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Gene: Igf1r (insulin-like growth factor I receptor) Mus musculus
Symbol: Igf1r
Name: insulin-like growth factor I receptor
RGD ID: 10766
Description: Exhibits insulin-like growth factor binding activity. Involved in several processes, including gland development; positive regulation of cell cycle; and regulation of intracellular signal transduction. Localizes to T-tubule and integral component of membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and lung. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); kidney cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and neurodegenerative disease (multiple). Orthologous to human IGF1R (insulin like growth factor 1 receptor); PARTICIPATES IN E-cadherin signaling pathway; insulin-like growth factor signaling pathway; endocytosis pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A330103N21Rik; CD221; D930020L01; hyft; IGF-; IGF-1R; IGF-I receptor; insulin-like growth factor 1 receptor; line 186
Homo sapiens (human) : IGF1R (insulin like growth factor 1 receptor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Igf1r (insulin-like growth factor 1 receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Igf1r (insulin like growth factor 1 receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : IGF1R (insulin like growth factor 1 receptor)
Canis lupus familiaris (dog) : IGF1R (insulin like growth factor 1 receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Igf1r (insulin like growth factor 1 receptor)
Sus scrofa (pig) : IGF1R (insulin like growth factor 1 receptor)
Chlorocebus sabaeus (African green monkey) : IGF1R (insulin like growth factor 1 receptor)
Heterocephalus glaber (naked mole-rat) : Igf1r (insulin like growth factor 1 receptor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl767,952,827 - 68,233,668 (+)EnsemblGRCm38mm10GRCm38
GRCm38767,952,257 - 68,233,668 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37775,097,143 - 75,378,553 (+)NCBIGRCm37mm9NCBIm37
MGSCv36767,826,372 - 68,100,293 (+)NCBImm8
Celera765,407,649 - 65,690,413 (+)NCBICelera
Cytogenetic Map7CNCBI
cM Map737.27NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Igf1r
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10766
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.