TSPO (translocator protein) - Rat Genome Database
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Gene: TSPO (translocator protein) Sus scrofa
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Symbol: TSPO
Name: translocator protein
RGD ID: 14237551
Description: ENCODES a protein that exhibits androgen binding (ortholog); benzodiazepine receptor activity (ortholog); ion channel binding (ortholog); INVOLVED IN adrenal gland development (ortholog); aging (ortholog); behavioral response to pain (ortholog); PARTICIPATES IN heme biosynthetic pathway; ASSOCIATED WITH COVID-19 (ortholog); End Stage Liver Disease (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN intracellular membrane-bounded organelle (ortholog); mitochondrial outer membrane (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: BZRP; PBR; peripheral benzodiazepine receptor; peripheral-type benzodiazepine receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl55,723,186 - 5,735,128 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.155,723,190 - 5,735,097 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.253,145,792 - 3,157,669 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
aging  (ISO)
behavioral response to pain  (ISO)
cellular hypotonic response  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to zinc ion  (ISO)
chloride transport  (ISO)
contact inhibition  (ISO)
establishment of protein localization to mitochondrion  (IEA,ISO)
glial cell migration  (ISO)
ion transport  (ISO)
lipid transport  (IEA)
maintenance of protein location in mitochondrion  (IEA,ISO)
negative regulation of ATP metabolic process  (IEA,ISO)
negative regulation of autophagy of mitochondrion  (IEA,ISO)
negative regulation of glial cell proliferation  (ISO)
negative regulation of mitochondrion organization  (ISO)
negative regulation of nitric oxide biosynthetic process  (ISO)
negative regulation of protein ubiquitination  (IEA,ISO)
negative regulation of tumor necrosis factor production  (ISO)
peripheral nervous system axon regeneration  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of calcium ion transport  (ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of mitochondrial depolarization  (ISO)
positive regulation of necrotic cell death  (ISO)
positive regulation of reactive oxygen species metabolic process  (IEA,ISO)
regulation of steroid biosynthetic process  (ISO)
response to axon injury  (ISO)
response to drug  (ISO)
response to manganese ion  (ISO)
response to pain  (ISO)
response to progesterone  (ISO)
response to testosterone  (ISO)
response to vitamin B1  (ISO)
steroid biosynthetic process  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:17019653   PMID:17622771   PMID:19386723  


Genomics

Comparative Map Data
TSPO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl55,723,186 - 5,735,128 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.155,723,190 - 5,735,097 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.253,145,792 - 3,157,669 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TSPO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2243,151,547 - 43,163,242 (+)EnsemblGRCh38hg38GRCh38
GRCh382243,151,559 - 43,163,242 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372243,547,565 - 43,559,248 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362241,877,479 - 41,889,192 (+)NCBINCBI36hg18NCBI36
Build 342241,872,050 - 41,883,745NCBI
Celera2227,457,910 - 27,469,623 (+)NCBI
Cytogenetic Map22q13.2NCBI
HuRef2226,505,727 - 26,517,455 (+)NCBIHuRef
CHM1_12243,507,104 - 43,518,509 (+)NCBICHM1_1
Tspo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391583,447,774 - 83,458,404 (+)NCBIGRCm39mm39
GRCm39 Ensembl1583,447,793 - 83,458,404 (+)Ensembl
GRCm381583,563,573 - 83,574,203 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1583,563,592 - 83,574,203 (+)EnsemblGRCm38mm10GRCm38
MGSCv371583,394,003 - 83,404,633 (+)NCBIGRCm37mm9NCBIm37
MGSCv361583,391,377 - 83,401,962 (+)NCBImm8
Celera1585,689,315 - 85,701,021 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1539.4NCBI
Tspo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27114,720,188 - 114,730,450 (+)NCBI
Rnor_6.0 Ensembl7124,460,358 - 124,470,609 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07124,460,358 - 124,470,610 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07124,449,361 - 124,459,090 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47121,597,084 - 121,599,342 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17121,631,313 - 121,633,572 (+)NCBI
Celera7111,031,561 - 111,041,788 (+)NCBICelera
RH 3.4 Map7906.4RGD
Cytogenetic Map7q34NCBI
Tspo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541328,308,658 - 28,315,075 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541328,309,105 - 28,315,075 (+)NCBIChiLan1.0ChiLan1.0
TSPO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12242,233,186 - 42,244,930 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2242,233,619 - 42,244,930 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02224,034,918 - 24,046,370 (+)NCBIMhudiblu_PPA_v0panPan3
TSPO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1022,274,405 - 22,399,297 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11022,388,498 - 22,399,329 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Tspo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936718992,301 - 995,172 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSPO
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11925,678,602 - 25,690,556 (+)NCBI
ChlSab1.1 Ensembl1925,686,981 - 25,690,768 (+)Ensembl
Tspo
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247525,814,784 - 5,820,250 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 2 5 2 3
Low 2 2 3 2 17 2 1
Below cutoff 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000000035   ⟹   ENSSSCP00000000035
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl55,723,187 - 5,735,128 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000058616   ⟹   ENSSSCP00000046941
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl55,723,186 - 5,725,066 (-)Ensembl
RefSeq Acc Id: NM_213753   ⟹   NP_998918
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.155,723,190 - 5,735,097 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_998918 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAQ72807 (Get FASTA)   NCBI Sequence Viewer  
  AAR30250 (Get FASTA)   NCBI Sequence Viewer  
  AAT66938 (Get FASTA)   NCBI Sequence Viewer  
  Q6UN27 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_998918   ⟸   NM_213753
- UniProtKB: Q6UN27 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000046941   ⟸   ENSSSCT00000058616
RefSeq Acc Id: ENSSSCP00000000035   ⟸   ENSSSCT00000000035


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000000033 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025012766 UniProtKB/Swiss-Prot
  ENSSSCG00035024827 UniProtKB/Swiss-Prot
  ENSSSCG00045008320 UniProtKB/Swiss-Prot
Ensembl Protein ENSSSCP00000000035 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000046941 UniProtKB/TrEMBL
  ENSSSCP00025006754 UniProtKB/Swiss-Prot
  ENSSSCP00035012859 UniProtKB/Swiss-Prot
  ENSSSCP00045009709 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000000035 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000058616 UniProtKB/TrEMBL
  ENSSSCT00025016911 UniProtKB/Swiss-Prot
  ENSSSCT00035032659 UniProtKB/Swiss-Prot
  ENSSSCT00045014035 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1260.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro TSPO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TspO/MBR-related_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TspO_MBR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:396592 UniProtKB/Swiss-Prot
NCBI Gene TSPO ENTREZGENE
PANTHER PTHR10057 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10057:SF5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TspO_MBR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF PBR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A287AS84_PIG UniProtKB/TrEMBL
  F1SJR8_PIG UniProtKB/TrEMBL
  Q6UN27 ENTREZGENE, UniProtKB/Swiss-Prot