IL21 (interleukin 21) - Rat Genome Database

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Gene: IL21 (interleukin 21) Sus scrofa
Analyze
Symbol: IL21
Name: interleukin 21
RGD ID: 14161755
Description: ENCODES a protein that exhibits cytokine activity (inferred); cytokine receptor binding (inferred); interleukin-2 receptor binding (inferred); INVOLVED IN cellular response to virus (ortholog); germinal center B cell differentiation (ortholog); positive regulation of immunoglobulin production (ortholog); ASSOCIATED WITH Acute-On-Chronic Liver Failure (ortholog); Animal Toxoplasmosis (ortholog); anogenital venereal wart (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: IL-21; interleukin-21
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8101,532,531 - 101,541,713 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18101,532,742 - 101,540,712 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28108,688,772 - 108,696,742 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 44 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
IL21PigAcute-On-Chronic Liver Failure amelioratesISOIL21 (Homo sapiens)9068941associated with Chronic Hepatitis B and protein:decreased expression:blood serum (human)RGDPMID:21692955 and REF_RGD_ID:127285541
IL21PigAnimal Toxoplasmosis  ISOIl21 (Mus musculus)9068941 RGDPMID:23667536 and REF_RGD_ID:127285360
IL21Piganogenital venereal wart  ISOIL21 (Homo sapiens)9068941protein:decreased expression:blood serum (human)RGDPMID:31414711 and REF_RGD_ID:127285371
IL21PigArenaviridae infectious disease  ISOIl21 (Mus musculus)9068941 RGDPMID:21423809 and REF_RGD_ID:127285543
IL21Pigasthma  ISOIL21 (Homo sapiens)9068941DNA:SNP:exon:5250C>T (human)RGDPMID:18802358 and REF_RGD_ID:5147396
IL21Pigautoimmune hepatitis exacerbatesISOIL21 (Homo sapiens)9068941protein:increased expression:blood serum and peripheral blood mononuclear cell (human)RGDPMID:27386263 and REF_RGD_ID:127285554
IL21Pigceliac disease susceptibilityISOIL21 (Homo sapiens)9068941protein:increased expression:blood serum (human)RGDPMID:22077623 and REF_RGD_ID:127285362
IL21PigChronic Hepatitis B exacerbatesISOIL21 (Homo sapiens)9068941protein:increased expression:blood serum (human)RGDPMID:25243706 and REF_RGD_ID:127285378
IL21PigChronic Hepatitis B treatmentISOIL21 (Homo sapiens)9068941DNA:SNPs:introns: (rs2221903 and rs907715) (human)RGDPMID:29879024 and REF_RGD_ID:127285539
IL21PigChronic Hepatitis B susceptibilityISOIL21 (Homo sapiens)9068941DNA:SNP:intron: (rs2221903) (human)RGDPMID:23354321 and REF_RGD_ID:127285353
IL21PigChronic Hepatitis B exacerbatesISOIL21 (Homo sapiens)9068941protein:decreased expression:blood serum (human)RGDPMID:28500636 and REF_RGD_ID:127285361
IL21PigChronic Hepatitis B treatmentISOIL21 (Homo sapiens)9068941associated with non-alcoholic fatty liver diseaseRGDPMID:26840345 and REF_RGD_ID:127285549
IL21PigChronic Hepatitis B treatmentISOIl21 (Mus musculus)9068941 RGDPMID:30260401 more ...
IL21PigChronic Hepatitis C amelioratesISOIL21 (Homo sapiens)9068941protein:increased expression:liver more ...RGDPMID:24170093 and REF_RGD_ID:127285373
IL21Pigcolon adenocarcinoma treatmentISOIl21 (Mus musculus)9068941 RGDPMID:17695518 and REF_RGD_ID:127285540
IL21PigColorectal Neoplasms  ISOIL21 (Homo sapiens)9068941protein:decreased expression:colorectum (human)RGDPMID:28483840 and REF_RGD_ID:127285377
IL21Pigdengue hemorrhagic fever severityISOIL21 (Homo sapiens)9068941protein:increased expression:blood serum (human)RGDPMID:24858204 and REF_RGD_ID:127285368
IL21PigDysbiosis treatmentISOIl21 (Rattus norvegicus)9068941 RGDPMID:32227764 and REF_RGD_ID:38549571
IL21Pigencephalitozoonosis  ISOIl21 (Mus musculus)9068941protein:increased expression:CD4-positive helper T cell (mouse)RGDPMID:26597007 and REF_RGD_ID:11086452
IL21PigExperimental Autoimmune Encephalomyelitis  ISOIl21 (Rattus norvegicus)9068941 RGDPMID:18997868 and REF_RGD_ID:5147399
1 to 20 of 44 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
IL21Pigcommon variable immunodeficiency  ISOIL21 (Homo sapiens)8554872ClinVar Annotator: match by term: IL21 DEFICIENCYClinVarPMID:24033266 more ...
IL21Pigcommon variable immunodeficiency 11  ISOIL21 (Homo sapiens)8554872ClinVar Annotator: match by term: Common variable immunodeficiency 11ClinVarPMID:24033266 more ...
IL21Pigneurodevelopmental disorder with hearing loss, seizures, and brain abnormalities  ISOIL21 (Homo sapiens)8554872ClinVar Annotator: match by term: NEURODEVELOPMENTAL DISORDER WITH HEARING LOSS more ...ClinVarPMID:28492532
IL21PigNeurodevelopmental Disorders  ISOIL21 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
IL21Pigceliac disease  ISOIL21 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:17558408
IL21Pigsystemic lupus erythematosus  ISOIL21 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:17911475
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
IL21Pigcommon variable immunodeficiency 11  ISOIL21 (Homo sapiens)7240710 OMIM 


  
Object Symbol
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Term
Qualifier
Evidence
With
Reference
Notes
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Original Reference(s)
IL21Pigdeoxynivalenol increases expressionEXP 6480464deoxynivalenol results in increased expression of IL21 mRNACTDPMID:23326479


Biological Process
1 to 20 of 30 rows

  
Object Symbol
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Reference
Notes
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Original Reference(s)
IL21Pigcell maturation involved_inIEAUniProtKB:Q9HBE4 and ensembl:ENSP00000497915150520179 EnsemblGO_REF:0000107
IL21Pigcellular response to virus involved_inIEAUniProtKB:Q9ES17 and ensembl:ENSMUSP00000029273150520179 EnsemblGO_REF:0000107
IL21Pigcellular response to virus involved_inISSUniProtKB:Q9ES17150520179 UniProtGO_REF:0000024
IL21Piggerminal center B cell differentiation involved_inIEAUniProtKB:Q9ES17 and ensembl:ENSMUSP00000029273150520179 EnsemblGO_REF:0000107
IL21Piggerminal center B cell differentiation involved_inISSUniProtKB:Q9ES17150520179 UniProtGO_REF:0000024
IL21Pigimmune response involved_inIEAInterPro:IPR003443150520179 InterProGO_REF:0000002
IL21Pignatural killer cell differentiation acts_upstream_ofIEAUniProtKB:Q9ES17 and ensembl:ENSMUSP00000029273150520179 EnsemblGO_REF:0000107
IL21Pignatural killer cell mediated cytotoxicity acts_upstream_ofIEAUniProtKB:Q9ES17 and ensembl:ENSMUSP00000029273150520179 EnsemblGO_REF:0000107
IL21Pigpositive regulation of B cell proliferation acts_upstream_of_or_withinIEAUniProtKB:Q9HBE4 and ensembl:ENSP00000497915150520179 EnsemblGO_REF:0000107
IL21Pigpositive regulation of cell population proliferation acts_upstream_of_or_withinIEAUniProtKB:Q9HBE4 and ensembl:ENSP00000497915150520179 EnsemblGO_REF:0000107
IL21Pigpositive regulation of cytokine production involved_inIEAUniProtKB:Q9HBE4 and ensembl:ENSP00000497915150520179 EnsemblGO_REF:0000107
IL21Pigpositive regulation of cytokine production involved_inIBAMGI:1890474 more ...150520179 GO_CentralGO_REF:0000033
IL21Pigpositive regulation of immunoglobulin production involved_inIEAUniProtKB:Q9ES17 and ensembl:ENSMUSP00000029273150520179 EnsemblGO_REF:0000107
IL21Pigpositive regulation of immunoglobulin production involved_inISSUniProtKB:Q9ES17150520179 UniProtGO_REF:0000024
IL21Pigpositive regulation of interleukin-10 production acts_upstream_of_or_withinIEAUniProtKB:Q9ES17 and ensembl:ENSMUSP00000029273150520179 EnsemblGO_REF:0000107
IL21Pigpositive regulation of interleukin-17 production involved_inIEAUniProtKB:Q9HBE4 and ensembl:ENSP00000497915150520179 EnsemblGO_REF:0000107
IL21Pigpositive regulation of natural killer cell cytokine production acts_upstream_of_or_withinIEAUniProtKB:Q9ES17 and ensembl:ENSMUSP00000029273150520179 EnsemblGO_REF:0000107
IL21Pigpositive regulation of natural killer cell differentiation acts_upstream_of_or_withinIEAUniProtKB:Q9ES17 and ensembl:ENSMUSP00000029273150520179 EnsemblGO_REF:0000107
IL21Pigpositive regulation of natural killer cell mediated cytotoxicity involved_inIEAUniProtKB:Q9HBE4 and ensembl:ENSP00000497915150520179 EnsemblGO_REF:0000107
IL21Pigpositive regulation of natural killer cell mediated cytotoxicity involved_inIBAMGI:1890474 more ...150520179 GO_CentralGO_REF:0000033
1 to 20 of 30 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
IL21Pigextracellular region located_inIEAUniProtKB-SubCell:SL-0243150520179 UniProtGO_REF:0000044
IL21Pigextracellular region located_inIEAInterPro:IPR003443150520179 InterProGO_REF:0000002
IL21Pigextracellular region located_inIEAUniProtKB-KW:KW-0964150520179 UniProtGO_REF:0000043
IL21Pigextracellular space located_inIEAUniProtKB-KW:KW-0202150520179 UniProtGO_REF:0000043

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
IL21Pigcytokine activity enablesIEAUniProtKB-KW:KW-0202150520179 UniProtGO_REF:0000043
IL21Pigcytokine receptor binding enablesIEAUniProtKB:Q9ES17 and ensembl:ENSMUSP00000029273150520179 EnsemblGO_REF:0000107
IL21Pigcytokine receptor binding enablesIEAInterPro:IPR003443150520179 InterProGO_REF:0000002
IL21Piginterleukin-2 receptor binding enablesIEAUniProtKB:Q9HBE4 and ensembl:ENSP00000497915150520179 EnsemblGO_REF:0000107
IL21Pigprotein binding enablesISOUniProtKB:Q12797-69068941 PMID:32296183IntActPMID:32296183

PMID:12969638   PMID:15107555   PMID:22301074   PMID:30032202  



IL21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8101,532,531 - 101,541,713 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18101,532,742 - 101,540,712 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28108,688,772 - 108,696,742 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384122,610,108 - 122,621,066 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4122,610,108 - 122,621,066 (-)EnsemblGRCh38hg38GRCh38
GRCh374123,531,263 - 123,542,221 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364123,739,272 - 123,761,662 (-)NCBINCBI36Build 36hg18NCBI36
Build 344123,891,388 - 123,899,817NCBI
Celera4120,916,832 - 120,925,261 (-)NCBICelera
Cytogenetic Map4q27NCBI
HuRef4119,260,228 - 119,268,550 (-)NCBIHuRef
CHM1_14123,510,250 - 123,518,679 (-)NCBICHM1_1
T2T-CHM13v2.04125,914,209 - 125,925,168 (-)NCBIT2T-CHM13v2.0
Il21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39337,276,908 - 37,286,785 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl337,276,908 - 37,286,785 (-)EnsemblGRCm39 Ensembl
GRCm38337,222,759 - 37,232,636 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl337,222,759 - 37,232,636 (-)EnsemblGRCm38mm10GRCm38
MGSCv37337,121,681 - 37,131,540 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36337,107,141 - 37,117,000 (-)NCBIMGSCv36mm8
MGSCv36337,414,308 - 37,424,167 (-)NCBIMGSCv36mm8
Celera337,106,874 - 37,116,609 (-)NCBICelera
Cytogenetic Map3BNCBI
cM Map318.36NCBI
Il21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82122,045,240 - 122,055,142 (-)NCBIGRCr8
mRatBN7.22120,117,105 - 120,127,012 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2120,119,444 - 120,126,996 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2126,682,458 - 126,689,816 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02124,794,962 - 124,802,318 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02119,423,940 - 119,431,294 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02123,965,021 - 123,972,356 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2123,965,021 - 123,972,356 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02143,573,215 - 143,580,530 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42123,774,331 - 123,781,697 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12123,697,822 - 123,750,231 (-)NCBI
Celera2115,067,969 - 115,075,326 (-)NCBICelera
Cytogenetic Map2q25NCBI
Il21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542818,057,096 - 18,065,492 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542818,057,096 - 18,065,492 (+)NCBIChiLan1.0ChiLan1.0
IL21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23120,394,845 - 120,405,796 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14120,660,750 - 120,671,701 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04114,795,979 - 114,806,936 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14125,940,979 - 125,951,915 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4125,943,495 - 125,951,915 (-)Ensemblpanpan1.1panPan2
IL21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11917,641,833 - 17,651,275 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1917,641,833 - 17,651,266 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1917,860,011 - 17,869,452 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01917,760,158 - 17,769,609 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1917,760,158 - 17,769,600 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11917,712,780 - 17,722,226 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01917,993,018 - 18,002,469 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01918,463,313 - 18,472,753 (+)NCBIUU_Cfam_GSD_1.0
Il21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530165,422,896 - 65,429,900 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366621,689,879 - 1,696,883 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366621,689,879 - 1,696,883 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1769,859,793 - 69,872,237 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl769,863,535 - 69,872,025 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603748,822,863 - 48,834,392 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247773,054,368 - 3,061,304 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247773,054,368 - 3,061,304 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in IL21
167 total Variants



alimentary part of gastrointestinal system
circulatory system
ectoderm
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
8 2 5 2 5 7 5 5 1 3



Ensembl Acc Id: ENSSSCT00000009953   ⟹   ENSSSCP00000009696
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8101,530,949 - 101,540,713 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000043075   ⟹   ENSSSCP00000043300
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8101,532,531 - 101,541,713 (+)Ensembl
RefSeq Acc Id: NM_214415   ⟹   NP_999580
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18101,532,742 - 101,540,712 (+)NCBI
Sequence:
Protein RefSeqs NP_999580 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAD11128 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000043300
GenBank Protein Q76LU6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_999580   ⟸   NM_214415
- Peptide Label: precursor
- UniProtKB: Q76LU6 (UniProtKB/Swiss-Prot),   A0A8D0XZR7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000009696   ⟸   ENSSSCT00000009953
Ensembl Acc Id: ENSSSCP00000043300   ⟸   ENSSSCT00000043075



1 to 17 of 17 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSSSCG00000009087 Ensembl, ENTREZGENE
Ensembl Transcript ENSSSCT00000043075 ENTREZGENE
Gene3D-CATH 1.20.1250.70 UniProtKB/Swiss-Prot
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  IL-15/IL-21_fam UniProtKB/Swiss-Prot
KEGG Report ssc:403123 UniProtKB/Swiss-Prot
NCBI Gene IL21 ENTREZGENE
PANTHER INTERLEUKIN-21 UniProtKB/Swiss-Prot
  PTHR14356 UniProtKB/Swiss-Prot
Pfam IL15 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot
UniProt A0A287AHG3_PIG UniProtKB/TrEMBL
  A0A8D0KCY2_PIG UniProtKB/TrEMBL
  A0A8D0PYJ9_PIG UniProtKB/TrEMBL
  A0A8D0XZR7 ENTREZGENE, UniProtKB/TrEMBL
  IL21_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:98936 ENTREZGENE
1 to 17 of 17 rows