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Gene: Igf1r (insulin-like growth factor I receptor) Mus musculus
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Symbol: Igf1r
Name: insulin-like growth factor I receptor
RGD ID: 10766
Description: Exhibits insulin-like growth factor binding activity. Involved in several processes, including gland development; positive regulation of cell cycle; and regulation of intracellular signal transduction. Localizes to T-tubule and integral component of membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and lung. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); kidney cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and neurodegenerative disease (multiple). Orthologous to human IGF1R (insulin like growth factor 1 receptor); PARTICIPATES IN E-cadherin signaling pathway; insulin-like growth factor signaling pathway; endocytosis pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A330103N21Rik; CD221; D930020L01; hyft; IGF-; IGF-1R; IGF-I receptor; insulin-like growth factor 1 receptor; line 186
Orthologs:
Homo sapiens (human) : IGF1R (insulin like growth factor 1 receptor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Igf1r (insulin-like growth factor 1 receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Igf1r (insulin like growth factor 1 receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : IGF1R (insulin like growth factor 1 receptor)
Canis lupus familiaris (dog) : IGF1R (insulin like growth factor 1 receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Igf1r (insulin like growth factor 1 receptor)
Sus scrofa (pig) : IGF1R (insulin like growth factor 1 receptor)
Chlorocebus sabaeus (African green monkey) : IGF1R (insulin like growth factor 1 receptor)
Heterocephalus glaber (naked mole-rat) : Igf1r (insulin like growth factor 1 receptor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl767,952,827 - 68,233,668 (+)EnsemblGRCm38mm10GRCm38
GRCm38767,952,257 - 68,233,668 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37775,097,143 - 75,378,553 (+)NCBIGRCm37mm9NCBIm37
MGSCv36767,826,372 - 68,100,293 (+)NCBImm8
Celera765,407,649 - 65,690,413 (+)NCBICelera
Cytogenetic Map7CNCBI
cM Map737.27NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Igf1r
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10766
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.