RGD Reference Report - Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29. - Rat Genome Database

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Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29.

Authors: Rotem-Yehudar, R  Galperin, E  Horowitz, M 
Citation: Rotem-Yehudar R, etal., J Biol Chem. 2001 Aug 31;276(35):33054-60. Epub 2001 Jun 21.
RGD ID: 1579732
Pubmed: PMID:11423532   (View Abstract at PubMed)
DOI: DOI:10.1074/jbc.M009913200   (Journal Full-text)

Ligand-induced receptor-mediated endocytosis plays a central role in regulating signaling conveyed by tyrosine kinase receptors. This process depends on the recruitment of the adaptor protein 2 (AP-2) complex, clathrin, dynamin, and other accessory proteins to the ligand-bound receptor. We show here that besides AP-2 and clathrin, two other proteins participate in the endocytic process of the insulin-like growth factor receptor (IGF-1R); they are EHD1, an Eps15 homology (EH) domain-containing protein 1, and SNAP29, a synaptosomal-associated protein. EHD1 and SNAP29 form complexes with alpha-adaptin of AP-2 and co-localize in endocytic vesicles, indicating a role for them in endocytosis. EHD1 and SNAP29 interact directly with each other and are present in complexes with IGF-1R. After IGF-1 induction, EHD1 and IGF-1R co-localize intracellularly. Overexpression of EHD1 in Chinese hamster ovary cells represses IGF-1-mediated signaling, as measured by mitogen-activated protein kinase phosphorylation and Akt phosphorylation, indicating that EHD1 plays a role as a down-regulator in IGF-1 signaling pathway.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Ap2a1Ratprotein-containing complex  IDA  RGD 

Molecular Function

  

Objects Annotated

Genes (Rattus norvegicus)
Ap2a1  (adaptor related protein complex 2 subunit alpha 1)
Ehd1  (EH-domain containing 1)
Igf1r  (insulin-like growth factor 1 receptor)
Snap29  (synaptosome associated protein 29)


Additional Information