PDE5A (phosphodiesterase 5A) - Rat Genome Database
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Gene: PDE5A (phosphodiesterase 5A) Sus scrofa
Analyze
Symbol: PDE5A
Name: phosphodiesterase 5A
RGD ID: 14012509
Description: ENCODES a protein that exhibits 3',5'-cyclic-GMP phosphodiesterase activity (ortholog); 3',5'-cyclic-nucleotide phosphodiesterase activity (ortholog); cGMP binding (ortholog); INVOLVED IN cGMP catabolic process (ortholog); cGMP metabolic process (ortholog); negative regulation of cardiac muscle contraction (ortholog); ASSOCIATED WITH Cardiomegaly (ortholog); Experimental Diabetes Mellitus (ortholog); Hearing Loss (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH 3',5'-cyclic GMP
Type: protein-coding
RefSeq Status: MODEL
Also known as: cGMP-dependent 3',5'-cyclic phosphodiesterase 5A; cGMP-specific 3',5'-cyclic phosphodiesterase; PDE5; phosphodiesterase isozyme 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8104,270,881 - 104,420,947 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18104,270,858 - 104,420,955 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28111,948,578 - 112,077,533 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:10393044   PMID:15295092   PMID:22312057   PMID:24414253   PMID:24464751  


Genomics

Comparative Map Data
PDE5A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8104,270,881 - 104,420,947 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18104,270,858 - 104,420,955 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28111,948,578 - 112,077,533 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDE5A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4119,494,397 - 119,628,804 (-)EnsemblGRCh38hg38GRCh38
GRCh384119,494,403 - 119,628,804 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374120,415,558 - 120,549,959 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh374120,415,550 - 120,549,981 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364120,634,998 - 120,769,429 (-)NCBINCBI36hg18NCBI36
Build 344120,777,035 - 120,907,578NCBI
Celera4117,795,077 - 117,929,505 (-)NCBI
Cytogenetic Map4q26NCBI
HuRef4116,136,584 - 116,271,133 (-)NCBIHuRef
CHM1_14120,392,140 - 120,526,523 (-)NCBICHM1_1
Pde5a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393122,522,807 - 122,653,023 (+)NCBIGRCm39mm39
GRCm383122,729,158 - 122,859,374 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3122,728,947 - 122,859,374 (+)EnsemblGRCm38mm10GRCm38
MGSCv373122,432,076 - 122,562,292 (+)NCBIGRCm37mm9NCBIm37
MGSCv363122,721,209 - 122,848,174 (+)NCBImm8
Celera3129,135,905 - 129,269,158 (+)NCBICelera
Cytogenetic Map3G1NCBI
Pde5a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22210,858,515 - 211,003,480 (+)NCBI
Rnor_6.0 Ensembl2226,900,619 - 227,041,576 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02226,899,604 - 227,044,916 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02246,260,843 - 246,406,296 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42219,410,394 - 219,550,910 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12219,373,455 - 219,513,972 (+)NCBI
Celera2203,287,460 - 203,425,472 (+)NCBICelera
Cytogenetic Map2q42NCBI
Pde5a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542820,785,423 - 20,904,717 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542820,785,497 - 20,904,717 (+)NCBIChiLan1.0ChiLan1.0
PDE5A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14122,832,175 - 122,966,636 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4122,832,175 - 122,966,636 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04111,682,772 - 111,817,234 (-)NCBIMhudiblu_PPA_v0panPan3
PDE5A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3238,244,338 - 38,407,522 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13238,272,573 - 38,407,517 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Pde5a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493686924,265 - 117,120 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE5A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1766,826,316 - 66,955,220 (-)NCBI
ChlSab1.1 Ensembl766,826,315 - 66,955,036 (-)Ensembl
Pde5a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462496411,085 - 126,027 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 3 2 5 2
Low 4 3 2 18 2 1 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000041263   ⟹   ENSSSCP00000049522
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8104,272,626 - 104,420,943 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000053509   ⟹   ENSSSCP00000050898
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8104,272,600 - 104,420,946 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000055154   ⟹   ENSSSCP00000036046
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8104,270,881 - 104,420,947 (+)Ensembl
RefSeq Acc Id: XM_021101648   ⟹   XP_020957307
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18104,270,858 - 104,420,955 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021101649   ⟹   XP_020957308
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18104,271,935 - 104,420,955 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021101650   ⟹   XP_020957309
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18104,271,395 - 104,420,955 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021101652   ⟹   XP_020957311
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18104,270,881 - 104,420,920 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021101653   ⟹   XP_020957312
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18104,272,586 - 104,420,920 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021101654   ⟹   XP_020957313
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18104,271,851 - 104,420,920 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020957307   ⟸   XM_021101648
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020957311   ⟸   XM_021101652
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_020957309   ⟸   XM_021101650
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020957313   ⟸   XM_021101654
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_020957308   ⟸   XM_021101649
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020957312   ⟸   XM_021101653
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSSSCP00000049522   ⟸   ENSSSCT00000041263
RefSeq Acc Id: ENSSSCP00000036046   ⟸   ENSSSCT00000055154
RefSeq Acc Id: ENSSSCP00000050898   ⟸   ENSSSCT00000053509
Protein Domains
PDEase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000009106 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070022399 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000036046 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000049522 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000050898 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070037624 UniProtKB/TrEMBL
  ENSSSCP00070037628 UniProtKB/TrEMBL
  ENSSSCP00070037636 UniProtKB/TrEMBL
  ENSSSCP00070037644 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000041263 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000053509 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000055154 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070044658 UniProtKB/TrEMBL
  ENSSSCT00070044662 UniProtKB/TrEMBL
  ENSSSCT00070044670 UniProtKB/TrEMBL
  ENSSSCT00070044678 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1300.10 UniProtKB/TrEMBL
  3.30.450.40 UniProtKB/TrEMBL
InterPro GAF UniProtKB/TrEMBL
  GAF-like_dom_sf UniProtKB/TrEMBL
  HD/PDEase_dom UniProtKB/TrEMBL
  PDEase UniProtKB/TrEMBL
  PDEase_catalytic_dom UniProtKB/TrEMBL
  PDEase_catalytic_dom_sf UniProtKB/TrEMBL
  PDEase_CS UniProtKB/TrEMBL
NCBI Gene PDE5A ENTREZGENE
Pfam GAF UniProtKB/TrEMBL
  PDEase_I UniProtKB/TrEMBL
PRINTS PDIESTERASE1 UniProtKB/TrEMBL
PROSITE PDEASE_I_1 UniProtKB/TrEMBL
  PDEASE_I_2 UniProtKB/TrEMBL
SMART GAF UniProtKB/TrEMBL
  HDc UniProtKB/TrEMBL
UniProt A0A286ZX07_PIG UniProtKB/TrEMBL
  A0A287AZD4_PIG UniProtKB/TrEMBL
  A0A287B475_PIG UniProtKB/TrEMBL
  A0A4X1V4E8_PIG UniProtKB/TrEMBL
  A0A4X1V8Q8_PIG UniProtKB/TrEMBL
  A0A4X1V8S9_PIG UniProtKB/TrEMBL
  A0A4X1VA09_PIG UniProtKB/TrEMBL
VGNC ID VGNC:91257 ENTREZGENE