ANXA1 (annexin A1) - Rat Genome Database

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Gene: ANXA1 (annexin A1) Sus scrofa
Analyze
Symbol: ANXA1
Name: annexin A1
RGD ID: 13997432
Description: ENCODES a protein that exhibits calcium ion binding; calcium-dependent phospholipid binding; DNA/DNA annealing activity (ortholog); INVOLVED IN actin cytoskeleton reorganization (ortholog); arachidonic acid secretion (ortholog); cell surface receptor signaling pathway (ortholog); PARTICIPATES IN cyclooxygenase mediated pathway of arachidonic acid metabolism; ASSOCIATED WITH acute kidney failure (ortholog); Animal Mammary Neoplasms (ortholog); asthma (ortholog); FOUND IN early endosome membrane; extrinsic component of endosome membrane; actin filament (ortholog); INTERACTS WITH bis(2-chloroethyl) sulfide
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: annexin I; annexin-1; ANX1; calpactin II; calpactin-2; chromobindin-9; lipocortin I; p35; phospholipase A2 inhibitory protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1226,414,306 - 226,432,279 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11226,414,200 - 226,431,963 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21252,989,694 - 253,007,485 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Animal Mammary Neoplasms  (ISO)
asthma  (ISO)
autistic disorder  (ISO)
Blister  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
cataract  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
colitis  (ISO)
contact dermatitis  (ISO)
COVID-19  (ISO)
Craniofacial Abnormalities  (ISO)
Delayed Hypersensitivity  (ISO)
Discoid Lupus Erythematosus  (ISO)
dry eye syndrome  (ISO)
ductal carcinoma in situ  (ISO)
encephalitis  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
genetic disease  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
hypothyroidism  (ISO)
Inflammation  (ISO)
invasive ductal carcinoma  (ISO)
ischemia  (ISO)
keratosis follicularis  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
lung adenocarcinoma  (ISO)
Lymphatic Metastasis  (ISO)
malignant astrocytoma  (ISO)
Mouth Neoplasms  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Ocular Toxoplasmosis  (ISO)
pancreatic cancer  (ISO)
paranasal sinus benign neoplasm  (ISO)
pleurisy  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
pulmonary fibrosis  (ISO)
renal cell carcinoma  (ISO)
Rhinosinusitis  (ISO)
seborrheic keratosis  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
stomach disease  (ISO)
transitional cell carcinoma  (ISO)
uveitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton reorganization  (IBA,IEA,ISS)
adaptive immune response  (IEA)
alpha-beta T cell differentiation  (IBA,IEA)
arachidonic acid secretion  (IBA,IEA,ISO)
cell surface receptor signaling pathway  (IBA,ISO)
cellular response to glucocorticoid stimulus  (IBA,IEA,ISS)
cellular response to hydrogen peroxide  (IBA,ISO)
cellular response to vascular endothelial growth factor stimulus  (IBA,IEA)
DNA duplex unwinding  (IBA,ISO)
endocrine pancreas development  (IBA,ISO)
estrous cycle  (IBA,ISO)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  (IEA,ISS)
gliogenesis  (IBA,ISO)
granulocyte chemotaxis  (IBA,IEA,ISS)
hepatocyte differentiation  (IBA,ISO)
immune system process  (IEA)
inflammatory response  (IBA)
inflammatory response  (IBA,IEA)
inflammatory response  (ISS)
inflammatory response  (ISS)
innate immune response  (IEA)
insulin secretion  (IBA,ISO)
keratinocyte differentiation  (IBA,IEA)
localization  (ISO)
monocyte chemotaxis  (IEA,ISS)
myoblast migration involved in skeletal muscle regeneration  (IBA,IEA)
negative regulation of catalytic activity  (IEA)
negative regulation of exocytosis  (IBA,IEA,ISS)
negative regulation of interleukin-8 production  (IEA)
negative regulation of phospholipase A2 activity  (IBA,ISO)
negative regulation of protein secretion  (ISO)
negative regulation of T-helper 2 cell differentiation  (IBA,IEA,ISS)
neutrophil activation  (IEA,ISS)
neutrophil clearance  (IBA,IEA)
neutrophil homeostasis  (IEA)
peptide cross-linking  (IEA)
phagocytosis  (IEA,ISS)
positive regulation of apoptotic process  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (IBA,IEA)
positive regulation of G1/S transition of mitotic cell cycle  (IBA,IEA,ISO)
positive regulation of interleukin-2 production  (IBA,IEA,ISS)
positive regulation of neutrophil apoptotic process  (IBA,IEA)
positive regulation of prostaglandin biosynthetic process  (IBA,ISO)
positive regulation of T cell proliferation  (IBA,IEA,ISS)
positive regulation of T-helper 1 cell differentiation  (IBA,IEA,ISS)
positive regulation of vesicle fusion  (IBA,IEA)
positive regulation of wound healing  (IBA,IEA,ISS)
prolactin secretion  (IBA,ISO)
prostate gland development  (IBA,ISO)
regulation of cell population proliferation  (IEA,ISO)
regulation of cell shape  (IBA,IEA,ISS)
regulation of hormone secretion  (IBA)
regulation of hormone secretion  (IBA,IEA)
regulation of hormone secretion  (ISS)
regulation of hormone secretion  (ISS)
regulation of inflammatory response  (IBA)
regulation of inflammatory response  (IBA,IEA)
regulation of inflammatory response  (ISS)
regulation of inflammatory response  (ISS)
regulation of interleukin-1 production  (IBA,IEA,ISS)
regulation of leukocyte migration  (IBA,IEA,ISS)
response to corticosteroid  (ISO)
response to estradiol  (IBA,ISO)
response to glucocorticoid  (ISO)
response to hormone  (ISO)
response to interleukin-1  (IBA,ISO)
response to organic cyclic compound  (ISO)
response to peptide hormone  (IBA,ISO)
response to X-ray  (IBA,ISO)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:3020049   PMID:8885232   PMID:11178908   PMID:12595246   PMID:14681463   PMID:15544840   PMID:15679890   PMID:17145712   PMID:25204809  


Genomics

Comparative Map Data
ANXA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1226,414,306 - 226,432,279 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11226,414,200 - 226,431,963 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21252,989,694 - 253,007,485 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ANXA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38973,151,865 - 73,170,393 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl973,151,865 - 73,170,393 (+)EnsemblGRCh38hg38GRCh38
GRCh37975,766,781 - 75,785,309 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36974,956,601 - 74,975,127 (+)NCBINCBI36Build 36hg18NCBI36
Build 34972,996,334 - 73,014,861NCBI
Celera946,339,417 - 46,357,944 (+)NCBICelera
Cytogenetic Map9q21.13ENTREZGENE
HuRef945,589,147 - 45,607,684 (+)NCBIHuRef
CHM1_1975,913,630 - 75,932,174 (+)NCBICHM1_1
T2T-CHM13v2.0985,303,301 - 85,321,829 (+)NCBIT2T-CHM13v2.0
Anxa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391920,350,798 - 20,368,035 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1920,350,792 - 20,368,308 (-)EnsemblGRCm39 Ensembl
GRCm381920,373,434 - 20,390,671 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1920,373,428 - 20,390,944 (-)EnsemblGRCm38mm10GRCm38
MGSCv371920,447,924 - 20,465,161 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361920,440,455 - 20,457,696 (-)NCBIMGSCv36mm8
Celera1921,098,423 - 21,115,607 (-)NCBICelera
Cytogenetic Map19BNCBI
cM Map1913.83NCBI
Anxa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21217,861,175 - 217,877,205 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1217,861,175 - 217,877,343 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1226,201,607 - 226,217,642 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01233,138,171 - 233,154,203 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01225,956,194 - 225,972,229 (-)NCBIRnor_WKY
Rnor_6.01237,893,983 - 237,910,002 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1237,893,966 - 237,910,012 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01245,192,875 - 245,220,057 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,478,436 - 223,494,455 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11223,642,460 - 223,658,478 (-)NCBI
Celera1215,138,950 - 215,154,969 (-)NCBICelera
Cytogenetic Map1q51NCBI
Anxa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555125,686,508 - 5,703,645 (-)NCBIChiLan1.0ChiLan1.0
ANXA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1971,930,148 - 71,948,779 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl971,929,728 - 71,948,779 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0951,647,404 - 51,665,990 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ANXA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1184,744,159 - 84,763,011 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl184,744,163 - 84,763,011 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha185,210,169 - 85,229,021 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0185,194,249 - 85,213,101 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl185,194,253 - 85,213,101 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1184,963,509 - 84,982,291 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0184,666,120 - 84,684,901 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0185,425,388 - 85,444,242 (-)NCBIUU_Cfam_GSD_1.0
Anxa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947132,030,632 - 132,048,702 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365039,124,264 - 9,142,413 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365039,124,314 - 9,142,372 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANXA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11284,207,818 - 84,226,438 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1284,207,820 - 84,226,562 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603872,640,484 - 72,659,219 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Anxa1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624811764,940 - 782,198 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624811765,338 - 782,203 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 9 1 4 1 5 3 3
Low 1 3 3 1 1 18 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000005802   ⟹   ENSSSCP00000005658
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1226,414,306 - 226,432,279 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000033404   ⟹   ENSSSCP00000028670
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1226,414,307 - 226,431,962 (+)Ensembl
RefSeq Acc Id: NM_001163998   ⟹   NP_001157470
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11226,414,200 - 226,431,963 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001157470 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA64477 (Get FASTA)   NCBI Sequence Viewer  
  P19619 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001157470   ⟸   NM_001163998
- UniProtKB: Q29547 (UniProtKB/Swiss-Prot),   P19619 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000005658   ⟸   ENSSSCT00000005802
RefSeq Acc Id: ENSSSCP00000028670   ⟸   ENSSSCT00000033404


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000005267 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005038672 UniProtKB/TrEMBL
  ENSSSCG00015080686 UniProtKB/TrEMBL
  ENSSSCG00040061965 UniProtKB/TrEMBL
  ENSSSCG00050026182 UniProtKB/TrEMBL
  ENSSSCG00055028242 UniProtKB/TrEMBL
  ENSSSCG00060023603 UniProtKB/TrEMBL
  ENSSSCG00070028526 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000005658 ENTREZGENE
  ENSSSCP00000005658.3 UniProtKB/TrEMBL
  ENSSSCP00000028670.2 UniProtKB/TrEMBL
  ENSSSCP00005038253.1 UniProtKB/TrEMBL
  ENSSSCP00005038305.1 UniProtKB/TrEMBL
  ENSSSCP00015046763.1 UniProtKB/TrEMBL
  ENSSSCP00015046770.1 UniProtKB/TrEMBL
  ENSSSCP00015046773.1 UniProtKB/TrEMBL
  ENSSSCP00015046778.1 UniProtKB/TrEMBL
  ENSSSCP00040036788.1 UniProtKB/TrEMBL
  ENSSSCP00040036863.1 UniProtKB/TrEMBL
  ENSSSCP00050014659.1 UniProtKB/TrEMBL
  ENSSSCP00055044699.1 UniProtKB/TrEMBL
  ENSSSCP00055044750.1 UniProtKB/TrEMBL
  ENSSSCP00060013715.1 UniProtKB/TrEMBL
  ENSSSCP00060013726.1 UniProtKB/TrEMBL
  ENSSSCP00070048641.1 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000005802 ENTREZGENE
  ENSSSCT00000005802.5 UniProtKB/TrEMBL
  ENSSSCT00000033404.4 UniProtKB/TrEMBL
  ENSSSCT00005061847.1 UniProtKB/TrEMBL
  ENSSSCT00005061918.1 UniProtKB/TrEMBL
  ENSSSCT00015109795.1 UniProtKB/TrEMBL
  ENSSSCT00015109805.1 UniProtKB/TrEMBL
  ENSSSCT00015109810.1 UniProtKB/TrEMBL
  ENSSSCT00015109821.1 UniProtKB/TrEMBL
  ENSSSCT00040084358.1 UniProtKB/TrEMBL
  ENSSSCT00040084489.1 UniProtKB/TrEMBL
  ENSSSCT00050035242.1 UniProtKB/TrEMBL
  ENSSSCT00055055974.1 UniProtKB/TrEMBL
  ENSSSCT00055056034.1 UniProtKB/TrEMBL
  ENSSSCT00060032010.1 UniProtKB/TrEMBL
  ENSSSCT00060032034.1 UniProtKB/TrEMBL
  ENSSSCT00070057215.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.220.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Annexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Annexin_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Annexin_repeat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Annexin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANX1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:396942 UniProtKB/Swiss-Prot
NCBI Gene ANXA1 ENTREZGENE
PANTHER ANNEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10502:SF17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Annexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ANNEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANNEXINI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANNEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANNEXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ANX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47874 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1W3B6_PIG UniProtKB/TrEMBL
  A0A8D0K5U3_PIG UniProtKB/TrEMBL
  A0A8D0QBT0_PIG UniProtKB/TrEMBL
  A0A8D1UD24_PIG UniProtKB/TrEMBL
  ANXA1_PIG UniProtKB/Swiss-Prot
  F1SJB5_PIG UniProtKB/TrEMBL
  K7GLE1_PIG UniProtKB/TrEMBL
  P19619 ENTREZGENE
  Q29547 ENTREZGENE
UniProt Secondary Q29547 UniProtKB/Swiss-Prot
VGNC ID VGNC:103026 ENTREZGENE