DRD4 (dopamine receptor D4) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: DRD4 (dopamine receptor D4) Sus scrofa
Analyze
Symbol: DRD4
Name: dopamine receptor D4
RGD ID: 14296780
Description: ENCODES a protein that exhibits dopamine binding (ortholog); dopamine neurotransmitter receptor activity, coupled via Gi/Go (ortholog); heterocyclic compound binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting dopamine receptor signaling pathway (ortholog); adult locomotory behavior (ortholog); associative learning (ortholog); PARTICIPATES IN dopamine signaling pathway; dopamine signaling pathway via D2 family of receptors; excitatory synaptic transmission pathway; ASSOCIATED WITH alcohol use disorder (ortholog); alcohol withdrawal syndrome (ortholog); Alzheimer's disease (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); cell cortex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: D(4) dopamine receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2398,766 - 402,433 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12398,766 - 401,539 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22272,619 - 275,757 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting dopamine receptor signaling pathway  (IEA,ISO)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (IBA)
adult locomotory behavior  (IEA,ISO)
arachidonate secretion  (IEA)
associative learning  (ISO)
behavioral fear response  (ISO)
behavioral response to cocaine  (IEA,ISO)
chemical synaptic transmission  (IBA)
circadian rhythm  (ISO)
fear response  (IEA,ISO)
G protein-coupled dopamine receptor signaling pathway  (ISO)
G protein-coupled receptor signaling pathway  (IEA)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  (IBA)
G protein-coupled serotonin receptor signaling pathway  (IEA)
inhibitory postsynaptic potential  (IEA,ISO)
intracellular calcium ion homeostasis  (IEA)
modulation of inhibitory postsynaptic potential  (ISO)
negative regulation of protein secretion  (IEA)
negative regulation of synaptic transmission  (ISO)
negative regulation of synaptic transmission, GABAergic  (ISO)
negative regulation of vascular associated smooth muscle cell migration  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
olfactory learning  (ISO)
phospholipase C-activating dopamine receptor signaling pathway  (IEA)
photoperiodism  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of penile erection  (ISO)
prepulse inhibition  (ISO)
presynaptic modulation of chemical synaptic transmission  (ISO)
regulation of calcium-mediated signaling  (ISO)
regulation of circadian rhythm  (IEA)
regulation of dopamine metabolic process  (IEA,ISO)
regulation of neurotransmitter secretion  (ISO)
regulation of postsynaptic membrane neurotransmitter receptor levels  (ISO)
regulation of postsynaptic neurotransmitter receptor internalization  (IEA)
regulation of protein kinase A signaling  (ISO)
response to amphetamine  (IEA,ISO)
response to epinephrine  (ISO)
response to ethanol  (ISO)
response to histamine  (IEA)
response to light stimulus  (ISO)
response to steroid hormone  (ISO)
response to thyroid hormone  (ISO)
retina development in camera-type eye  (ISO)
short-term memory  (ISO)
synaptic transmission, dopaminergic  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DRD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2398,766 - 402,433 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12398,766 - 401,539 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22272,619 - 275,757 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DRD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811637,269 - 640,706 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11637,269 - 640,706 (+)EnsemblGRCh38hg38GRCh38
GRCh3711637,269 - 640,706 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611627,305 - 630,703 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411627,304 - 630,703NCBI
Celera11702,422 - 705,821 (+)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef11452,513 - 456,039 (+)NCBIHuRef
CHM1_111636,234 - 639,634 (+)NCBICHM1_1
T2T-CHM13v2.011685,792 - 689,369 (+)NCBIT2T-CHM13v2.0
Drd4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,871,931 - 140,874,868 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7140,871,919 - 140,876,377 (+)EnsemblGRCm39 Ensembl
GRCm387141,291,974 - 141,296,464 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,292,006 - 141,296,464 (+)EnsemblGRCm38mm10GRCm38
MGSCv377148,477,905 - 148,480,900 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367141,143,326 - 141,146,321 (+)NCBIMGSCv36mm8
Celera7141,085,754 - 141,088,749 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map786.6NCBI
Drd4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,825,937 - 205,829,124 (+)NCBIGRCr8
mRatBN7.21196,396,366 - 196,400,824 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,396,366 - 196,399,553 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1204,741,809 - 204,744,982 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,868,591 - 211,871,768 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,542,729 - 204,545,906 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01214,278,296 - 214,282,818 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,278,296 - 214,281,483 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,195,844 - 221,200,366 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,485,597 - 201,488,784 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11201,636,931 - 201,640,119 (+)NCBI
Celera1194,030,237 - 194,033,424 (+)NCBICelera
RH 3.4 Map11437.21RGD
Cytogenetic Map1q41NCBI
Drd4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,424,411 - 11,426,960 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547611,424,347 - 11,426,962 (-)NCBIChiLan1.0ChiLan1.0
DRD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v293,007,058 - 3,019,627 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,222,678 - 2,235,881 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011640,401 - 646,775 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111671,445 - 674,412 (+)NCBIpanpan1.1PanPan1.1panPan2
DRD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha1825,378,476 - 25,381,179 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01826,314,100 - 26,316,803 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1826,314,085 - 26,316,803 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11825,823,586 - 25,826,358 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01825,468,566 - 25,471,386 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01826,081,003 - 26,083,706 (+)NCBIUU_Cfam_GSD_1.0
Drd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947468,387 - 471,254 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936888468,403 - 471,205 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936888468,334 - 471,254 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DRD4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11454,018 - 459,582 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603897,516,746 - 97,520,656 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Drd4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476621,834,169 - 21,836,710 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476621,834,093 - 21,837,314 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DRD4
41 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
mesenchyme
1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003122390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSSCT00000014046   ⟹   ENSSSCP00000013661
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2398,766 - 402,433 (+)Ensembl
RefSeq Acc Id: XM_003122390   ⟹   XP_003122438
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12398,766 - 401,539 (+)NCBI
Sequence:
RefSeq Acc Id: XP_003122438   ⟸   XM_003122390
- UniProtKB: A0A8D1B3J8 (UniProtKB/TrEMBL),   A0A8D1M3K9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000013661   ⟸   ENSSSCT00000014046

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000012851 Ensembl, UniProtKB/TrEMBL
  ENSSSCG00030035348 UniProtKB/TrEMBL
  ENSSSCG00035067104 UniProtKB/TrEMBL
  ENSSSCG00040033400 UniProtKB/TrEMBL
  ENSSSCG00045012942 UniProtKB/TrEMBL
  ENSSSCG00050032161 UniProtKB/TrEMBL
  ENSSSCG00060044055 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000014046.4 UniProtKB/TrEMBL
  ENSSSCT00030049055.1 UniProtKB/TrEMBL
  ENSSSCT00030049086.1 UniProtKB/TrEMBL
  ENSSSCT00035090508.1 UniProtKB/TrEMBL
  ENSSSCT00035090519.1 UniProtKB/TrEMBL
  ENSSSCT00040045047.1 UniProtKB/TrEMBL
  ENSSSCT00040045088.1 UniProtKB/TrEMBL
  ENSSSCT00045022076.1 UniProtKB/TrEMBL
  ENSSSCT00050043199.1 UniProtKB/TrEMBL
  ENSSSCT00050043203.1 UniProtKB/TrEMBL
  ENSSSCT00060059754.1 UniProtKB/TrEMBL
  ENSSSCT00060059763.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro Dopamine_D4_rcpt UniProtKB/TrEMBL
  Dopamine_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
NCBI Gene DRD4 ENTREZGENE
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  PTHR24248:SF143 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS DOPAMINED4R UniProtKB/TrEMBL
  DOPAMINER UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8D1B3J8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1C6V6_PIG UniProtKB/TrEMBL
  A0A8D1HC05_PIG UniProtKB/TrEMBL
  A0A8D1M3K9 ENTREZGENE, UniProtKB/TrEMBL
  F1RYX4_PIG UniProtKB/TrEMBL
VGNC ID VGNC:87446 ENTREZGENE