SRI (sorcin) - Rat Genome Database

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Gene: SRI (sorcin) Sus scrofa
Analyze
Symbol: SRI
Name: sorcin
RGD ID: 13964092
Description: ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN calcium ion transport (ortholog); heart development (ortholog); ASSOCIATED WITH Cardiomegaly (ortholog); congestive heart failure (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); dendritic spine neck (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl968,490,890 - 68,515,322 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1968,492,235 - 68,515,247 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2974,928,185 - 74,950,459 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:17407547   PMID:22301074   PMID:23764275  


Genomics

Comparative Map Data
SRI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl968,490,890 - 68,515,322 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1968,492,235 - 68,515,247 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2974,928,185 - 74,950,459 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SRI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38788,205,115 - 88,226,976 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl788,205,115 - 88,226,993 (-)EnsemblGRCh38hg38GRCh38
GRCh37787,834,430 - 87,856,291 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36787,672,368 - 87,694,244 (-)NCBINCBI36Build 36hg18NCBI36
Celera782,539,034 - 82,560,910 (-)NCBICelera
Cytogenetic Map7q21.12NCBI
HuRef782,444,285 - 82,466,161 (-)NCBIHuRef
CHM1_1787,764,960 - 87,786,830 (-)NCBICHM1_1
T2T-CHM13v2.0789,455,604 - 89,477,464 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2787,165,789 - 87,187,665 (-)NCBI
Sri
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3958,096,078 - 8,119,314 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl58,096,078 - 8,119,379 (+)EnsemblGRCm39 Ensembl
GRCm3858,046,078 - 8,069,314 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl58,046,078 - 8,069,379 (+)EnsemblGRCm38mm10GRCm38
MGSCv3758,046,080 - 8,069,245 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3658,052,084 - 8,073,860 (+)NCBIMGSCv36mm8
Celera57,979,518 - 8,002,729 (+)NCBICelera
Cytogenetic Map5A1NCBI
cM Map53.38NCBI
Sri
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8426,928,338 - 26,952,980 (-)NCBIGRCr8
mRatBN7.2425,973,493 - 25,997,879 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl425,966,750 - 25,998,077 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx430,960,404 - 30,973,377 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0426,886,620 - 26,899,593 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0425,263,902 - 25,276,454 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0423,004,657 - 23,029,233 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl423,006,243 - 23,018,983 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0422,937,276 - 22,962,347 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera421,457,445 - 21,469,637 (-)NCBICelera
Cytogenetic Map4q12NCBI
Sri
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554325,541,311 - 5,560,294 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554325,541,311 - 5,559,781 (-)NCBIChiLan1.0ChiLan1.0
SRI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26106,086,942 - 106,101,957 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17154,351,580 - 154,366,595 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0780,199,719 - 80,214,733 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1793,849,129 - 93,864,088 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl793,850,496 - 93,864,029 (-)Ensemblpanpan1.1panPan2
SRI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11414,257,375 - 14,274,816 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1414,260,052 - 14,274,801 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1413,829,493 - 13,846,925 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01414,022,300 - 14,039,737 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1414,020,645 - 14,039,218 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11414,232,295 - 14,250,007 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01413,951,888 - 13,969,513 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01414,237,364 - 14,255,079 (-)NCBIUU_Cfam_GSD_1.0
Sri
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511827,273,150 - 27,285,562 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936763710,777 - 730,276 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936763715,884 - 728,548 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12160,730,164 - 60,751,054 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2160,730,051 - 60,749,678 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604243,353,983 - 43,369,330 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sri
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248095,160,737 - 5,191,514 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248095,160,731 - 5,187,914 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SRI
908 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 2 3 5 23 2 3 3
Low 2 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001244142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001244143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002346923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK231770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK345103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK392529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK395791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK398866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK400616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK400684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU695059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB811366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB816310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EW289129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EW326025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EW412279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EW520500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01040278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000016669   ⟹   ENSSSCP00000016223
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl968,493,008 - 68,508,867 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000040301   ⟹   ENSSSCP00000046442
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl968,493,042 - 68,515,247 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000072583   ⟹   ENSSSCP00000062320
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl968,495,815 - 68,515,322 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000104061   ⟹   ENSSSCP00000080039
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl968,490,890 - 68,515,184 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000105238   ⟹   ENSSSCP00000076886
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl968,490,890 - 68,508,853 (-)Ensembl
RefSeq Acc Id: NM_001244142   ⟹   NP_001231071
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1968,493,018 - 68,508,868 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001244143   ⟹   NP_001231072
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1968,493,018 - 68,515,247 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002346923
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1968,492,235 - 68,508,907 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001231072   ⟸   NM_001244143
- Peptide Label: isoform 2
- UniProtKB: A0A287AR67 (UniProtKB/TrEMBL),   A0A5G2QF28 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001231071   ⟸   NM_001244142
- Peptide Label: isoform 1
- UniProtKB: F1S340 (UniProtKB/TrEMBL),   A0A8D1AZ45 (UniProtKB/TrEMBL),   A0A5G2QF28 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000046442   ⟸   ENSSSCT00000040301
RefSeq Acc Id: ENSSSCP00000016223   ⟸   ENSSSCT00000016669
RefSeq Acc Id: ENSSSCP00000062320   ⟸   ENSSSCT00000072583
RefSeq Acc Id: ENSSSCP00000080039   ⟸   ENSSSCT00000104061
RefSeq Acc Id: ENSSSCP00000076886   ⟸   ENSSSCT00000105238
Protein Domains
EF-hand


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000015298 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005000493 UniProtKB/TrEMBL
  ENSSSCG00035064231 UniProtKB/TrEMBL
  ENSSSCG00040022668 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000040301 ENTREZGENE
  ENSSSCT00000040301.2 UniProtKB/TrEMBL
  ENSSSCT00000072583.1 UniProtKB/TrEMBL
  ENSSSCT00000104061.1 UniProtKB/TrEMBL
  ENSSSCT00000105238 ENTREZGENE
  ENSSSCT00000105238.1 UniProtKB/TrEMBL
  ENSSSCT00005000643.1 UniProtKB/TrEMBL
  ENSSSCT00035086453.1 UniProtKB/TrEMBL
  ENSSSCT00040030718.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.900 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
KEGG Report ssc:100514123 UniProtKB/TrEMBL
NCBI Gene SRI ENTREZGENE
PANTHER CALPAIN, SMALL SUBUNIT 1 A-RELATED UniProtKB/TrEMBL
  SORCIN UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/TrEMBL
  EF-hand_8 UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0A287AR67 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UFQ4_PIG UniProtKB/TrEMBL
  A0A5G2QF28 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1AZ45 ENTREZGENE, UniProtKB/TrEMBL
  F1S340 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A8W4FL23 UniProtKB/TrEMBL
VGNC ID VGNC:93457 ENTREZGENE