CASP8 (caspase 8) - Rat Genome Database
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Gene: CASP8 (caspase 8) Sus scrofa
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Symbol: CASP8
Name: caspase 8
RGD ID: 14187349
Description: ENCODES a protein that exhibits cysteine-type endopeptidase activity (ortholog); cysteine-type endopeptidase activity involved in apoptotic process (ortholog); death receptor binding (ortholog); INVOLVED IN activation of cysteine-type endopeptidase activity involved in apoptotic process (ortholog); angiogenesis (ortholog); apoptotic process (ortholog); PARTICIPATES IN ceramide signaling pathway; extrinsic apoptotic pathway; FasL mediated signaling pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); Acute Lung Injury (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN CD95 death-inducing signaling complex (ortholog); cell body (ortholog); cytoplasm (ortholog); INTERACTS WITH 3-methyladenine; ATP; cilastatin
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: caspase 8, apoptosis-related cysteine peptidase; caspase-8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15104,923,953 - 104,948,470 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115104,923,659 - 104,948,470 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215116,337,232 - 116,340,859 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
acute lymphoblastic leukemia  (ISO)
adenocarcinoma  (ISO)
Alcohol-Related Disorders  (ISO)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (ISO)
autoimmune disease  (ISO)
autoimmune lymphoproliferative syndrome  (ISO)
autoimmune lymphoproliferative syndrome type 2B  (ISO)
bacterial infectious disease  (ISO)
Brain Contusion  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Bronchopulmonary Dysplasia  (ISO)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chronic obstructive pulmonary disease  (ISO)
Colorectal Neoplasms  (ISO)
contact dermatitis  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
dilated cardiomyopathy  (ISO)
Edema  (ISO)
Esophageal Neoplasms  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Familial Prostate Cancer  (ISO)
head and neck squamous cell carcinoma  (ISO)
heart disease  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
Huntington's disease  (ISO)
hyperglycemia  (ISO)
hypertension  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
Insulin Resistance  (ISO)
kidney disease  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
melanoma  (ISO)
mitochondrial metabolism disease  (ISO)
Myocardial Reperfusion Injury  (ISO)
nephritis  (ISO)
Neurodevelopmental Disorders  (ISO)
Osteoarthritis, Experimental  (ISO)
pancreatic cancer  (ISO)
papillomavirus infectious disease  (ISO)
pre-malignant neoplasm  (ISO)
primary immunodeficiency disease  (ISO)
Pulmonary Arterial Hypertension  (ISO)
Radiation Injuries, Experimental  (ISO)
Reperfusion Injury  (ISO)
retinal detachment  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
Skin Neoplasms  (ISO)
status epilepticus  (ISO)
Stomach Neoplasms  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Uterine Cervical Neoplasms  (ISO)
Viral Myocarditis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity  (IEA)
activation of cysteine-type endopeptidase activity involved in apoptotic process  (IBA,ISO)
angiogenesis  (ISO)
apoptotic process  (IBA,IEA,ISO)
apoptotic signaling pathway  (ISO)
cellular response to mechanical stimulus  (IEA)
cellular response to organic cyclic compound  (ISO)
execution phase of apoptosis  (IEA,ISO)
extrinsic apoptotic signaling pathway  (ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (IBA,ISO)
heart development  (ISO)
hepatocyte apoptotic process  (ISO)
macrophage differentiation  (IBA,ISO)
negative regulation of I-kappaB kinase/NF-kappaB signaling  (IEA)
negative regulation of necroptotic process  (IEA,ISO)
neural tube formation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IEA)
positive regulation of interleukin-1 beta production  (IEA)
positive regulation of macrophage differentiation  (IEA)
positive regulation of neuron death  (ISO)
positive regulation of proteolysis  (ISO)
protein processing  (ISO)
proteolysis  (IEA,ISO)
proteolysis involved in cellular protein catabolic process  (IEA)
pyroptosis  (ISO)
regulation of apoptotic process  (IEA)
regulation of apoptotic signaling pathway  (ISO)
regulation of thymocyte apoptotic process  (ISO)
response to antibiotic  (ISO)
response to auditory stimulus  (ISO)
response to cobalt ion  (ISO)
response to cold  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to lipopolysaccharide  (ISO)
response to tumor necrosis factor  (IEA)
self proteolysis  (ISO)
TRAIL-activated apoptotic signaling pathway  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:14681463   PMID:17109142   PMID:17145712   PMID:17179649   PMID:17565448   PMID:19520150   PMID:26342830  


Genomics

Comparative Map Data
CASP8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15104,923,953 - 104,948,470 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115104,923,659 - 104,948,470 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215116,337,232 - 116,340,859 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CASP8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2201,233,443 - 201,287,711 (+)EnsemblGRCh38hg38GRCh38
GRCh382201,233,443 - 201,287,711 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372202,098,166 - 202,152,434 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362201,806,411 - 201,860,679 (+)NCBINCBI36hg18NCBI36
Build 342201,923,718 - 201,972,144NCBI
Celera2195,852,777 - 195,904,249 (+)NCBI
Cytogenetic Map2q33.1NCBI
HuRef2193,949,530 - 194,000,819 (+)NCBIHuRef
CHM1_12202,104,145 - 202,158,454 (+)NCBICHM1_1
Casp8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39158,834,398 - 58,886,662 (+)NCBIGRCm39mm39
GRCm39 Ensembl158,834,533 - 58,886,662 (+)Ensembl
GRCm38158,795,233 - 58,847,503 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl158,795,374 - 58,847,503 (+)EnsemblGRCm38mm10GRCm38
MGSCv37158,852,218 - 58,904,347 (+)NCBIGRCm37mm9NCBIm37
MGSCv36158,740,040 - 58,791,559 (+)NCBImm8
Celera159,314,392 - 59,366,511 (+)NCBICelera
Cytogenetic Map1C1.3NCBI
cM Map129.19NCBI
Casp8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2960,263,863 - 60,312,542 (+)NCBI
Rnor_6.0 Ensembl965,614,142 - 65,662,106 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0965,614,142 - 65,662,624 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0965,420,843 - 65,469,468 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4957,389,353 - 57,437,803 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1957,536,334 - 57,584,785 (+)NCBI
Celera957,705,001 - 57,753,027 (+)NCBICelera
Cytogenetic Map9q31NCBI
Casp8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955403322,555 - 347,053 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955403322,082 - 348,591 (-)NCBIChiLan1.0ChiLan1.0
CASP8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B206,645,803 - 206,696,468 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B206,669,544 - 206,696,468 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B88,490,611 - 88,542,132 (+)NCBIMhudiblu_PPA_v0panPan3
CASP8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3710,391,048 - 10,401,822 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13710,362,071 - 10,402,108 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Casp8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936726554,627 - 596,334 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASP8
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11086,888,654 - 86,944,159 (+)NCBI
ChlSab1.1 Ensembl1086,916,527 - 86,943,829 (+)Ensembl
Casp8
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624899427,064 - 450,931 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 1 2 1 1
Low 2 3 3 3 2 22 2 2 2
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000024231   ⟹   ENSSSCP00000026484
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15104,923,953 - 104,948,470 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000048730   ⟹   ENSSSCP00000044241
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15104,923,953 - 104,948,470 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000071759   ⟹   ENSSSCP00000070463
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15104,926,326 - 104,946,988 (+)Ensembl
RefSeq Acc Id: NM_001031779   ⟹   NP_001026949
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115104,926,357 - 104,948,177 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021074710   ⟹   XP_020930369
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115104,923,832 - 104,948,470 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021074712   ⟹   XP_020930371
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115104,923,659 - 104,948,470 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021074713   ⟹   XP_020930372
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115104,923,940 - 104,948,470 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021074714   ⟹   XP_020930373
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115104,923,659 - 104,948,470 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020930371   ⟸   XM_021074712
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020930373   ⟸   XM_021074714
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020930369   ⟸   XM_021074710
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020930372   ⟸   XM_021074713
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001026949   ⟸   NM_001031779
- UniProtKB: Q56VC3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000044241   ⟸   ENSSSCT00000048730
RefSeq Acc Id: ENSSSCP00000070463   ⟸   ENSSSCT00000071759
RefSeq Acc Id: ENSSSCP00000026484   ⟸   ENSSSCT00000024231
Protein Domains
CASPASE_P10   CASPASE_P20   DED


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000028157 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070022958 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000026484 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000044241 UniProtKB/TrEMBL
  ENSSSCP00000070463 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070038513 UniProtKB/TrEMBL
  ENSSSCP00070038514 UniProtKB/TrEMBL
  ENSSSCP00070038521 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000024231 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000048730 UniProtKB/TrEMBL
  ENSSSCT00000071759 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070045692 UniProtKB/TrEMBL
  ENSSSCT00070045694 UniProtKB/TrEMBL
  ENSSSCT00070045704 UniProtKB/TrEMBL
InterPro Caspase-8 UniProtKB/TrEMBL
  Caspase-like_dom_sf UniProtKB/TrEMBL
  Caspase_cys_AS UniProtKB/TrEMBL
  Caspase_his_AS UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  DED_dom UniProtKB/TrEMBL
  Pept_C14 UniProtKB/TrEMBL
  Pept_C14_p10 UniProtKB/TrEMBL
  Pept_C14_p20 UniProtKB/TrEMBL
  Pept_C14A UniProtKB/TrEMBL
KEGG Report ssc:595105 UniProtKB/TrEMBL
NCBI Gene CASP8 ENTREZGENE
PANTHER PTHR10454 UniProtKB/TrEMBL
  PTHR10454:SF162 UniProtKB/TrEMBL
Pfam DED UniProtKB/TrEMBL
PRINTS IL1BCENZYME UniProtKB/TrEMBL
PROSITE CASPASE_CYS UniProtKB/TrEMBL
  CASPASE_HIS UniProtKB/TrEMBL
  CASPASE_P10 UniProtKB/TrEMBL
  CASPASE_P20 UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
SMART CASc UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
  SSF52129 UniProtKB/TrEMBL
UniProt A0A287AK16_PIG UniProtKB/TrEMBL
  A0A4X1V6R2_PIG UniProtKB/TrEMBL
  A0A4X1VA27_PIG UniProtKB/TrEMBL
  A0A5G2R8L0_PIG UniProtKB/TrEMBL
  Q56VC3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary I3LQV2 UniProtKB/TrEMBL
VGNC ID VGNC:95639 ENTREZGENE