RGD Reference Report - Expression of insulin-like growth factor 1 receptor in rat retina following optic nerve injury. - Rat Genome Database

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Expression of insulin-like growth factor 1 receptor in rat retina following optic nerve injury.

Authors: Bu, SY  Yu, GH  Xu, GX 
Citation: Bu SY, etal., Acta Ophthalmol. 2013 Sep;91(6):e427-31. doi: 10.1111/aos.12096. Epub 2013 May 7.
RGD ID: 10046025
Pubmed: PMID:23648097   (View Abstract at PubMed)
DOI: DOI:10.1111/aos.12096   (Journal Full-text)

PURPOSE: To investigate the apoptosis in retinal ganglion cells (RGCs) and insulin-like growth factor 1 receptor (IGF-1R) in the retina following optic nerve crush. METHODS: Healthy Wistar rats (N = 70) were divided into two groups: a normal control group and an optic nerve injury group. Immunohistochemistry and flow cytometry were performed to detect the expression of IGF-1R and to measure the apoptosis of RGCs, respectively. RESULTS: Immunohistochemistry revealed that at 1 hr after optic nerve injury, IGF-1R immunoreactivity began to increase and reached a maximal level at 24 hr (p < 0.05), where it remained elevated up to 14 days after injury. RGC apoptosis in the normal control group was 0.53%, while the apoptosis rate in the optic nerve injury group increased over time. The apoptosis rate in the optic nerve injury group was 1.4% at 1 hr, 4.4% at 6 hr, 5.2% at 12 hr and reached a maximal level (8.5%) at 24 hr. Subsequently, the rate declined to 1.9% 7 days after injury and 0.9% 2 weeks after injury. CONCLUSION: The IGF-1R immunereactivity in the retina increased after optic nerve injury. IGF-1R may regulate the apoptosis and regeneration of RGCs at different stages after optic nerve injury.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Optic Nerve Injuries  ISOIgf1r (Rattus norvegicus)10046025; 10046025protein:increased expression:retina:RGD 
Optic Nerve Injuries  IEP 10046025protein:increased expression:retina:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Igf1r  (insulin-like growth factor 1 receptor)

Genes (Mus musculus)
Igf1r  (insulin-like growth factor I receptor)

Genes (Homo sapiens)
IGF1R  (insulin like growth factor 1 receptor)


Additional Information