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Gene: Il21 (interleukin 21) Mus musculus
Symbol: Il21
Name: interleukin 21
RGD ID: 1316554
Description: Exhibits cytokine receptor binding activity. Involved in several processes, including lymphocyte activation involved in immune response; positive regulation of cytokine production; and positive regulation of natural killer cell differentiation. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in asthma and common variable immunodeficiency. Orthologous to human IL21 (interleukin 21); PARTICIPATES IN Jak-Stat signaling pathway; INTERACTS WITH 1-chloro-2,4-dinitrobenzene; alpha-hexylcinnamaldehyde; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: IL-21; interleukin-21
Homo sapiens (human) : IL21 (interleukin 21)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Il21 (interleukin 21)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il21 (interleukin 21)
Pan paniscus (bonobo/pygmy chimpanzee) : IL21 (interleukin 21)
Canis lupus familiaris (dog) : IL21 (interleukin 21)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il21 (interleukin 21)
Sus scrofa (pig) : IL21 (interleukin 21)
Chlorocebus sabaeus (African green monkey) : IL21 (interleukin 21)
Heterocephalus glaber (naked mole-rat) : Il21 (interleukin 21)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39337,276,908 - 37,286,785 (-)NCBI
GRCm38337,222,759 - 37,232,636 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl337,222,759 - 37,232,636 (-)EnsemblGRCm38mm10GRCm38
MGSCv37337,121,681 - 37,131,540 (-)NCBIGRCm37mm9NCBIm37
MGSCv36337,414,308 - 37,424,167 (-)NCBImm8
MGSCv36337,107,141 - 37,117,000 (-)NCBImm8
Celera337,106,874 - 37,116,609 (-)NCBICelera
Cytogenetic Map3BNCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Il21
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1316554
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.