RGD Reference Report - Xanthoceraside attenuates learning and memory deficits via improving insulin signaling in STZ-induced AD rats. - Rat Genome Database

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Xanthoceraside attenuates learning and memory deficits via improving insulin signaling in STZ-induced AD rats.

Authors: Liu, Peng  Zou, Libo  Jiao, Qing  Chi, Tianyan  Ji, Xuefei  Qi, Yue  Xu, Qian  Wang, Lihua 
Citation: Liu P, etal., Neurosci Lett. 2013 May 24;543:115-20. doi: 10.1016/j.neulet.2013.02.065. Epub 2013 Apr 3.
RGD ID: 12904921
Pubmed: PMID:23562514   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neulet.2013.02.065   (Journal Full-text)

Xanthoceraside, a triterpenoid saponin extracted from the fruit husks of Xanthoceras sorbifolia Bunge, has been shown to reverse the cognitive deficits observed in several Alzheimer's disease (AD) animal models. Increasing evidence suggests the involvement of the insulin signaling pathway in neurodegenerative disorders such as AD. Thus, we used an AD animal model of cognitive impairment induced by the intracerebroventricular (ICV) injection of streptozotocin (STZ) to test the effects of xanthoceraside on behavioral impairments and insulin signaling mechanisms. In our present study, memory impairment was assessed using the Morris water maze test. The expression of IR, IGF-1R and Raf-1/ERK/CREB was tested by western blotting. The STZ group showed memory deficits in the Morris water maze test and significant decreases in IR and IGF-1R protein levels in the hippocampus. Xanthoceraside treatment significantly rescued memory deficits, as well as IR and IGF-1R protein expression levels. STZ inhibited the Ras/ERK signaling cascade and decreased the phosphorylation of CREB; these effects were also attenuated by xanthoceraside treatment. These results suggest the potential use of xanthoceraside for the treatment of neurodegenerative disorders in which brain insulin signaling may be involved.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Alzheimer's disease treatmentISOIgf1r (Rattus norvegicus)12904921; 12904921 RGD 
Alzheimer's disease treatmentIEP 12904921 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Igf1r  (insulin-like growth factor 1 receptor)

Genes (Mus musculus)
Igf1r  (insulin-like growth factor I receptor)

Genes (Homo sapiens)
IGF1R  (insulin like growth factor 1 receptor)


Additional Information