AZGP1 (alpha-2-glycoprotein 1, zinc-binding)

Gene: AZGP1 (alpha-2-glycoprotein 1, zinc-binding) Sus scrofa

Analyze

Symbol:

AZGP1

Name:

alpha-2-glycoprotein 1, zinc-binding

RGD ID:

14066192

Description:

INVOLVED IN cell adhesion (ortholog); cellular response to insulin stimulus (ortholog); cellular response to magnesium ion (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); Cachexia (ortholog); FOUND IN external side of plasma membrane (inferred); extracellular space (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

zinc-alpha-2-glycoprotein

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	3	7,867,521 - 7,874,857 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	7,121,544 - 7,129,596 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute kidney failure (ISO)

adenocarcinoma (ISO)

Cachexia (ISO)

Cardiac Fibrosis (ISO)

chronic kidney disease (ISO)

colon cancer (ISO)

colorectal cancer (ISO)

epilepsy (ISO)

esophagus squamous cell carcinoma (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

liver cirrhosis (ISO)

lung adenocarcinoma (ISO)

lung metastasis (ISO)

Lung Neoplasms (ISO)

metabolic dysfunction-associated steatohepatitis (ISO)

metabolic dysfunction-associated steatotic liver disease (ISO)

obesity (ISO)

oral squamous cell carcinoma (ISO)

pleomorphic xanthoastrocytoma (ISO)

polycystic ovary syndrome (ISO)

prostate cancer (ISO)

prostate carcinoma (ISO)

Prostatic Neoplasms (ISO)

rheumatoid arthritis (ISO)

sinusitis (ISO)

stomach carcinoma (ISO)

temporal lobe epilepsy (ISO)

Tubulointerstitial Fibrosis (ISO)

Yin Deficiency (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell adhesion (ISO)

cellular response to insulin stimulus (ISO)

cellular response to magnesium ion (ISO)

detection of chemical stimulus involved in sensory perception of bitter taste (ISO)

immune response (IBA,IEA)

Cellular Component

external side of plasma membrane (IBA,IEA)

extracellular space (IBA,IEA)

Molecular Function

protein binding (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

AZGP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	3	7,867,521 - 7,874,857 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	7,121,544 - 7,129,596 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AZGP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	99,966,730 - 99,976,031 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	99,966,720 - 99,976,042 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	99,564,353 - 99,573,654 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	99,402,286 - 99,411,623 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	99,209,002 - 99,218,338	NCBI
Celera	7	94,298,908 - 94,308,290 (-)	NCBI		Celera
Cytogenetic Map	7	q22.1	NCBI
HuRef	7	94,200,047 - 94,209,434 (-)	NCBI		HuRef
CHM1_1	7	99,494,515 - 99,503,901 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	101,206,237 - 101,220,128 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	98,924,486 - 98,933,868 (-)	NCBI

Azgp1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	137,979,783 - 137,988,495 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	137,979,782 - 137,988,495 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	137,981,521 - 137,990,233 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	137,981,520 - 137,990,233 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	138,422,749 - 138,431,461 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	138,211,348 - 138,220,018 (+)	NCBI		MGSCv36	mm8
Celera	5	134,967,149 - 134,978,633 (+)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	76.92	NCBI

Azgp1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	22,044,685 - 22,051,248 (+)	NCBI		GRCr8
mRatBN7.2	12	16,930,990 - 16,939,333 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	16,931,024 - 16,939,091 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	17,761,589 - 17,767,981 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	18,385,332 - 18,391,726 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	17,438,735 - 17,445,127 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	19,196,565 - 19,203,094 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	19,196,611 - 19,202,647 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	21,255,645 - 21,262,122 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	17,492,913 - 17,498,949 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	17,482,434 - 17,488,471 (+)	NCBI
Celera	12	18,867,978 - 18,873,945 (+)	NCBI		Celera
RH 3.4 Map	12	256.8	RGD
Cytogenetic Map	12	q11	NCBI

Azgp1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955573	899,798 - 912,272 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955573	902,153 - 910,481 (-)	NCBI	ChiLan1.0	ChiLan1.0

LOC100980965
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	117,883,884 - 117,897,021 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	166,148,518 - 166,161,655 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	91,999,717 - 92,009,066 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	105,432,782 - 105,442,219 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	105,432,782 - 105,442,219 (-)	Ensembl	panpan1.1		panPan2

AZGP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	9,622,991 - 9,629,154 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	9,622,992 - 9,629,154 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	11,261,385 - 11,267,549 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	9,560,452 - 9,566,604 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	9,560,452 - 9,566,605 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	9,409,423 - 9,415,561 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	9,389,742 - 9,395,878 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	9,568,881 - 9,575,021 (-)	NCBI		UU_Cfam_GSD_1.0

Azgp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	133,922,347 - 133,930,595 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936543	105,956 - 114,190 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936543	105,983 - 113,475 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AZGP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	13,104,262 - 13,120,329 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	13,104,323 - 13,120,363 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666070	3,149,715 - 3,159,344 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Azgp1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	17,054,221 - 17,063,226 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624740	17,054,221 - 17,062,420 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in AZGP1
330 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
High
Medium								1
Low	7	1	2	4		17	2	2	1
Below cutoff	2	3	1	1	2	5			2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021086185	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK234029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK397571	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK400868	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FP102393	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01016510	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_021086185 ⟹ XP_020941844

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	3	7,867,521 - 7,874,857 (+)	NCBI

Sequence:

show sequence

CACAGACTCCGCCATCTGGGCACCTCTCATTGGCCTGTGGATTCACCACCCCTGGACTGGGCTC
AAAGCCCAGCCATTCCCATAACTACACCTGGCTCGATCTCCACATCATCTGCTCCGAGCTCCAG
GCTCTGGGGAATTCTGGAAACTTCCAGCCAGGGACCGTGGGCACAATGGCACCTGTCCTGCTGC
CCCTGCTGCTCCTTTTGGGCCCTGCAGTCCCCAAGGAGACCCAAACTGGGCCTTACACTCTGAG
CTTCCTCTACACCGGGCTGTCCAGGCCCGGGAAAGGCTTCCCCAGCTTTCAGGCCATGGCCTAC
CTCAATGACCAGCCCTTCTTCCGCTACGAGAGCGATGGCAGGAAGGCTGAGCCCCTGGGCCCCT
GGAGCCAGGTGGAAGGGATGGAGGACTGGGAAAAGGAGAGCGAGCTTCAGAAGGCCAGGGAGGA
CATCTTCATGGCGACCCTGAGAGACATCATGGACTATTACAAGGACAGAGAAGGGTCGCACACC
TTTCAGGGCAGGTTTGGCTGTGAGCTCCGGAACGACCAGCGCCAGGCAGCGTTCTGGAGGTACG
CCTACGACGGTCGCGACTTCATCGAGTTCAACAAAGAAATCCCAGCCTGGGTGGCTCTGGACCC
AGCAGCCGTGAACACCAAGCTGAAGTGGGAGGCCGAAGCGGTCTACGTGCAGCGGGCCAAGGCC
TACCTGGAGGAGGAGTGTCCGGGGATGCTGCGGAGGTACCTGGAACACGGCAGGGGCCACCTGG
ACCAGCAAAGCCCTCCCTCCGTGTCGATCACCCGCCACGTGGCCCCAGGACAGAACGGGACCCT
CAAGTGCCTGGCCTATGACTTCTACCCAGGAAGAATCGGTCTGCGCTGGACTGGCGCTGGTGGA
GCACAAGAGGCTGAGTCTGGGGGAGACGTTCTTCCCAGTGGAAATGGCTCTTACCAGTCCTGGG
TGGTGGTGGGGNGTCCCCCTCAGGACAGAGCCCCTCACTCGTGCCACGTGGAGCACAGCAGCCT
GGCCCAGCCCCTCACTGTCCCTTGGGCAGGGCTGCAAGAACTGAGGGTGGGAGGCAACATTGGG
ACTCCGGCCCAGTAGGTGCCCTTGCTGTGGGACAGGAGCCATGTGAACTCTGGCAATGCCAGCC
AAGGCGAGCAGCCAGGCCCAGGGGGCCGGGGGTGGATTCCCAGAAGAGTGCCAGCACTGGGCAC
CATCACTGCTAAATTGCCTTCCCAAATCCCATTATCTATGTGTAAAATCAATCAGCGGTCATTG
CATGGCCTAGAACACCGTATGTAAAGGATT

hide sequence

Protein Sequences


Protein RefSeqs	XP_020941844	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000056197
	ENSSSCP00000056197.1
	ENSSSCP00000079776.1
	ENSSSCP00035018569.1
	ENSSSCP00045021032.1

RefSeq Acc Id:

XP_020941844 ⟸ XM_021086185

- UniProtKB:

A0A8D1KXS1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAPVLLPLLLLLGPAVPKETQTGPYTLSFLYTGLSRPGKGFPSFQAMAYLNDQPFFRYESDGRK
AEPLGPWSQVEGMEDWEKESELQKAREDIFMATLRDIMDYYKDREGSHTFQGRFGCELRNDQRQ
AAFWRYAYDGRDFIEFNKEIPAWVALDPAAVNTKLKWEAEAVYVQRAKAYLEEECPGMLRRYLE
HGRGHLDQQSPPSVSITRHVAPGQNGTLKCLAYDFYPGRIGLRWTGAGGAQEAESGGDVLPSGN
GSYQSWVVVGXPPQDRAPHSCHVEHSSLAQPLTVPWAGLQELRVGGNIGTPAQ

hide sequence

Protein Domains

Ig-like MHC class I-like antigen recognition-like

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000007642	ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00035035013	UniProtKB/TrEMBL
	ENSSSCG00045017762	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000050499	ENTREZGENE
	ENSSSCT00000050499.2	UniProtKB/TrEMBL
	ENSSSCT00000106721.1	UniProtKB/TrEMBL
	ENSSSCT00035046453.1	UniProtKB/TrEMBL
	ENSSSCT00045030352.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.500.10	UniProtKB/TrEMBL
	Immunoglobulins	UniProtKB/TrEMBL
InterPro	Ig-like_dom	UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	Ig_C1-set	UniProtKB/TrEMBL
	MHC_I-like_Ag-recog	UniProtKB/TrEMBL
	MHC_I-like_Ag-recog_sf	UniProtKB/TrEMBL
	MHC_I/II-like_Ag-recog	UniProtKB/TrEMBL
	MHC_I_a_a1/a2	UniProtKB/TrEMBL
NCBI Gene	AZGP1	ENTREZGENE
PANTHER	MHC CLASS I-RELATED	UniProtKB/TrEMBL
	ZINC-ALPHA-2-GLYCOPROTEIN	UniProtKB/TrEMBL
Pfam	C1-set	UniProtKB/TrEMBL
	MHC_I	UniProtKB/TrEMBL
PRINTS	MHCCLASSI	UniProtKB/TrEMBL
PROSITE	IG_LIKE	UniProtKB/TrEMBL
SMART	IGc1	UniProtKB/TrEMBL
Superfamily-SCOP	Immunoglobulin	UniProtKB/TrEMBL
	SSF54452	UniProtKB/TrEMBL
UniProt	A0A287BJ64_PIG	UniProtKB/TrEMBL
	A0A8D1KXS1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8W4FJY8_PIG	UniProtKB/TrEMBL
VGNC ID	VGNC:85710	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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