ABCB4 (ATP binding cassette subfamily B member 4) - Rat Genome Database

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Gene: ABCB4 (ATP binding cassette subfamily B member 4) Sus scrofa
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Symbol: ABCB4
Name: ATP binding cassette subfamily B member 4
RGD ID: 14031420
Description: ENCODES a protein that exhibits ceramide floppase activity (ortholog); INVOLVED IN bile acid secretion (ortholog); cellular response to bile acid (ortholog); ceramide translocation (ortholog); PARTICIPATES IN multidrug resistance protein mediated transport pathway; ASSOCIATED WITH Animal Disease Models (ortholog); cholangitis (ortholog); cholestasis (ortholog); FOUND IN actin cytoskeleton (ortholog); apical plasma membrane (ortholog); cytoplasm (ortholog); INTERACTS WITH 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile; 2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one; itraconazole
Type: protein-coding
RefSeq Status: MODEL
Also known as: ATP-binding cassette, sub-family B (MDR/TAP), member 4; MDR3; multidrug resistance 3; P-glycoprotein class III; Pgp3; phosphatidylcholine translocator ABCB4
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1993,171,371 - 93,262,124 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29102,651,665 - 102,741,039 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
ABCB4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1993,171,371 - 93,262,124 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29102,651,665 - 102,741,039 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCB4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl787,401,696 - 87,480,435 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl787,401,697 - 87,480,435 (-)EnsemblGRCh38hg38GRCh38
GRCh38787,398,988 - 87,476,722 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37787,031,012 - 87,104,996 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36786,869,297 - 86,942,955 (-)NCBINCBI36hg18NCBI36
Build 34786,676,016 - 86,754,402NCBI
Celera781,736,239 - 81,809,903 (-)NCBI
Cytogenetic Map7q21.12NCBI
HuRef781,642,357 - 81,716,022 (-)NCBIHuRef
CHM1_1786,961,467 - 87,035,121 (-)NCBICHM1_1
CRA_TCAGchr7v2786,362,871 - 86,436,531 (-)NCBI
Abcb4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3958,943,614 - 9,009,226 (+)NCBIGRCm39mm39
GRCm39 Ensembl58,943,717 - 9,009,231 (+)Ensembl
GRCm3858,893,614 - 8,959,226 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl58,893,717 - 8,959,231 (+)EnsemblGRCm38mm10GRCm38
MGSCv3758,893,721 - 8,959,226 (+)NCBIGRCm37mm9NCBIm37
MGSCv3658,899,723 - 8,965,232 (+)NCBImm8
Celera58,813,446 - 8,878,635 (+)NCBICelera
Cytogenetic Map5A1NCBI
cM Map53.43NCBI
Abcb4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2425,150,998 - 25,209,489 (-)NCBI
Rnor_6.0 Ensembl422,133,521 - 22,425,515 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0422,133,984 - 22,192,687 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0422,070,806 - 22,128,781 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4421,946,274 - 22,004,328 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1421,946,273 - 22,004,328 (+)NCBI
Celera420,645,103 - 20,702,285 (-)NCBICelera
Cytogenetic Map4q12NCBI
ABCB4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1793,046,085 - 93,119,439 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl793,046,085 - 93,119,439 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0779,395,924 - 79,469,755 (-)NCBIMhudiblu_PPA_v0panPan3
ABCB4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11413,542,610 - 13,614,334 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1413,548,462 - 13,614,571 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1413,114,115 - 13,185,936 (-)NCBI
ROS_Cfam_1.01413,307,604 - 13,379,530 (-)NCBI
UMICH_Zoey_3.11413,510,779 - 13,582,706 (-)NCBI
UNSW_CanFamBas_1.01413,236,739 - 13,308,588 (-)NCBI
UU_Cfam_GSD_1.01413,520,259 - 13,592,210 (-)NCBI
Abcb4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511826,585,866 - 26,661,600 (-)NCBI
SpeTri2.0NW_0049367631,339,849 - 1,415,528 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCB4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12161,459,344 - 61,529,017 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system nervous system reproductive system
High
Medium
Low 1
Below cutoff 7 4 1

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005656694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013989596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021063454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021063455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021063456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021063457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021063458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021063459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021063460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021063461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021063462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021063463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021063464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021063465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021063466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021063467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021063468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002335872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU855672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU915624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU929528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF067318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01129795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U27703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_005656694   ⟹   XP_005656751
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1993,171,671 - 93,262,124 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013989596   ⟹   XP_013845050
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1993,171,371 - 93,262,124 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063454   ⟹   XP_020919113
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1993,171,371 - 93,262,124 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063455   ⟹   XP_020919114
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1993,171,671 - 93,262,124 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063456   ⟹   XP_020919115
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1993,171,883 - 93,262,124 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063457   ⟹   XP_020919116
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1993,171,739 - 93,262,124 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063458   ⟹   XP_020919117
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1993,171,718 - 93,262,124 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063459   ⟹   XP_020919118
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1993,171,993 - 93,262,124 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063460   ⟹   XP_020919119
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1993,171,739 - 93,262,124 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063461   ⟹   XP_020919120
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1993,187,891 - 93,262,124 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063462   ⟹   XP_020919121
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1993,171,739 - 93,262,124 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063463   ⟹   XP_020919122
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1993,171,739 - 93,262,124 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063464   ⟹   XP_020919123
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1993,171,697 - 93,262,124 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063465   ⟹   XP_020919124
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1993,171,956 - 93,262,124 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063466   ⟹   XP_020919125
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1993,171,371 - 93,205,341 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063467   ⟹   XP_020919126
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1993,171,371 - 93,212,592 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063468   ⟹   XP_020919127
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1993,171,742 - 93,205,332 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002335872
RefSeq Status:
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1993,171,371 - 93,262,124 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_013845050   ⟸   XM_013989596
- Peptide Label: isoform X1
- UniProtKB: I3LV60 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020919113   ⟸   XM_021063454
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020919126   ⟸   XM_021063467
- Peptide Label: isoform X11
- Sequence:
RefSeq Acc Id: XP_020919125   ⟸   XM_021063466
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_005656751   ⟸   XM_005656694
- Peptide Label: isoform X1
- UniProtKB: I3LV60 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020919114   ⟸   XM_021063455
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020919123   ⟸   XM_021063464
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_020919117   ⟸   XM_021063458
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_020919121   ⟸   XM_021063462
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_020919122   ⟸   XM_021063463
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_020919116   ⟸   XM_021063457
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_020919119   ⟸   XM_021063460
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_020919127   ⟸   XM_021063468
- Peptide Label: isoform X12
- Sequence:
RefSeq Acc Id: XP_020919115   ⟸   XM_021063456
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020919124   ⟸   XM_021063465
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_020919118   ⟸   XM_021063459
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_020919120   ⟸   XM_021063461
- Peptide Label: isoform X8
- Sequence:

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000024520 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000028012 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000031503 UniProtKB/TrEMBL
  ENSSSCP00000033293 UniProtKB/TrEMBL
  ENSSSCP00000049416 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000031774 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000039149 UniProtKB/TrEMBL
  ENSSSCT00000042672 UniProtKB/TrEMBL
  ENSSSCT00000043956 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1560.10 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  ABC1_TM_dom UniProtKB/TrEMBL
  ABC1_TM_sf UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/TrEMBL
  MDR1 UniProtKB/TrEMBL
  MDR3 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Type_I_exporter UniProtKB/TrEMBL
KEGG Report ssc:100144586 UniProtKB/TrEMBL
NCBI Gene ABCB4 ENTREZGENE
PANTHER PTHR24221 UniProtKB/TrEMBL
  PTHR24221:SF241 UniProtKB/TrEMBL
  PTHR24221:SF251 UniProtKB/TrEMBL
Pfam ABC_membrane UniProtKB/TrEMBL
  ABC_tran UniProtKB/TrEMBL
PROSITE ABC_TM1F UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
  SSF90123 UniProtKB/TrEMBL
UniProt A0A286ZJ46_PIG UniProtKB/TrEMBL
  A0A286ZNX9_PIG UniProtKB/TrEMBL
  A0A287AZ48_PIG UniProtKB/TrEMBL
  A0SZY7_PIG UniProtKB/TrEMBL
  I3LV60 ENTREZGENE, UniProtKB/TrEMBL