   PMID:19844775   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ABCC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14110,955,582 - 111,038,898 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114110,955,698 - 111,038,898 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214120,400,787 - 120,484,137 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381099,782,640 - 99,852,594 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1099,782,640 - 99,852,594 (+)EnsemblGRCh38hg38GRCh38
GRCh3710101,542,397 - 101,612,351 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610101,532,493 - 101,601,571 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410101,532,562 - 101,601,571NCBI
Celera1095,279,806 - 95,349,643 (+)NCBICelera
Cytogenetic Map10q24.2NCBI
HuRef1095,169,835 - 95,239,503 (+)NCBIHuRef
CHM1_110101,824,911 - 101,894,368 (+)NCBICHM1_1
T2T-CHM13v2.010100,665,562 - 100,736,331 (+)NCBIT2T-CHM13v2.0
Abcc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391943,770,747 - 43,826,771 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1943,770,631 - 43,829,179 (+)EnsemblGRCm39 Ensembl
GRCm381943,782,308 - 43,838,332 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1943,782,192 - 43,840,740 (+)EnsemblGRCm38mm10GRCm38
MGSCv371943,856,798 - 43,912,708 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361943,835,715 - 43,891,248 (+)NCBIMGSCv36mm8
Celera1944,567,463 - 44,621,438 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1936.67NCBI
Abcc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81252,613,875 - 252,672,459 (+)NCBIGRCr8
mRatBN7.21242,664,657 - 242,723,239 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,664,657 - 242,723,238 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1250,813,581 - 250,872,198 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01257,510,469 - 257,569,198 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01250,163,726 - 250,222,340 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01263,554,426 - 263,612,556 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1263,554,453 - 263,613,252 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01270,999,832 - 271,057,750 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1238,483,399 - 238,539,595 (+)NCBICelera
Cytogenetic Map1q54NCBI
Abcc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555075,724,762 - 5,790,812 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555075,724,788 - 5,791,281 (+)NCBIChiLan1.0ChiLan1.0
ABCC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28111,665,912 - 111,749,129 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110111,688,214 - 111,755,876 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01096,385,534 - 96,458,571 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11099,889,021 - 99,947,452 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1099,889,160 - 99,947,270 (+)Ensemblpanpan1.1panPan2
ABCC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12812,670,885 - 12,740,124 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2812,670,885 - 12,740,740 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2812,854,192 - 12,923,368 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02813,138,667 - 13,208,016 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2813,138,667 - 13,208,633 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12812,685,440 - 12,754,683 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02812,716,120 - 12,786,599 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02812,857,984 - 12,927,300 (+)NCBIUU_Cfam_GSD_1.0
Abcc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721334,253,163 - 34,302,933 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936636292,709 - 340,393 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936636292,631 - 341,999 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1992,826,423 - 92,902,389 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl992,841,818 - 92,902,265 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604853,844,985 - 53,909,244 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473711,593,864 - 11,688,460 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473711,593,701 - 11,686,790 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ABCC2
2763 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 3 6 3 1 4 10 8 6 3 6 2

Sequence


Ensembl Acc Id: ENSSSCT00000011534   ⟹   ENSSSCP00000011233
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14110,955,582 - 111,038,898 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000067952   ⟹   ENSSSCP00000072228
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14110,955,675 - 111,078,873 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000075679   ⟹   ENSSSCP00000074381
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14110,955,656 - 110,990,455 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000087575   ⟹   ENSSSCP00000066180
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14110,955,633 - 111,037,537 (+)Ensembl
RefSeq Acc Id: XM_021073710   ⟹   XP_020929369
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.114110,955,698 - 111,038,898 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020929369 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAO17316 (Get FASTA)   NCBI Sequence Viewer  
  ABF81825 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000011233
  ENSSSCP00000011233.3
  ENSSSCP00000066180.1
  ENSSSCP00065042065.1
RefSeq Acc Id: XP_020929369   ⟸   XM_021073710
- UniProtKB: A0A8D2A1A1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000074381   ⟸   ENSSSCT00000075679
Ensembl Acc Id: ENSSSCP00000011233   ⟸   ENSSSCT00000011534
Ensembl Acc Id: ENSSSCP00000072228   ⟸   ENSSSCT00000067952
Ensembl Acc Id: ENSSSCP00000066180   ⟸   ENSSSCT00000087575
Protein Domains
ABC transmembrane type-1   ABC transporter


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010543 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00065069985 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000011534 ENTREZGENE
  ENSSSCT00000011534.5 UniProtKB/TrEMBL
  ENSSSCT00000087575.2 UniProtKB/TrEMBL
  ENSSSCT00065096134.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1560.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  ABC1_TM_dom UniProtKB/TrEMBL
  ABC1_TM_sf UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/TrEMBL
  ABC_transporter_C UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/TrEMBL
  Multidrug-R_assoc UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene ABCC2 ENTREZGENE
PANTHER ATP-BINDING CASSETTE SUB-FAMILY C UniProtKB/TrEMBL
  PTHR24223:SF176 UniProtKB/TrEMBL
Pfam ABC_membrane UniProtKB/TrEMBL
  ABC_tran UniProtKB/TrEMBL
PROSITE ABC_TM1F UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
  SSF90123 UniProtKB/TrEMBL
UniProt A0A5G2R6G0_PIG UniProtKB/TrEMBL
  A0A8D2A1A1 ENTREZGENE, UniProtKB/TrEMBL
  F1S8V9_PIG UniProtKB/TrEMBL
VGNC ID VGNC:84956 ENTREZGENE