RGD Reference Report - Increased expression of insulin-like growth factor I and/or its receptor in gastrinomas is associated with low curability, increased growth, and development of metastases. - Rat Genome Database

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Increased expression of insulin-like growth factor I and/or its receptor in gastrinomas is associated with low curability, increased growth, and development of metastases.

Authors: Furukawa, M  Raffeld, M  Mateo, C  Sakamoto, A  Moody, TW  Ito, T  Venzon, DJ  Serrano, J  Jensen, RT 
Citation: Furukawa M, etal., Clin Cancer Res. 2005 May 1;11(9):3233-42.
RGD ID: 7242847
Pubmed: PMID:15867218   (View Abstract at PubMed)
DOI: DOI:10.1158/1078-0432.CCR-04-1915   (Journal Full-text)

PURPOSE: Growth factors, particularly insulin-like growth factor I (IGF-I) and IGF-I receptor (IGF-IR) in some nonendocrine and a few endocrine tumors, are thought important in recurrence, growth, and aggressiveness. Whether this is true of neuroendocrine tumors such as gastrinomas is unclear. The aim of this study was to address this question in gastrinomas. EXPERIMENTAL DESIGN: IGF-I and IGF-IR expression in gastrinomas from 54 patients with Zollinger-Ellison syndrome were analyzed and correlated with clinical/tumor characteristics. IGF-I and IGF-IR mRNA levels were determined by competitive reverse transcription-PCR. IGF-IR expression, assessed by immunohistochemistry, was done on a subset. RESULTS: IGF-IR mRNA was found in 100% and IGF-I in 89%. IGF-I mRNA expression varied by >254-fold, IGF-IR by 2,670-fold, and the levels correlated in a given tumor. The IGF-IR level was lower in gastrinomas of patients who were rendered disease free and increased levels correlated with tumor growth, aggressiveness, extent, and with liver metastases. Increased IGF-I levels correlated with increased growth, tumor extent, and aggressiveness. Neither IGF-IR nor IGF-I levels correlated with tumor location, size, or its clinical/functional features. The IGF-IR correlated with disease-free survival. IGF-IRbeta was found in 31 of 32 tumors (97%) by immunohistochemistry. CONCLUSIONS: These results indicate that IGF-I and IGF-IR are expressed in almost all gastrinomas. Furthermore, assessment of IGF-I/IGF-IR expression in gastrinomas may be clinically useful in identifying those patients with more aggressive tumors who might benefit from more aggressive treatment.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IGF1RHumangastrinoma  IEP mRNA and protein: increased expression::poor prognosis for high expression RGD 
Igf1rRatgastrinoma  ISOIGF1R (Homo sapiens)mRNA and protein: increased expression::poor prognosis for high expression RGD 
Igf1rMousegastrinoma  ISOIGF1R (Homo sapiens)mRNA and protein: increased expression::poor prognosis for high expression RGD 
IGF1RHumanZollinger-Ellison syndrome  IEP mRNA and protein: increased expression::poor prognosis for high expression RGD 
Igf1rRatZollinger-Ellison syndrome  ISOIGF1R (Homo sapiens)mRNA and protein: increased expression::poor prognosis for high expression RGD 
Igf1rMouseZollinger-Ellison syndrome  ISOIGF1R (Homo sapiens)mRNA and protein: increased expression::poor prognosis for high expression RGD 

Objects Annotated

Genes (Rattus norvegicus)
Igf1r  (insulin-like growth factor 1 receptor)

Genes (Mus musculus)
Igf1r  (insulin-like growth factor I receptor)

Genes (Homo sapiens)
IGF1R  (insulin like growth factor 1 receptor)


Additional Information