TSPO (translocator protein) - Rat Genome Database

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Gene: TSPO (translocator protein) Sus scrofa
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Symbol: TSPO
Name: translocator protein
RGD ID: 14237551
Description: ENCODES a protein that exhibits androgen binding (ortholog); benzodiazepine receptor activity (ortholog); INVOLVED IN adrenal gland development (ortholog); behavioral response to pain (ortholog); cellular hypotonic response (ortholog); PARTICIPATES IN heme biosynthetic pathway; ASSOCIATED WITH cholesterol ester storage disease (ortholog); COVID-19 (ortholog); Developmental Delay with Variable Intellectual Impairment and Behavioral Abnormalities (ortholog); FOUND IN mitochondrial outer membrane (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BZRP; PBR; peripheral benzodiazepine receptor; peripheral-type benzodiazepine receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl55,723,190 - 5,735,131 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.155,723,190 - 5,735,097 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.253,145,792 - 3,157,669 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
behavioral response to pain  (ISO)
cellular hypotonic response  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to zinc ion  (ISO)
chloride transport  (ISO)
cholesterol homeostasis  (ISO)
contact inhibition  (ISO)
establishment of protein localization to mitochondrion  (IEA)
glial cell migration  (ISO)
lipid transport  (IEA)
maintenance of protein location in mitochondrion  (IEA)
monoatomic ion transport  (ISO)
negative regulation of ATP metabolic process  (IEA)
negative regulation of corticosterone secretion  (ISO)
negative regulation of glial cell proliferation  (ISO)
negative regulation of mitophagy  (IEA)
negative regulation of nitric oxide biosynthetic process  (ISO)
negative regulation of protein ubiquitination  (IEA)
negative regulation of tumor necrosis factor production  (ISO)
peripheral nervous system axon regeneration  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of calcium ion transport  (ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of mitochondrial depolarization  (ISO)
positive regulation of programmed necrotic cell death  (ISO)
positive regulation of reactive oxygen species metabolic process  (IEA,ISO)
regulation of steroid biosynthetic process  (ISO)
response to acetylcholine  (ISO)
response to axon injury  (ISO)
response to manganese ion  (ISO)
response to pain  (ISO)
response to progesterone  (ISO)
response to testosterone  (ISO)
response to vitamin B1  (ISO)
response to xenobiotic stimulus  (ISO)
steroid biosynthetic process  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:17019653   PMID:17622771   PMID:19386723   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TSPO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl55,723,190 - 5,735,131 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.155,723,190 - 5,735,097 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.253,145,792 - 3,157,669 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TSPO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382243,151,559 - 43,163,242 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2243,151,547 - 43,163,242 (+)EnsemblGRCh38hg38GRCh38
GRCh372243,547,565 - 43,559,248 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362241,877,479 - 41,889,192 (+)NCBINCBI36Build 36hg18NCBI36
Build 342241,872,050 - 41,883,745NCBI
Celera2227,457,910 - 27,469,623 (+)NCBICelera
Cytogenetic Map22q13.2NCBI
HuRef2226,505,727 - 26,517,455 (+)NCBIHuRef
CHM1_12243,507,104 - 43,518,509 (+)NCBICHM1_1
T2T-CHM13v2.02243,632,715 - 43,644,077 (+)NCBIT2T-CHM13v2.0
Tspo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391583,447,774 - 83,458,404 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1583,447,793 - 83,458,404 (+)EnsemblGRCm39 Ensembl
GRCm381583,563,573 - 83,574,203 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1583,563,592 - 83,574,203 (+)EnsemblGRCm38mm10GRCm38
MGSCv371583,394,003 - 83,404,633 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361583,391,377 - 83,401,962 (+)NCBIMGSCv36mm8
Celera1585,689,315 - 85,701,021 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1539.4NCBI
Tspo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87116,600,214 - 116,610,461 (+)NCBIGRCr8
mRatBN7.27114,720,188 - 114,730,450 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7114,720,188 - 114,730,450 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7116,467,236 - 116,477,482 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07118,693,096 - 118,703,201 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07118,662,565 - 118,672,671 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07124,460,358 - 124,470,610 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7124,460,358 - 124,470,609 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07124,449,361 - 124,459,090 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47121,597,084 - 121,599,342 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17121,631,313 - 121,633,572 (+)NCBI
Celera7111,031,561 - 111,041,788 (+)NCBICelera
RH 3.4 Map7906.4RGD
Cytogenetic Map7q34NCBI
Tspo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541328,308,658 - 28,315,075 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541328,309,105 - 28,315,075 (+)NCBIChiLan1.0ChiLan1.0
TSPO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22352,974,420 - 52,985,872 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12255,667,318 - 55,678,778 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02224,034,918 - 24,046,370 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12242,233,186 - 42,244,930 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2242,233,619 - 42,244,930 (+)Ensemblpanpan1.1panPan2
TSPO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11022,388,498 - 22,399,329 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1022,274,405 - 22,399,297 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1022,325,190 - 22,336,049 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01023,132,949 - 23,143,978 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1023,132,954 - 23,135,891 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11022,852,287 - 22,863,109 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01023,171,467 - 23,182,483 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01023,347,120 - 23,357,948 (-)NCBIUU_Cfam_GSD_1.0
Tspo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049455,984,991 - 5,987,864 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936718992,301 - 995,995 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936718992,301 - 995,172 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSPO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11925,678,602 - 25,690,556 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1925,686,981 - 25,690,768 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604599,748,097 - 99,760,895 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tspo
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247525,814,784 - 5,820,141 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247525,814,784 - 5,820,250 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TSPO
607 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 21 3 2 5 14 12 21 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000000035   ⟹   ENSSSCP00000000035
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl55,723,192 - 5,735,131 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000058616   ⟹   ENSSSCP00000046941
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl55,723,190 - 5,725,066 (-)Ensembl
RefSeq Acc Id: NM_213753   ⟹   NP_998918
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.155,723,190 - 5,735,097 (-)NCBI
Sequence:
RefSeq Acc Id: NP_998918   ⟸   NM_213753
- UniProtKB: Q6UN27 (UniProtKB/Swiss-Prot),   A0A8D1FEX5 (UniProtKB/TrEMBL),   F1SJR8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000046941   ⟸   ENSSSCT00000058616
Ensembl Acc Id: ENSSSCP00000000035   ⟸   ENSSSCT00000000035


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000000033 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015072440 UniProtKB/TrEMBL
  ENSSSCG00025012766 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00030009518 UniProtKB/TrEMBL
  ENSSSCG00035024827 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00040058586 UniProtKB/TrEMBL
  ENSSSCG00045008320 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00050030809 UniProtKB/TrEMBL
  ENSSSCG00055026993 UniProtKB/TrEMBL
  ENSSSCG00060066857 UniProtKB/TrEMBL
  ENSSSCG00065059850 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000000035 ENTREZGENE
  ENSSSCT00000000035.5 UniProtKB/TrEMBL
  ENSSSCT00000058616.3 UniProtKB/TrEMBL
  ENSSSCT00015097421.1 UniProtKB/TrEMBL
  ENSSSCT00015097580.1 UniProtKB/TrEMBL
  ENSSSCT00025016911.1 UniProtKB/Swiss-Prot
  ENSSSCT00025016934.1 UniProtKB/TrEMBL
  ENSSSCT00025016995.1 UniProtKB/TrEMBL
  ENSSSCT00030013031.1 UniProtKB/TrEMBL
  ENSSSCT00030013044.1 UniProtKB/TrEMBL
  ENSSSCT00030013069.1 UniProtKB/TrEMBL
  ENSSSCT00035032650.1 UniProtKB/TrEMBL
  ENSSSCT00035032659.1 UniProtKB/Swiss-Prot
  ENSSSCT00035032665.1 UniProtKB/TrEMBL
  ENSSSCT00040079548.1 UniProtKB/TrEMBL
  ENSSSCT00040079758.1 UniProtKB/TrEMBL
  ENSSSCT00040079796.1 UniProtKB/TrEMBL
  ENSSSCT00045013985.1 UniProtKB/TrEMBL
  ENSSSCT00045014035.1 UniProtKB/Swiss-Prot
  ENSSSCT00045014057.1 UniProtKB/TrEMBL
  ENSSSCT00050041420.1 UniProtKB/TrEMBL
  ENSSSCT00050041426.1 UniProtKB/TrEMBL
  ENSSSCT00050041435.1 UniProtKB/TrEMBL
  ENSSSCT00055053407.1 UniProtKB/TrEMBL
  ENSSSCT00055053452.1 UniProtKB/TrEMBL
  ENSSSCT00055053531.1 UniProtKB/TrEMBL
  ENSSSCT00060091264.1 UniProtKB/TrEMBL
  ENSSSCT00060091316.1 UniProtKB/TrEMBL
  ENSSSCT00060091352.1 UniProtKB/TrEMBL
  ENSSSCT00065081978.1 UniProtKB/TrEMBL
  ENSSSCT00065081987.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1260.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro TspO/MBR-related_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TspO_MBR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:396592 UniProtKB/Swiss-Prot
NCBI Gene TSPO ENTREZGENE
PANTHER PTHR10057 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10057:SF5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TspO_MBR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF PBR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A287AS84_PIG UniProtKB/TrEMBL
  A0A8D0PW43_PIG UniProtKB/TrEMBL
  A0A8D0QU11_PIG UniProtKB/TrEMBL
  A0A8D1FEX5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1FEZ4_PIG UniProtKB/TrEMBL
  A0A8D1WJL8_PIG UniProtKB/TrEMBL
  A0A8D1ZJ35_PIG UniProtKB/TrEMBL
  F1SJR8 ENTREZGENE, UniProtKB/TrEMBL
  Q6UN27 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:112558 ENTREZGENE