A2M (alpha-2-macroglobulin) - Rat Genome Database

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Gene: A2M (alpha-2-macroglobulin) Sus scrofa
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Symbol: A2M
Name: alpha-2-macroglobulin
RGD ID: 14141026
Description: ENCODES a protein that exhibits brain-derived neurotrophic factor binding (ortholog); endopeptidase inhibitor activity (ortholog); enzyme binding (ortholog); INVOLVED IN acute inflammatory response to antigenic stimulus (ortholog); acute-phase response (ortholog); embryonic liver development (ortholog); PARTICIPATES IN Alzheimer's disease pathway; immune response pathway; inflammatory response pathway; ASSOCIATED WITH acute kidney failure (ortholog); Alzheimer's disease (ortholog); Alzheimer's disease 1 (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl562,438,017 - 62,485,537 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1562,406,928 - 62,483,690 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2565,274,903 - 65,320,342 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:19688730  


Genomics

Comparative Map Data
A2M
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl562,438,017 - 62,485,537 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1562,406,928 - 62,483,690 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2565,274,903 - 65,320,342 (+)NCBISscrofa10.2Sscrofa10.2susScr3
A2M
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl129,067,664 - 9,116,229 (-)EnsemblGRCh38hg38GRCh38
GRCh38129,067,708 - 9,116,229 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37129,220,304 - 9,268,825 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36129,111,571 - 9,159,825 (-)NCBINCBI36hg18NCBI36
Build 34129,111,576 - 9,159,754NCBI
Celera1210,757,430 - 10,805,676 (-)NCBI
Cytogenetic Map12p13.31NCBI
HuRef129,000,837 - 9,049,088 (-)NCBIHuRef
CHM1_1129,189,284 - 9,237,532 (-)NCBICHM1_1
A2m
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396121,612,920 - 121,656,197 (+)NCBIGRCm39mm39
GRCm39 Ensembl6121,612,335 - 121,656,186 (+)Ensembl
GRCm386121,636,165 - 121,679,238 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6121,635,376 - 121,679,227 (+)EnsemblGRCm38mm10GRCm38
MGSCv376121,586,191 - 121,629,256 (+)NCBIGRCm37mm9NCBIm37
MGSCv366121,593,574 - 121,644,846 (+)NCBImm8
MGSCv366122,445,338 - 122,497,328 (+)NCBImm8
Celera6123,474,284 - 123,517,770 (+)NCBICelera
Cytogenetic Map6F1NCBI
cM Map657.49NCBI
A2m
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24154,897,770 - 154,947,787 (+)NCBI
Rnor_6.0 Ensembl4154,309,426 - 154,359,137 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl4154,423,209 - 154,472,924 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04154,309,426 - 154,359,138 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04221,393,233 - 221,442,945 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44158,103,711 - 158,153,423 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14158,348,624 - 158,398,358 (+)NCBI
Celera4143,730,195 - 143,781,190 (+)NCBICelera
Cytogenetic Map4q42NCBI
LOC102021956
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554136,019,082 - 6,062,529 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554136,019,457 - 6,062,366 (+)NCBIChiLan1.0ChiLan1.0
LOC477699
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12736,654,328 - 36,695,775 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha279,920,641 - 9,962,291 (-)NCBI
ROS_Cfam_1.02737,002,478 - 37,044,674 (+)NCBI
UMICH_Zoey_3.12736,883,699 - 36,925,608 (+)NCBI
UNSW_CanFamBas_1.02736,918,717 - 36,960,000 (+)NCBI
UU_Cfam_GSD_1.0279,452,043 - 9,493,920 (-)NCBI
LOC101959212
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494598,303,198 - 98,346,620 (+)NCBI
SpeTri2.0NW_004936870424,832 - 468,303 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 5 3 2 4 5 2 2
Low 5 1 1 1 18 3 1
Below cutoff 2

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_013988396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021092376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK232880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK233134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK233455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK389256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK389449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK389467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK389501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK394265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK395688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK398736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK398786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK398806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY509877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU457451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU457747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GACC01000233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01099104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000000716   ⟹   ENSSSCP00000000701
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl562,438,017 - 62,485,537 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000032732   ⟹   ENSSSCP00000030014
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl562,440,810 - 62,485,537 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000073778   ⟹   ENSSSCP00000060530
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl562,438,017 - 62,483,676 (+)Ensembl
RefSeq Acc Id: XM_013988396   ⟹   XP_013843850
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1562,438,024 - 62,483,690 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021092376   ⟹   XP_020948035
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1562,406,928 - 62,483,689 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013843850 (Get FASTA)   NCBI Sequence Viewer  
  XP_020948035 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAR99596 (Get FASTA)   NCBI Sequence Viewer  
  JAA53574 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020948035   ⟸   XM_021092376
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013843850   ⟸   XM_013988396
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSSSCP00000000701   ⟸   ENSSSCT00000000716
RefSeq Acc Id: ENSSSCP00000060530   ⟸   ENSSSCT00000073778
RefSeq Acc Id: ENSSSCP00000030014   ⟸   ENSSSCT00000032732
Protein Domains
A2M   A2M_N_2   A2M_recep


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000000660 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070013987 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000000701 UniProtKB/TrEMBL
  ENSSSCP00000030014 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000060530 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070022769 UniProtKB/TrEMBL
  ENSSSCP00070022802 UniProtKB/TrEMBL
  ENSSSCP00070022829 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000000716 UniProtKB/TrEMBL
  ENSSSCT00000032732 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000073778 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070027376 UniProtKB/TrEMBL
  ENSSSCT00070027410 UniProtKB/TrEMBL
  ENSSSCT00070027442 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  2.60.40.690 UniProtKB/TrEMBL
InterPro A-macroglobulin_rcpt-bd UniProtKB/TrEMBL
  A-macroglobulin_rcpt-bd_sf UniProtKB/TrEMBL
  A2M_N_BRD UniProtKB/TrEMBL
  A2M_TED UniProtKB/TrEMBL
  Alpha-macroglobulin_TED UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
  Macroglobln_a2 UniProtKB/TrEMBL
  MacrogloblnA2_CS UniProtKB/TrEMBL
  MG2 UniProtKB/TrEMBL
  MG3 UniProtKB/TrEMBL
  MG4 UniProtKB/TrEMBL
  Terpenoid_cyclase/PrenylTrfase UniProtKB/TrEMBL
  TonB_box_CS UniProtKB/TrEMBL
NCBI Gene A2M ENTREZGENE
Pfam A2M UniProtKB/TrEMBL
  A2M_BRD UniProtKB/TrEMBL
  A2M_recep UniProtKB/TrEMBL
  MG2 UniProtKB/TrEMBL
  MG3 UniProtKB/TrEMBL
  MG4 UniProtKB/TrEMBL
  TED_complement UniProtKB/TrEMBL
PROSITE ALPHA_2_MACROGLOBULIN UniProtKB/TrEMBL
  TONB_DEPENDENT_REC_1 UniProtKB/TrEMBL
SMART A2M UniProtKB/TrEMBL
  A2M_N_2 UniProtKB/TrEMBL
  A2M_recep UniProtKB/TrEMBL
Superfamily-SCOP SSF48239 UniProtKB/TrEMBL
  SSF49410 UniProtKB/TrEMBL
  SSF81296 UniProtKB/TrEMBL
UniProt A0A4X1TZA7_PIG UniProtKB/TrEMBL
  A0A4X1U4K9_PIG UniProtKB/TrEMBL
  A0A4X1U4V6_PIG UniProtKB/TrEMBL
  A0A5G2Q8I9_PIG UniProtKB/TrEMBL
  F1SLX2_PIG UniProtKB/TrEMBL
  K7GQ48_PIG UniProtKB/TrEMBL
  K9J6H8_PIG UniProtKB/TrEMBL
VGNC ID VGNC:103209 ENTREZGENE