IGF1R (insulin like growth factor 1 receptor) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: IGF1R (insulin like growth factor 1 receptor) Sus scrofa
Analyze
Symbol: IGF1R
Name: insulin like growth factor 1 receptor
RGD ID: 14131810
Description: ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); insulin receptor substrate binding (ortholog); insulin-like growth factor binding (ortholog); INVOLVED IN adrenal gland development (ortholog); aging (ortholog); animal organ morphogenesis (ortholog); PARTICIPATES IN E-cadherin signaling pathway; insulin-like growth factor signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); adrenocortical carcinoma (ortholog); alcoholic neuropathy (ortholog); FOUND IN axon (ortholog); caveola (ortholog); cytoplasm (ortholog); INTERACTS WITH bisphenol A; dexamethasone; glycerol 2-phosphate
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: IGF-1 receptor; IGF-I receptor; insulin-like growth factor 1 receptor; insulin-like growth factor 1 receptor beta subunit; insulin-like growth factor receptor 1; insulin-like growth factor-I receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1137,387,925 - 137,690,666 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11137,383,623 - 137,691,038 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21153,523,944 - 153,853,776 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q17-q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
adrenocortical carcinoma  (ISO)
alcoholic neuropathy  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
atrial fibrillation  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Burns  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
Carotid Artery Injuries  (ISO)
Choroidal Neovascularization  (ISO)
chromosome 15q26-qter deletion syndrome  (ISO)
clear cell renal cell carcinoma  (ISO)
congenital diaphragmatic hernia  (ISO)
coronary stenosis  (ISO)
Craniosynostosis Syndrome, Autosomal Recessive  (ISO)
cryptorchidism  (ISO)
dementia  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Endometrial Neoplasms  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
fetal alcohol spectrum disorder  (ISO)
Fetal Growth Retardation  (ISO)
gastrinoma  (ISO)
gastroschisis  (ISO)
genetic disease  (ISO)
gestational diabetes  (ISO)
Graves' disease  (ISO)
Growth Disorders  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
Huntington's disease  (ISO)
Hyperphagia  (ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
hypertrophic cardiomyopathy  (ISO)
IgA glomerulonephritis  (ISO)
Insulin-Like Growth Factor I, Resistance To  (ISO)
intellectual disability  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kidney Reperfusion Injury  (ISO)
Knee Osteoarthritis  (ISO)
Kuhnt-Junius degeneration  (ISO)
Lewy body dementia  (ISO)
liver cirrhosis  (ISO)
lung disease  (ISO)
Malocclusion  (ISO)
Metabolic Bone Diseases  (ISO)
myocardial infarction  (ISO)
NATURAL KILLER CELL ENTEROPATHY  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephroblastoma  (ISO)
neuroblastoma  (ISO)
Neurodevelopmental Disorders  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (ISO)
Optic Nerve Injuries  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
Parkinson's disease  (ISO)
peripheral nervous system disease  (ISO)
portal vein thrombosis  (ISO)
Premature Aging  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
prostate carcinoma  (ISO)
prostatic hypertrophy  (ISO)
renal cell carcinoma  (ISO)
respiratory failure  (ISO)
Right Ventricular Hypertrophy  (ISO)
Skin Neoplasms  (ISO)
Stroke  (ISO)
toxic encephalopathy  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
vascular dementia  (ISO)
vesicoureteral reflux  (ISO)
Zollinger-Ellison syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
aging  (ISO)
amyloid-beta clearance  (IEA)
animal organ morphogenesis  (ISO)
axonogenesis  (ISO)
brain development  (ISO)
cardiac atrium development  (ISO)
cellular response to aldosterone  (ISO)
cellular response to amyloid-beta  (IEA)
cellular response to angiotensin  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to progesterone stimulus  (ISO)
cellular response to testosterone stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular senescence  (ISO)
cerebellum development  (ISO)
dendritic spine maintenance  (ISO)
epidermis development  (ISO)
establishment of cell polarity  (ISO)
estrous cycle  (ISO)
exocrine pancreas development  (ISO)
hippocampus development  (ISO)
immune response  (IEA)
insulin receptor signaling pathway  (ISO)
insulin-like growth factor receptor signaling pathway  (IEA)
male sex determination  (ISO)
mammary gland development  (ISO)
negative regulation of apoptotic process  (IEA,ISS)
negative regulation of cholangiocyte apoptotic process  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of hepatocyte apoptotic process  (ISO)
negative regulation of MAPK cascade  (IEA,ISO,ISS)
negative regulation of muscle cell apoptotic process  (ISO)
negative regulation of protein kinase B signaling  (ISO)
neuron projection development  (ISO)
peptidyl-tyrosine autophosphorylation  (IEA,ISO)
peptidyl-tyrosine phosphorylation  (IEA)
phosphatidylinositol-mediated signaling  (IEA)
positive regulation of axon regeneration  (ISO)
positive regulation of cell migration  (IEA)
positive regulation of cell population proliferation  (IEA)
positive regulation of cold-induced thermogenesis  (ISO)
positive regulation of cytokinesis  (ISO)
positive regulation of developmental growth  (ISO)
positive regulation of DNA metabolic process  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of meiotic cell cycle  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of osteoblast proliferation  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein-containing complex disassembly  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of steroid hormone biosynthetic process  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
prostate gland epithelium morphogenesis  (ISO)
protein autophosphorylation  (IEA)
protein phosphorylation  (ISO)
regulation of JNK cascade  (IEA,ISS)
response to ethanol  (ISO)
response to insulin  (ISO)
response to L-glutamate  (ISO)
response to nicotine  (ISO)
response to nutrient levels  (ISO)
response to vitamin E  (ISO)
transcytosis  (IEA)
transmembrane receptor protein tyrosine kinase signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:7587382   PMID:7649105   PMID:9250860   PMID:11006152   PMID:11736811   PMID:12354161   PMID:15187154   PMID:15701570   PMID:15708546   PMID:18424208   PMID:21570979   PMID:30324092  
PMID:32109480  


Genomics

Comparative Map Data
IGF1R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1137,387,925 - 137,690,666 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11137,383,623 - 137,691,038 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21153,523,944 - 153,853,776 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q17-q21NCBI
IGF1R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1598,648,539 - 98,964,530 (+)EnsemblGRCh38hg38GRCh38
GRCh381598,648,539 - 98,964,530 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371599,191,768 - 99,507,759 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361597,010,284 - 97,325,282 (+)NCBINCBI36hg18NCBI36
Build 341597,010,287 - 97,319,034NCBI
Celera1575,609,678 - 75,924,704 (+)NCBI
Cytogenetic Map15q26.3NCBI
HuRef1575,320,348 - 75,635,223 (+)NCBIHuRef
CHM1_11599,034,201 - 99,349,171 (+)NCBICHM1_1
Igf1r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39767,601,486 - 67,883,416 (+)NCBIGRCm39mm39
GRCm39 Ensembl767,602,575 - 67,883,416 (+)Ensembl
GRCm38767,952,257 - 68,233,668 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl767,952,827 - 68,233,668 (+)EnsemblGRCm38mm10GRCm38
MGSCv37775,097,143 - 75,378,553 (+)NCBIGRCm37mm9NCBIm37
MGSCv36767,826,372 - 68,100,293 (+)NCBImm8
Celera765,407,649 - 65,690,413 (+)NCBICelera
Cytogenetic Map7CNCBI
cM Map737.27NCBI
Igf1r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21121,549,839 - 121,838,545 (+)NCBI
Rnor_6.0 Ensembl1128,924,966 - 129,206,516 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01128,924,921 - 129,213,816 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01129,985,761 - 130,272,589 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41122,704,976 - 122,990,007 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11122,783,318 - 123,068,350 (+)NCBI
Celera1113,751,636 - 114,029,884 (+)NCBICelera
Cytogenetic Map1q22NCBI
Igf1r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541626,102,628 - 26,382,666 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541626,101,090 - 26,382,660 (-)NCBIChiLan1.0ChiLan1.0
IGF1R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11596,576,930 - 96,832,974 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1596,535,164 - 96,832,974 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01577,332,926 - 77,648,474 (+)NCBIMhudiblu_PPA_v0panPan3
IGF1R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1341,795,337 - 42,096,255 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl341,794,623 - 42,090,387 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha344,494,039 - 44,797,005 (+)NCBI
ROS_Cfam_1.0342,203,106 - 42,506,274 (+)NCBI
UMICH_Zoey_3.1341,727,974 - 42,030,799 (+)NCBI
UNSW_CanFamBas_1.0341,958,900 - 42,261,698 (+)NCBI
UU_Cfam_GSD_1.0342,179,556 - 42,481,580 (+)NCBI
Igf1r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640141,474,253 - 141,770,018 (-)NCBI
SpeTri2.0NW_0049364834,563,995 - 4,860,231 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGF1R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12917,212,206 - 17,534,036 (+)NCBI
ChlSab1.1 Ensembl2917,459,404 - 17,526,930 (+)Ensembl
Vero_WHO_p1.0NW_02366605929,058,966 - 29,370,219 (-)NCBI
Igf1r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247685,396,027 - 5,688,435 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 2 3 2 6 2 3
Low 8 2 3 2 17 2
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000005311   ⟹   ENSSSCP00000005181
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1137,387,925 - 137,690,666 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000005312   ⟹   ENSSSCP00000005182
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1137,387,925 - 137,690,666 (-)Ensembl
RefSeq Acc Id: NM_214172   ⟹   NP_999337
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11137,390,085 - 137,690,433 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021082915   ⟹   XP_020938574
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11137,383,623 - 137,691,038 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021082918   ⟹   XP_020938577
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11137,383,623 - 137,689,849 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021082920   ⟹   XP_020938579
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11137,383,623 - 137,638,348 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020938574   ⟸   XM_021082915
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020938577   ⟸   XM_021082918
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020938579   ⟸   XM_021082920
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: NP_999337   ⟸   NM_214172
- Peptide Label: precursor
- UniProtKB: F1CK17 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000005182   ⟸   ENSSSCT00000005312
RefSeq Acc Id: ENSSSCP00000005181   ⟸   ENSSSCT00000005311

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000030560 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070017477 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000005181 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000005182 UniProtKB/TrEMBL
  ENSSSCP00070028834 UniProtKB/TrEMBL
  ENSSSCP00070028856 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000005311 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000005312 UniProtKB/TrEMBL
  ENSSSCT00070034518 UniProtKB/TrEMBL
  ENSSSCT00070034542 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.80.20.20 UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Furin-like_Cys-rich_dom UniProtKB/TrEMBL
  Furin_repeat UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Rcpt_L-dom UniProtKB/TrEMBL
  Rcpt_L-dom_sf UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_insulin-like_rcpt UniProtKB/TrEMBL
  Tyr_kinase_rcpt_2_CS UniProtKB/TrEMBL
KEGG Report ssc:397350 UniProtKB/TrEMBL
NCBI Gene IGF1R ENTREZGENE
Pfam fn3 UniProtKB/Swiss-Prot
  Furin-like UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  Recep_L_domain UniProtKB/TrEMBL
PIRSF Insulin_receptor UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_II UniProtKB/TrEMBL
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00261 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A4X1UKG1_PIG UniProtKB/TrEMBL
  A0A4X1UL29_PIG UniProtKB/TrEMBL
  A0JGJ5_PIG UniProtKB/TrEMBL
  F1CK17 ENTREZGENE, UniProtKB/TrEMBL
  F1SRY1_PIG UniProtKB/TrEMBL
  IGF1R_PIG UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q28951 UniProtKB/Swiss-Prot