ID2 (inhibitor of DNA binding 2) - Rat Genome Database

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Gene: ID2 (inhibitor of DNA binding 2) Sus scrofa
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Symbol: ID2
Name: inhibitor of DNA binding 2
RGD ID: 13929843
Description: ENCODES a protein that exhibits protein dimerization activity (inferred); RNA polymerase II-specific DNA-binding transcription factor binding (inferred); transcription regulator inhibitor activity (inferred); INVOLVED IN cellular response to follicle-stimulating hormone stimulus (ortholog); cellular senescence (ortholog); circadian regulation of gene expression (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); Arsenic Poisoning (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); protein-containing complex (ortholog); INTERACTS WITH deoxynivalenol; ochratoxin A
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DNA-binding protein inhibitor ID-2; inhibitor of differentiation 2; inhibitor of DNA binding 2, HLH protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3127,500,763 - 127,503,257 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13127,500,759 - 127,503,207 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23135,801,813 - 135,804,261 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adipose tissue development  (IEA)
adult locomotory behavior  (IEA)
astrocyte differentiation  (IEA)
B cell differentiation  (IEA)
bundle of His development  (IEA)
cell development  (IEA)
cell maturation  (IEA)
cell morphogenesis involved in neuron differentiation  (IEA)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to lithium ion  (IEA)
cellular senescence  (IEA,ISS)
circadian regulation of gene expression  (IEA,ISS)
circadian rhythm  (IEA)
dopaminergic neuron differentiation  (IEA)
embryonic digestive tract morphogenesis  (IEA,ISS)
endodermal digestive tract morphogenesis  (IEA,ISS)
entrainment of circadian clock  (IEA)
entrainment of circadian clock by photoperiod  (IEA,ISS)
enucleate erythrocyte differentiation  (IEA)
epithelial cell differentiation involved in mammary gland alveolus development  (IEA,ISS)
erythrocyte differentiation  (IEA)
heart development  (IEA)
leukocyte differentiation  (IEA)
locomotor rhythm  (IEA,ISS)
mammary gland alveolus development  (IEA,ISS)
mammary gland epithelial cell proliferation  (IEA,ISS)
membranous septum morphogenesis  (IEA)
metanephros development  (IEA)
natural killer cell differentiation  (IEA)
negative regulation of B cell differentiation  (IEA)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of dopaminergic neuron differentiation  (IEA)
negative regulation of gene expression  (IEA,ISO,ISS)
negative regulation of muscle cell differentiation  (IEA)
negative regulation of oligodendrocyte differentiation  (IEA)
negative regulation of osteoblast differentiation  (IEA)
negative regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
neuron differentiation  (IBA,ISO)
neuron fate commitment  (IEA,ISS)
olfactory bulb development  (IEA)
oligodendrocyte development  (IEA)
oligodendrocyte differentiation  (IEA)
Peyer's patch development  (IEA)
positive regulation of astrocyte differentiation  (IEA)
positive regulation of blood pressure  (IEA,ISS)
positive regulation of cell cycle  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (IEA,ISS)
positive regulation of erythrocyte differentiation  (IEA)
positive regulation of fat cell differentiation  (IEA)
positive regulation of gene expression  (IEA,ISO,ISS)
positive regulation of macrophage differentiation  (IEA)
positive regulation of smooth muscle cell proliferation  (IEA,ISS)
regulation of circadian rhythm  (IEA,ISS)
regulation of G1/S transition of mitotic cell cycle  (IEA)
regulation of gene expression  (IEA,ISS)
regulation of lipid metabolic process  (IEA,ISS)
regulation of neural precursor cell proliferation  (IEA,ISS)
regulation of neuron differentiation  (IEA,ISS)
regulation of transcription by RNA polymerase II  (IEA)
rhythmic process  (IEA)
thigmotaxis  (IEA)
white fat cell differentiation  (IEA)

Cellular Component
chromatin  (ISO)
cytoplasm  (IEA,ISS)
cytosol  (IEA)
euchromatin  (IEA)
nucleus  (IBA,IEA)
protein-containing complex  (IEA,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:15679890   PMID:20477796   PMID:21305651   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ID2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3127,500,763 - 127,503,257 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13127,500,759 - 127,503,207 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23135,801,813 - 135,804,261 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ID2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3828,682,056 - 8,684,461 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl28,678,845 - 8,684,461 (+)EnsemblGRCh38hg38GRCh38
GRCh3728,822,186 - 8,824,591 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3628,739,564 - 8,742,034 (+)NCBINCBI36Build 36hg18NCBI36
Build 3428,772,710 - 8,775,179NCBI
Celera28,735,903 - 8,738,373 (+)NCBICelera
Cytogenetic Map2p25.1NCBI
HuRef28,668,297 - 8,670,767 (+)NCBIHuRef
CHM1_128,751,514 - 8,753,984 (+)NCBICHM1_1
T2T-CHM13v2.028,705,779 - 8,708,184 (+)NCBIT2T-CHM13v2.0
Id2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391225,143,798 - 25,146,091 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1225,143,798 - 25,147,139 (-)EnsemblGRCm39 Ensembl
GRCm381225,093,799 - 25,096,092 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1225,093,799 - 25,097,140 (-)EnsemblGRCm38mm10GRCm38
MGSCv371225,778,664 - 25,780,957 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361225,682,879 - 25,685,148 (-)NCBIMGSCv36mm8
Celera1226,550,909 - 26,553,204 (-)NCBICelera
Cytogenetic Map12A1.3NCBI
cM Map128.57NCBI
Id2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8647,469,162 - 47,470,995 (-)NCBIGRCr8
mRatBN7.2641,740,556 - 41,742,393 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl641,728,946 - 41,744,400 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx642,055,220 - 42,057,023 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0642,370,032 - 42,371,841 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0641,803,153 - 41,804,964 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0644,360,077 - 44,361,908 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl644,348,501 - 44,363,915 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0653,084,391 - 53,086,222 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4642,781,476 - 42,783,307 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1642,784,059 - 42,786,427 (-)NCBI
Celera641,019,266 - 41,021,097 (-)NCBICelera
RH 3.4 Map6240.21RGD
Cytogenetic Map6q16NCBI
Id2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955487878,326 - 880,783 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955487878,326 - 880,783 (-)NCBIChiLan1.0ChiLan1.0
ID2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212117,832,530 - 117,834,913 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A117,836,503 - 117,838,791 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A8,681,592 - 8,684,014 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A8,847,776 - 8,850,720 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A8,847,776 - 8,850,720 (+)Ensemblpanpan1.1panPan2
LOC102151783
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11054,954,852 - 54,957,116 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1054,908,126 - 54,908,533 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01055,955,571 - 55,955,978 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11055,647,787 - 55,648,194 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01055,934,604 - 55,935,011 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01056,221,310 - 56,221,717 (+)NCBIUU_Cfam_GSD_1.0
Id2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629250,481,184 - 50,483,643 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365325,236,037 - 5,238,881 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365325,236,175 - 5,238,689 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ID2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11498,962,001 - 98,964,486 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604513,366,676 - 13,369,585 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Id2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248462,277,961 - 2,283,571 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248462,281,292 - 2,283,596 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ID2
73 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000009458   ⟹   ENSSSCP00000009215
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl3127,500,763 - 127,503,257 (-)Ensembl
RefSeq Acc Id: NM_001037965   ⟹   NP_001033054
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.13127,500,759 - 127,503,207 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001033054   ⟸   NM_001037965
- UniProtKB: Q2VIU1 (UniProtKB/Swiss-Prot),   D2EDR1 (UniProtKB/TrEMBL),   A0A8D0RFG7 (UniProtKB/TrEMBL),   A0A8D0XCN4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000009215   ⟸   ENSSSCT00000009458
Protein Domains
bHLH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000008645 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCG00015033054 UniProtKB/Swiss-Prot
  ENSSSCG00025020348 UniProtKB/Swiss-Prot
  ENSSSCG00030051714 UniProtKB/Swiss-Prot
  ENSSSCG00035004371 UniProtKB/Swiss-Prot
  ENSSSCG00040018027 UniProtKB/Swiss-Prot
  ENSSSCG00045021986 UniProtKB/Swiss-Prot
  ENSSSCG00050016097 UniProtKB/Swiss-Prot
  ENSSSCG00055015822 UniProtKB/Swiss-Prot
  ENSSSCG00060061165 UniProtKB/Swiss-Prot
  ENSSSCG00065051194 UniProtKB/Swiss-Prot
  ENSSSCG00070016975 UniProtKB/Swiss-Prot
  ENSSSCG00085024522 UniProtKB/Swiss-Prot
  ENSSSCG00090024466 UniProtKB/Swiss-Prot
  ENSSSCG00105000132 UniProtKB/Swiss-Prot
  ENSSSCG00110001907 UniProtKB/Swiss-Prot
  ENSSSCG00115010691 UniProtKB/Swiss-Prot
  ENSSSCG00130002371 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000009458 ENTREZGENE
  ENSSSCT00000009458.5 UniProtKB/Swiss-Prot
  ENSSSCT00015043912.1 UniProtKB/Swiss-Prot
  ENSSSCT00025027637.1 UniProtKB/Swiss-Prot
  ENSSSCT00030072065.1 UniProtKB/Swiss-Prot
  ENSSSCT00035005472.1 UniProtKB/Swiss-Prot
  ENSSSCT00040024377.1 UniProtKB/Swiss-Prot
  ENSSSCT00045037537.1 UniProtKB/Swiss-Prot
  ENSSSCT00050021908.1 UniProtKB/Swiss-Prot
  ENSSSCT00055031181.1 UniProtKB/Swiss-Prot
  ENSSSCT00055031210.1 UniProtKB/Swiss-Prot
  ENSSSCT00060083493.1 UniProtKB/Swiss-Prot
  ENSSSCT00065070121.1 UniProtKB/Swiss-Prot
  ENSSSCT00065070124.1 UniProtKB/Swiss-Prot
  ENSSSCT00070033427.1 UniProtKB/Swiss-Prot
  ENSSSCT00070033436.1 UniProtKB/Swiss-Prot
  ENSSSCT00085047043 UniProtKB/Swiss-Prot
  ENSSSCT00090043429 UniProtKB/Swiss-Prot
  ENSSSCT00105000246 UniProtKB/Swiss-Prot
  ENSSSCT00110003939 UniProtKB/Swiss-Prot
  ENSSSCT00115018412 UniProtKB/Swiss-Prot
  ENSSSCT00130004584 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot
InterPro bHLH_dom UniProtKB/Swiss-Prot
  DNA-bd_prot-inh UniProtKB/Swiss-Prot
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report ssc:654298 UniProtKB/Swiss-Prot
NCBI Gene ID2 ENTREZGENE
PANTHER DNA-BINDING PROTEIN INHIBITOR ID-2 UniProtKB/Swiss-Prot
  PTHR11723 UniProtKB/Swiss-Prot
Pfam HLH UniProtKB/Swiss-Prot
PROSITE BHLH UniProtKB/Swiss-Prot
SMART HLH UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot
UniProt A0A8D0RFG7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0XCN4 ENTREZGENE, UniProtKB/TrEMBL
  D2EDR1 ENTREZGENE, UniProtKB/TrEMBL
  ID2_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:98041 ENTREZGENE