KNG1 (kininogen 1) - Rat Genome Database

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Gene: KNG1 (kininogen 1) Sus scrofa
Analyze
Symbol: KNG1
Name: kininogen 1
RGD ID: 13848418
Description: ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity (inferred); hormone activity (inferred); signaling receptor binding (inferred); INVOLVED IN negative regulation of blood coagulation (inferred); negative regulation of cell adhesion (inferred); negative regulation of proteolysis (inferred); PARTICIPATES IN kallikrein-kinin cascade pathway; kinin signaling pathway; syndecan signaling pathway; ASSOCIATED WITH 3MC syndrome 1 (ortholog); acquired angioedema (ortholog); acute kidney failure (ortholog); FOUND IN extracellular space (inferred); INTERACTS WITH benazepril; clofibrate; enalaprilat dihydrate
Type: protein-coding
RefSeq Status: MODEL
Previously known as: kininogen-1; KNG; low molecular weight kininogen
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13124,521,340 - 124,557,958 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113124,521,276 - 124,557,384 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213133,911,227 - 133,947,757 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:13679312   PMID:14681463   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KNG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13124,521,340 - 124,557,958 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113124,521,276 - 124,557,384 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213133,911,227 - 133,947,757 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KNG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383186,717,359 - 186,744,410 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3186,717,348 - 186,744,410 (+)EnsemblGRCh38hg38GRCh38
GRCh373186,435,148 - 186,462,199 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363187,917,814 - 187,944,437 (+)NCBINCBI36Build 36hg18NCBI36
Celera3184,871,536 - 184,898,662 (+)NCBICelera
Cytogenetic Map3q27.3NCBI
HuRef3183,844,775 - 183,871,713 (+)NCBIHuRef
CHM1_13186,399,036 - 186,425,781 (+)NCBICHM1_1
T2T-CHM13v2.03189,539,122 - 189,566,165 (+)NCBIT2T-CHM13v2.0
Kng2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391622,804,602 - 22,847,851 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1622,804,604 - 22,848,232 (-)EnsemblGRCm39 Ensembl
GRCm381622,985,852 - 23,029,101 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1622,985,854 - 23,029,482 (-)EnsemblGRCm38mm10GRCm38
MGSCv371622,985,925 - 23,029,174 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361622,902,680 - 22,944,351 (-)NCBIMGSCv36mm8
Celera1623,545,793 - 23,588,919 (-)NCBICelera
Cytogenetic Map16B1NCBI
cM Map1613.82NCBI
Kng2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,418,470 - 91,440,841 (+)NCBIGRCr8
mRatBN7.21177,913,876 - 77,936,247 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1177,909,612 - 78,002,971 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1186,664,319 - 86,686,690 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01179,302,200 - 79,324,460 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01178,378,641 - 78,401,008 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01181,509,185 - 81,516,759 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01184,605,412 - 84,612,986 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41180,109,499 - 80,131,887 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11180,167,317 - 80,189,475 (+)NCBI
Celera1176,789,106 - 76,811,459 (+)NCBICelera
Cytogenetic Map11q23NCBI
Kng1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542020,989,197 - 21,016,084 (-)NCBIChiLan1.0ChiLan1.0
KNG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22184,593,336 - 184,620,177 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13184,598,051 - 184,624,892 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03183,751,598 - 183,778,655 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13192,219,675 - 192,245,318 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3192,219,462 - 192,245,149 (+)Ensemblpanpan1.1panPan2
KNG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13419,288,629 - 19,318,096 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3419,287,109 - 19,318,081 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3423,373,992 - 23,403,581 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03419,199,856 - 19,229,431 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3419,199,904 - 19,229,419 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13419,231,763 - 19,260,578 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03419,231,843 - 19,260,884 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03419,460,203 - 19,488,753 (+)NCBIUU_Cfam_GSD_1.0
Kng1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602117,161,767 - 117,189,596 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365783,253,749 - 3,281,296 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365783,255,335 - 3,281,296 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KNG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11581,002,287 - 81,027,893 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604154,492,596 - 54,518,121 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kng1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473070,022,449 - 70,065,115 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KNG1
870 total Variants

Sequence


Ensembl Acc Id: ENSSSCT00000012914   ⟹   ENSSSCP00000012573
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13124,521,362 - 124,557,037 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000036812   ⟹   ENSSSCP00000043463
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13124,521,353 - 124,557,956 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000046736   ⟹   ENSSSCP00000051218
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13124,521,830 - 124,557,053 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000066840   ⟹   ENSSSCP00000069533
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13124,521,277 - 124,555,923 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000076765   ⟹   ENSSSCP00000061752
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13124,521,340 - 124,557,958 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000086155   ⟹   ENSSSCP00000059888
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13124,521,353 - 124,557,956 (+)Ensembl
RefSeq Acc Id: XM_003483288   ⟹   XP_003483336
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113124,521,282 - 124,557,384 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005652370   ⟹   XP_005652427
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113124,521,282 - 124,557,384 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013988208   ⟹   XP_013843662
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113124,521,276 - 124,557,382 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003483336 (Get FASTA)   NCBI Sequence Viewer  
  XP_005652427 (Get FASTA)   NCBI Sequence Viewer  
  XP_013843662 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAP85260 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000012573.4
  ENSSSCP00000043463
  ENSSSCP00000043463.1
  ENSSSCP00000051218.1
  ENSSSCP00000059888.1
  ENSSSCP00000061752
  ENSSSCP00000061752.2
  ENSSSCP00005036386.1
  ENSSSCP00025000508.1
  ENSSSCP00025000520.1
  ENSSSCP00025000528.1
  ENSSSCP00025000537.1
  ENSSSCP00025000549.1
  ENSSSCP00030007145.1
  ENSSSCP00030007151.1
  ENSSSCP00030007152.1
  ENSSSCP00030007155.1
  ENSSSCP00030007158.1
  ENSSSCP00035018738.1
  ENSSSCP00035018741.1
  ENSSSCP00035018742.1
  ENSSSCP00035018746.1
  ENSSSCP00035018750.1
  ENSSSCP00040040487.1
  ENSSSCP00040040560.1
  ENSSSCP00040040679.1
  ENSSSCP00040040742.1
  ENSSSCP00040040833.1
  ENSSSCP00040040891.1
  ENSSSCP00045037916.1
  ENSSSCP00045038046.1
  ENSSSCP00045038131.1
  ENSSSCP00045038218.1
  ENSSSCP00045038301.1
  ENSSSCP00050024244.1
  ENSSSCP00050024252.1
  ENSSSCP00050024255.1
  ENSSSCP00050024258.1
  ENSSSCP00050024260.1
  ENSSSCP00055027147.1
  ENSSSCP00055027241.1
  ENSSSCP00055027391.1
  ENSSSCP00055027438.1
  ENSSSCP00055027523.1
  ENSSSCP00055027614.1
  ENSSSCP00055027704.1
  ENSSSCP00060026620.1
  ENSSSCP00060026627.1
  ENSSSCP00060026630.1
  ENSSSCP00060026635.1
  ENSSSCP00060026639.1
  ENSSSCP00070027060.1
  ENSSSCP00070027079.1
  ENSSSCP00070027084.1
  ENSSSCP00070027097.1
  ENSSSCP00070027112.1
  ENSSSCP00070027117.1
RefSeq Acc Id: XP_013843662   ⟸   XM_013988208
- Peptide Label: isoform X1
- UniProtKB: A0A4X1UF91 (UniProtKB/TrEMBL),   A0A5G2QBB0 (UniProtKB/TrEMBL),   A0A480Y2E3 (UniProtKB/TrEMBL),   A0A8D1FQ18 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003483336   ⟸   XM_003483288
- Peptide Label: isoform X2
- UniProtKB: A0A287AHT8 (UniProtKB/TrEMBL),   A0A4X1UGH1 (UniProtKB/TrEMBL),   A0A8D0JZH4 (UniProtKB/TrEMBL),   A0A8D1IVL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005652427   ⟸   XM_005652370
- Peptide Label: isoform X3
- UniProtKB: A0A4X1UGH5 (UniProtKB/TrEMBL),   A0A8D0ZQV2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000069533   ⟸   ENSSSCT00000066840
Ensembl Acc Id: ENSSSCP00000061752   ⟸   ENSSSCT00000076765
Ensembl Acc Id: ENSSSCP00000059888   ⟸   ENSSSCT00000086155
Ensembl Acc Id: ENSSSCP00000043463   ⟸   ENSSSCT00000036812
Ensembl Acc Id: ENSSSCP00000012573   ⟸   ENSSSCT00000012914
Ensembl Acc Id: ENSSSCP00000051218   ⟸   ENSSSCT00000046736
Protein Domains
Cystatin kininogen-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000011802 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005036264 UniProtKB/TrEMBL
  ENSSSCG00025001291 UniProtKB/TrEMBL
  ENSSSCG00030011622 UniProtKB/TrEMBL
  ENSSSCG00035035363 UniProtKB/TrEMBL
  ENSSSCG00040067108 UniProtKB/TrEMBL
  ENSSSCG00045031870 UniProtKB/TrEMBL
  ENSSSCG00050041879 UniProtKB/TrEMBL
  ENSSSCG00055017387 UniProtKB/TrEMBL
  ENSSSCG00060045787 UniProtKB/TrEMBL
  ENSSSCG00070016413 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000012914.4 UniProtKB/TrEMBL
  ENSSSCT00000036812 ENTREZGENE
  ENSSSCT00000036812.3 UniProtKB/TrEMBL
  ENSSSCT00000046736.1 UniProtKB/TrEMBL
  ENSSSCT00000076765 ENTREZGENE
  ENSSSCT00000076765.2 UniProtKB/TrEMBL
  ENSSSCT00000086155.2 UniProtKB/TrEMBL
  ENSSSCT00005058930.1 UniProtKB/TrEMBL
  ENSSSCT00025001626.1 UniProtKB/TrEMBL
  ENSSSCT00025001666.1 UniProtKB/TrEMBL
  ENSSSCT00025001686.1 UniProtKB/TrEMBL
  ENSSSCT00025001715.1 UniProtKB/TrEMBL
  ENSSSCT00025001741.1 UniProtKB/TrEMBL
  ENSSSCT00030015948.1 UniProtKB/TrEMBL
  ENSSSCT00030015963.1 UniProtKB/TrEMBL
  ENSSSCT00030015966.1 UniProtKB/TrEMBL
  ENSSSCT00030015973.1 UniProtKB/TrEMBL
  ENSSSCT00030015978.1 UniProtKB/TrEMBL
  ENSSSCT00035046872.1 UniProtKB/TrEMBL
  ENSSSCT00035046880.1 UniProtKB/TrEMBL
  ENSSSCT00035046882.1 UniProtKB/TrEMBL
  ENSSSCT00035046891.1 UniProtKB/TrEMBL
  ENSSSCT00035046898.1 UniProtKB/TrEMBL
  ENSSSCT00040091767.1 UniProtKB/TrEMBL
  ENSSSCT00040091922.1 UniProtKB/TrEMBL
  ENSSSCT00040092197.1 UniProtKB/TrEMBL
  ENSSSCT00040092308.1 UniProtKB/TrEMBL
  ENSSSCT00040092497.1 UniProtKB/TrEMBL
  ENSSSCT00040092600.1 UniProtKB/TrEMBL
  ENSSSCT00045054448.1 UniProtKB/TrEMBL
  ENSSSCT00045054625.1 UniProtKB/TrEMBL
  ENSSSCT00045054732.1 UniProtKB/TrEMBL
  ENSSSCT00045054842.1 UniProtKB/TrEMBL
  ENSSSCT00045054950.1 UniProtKB/TrEMBL
  ENSSSCT00050056855.1 UniProtKB/TrEMBL
  ENSSSCT00050056865.1 UniProtKB/TrEMBL
  ENSSSCT00050056870.1 UniProtKB/TrEMBL
  ENSSSCT00050056878.1 UniProtKB/TrEMBL
  ENSSSCT00050056880.1 UniProtKB/TrEMBL
  ENSSSCT00055034168.1 UniProtKB/TrEMBL
  ENSSSCT00055034293.1 UniProtKB/TrEMBL
  ENSSSCT00055034482.1 UniProtKB/TrEMBL
  ENSSSCT00055034542.1 UniProtKB/TrEMBL
  ENSSSCT00055034662.1 UniProtKB/TrEMBL
  ENSSSCT00055034769.1 UniProtKB/TrEMBL
  ENSSSCT00055034880.1 UniProtKB/TrEMBL
  ENSSSCT00060062133.1 UniProtKB/TrEMBL
  ENSSSCT00060062152.1 UniProtKB/TrEMBL
  ENSSSCT00060062157.1 UniProtKB/TrEMBL
  ENSSSCT00060062168.1 UniProtKB/TrEMBL
  ENSSSCT00060062177.1 UniProtKB/TrEMBL
  ENSSSCT00070032418.1 UniProtKB/TrEMBL
  ENSSSCT00070032442.1 UniProtKB/TrEMBL
  ENSSSCT00070032449.1 UniProtKB/TrEMBL
  ENSSSCT00070032463.1 UniProtKB/TrEMBL
  ENSSSCT00070032481.1 UniProtKB/TrEMBL
  ENSSSCT00070032487.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.450.10 UniProtKB/TrEMBL
InterPro Cystatin_dom UniProtKB/TrEMBL
  Cystatin_sf UniProtKB/TrEMBL
  Kininogen UniProtKB/TrEMBL
  Kininogen-type_cystatin_dom UniProtKB/TrEMBL
  Kininogen_Fetuin_HRG UniProtKB/TrEMBL
KEGG Report ssc:396568 UniProtKB/TrEMBL
NCBI Gene KNG1 ENTREZGENE
PANTHER FETUIN UniProtKB/TrEMBL
  KININOGEN-1 UniProtKB/TrEMBL
Pfam Cystatin UniProtKB/TrEMBL
PRINTS KININOGEN UniProtKB/TrEMBL
PROSITE CYSTATIN_KININOGEN UniProtKB/TrEMBL
SMART SM00043 UniProtKB/TrEMBL
Superfamily-SCOP SSF54403 UniProtKB/TrEMBL
UniProt A0A287AHT8 ENTREZGENE, UniProtKB/TrEMBL
  A0A287B546_PIG UniProtKB/TrEMBL
  A0A480Y2E3 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UDI9_PIG UniProtKB/TrEMBL
  A0A4X1UF91 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UFA7_PIG UniProtKB/TrEMBL
  A0A4X1UGF5_PIG UniProtKB/TrEMBL
  A0A4X1UGH1 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UGH5 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2Q763_PIG UniProtKB/TrEMBL
  A0A5G2QBB0 ENTREZGENE
  A0A8D0JZH4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0QEN4_PIG UniProtKB/TrEMBL
  A0A8D0UFA3_PIG UniProtKB/TrEMBL
  A0A8D0UFA4_PIG UniProtKB/TrEMBL
  A0A8D0ZQV2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1FQ18 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1IVL5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1QVN2_PIG UniProtKB/TrEMBL
  A0A8D1R1V5_PIG UniProtKB/TrEMBL
  A0A8D1R6P3_PIG UniProtKB/TrEMBL
  A0A8D1VMJ2_PIG UniProtKB/TrEMBL
  F1SFI4_PIG UniProtKB/TrEMBL
UniProt Secondary A0A5G2QBB0 UniProtKB/TrEMBL
VGNC ID VGNC:89557 ENTREZGENE