RGD Reference Report - The potential role of IGF-I receptor mRNA in rats with diabetic retinopathy. - Rat Genome Database

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The potential role of IGF-I receptor mRNA in rats with diabetic retinopathy.

Authors: Kuang, H  Zou, W  Liu, D  Shi, R  Cheng, L  Yin, H  Liu, X 
Citation: Kuang H, etal., Chin Med J (Engl). 2003 Mar;116(3):478-80.
RGD ID: 10046008
Pubmed: PMID:12781065   (View Abstract at PubMed)

OBJECTIVE: To evaluate the potential role of insulin-like growth factor-1 receptor mRNA (IGF-IR mRNA) in the onset and development of retinopathy in diabetic rats. METHODS: A diabetic model was duplicated in Wistar rats. The early changes in the retina were examined using light and transmission electron microscopy. Expression of IGF-IR mRNA was analyzed using in situ hybridization. RESULTS: Weak expression of IGF-IR mRNA (5%) was found in retinas of normal rats, but was significantly increased (15% and 18%) in the retinas of diabetic rats after 3 and 6 months of diabetes (P < 0.01). In situ hybridization and morphological study demonstrated that there was a positive correlation between IGF-IR mRNA expression and retinal changes at various stages. CONCLUSION: Increased IGF-IR mRNA might play an important role in the onset and development of diabetic retinopathy.




  
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Evidence
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Original Reference(s)
IGF1RHumandiabetic retinopathy disease_progressionISOIgf1r (Rattus norvegicus)mRNA:increased expression:retina:RGD 
Igf1rRatdiabetic retinopathy disease_progressionIEP mRNA:increased expression:retina:RGD 
Igf1rMousediabetic retinopathy disease_progressionISOIgf1r (Rattus norvegicus)mRNA:increased expression:retina:RGD 


Genes (Rattus norvegicus)
Igf1r  (insulin-like growth factor 1 receptor)

Genes (Mus musculus)
Igf1r  (insulin-like growth factor I receptor)

Genes (Homo sapiens)
IGF1R  (insulin like growth factor 1 receptor)